Keywords: 99mtc-Mibi, Apoptosis, Breast Cancer, Multidrug Resistance, Proliferation, Abc Transporter, Antineoplastic Agent, Biochemical Marker, Cation, Furifosmin Tc 99m, Glycoprotein P, Methoxy Isobutyl Isonitrile Technetium Tc 99m, Molecular Marker, Tetrofosmin Tc 99m, Diagnostic Agent, Radiopharmaceutical Agent, Tumor Marker, Cell Proliferation, Diagnostic Imaging, Drug Clearance, Drug Response, Drug Transport, Drug Uptake, Histology, Human, Image Analysis, Mitochondrion, Nuclear Medicine, Protein Expression, Review, Scintimammography, Treatment Failure, Tumor Growth, Tumor Vascularization, Animal, Breast Tumor, Laboratory Diagnosis, Metabolism, Neovascularization (pathology), Reproducibility, Scintiscanning, Sensitivity And Specificity, Breast Neoplasms, False Negative Reactions, False Positive Reactions, P-Glycoprotein, Reproducibility Of Results, Technetium Tc 99m Sestamibi, Biological,
Affiliations: *** IBB - CNR ***
Inst. of Biostructures and Bioimages, National Research Council (CNR), Naples, Italy
Dept. Biomorphological/Funct. Sci., University Federico II, Naples, Italy
References: Not available.
Tc-99m-MIBI in the evaluation of breast cancer biology
A major area of interest in nuclear medicine is the scintigraphic in vivo evaluation of complex cellular processes involved in tumour growth, progression and response to treatment with the aim of defining the biological properties that may orient clinicians towards different adjustments of therapy in individual patients. In the last decade, (99m) Tc-labelled lipophilic cations emerged as suitable tools to trace specific cellular processes and functions in a variety of malignant tumours, including breast cancer. Among these agents, (99m) Tc-methoxyisobutylisonitrile (MIBI) is the most widely evaluated tracer and may serve as a paradigm for this class of compounds. Many clinical studies have been performed to correlate (99m) Tc-MIBI uptake or clearance with histological, molecular and biochemical markers of various cellular processes, including apoptosis, proliferation, P-glycoprotein expression and neoangiogenesis. The final picture emerging from these studies is that the early tracer uptake reflects the mitochondrial status, which is affected by both apoptosis and proliferation, whereas the tracer clearance reflects the activity of drug transporters such as P-glycoprotein. On the basis of the imaging parameter chosen for the analysis of (99m) Tc-MIBI scan in breast cancer patients, the biological information provided may be related to different cellular processes that ultimately govern tumour response to treatment
Tc-99m-MIBI in the evaluation of breast cancer biology
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Cusanno F, Cisbani E, Colilli S, Fratoni R, Garibaldi F, Giuliani F, Gricia M, Lucentini M, Magliozzi ML, Santarivenere F, Torrioli S, Cinti MN, Pani R, Pellegrini R, Simonetti G, Schillaci O, Del Vecchio S, Salvatore M, Majewski S, De Vincentis G, Scopinaro F * Results of clinical trials with SPEM(340 views) Nucl Instrum Methods Phys Res Sect A, 2007 Feb 1; 497(1): 46-50. Impact Factor:3.221 ViewExport to BibTeXExport to EndNote