Ige-Binding Properties And Selectivity Of Peptide Mimics Of The Fcvarepsilonri Binding Site (1651 views)
Mol Immunol (ISSN: 0161-5890), 2009 Oct; 46(16): 3300-3309.
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Paper type: Journal Article,
Impact factor: 3.202, 5-year impact factor: 3.233
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-70349462818&partnerID=40&md5=ab53eae058bf0892271e8cd9906a2822
Keywords: Elisa, Fcεri, Peptide Mimics, Fc Receptor, Immunoglobulin A, Immunoglobulin E Receptor, Immunoglobulin E Trap, Polypeptide, Unclassified Drug, Animal Cell, Article, Binding Affinity, Binding Competition, Binding Site, Biotinylation, Concentration Response, Controlled Study, Enzyme Linked Immunosorbent Assay, Flow Cytometry, Immunoglobulin Production, Nonhuman, Peptide Synthesis, Priority Journal, Protein Binding, Protein Domain, Surface Plasmon Resonance, Cell Line, Hypersensitivity, Ligands, Protein Structure, Secondary, Tertiary,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone 16, 80134 Napoli, Italy
Dipartimento delle Scienze Biologiche, Università di Napoli Federico II, via Mezzocannone 16, 80134 Napoli, Italy
References:
Ames, S.A., Gleeson, C.D., Kirkpatrick, P., Omalizumab (2004) Nat. Rev. Drug Discov., 3, pp. 199-20
Basu, M., Hakimi, J., Dharm, E., Kondas, J.A., Tsien, W.H., Pilson, R.S., Lin, P., Braswell, E.H., Purification and characterization of human recombinant IgE-Fc fragments that bind to the human high affinity IgE receptor (1993) J. Biol. Chem., 268, pp. 13118-13127
Buku, A., Condie, B.A., Price, J.A., Mezei, M., [Ala12]MCD peptide: a lead peptide to inhibitors of immunoglobulin E binding to mast cell receptors (2005) J. Pept. Res., 66, pp. 132-137
Buku, A., Keselman, I., Lupyan, D., Mezei, M., Price, J.A., Effective mast cell degranulating peptide inhibitors of the IgE/Fc epsilonRI receptor interaction (2008) Chem. Biol. Drug Des., 72, pp. 133-139
Buku, A., Mendlowitz, M., Condie, B.A., Price, J.A., Histamine-releasing activity and binding to the FcepsilonRI alpha human mast cell receptor subunit of mast cell degranulating peptide analogues with alanine substitutions (2003) J. Med. Chem., 46, pp. 3008-3012
Buku, A., Price, J.A., Mendlowitz, M., Masur, S., Mast cell degranulating peptide binds to RBL-2H3 mast cell receptors and inhibits IgE binding (2001) Peptides, 22, pp. 1993-1998
Cook, J.P., Henry, A.J., McDonnell, J.M., Owens, R.J., Sutton, B.J., Gould, H.J., Identification of contact residues in the IgE binding site of human FcepsilonRIalpha (1997) Biochemistry, 36, pp. 15579-15588
Cookson, W., The alliance of gene and environmental in asthma and allergy (1999) Nature, 402, pp. 5-11
Corren, J., Casale, T.B., Lanier, B., Buhl, R., Holgate, S., Jimenez, P., Safety and tolerability of omalizumab (2009) Clin. Exp. Allergy
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Garman, S.C., Kinet, J.P., Jardetzky, T.S., Crystal structure of the human high-affinity IgE receptor (1998) Cell, 95, pp. 951-961
Garman, S.C., Sechi, S., Kinet, J.P., Jardetzky, T.S., The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms (2001) J. Mol. Biol., 311, pp. 1049-1062
Garman, S.C., Wurzburg, B.A., Tarchevskaya, S.S., Kinet, J.P., Jardetzky, T.S., Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha (2000) Nature, 406, pp. 259-266
Henry, A.J., Cook, J.P., McDonnell, J.M., Mackay, G.A., Shi, J., Sutton, B.J., Gould, H.J., Participation of the N-terminal region of Cepsilon3 in the binding of human IgE to its high-affinity receptor FcepsilonRI (1997) Biochemistry, 36, pp. 15568-15578
Jardieu, P., Anti-IgE therapy (1995) Curr. Opin. Immunol., 7, pp. 779-782
Johnsosson, B., Lofas, S., Lindquist, G., Immobilization of protein to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in SPR sensor (1991) Anal. Biochem., 198, pp. 268-277
Kinet, J.P., The high-affinity receptor for IgE (1989) Curr. Opin. Immunol., 2, pp. 499-505
Kochan, J., Pettine, L.F., Hakimi, J., Kishi, K., Kinet, J.P., Isolation of the gene coding for the alpha subunit of the human high affinity IgE receptor (1988) Nucleic Acids Res., 16, p. 3584
Kraft, S., Kinet, J.P., New developments in FcepsilonRI regulation, function and inhibition (2007) Nat. Rev. Immunol., 5, pp. 365-378
Letourneur, O., Sechi, S., Willette-Brown, J., Robertson, M.W., Kinet, J.P., Glycosylation of human truncated Fc epsilon RI α chain is necessary for efficient folding in the endoplasmic reticulum (1995) J. Biol. Chem., 270, pp. 8249-8256
MacGlashan Jr., D., Therapeutic efficacy of omalizumab (2009) J. Allergy Clin. Immunol., 123, pp. 114-115
McDonnell, J.M., Beavil, A.J., Mackay, G.A., Henry, A.J., Cook, J.P., Gould, H.J., Sutton, B.J., Structure-based design of peptides that inhibit IgE binding to its high-affinity receptor Fc epsilon RI (1997) Biochem. Soc. Trans., 25, pp. 387-392
McDonnell, J.M., Calvert, R., Beavil, R.L., Beavil, A.J., Henry, A.J., Sutton, B.J., Gould, H.J., Cowburn, D., The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha (2001) Nat. Struct. Biol., 8, pp. 437-441
Meltzer, E.O., Grant, J.A., Impact of cetirizine on the burden of allergic rhinitis (1999) Ann. Allergy Asthma Immunol., 83, pp. 455-463
Metzger, H., Kinet, J.P., Blank, U., Miller, L., Ra, C., The receptor with high affinity for IgE (1989) Ciba Found. Symp., 147, pp. 93-101. , (Discussion 101-13)
Nakamura, G.R., Reynolds, M.E., Chen, Y.M., Starovasnik, M.A., Lowman, H.B., Stable "zeta" peptides that act as potent antagonists of the high-affinity IgE receptor (2002) Proc. Natl. Acad. Sci. U.S.A., 99, pp. 1303-1308
Nakamura, G.R., Starovasnik, M.A., Reynolds, M.E., Lowman, H.B., A novel family of hairpin peptides that inhibit IgE activity by binding to the high-affinity IgE receptor (2001) Biochemistry, 40, pp. 9828-9835
Rigby, L.J., Epa, V.C., Mackay, G.A., Hulett, M.D., Sutton, B.J., Gould, H.J., Hogarth, P.M., Domain one of the high affinity IgE receptor, FcepsilonRI, regulates binding to IgE through its interface with domain two (2000) J. Biol. Chem., 275, pp. 9664-9672
Rigby, L.J., Trist, H., Snider, J., Hulett, M.D., Hogarth, P.M., Epa, V.C., Monoclonal antibodies and synthetic peptides define the active site of FcepsilonRI and a potential receptor antagonist (2000) Allergy, 55, pp. 609-619
Rossi, M., Ruvo, M., Marasco, D., Colombo, M., Cassani, G., Verdoliva, A., Anti-allergic properties of a new all-D synthetic immunoglobulin-binding peptide (2008) Mol. Immunol., 45, pp. 226-234
Scharenberg, A.M., Lin, S., Cuenod, B., Yamamura, H., Kinet, J.P., Reconstitution of interactions between tyrosine kinases and the high affinity IgE receptor which are controlled by receptor clustering (1995) Embo J., 14, pp. 3385-3394
Stamos, J., Eigenbrot, C., Nakamura, G.R., Reynolds, M.E., Yin, J., Lowman, H.B., Fairbrother, W.J., Starovasnik, M.A., Convergent recognition of the IgE binding site on the high-affinity IgE receptor (2004) Structure, 12, pp. 1289-1301
Turner, H., Kinet, J.P., Signalling through the high-affinity IgE receptor Fc epsilonRI (1999) Nature, 402, pp. B24-30
Vangelista, L., Cesco-Gaspere, M., Lamba, D., Burrone, O., Efficient folding of the Fc1RI α-chain membrane proximal domain D2 depends on the presence of the N-terminal domain D1 (2002) J. Mol. Biol., 322, pp. 815-825
Wan, T., Beavil, R.L., Fabiane, S.M., Beavil, A.J., Sohi, M.K., Keown, M., Young, R.J., Sutton, B.J., The crystal structure of IgE Fc reveals an asymmetrically bent conformation (2002) Nat. Immunol., 3, pp. 681-686
Ames, S. A., Gleeson, C. D., Kirkpatrick, P., Omalizumab (2004) Nat. Rev. Drug Discov., 3, pp. 199-20
Cook, J. P., Henry, A. J., McDonnell, J. M., Owens, R. J., Sutton, B. J., Gould, H. J., Identification of contact residues in the IgE binding site of human FcepsilonRIalpha (1997) Biochemistry, 36, pp. 15579-15588
Fields, G. B., Noble, R. L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Garman, S. C., Kinet, J. P., Jardetzky, T. S., Crystal structure of the human high-affinity IgE receptor (1998) Cell, 95, pp. 951-961
Garman, S. C., Sechi, S., Kinet, J. P., Jardetzky, T. S., The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms (2001) J. Mol. Biol., 311, pp. 1049-1062
Garman, S. C., Wurzburg, B. A., Tarchevskaya, S. S., Kinet, J. P., Jardetzky, T. S., Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha (2000) Nature, 406, pp. 259-266
Henry, A. J., Cook, J. P., McDonnell, J. M., Mackay, G. A., Shi, J., Sutton, B. J., Gould, H. J., Participation of the N-terminal region of Cepsilon3 in the binding of human IgE to its high-affinity receptor FcepsilonRI (1997) Biochemistry, 36, pp. 15568-15578
Kinet, J. P., The high-affinity receptor for IgE (1989) Curr. Opin. Immunol., 2, pp. 499-505
McDonnell, J. M., Beavil, A. J., Mackay, G. A., Henry, A. J., Cook, J. P., Gould, H. J., Sutton, B. J., Structure-based design of peptides that inhibit IgE binding to its high-affinity receptor Fc epsilon RI (1997) Biochem. Soc. Trans., 25, pp. 387-392
McDonnell, J. M., Calvert, R., Beavil, R. L., Beavil, A. J., Henry, A. J., Sutton, B. J., Gould, H. J., Cowburn, D., The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha (2001) Nat. Struct. Biol., 8, pp. 437-441
Meltzer, E. O., Grant, J. A., Impact of cetirizine on the burden of allergic rhinitis (1999) Ann. Allergy Asthma Immunol., 83, pp. 455-463
Nakamura, G. R., Reynolds, M. E., Chen, Y. M., Starovasnik, M. A., Lowman, H. B., Stable "zeta" peptides that act as potent antagonists of the high-affinity IgE receptor (2002) Proc. Natl. Acad. Sci. U. S. A., 99, pp. 1303-1308
Nakamura, G. R., Starovasnik, M. A., Reynolds, M. E., Lowman, H. B., A novel family of hairpin peptides that inhibit IgE activity by binding to the high-affinity IgE receptor (2001) Biochemistry, 40, pp. 9828-9835
Rigby, L. J., Epa, V. C., Mackay, G. A., Hulett, M. D., Sutton, B. J., Gould, H. J., Hogarth, P. M., Domain one of the high affinity IgE receptor, FcepsilonRI, regulates binding to IgE through its interface with domain two (2000) J. Biol. Chem., 275, pp. 9664-9672
Rigby, L. J., Trist, H., Snider, J., Hulett, M. D., Hogarth, P. M., Epa, V. C., Monoclonal antibodies and synthetic peptides define the active site of FcepsilonRI and a potential receptor antagonist (2000) Allergy, 55, pp. 609-619
Scharenberg, A. M., Lin, S., Cuenod, B., Yamamura, H., Kinet, J. P., Reconstitution of interactions between tyrosine kinases and the high affinity IgE receptor which are controlled by receptor clustering (1995) Embo J., 14, pp. 3385-3394
Mol Immunol (ISSN: 0161-5890), 2009 Oct; 46(16): 3300-3309.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.202, 5-year impact factor: 3.233
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-70349462818&partnerID=40&md5=ab53eae058bf0892271e8cd9906a2822
Keywords: Elisa, Fcεri, Peptide Mimics, Fc Receptor, Immunoglobulin A, Immunoglobulin E Receptor, Immunoglobulin E Trap, Polypeptide, Unclassified Drug, Animal Cell, Article, Binding Affinity, Binding Competition, Binding Site, Biotinylation, Concentration Response, Controlled Study, Enzyme Linked Immunosorbent Assay, Flow Cytometry, Immunoglobulin Production, Nonhuman, Peptide Synthesis, Priority Journal, Protein Binding, Protein Domain, Surface Plasmon Resonance, Cell Line, Hypersensitivity, Ligands, Protein Structure, Secondary, Tertiary,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone 16, 80134 Napoli, Italy
Dipartimento delle Scienze Biologiche, Università di Napoli Federico II, via Mezzocannone 16, 80134 Napoli, Italy
References:
Ames, S.A., Gleeson, C.D., Kirkpatrick, P., Omalizumab (2004) Nat. Rev. Drug Discov., 3, pp. 199-20
Basu, M., Hakimi, J., Dharm, E., Kondas, J.A., Tsien, W.H., Pilson, R.S., Lin, P., Braswell, E.H., Purification and characterization of human recombinant IgE-Fc fragments that bind to the human high affinity IgE receptor (1993) J. Biol. Chem., 268, pp. 13118-13127
Buku, A., Condie, B.A., Price, J.A., Mezei, M., [Ala12]MCD peptide: a lead peptide to inhibitors of immunoglobulin E binding to mast cell receptors (2005) J. Pept. Res., 66, pp. 132-137
Buku, A., Keselman, I., Lupyan, D., Mezei, M., Price, J.A., Effective mast cell degranulating peptide inhibitors of the IgE/Fc epsilonRI receptor interaction (2008) Chem. Biol. Drug Des., 72, pp. 133-139
Buku, A., Mendlowitz, M., Condie, B.A., Price, J.A., Histamine-releasing activity and binding to the FcepsilonRI alpha human mast cell receptor subunit of mast cell degranulating peptide analogues with alanine substitutions (2003) J. Med. Chem., 46, pp. 3008-3012
Buku, A., Price, J.A., Mendlowitz, M., Masur, S., Mast cell degranulating peptide binds to RBL-2H3 mast cell receptors and inhibits IgE binding (2001) Peptides, 22, pp. 1993-1998
Cook, J.P., Henry, A.J., McDonnell, J.M., Owens, R.J., Sutton, B.J., Gould, H.J., Identification of contact residues in the IgE binding site of human FcepsilonRIalpha (1997) Biochemistry, 36, pp. 15579-15588
Cookson, W., The alliance of gene and environmental in asthma and allergy (1999) Nature, 402, pp. 5-11
Corren, J., Casale, T.B., Lanier, B., Buhl, R., Holgate, S., Jimenez, P., Safety and tolerability of omalizumab (2009) Clin. Exp. Allergy
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Garman, S.C., Kinet, J.P., Jardetzky, T.S., Crystal structure of the human high-affinity IgE receptor (1998) Cell, 95, pp. 951-961
Garman, S.C., Sechi, S., Kinet, J.P., Jardetzky, T.S., The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms (2001) J. Mol. Biol., 311, pp. 1049-1062
Garman, S.C., Wurzburg, B.A., Tarchevskaya, S.S., Kinet, J.P., Jardetzky, T.S., Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha (2000) Nature, 406, pp. 259-266
Henry, A.J., Cook, J.P., McDonnell, J.M., Mackay, G.A., Shi, J., Sutton, B.J., Gould, H.J., Participation of the N-terminal region of Cepsilon3 in the binding of human IgE to its high-affinity receptor FcepsilonRI (1997) Biochemistry, 36, pp. 15568-15578
Jardieu, P., Anti-IgE therapy (1995) Curr. Opin. Immunol., 7, pp. 779-782
Johnsosson, B., Lofas, S., Lindquist, G., Immobilization of protein to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in SPR sensor (1991) Anal. Biochem., 198, pp. 268-277
Kinet, J.P., The high-affinity receptor for IgE (1989) Curr. Opin. Immunol., 2, pp. 499-505
Kochan, J., Pettine, L.F., Hakimi, J., Kishi, K., Kinet, J.P., Isolation of the gene coding for the alpha subunit of the human high affinity IgE receptor (1988) Nucleic Acids Res., 16, p. 3584
Kraft, S., Kinet, J.P., New developments in FcepsilonRI regulation, function and inhibition (2007) Nat. Rev. Immunol., 5, pp. 365-378
Letourneur, O., Sechi, S., Willette-Brown, J., Robertson, M.W., Kinet, J.P., Glycosylation of human truncated Fc epsilon RI α chain is necessary for efficient folding in the endoplasmic reticulum (1995) J. Biol. Chem., 270, pp. 8249-8256
MacGlashan Jr., D., Therapeutic efficacy of omalizumab (2009) J. Allergy Clin. Immunol., 123, pp. 114-115
McDonnell, J.M., Beavil, A.J., Mackay, G.A., Henry, A.J., Cook, J.P., Gould, H.J., Sutton, B.J., Structure-based design of peptides that inhibit IgE binding to its high-affinity receptor Fc epsilon RI (1997) Biochem. Soc. Trans., 25, pp. 387-392
McDonnell, J.M., Calvert, R., Beavil, R.L., Beavil, A.J., Henry, A.J., Sutton, B.J., Gould, H.J., Cowburn, D., The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha (2001) Nat. Struct. Biol., 8, pp. 437-441
Meltzer, E.O., Grant, J.A., Impact of cetirizine on the burden of allergic rhinitis (1999) Ann. Allergy Asthma Immunol., 83, pp. 455-463
Metzger, H., Kinet, J.P., Blank, U., Miller, L., Ra, C., The receptor with high affinity for IgE (1989) Ciba Found. Symp., 147, pp. 93-101. , (Discussion 101-13)
Nakamura, G.R., Reynolds, M.E., Chen, Y.M., Starovasnik, M.A., Lowman, H.B., Stable "zeta" peptides that act as potent antagonists of the high-affinity IgE receptor (2002) Proc. Natl. Acad. Sci. U.S.A., 99, pp. 1303-1308
Nakamura, G.R., Starovasnik, M.A., Reynolds, M.E., Lowman, H.B., A novel family of hairpin peptides that inhibit IgE activity by binding to the high-affinity IgE receptor (2001) Biochemistry, 40, pp. 9828-9835
Rigby, L.J., Epa, V.C., Mackay, G.A., Hulett, M.D., Sutton, B.J., Gould, H.J., Hogarth, P.M., Domain one of the high affinity IgE receptor, FcepsilonRI, regulates binding to IgE through its interface with domain two (2000) J. Biol. Chem., 275, pp. 9664-9672
Rigby, L.J., Trist, H., Snider, J., Hulett, M.D., Hogarth, P.M., Epa, V.C., Monoclonal antibodies and synthetic peptides define the active site of FcepsilonRI and a potential receptor antagonist (2000) Allergy, 55, pp. 609-619
Rossi, M., Ruvo, M., Marasco, D., Colombo, M., Cassani, G., Verdoliva, A., Anti-allergic properties of a new all-D synthetic immunoglobulin-binding peptide (2008) Mol. Immunol., 45, pp. 226-234
Scharenberg, A.M., Lin, S., Cuenod, B., Yamamura, H., Kinet, J.P., Reconstitution of interactions between tyrosine kinases and the high affinity IgE receptor which are controlled by receptor clustering (1995) Embo J., 14, pp. 3385-3394
Stamos, J., Eigenbrot, C., Nakamura, G.R., Reynolds, M.E., Yin, J., Lowman, H.B., Fairbrother, W.J., Starovasnik, M.A., Convergent recognition of the IgE binding site on the high-affinity IgE receptor (2004) Structure, 12, pp. 1289-1301
Turner, H., Kinet, J.P., Signalling through the high-affinity IgE receptor Fc epsilonRI (1999) Nature, 402, pp. B24-30
Vangelista, L., Cesco-Gaspere, M., Lamba, D., Burrone, O., Efficient folding of the Fc1RI α-chain membrane proximal domain D2 depends on the presence of the N-terminal domain D1 (2002) J. Mol. Biol., 322, pp. 815-825
Wan, T., Beavil, R.L., Fabiane, S.M., Beavil, A.J., Sohi, M.K., Keown, M., Young, R.J., Sutton, B.J., The crystal structure of IgE Fc reveals an asymmetrically bent conformation (2002) Nat. Immunol., 3, pp. 681-686
Ames, S. A., Gleeson, C. D., Kirkpatrick, P., Omalizumab (2004) Nat. Rev. Drug Discov., 3, pp. 199-20
Cook, J. P., Henry, A. J., McDonnell, J. M., Owens, R. J., Sutton, B. J., Gould, H. J., Identification of contact residues in the IgE binding site of human FcepsilonRIalpha (1997) Biochemistry, 36, pp. 15579-15588
Fields, G. B., Noble, R. L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res., 35, pp. 161-214
Garman, S. C., Kinet, J. P., Jardetzky, T. S., Crystal structure of the human high-affinity IgE receptor (1998) Cell, 95, pp. 951-961
Garman, S. C., Sechi, S., Kinet, J. P., Jardetzky, T. S., The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms (2001) J. Mol. Biol., 311, pp. 1049-1062
Garman, S. C., Wurzburg, B. A., Tarchevskaya, S. S., Kinet, J. P., Jardetzky, T. S., Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha (2000) Nature, 406, pp. 259-266
Henry, A. J., Cook, J. P., McDonnell, J. M., Mackay, G. A., Shi, J., Sutton, B. J., Gould, H. J., Participation of the N-terminal region of Cepsilon3 in the binding of human IgE to its high-affinity receptor FcepsilonRI (1997) Biochemistry, 36, pp. 15568-15578
Kinet, J. P., The high-affinity receptor for IgE (1989) Curr. Opin. Immunol., 2, pp. 499-505
McDonnell, J. M., Beavil, A. J., Mackay, G. A., Henry, A. J., Cook, J. P., Gould, H. J., Sutton, B. J., Structure-based design of peptides that inhibit IgE binding to its high-affinity receptor Fc epsilon RI (1997) Biochem. Soc. Trans., 25, pp. 387-392
McDonnell, J. M., Calvert, R., Beavil, R. L., Beavil, A. J., Henry, A. J., Sutton, B. J., Gould, H. J., Cowburn, D., The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha (2001) Nat. Struct. Biol., 8, pp. 437-441
Meltzer, E. O., Grant, J. A., Impact of cetirizine on the burden of allergic rhinitis (1999) Ann. Allergy Asthma Immunol., 83, pp. 455-463
Nakamura, G. R., Reynolds, M. E., Chen, Y. M., Starovasnik, M. A., Lowman, H. B., Stable "zeta" peptides that act as potent antagonists of the high-affinity IgE receptor (2002) Proc. Natl. Acad. Sci. U. S. A., 99, pp. 1303-1308
Nakamura, G. R., Starovasnik, M. A., Reynolds, M. E., Lowman, H. B., A novel family of hairpin peptides that inhibit IgE activity by binding to the high-affinity IgE receptor (2001) Biochemistry, 40, pp. 9828-9835
Rigby, L. J., Epa, V. C., Mackay, G. A., Hulett, M. D., Sutton, B. J., Gould, H. J., Hogarth, P. M., Domain one of the high affinity IgE receptor, FcepsilonRI, regulates binding to IgE through its interface with domain two (2000) J. Biol. Chem., 275, pp. 9664-9672
Rigby, L. J., Trist, H., Snider, J., Hulett, M. D., Hogarth, P. M., Epa, V. C., Monoclonal antibodies and synthetic peptides define the active site of FcepsilonRI and a potential receptor antagonist (2000) Allergy, 55, pp. 609-619
Scharenberg, A. M., Lin, S., Cuenod, B., Yamamura, H., Kinet, J. P., Reconstitution of interactions between tyrosine kinases and the high affinity IgE receptor which are controlled by receptor clustering (1995) Embo J., 14, pp. 3385-3394
Ige-Binding Properties And Selectivity Of Peptide Mimics Of The Fcvarepsilonri Binding Site
Fc epsilon RI alpha found on the surface of mast cells and basophiles mediates allergic diseases, anaphylaxis and asthma through binding of IgE. Disrupting this interaction with anti-IgE mAbs has proven an efficient approach to control these diseases. The crystallographic structure of the complex formed between the IgE-Fc and Fc epsilon RI alpha extracellular domain has shown that recognition is mediated by residues in the second Ig-like domain of the receptor (132) and in the loop connecting the D1 and D2 domains. In an attempt to obtain specific IgE antagonists, we have designed and prepared a polypeptide named IgE-Trap that partially reproduces the IgE receptor-binding sites and binds with micromolar affinity to soluble IgE. The polypepticle contains loops C'-E [residues 129-134] and F-G [residues 151-1611 from the D2 domain joined by a linker, and loop B-C [residues 110-113]. Peptide binding to IgE has been assessed by SPR analyses and the data fit with a biphasic model of interaction, in agreement with the two-site mechanism reported for the native receptor. The polypeptide binds to immobilized IgE in a dose-dependent manner with a K (D) estimated to be around 6 mu M, while it does not recognize IgG nor IgA. Polypeptide sub-domains involved in IgE binding have also been defined, showing that loop C-E connected to loop B-C, but also the isolated loop B-C alone suffice to bind immunoglobulins E with high selectively though with reduced affinity compared to IgE-Trap. ELISA and cytometric assays on RBL2H3 cells demonstrate that the interacting peptides are able to displace the binding of IgE to receptor, confirming affinity and specificity of these ligands and suggesting a potential application as modulators of disorders associated with inappropriate IgE production. (C) 2009 Elsevier Ltd. All rights reserved
Fc epsilon RI alpha found on the surface of mast cells and basophiles mediates allergic diseases, anaphylaxis and asthma through binding of IgE. Disrupting this interaction with anti-IgE mAbs has proven an efficient approach to control these diseases. The crystallographic structure of the complex formed between the IgE-Fc and Fc epsilon RI alpha extracellular domain has shown that recognition is mediated by residues in the second Ig-like domain of the receptor (132) and in the loop connecting the D1 and D2 domains. In an attempt to obtain specific IgE antagonists, we have designed and prepared a polypeptide named IgE-Trap that partially reproduces the IgE receptor-binding sites and binds with micromolar affinity to soluble IgE. The polypepticle contains loops C'-E [residues 129-134] and F-G [residues 151-1611 from the D2 domain joined by a linker, and loop B-C [residues 110-113]. Peptide binding to IgE has been assessed by SPR analyses and the data fit with a biphasic model of interaction, in agreement with the two-site mechanism reported for the native receptor. The polypeptide binds to immobilized IgE in a dose-dependent manner with a K (D) estimated to be around 6 mu M, while it does not recognize IgG nor IgA. Polypeptide sub-domains involved in IgE binding have also been defined, showing that loop C-E connected to loop B-C, but also the isolated loop B-C alone suffice to bind immunoglobulins E with high selectively though with reduced affinity compared to IgE-Trap. ELISA and cytometric assays on RBL2H3 cells demonstrate that the interacting peptides are able to displace the binding of IgE to receptor, confirming affinity and specificity of these ligands and suggesting a potential application as modulators of disorders associated with inappropriate IgE production. (C) 2009 Elsevier Ltd. All rights reserved
Ige-Binding Properties And Selectivity Of Peptide Mimics Of The Fcvarepsilonri Binding Site
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Ige-Binding Properties And Selectivity Of Peptide Mimics Of The Fcvarepsilonri Binding Site
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Zhou JS, Sandomenico A, Burton O, Oettgen HC, Ruvo M
* An IgE receptor mimetic peptide (PepE) protects mice from IgE mediated anaphylaxis (492 views)
Molecular Biosystems (ISSN: 1742-206x), 2013 Nov; 9(11): 2853-2859.
Impact Factor: 3.183
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Sandomenico A, Monti SM, Palumbo R, Ruvo M
* A New Fc Epsilon Ri Receptor-Mimetic Peptide (pepe) That Blocks Ige Binding To Its High Affinity Receptor And Prevents Mediator Release From Rbl 2h3 Cells (651 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Sep; 17(9): 604-609.
Impact Factor: 1.799
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Ruvo M, Sandomenico A, Tudisco L, De Falco S
* Branched peptides for the modulation of protein-protein interactions: More arms are better than one? (532 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2011 Jun; 18(16): 2429-2437.
Impact Factor: 4.859
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Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M
* A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (501 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2005 Jul; 6(7): 1242-1253.
Impact Factor: 3.94
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Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (399 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
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Perrella O, Liguori G, Cattaneo D, Morelli L, Precchia E, Morisco E, Fonti R, Marinelli P
Ig antibody levels to Helicobacter pylori and histology of antral gastritis and duodenal ulcer: What is the correlation? (254 views)
G Mal Infett Parassit (ISSN: 0017-0321), 1992; 44(1): 65-68.
Impact Factor: 0
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Perrella O, Liguori G, Cattaneo D, Morelli L, Precchia E, Morisco E, Fonti R, Marinelli P
Ig antibody levels to Helicobacter pylori and histology of antral gastritis and duodenal ulcer: What is the correlation? [LIVELLI DI IG AD ISOTIPO DIVERSO E QUADRO ISTOLOGICO NELLA PATOLOGIA GASTRICA ASSOCIATA ALL'HELICOBACTER PYLORI: QUALE CORRELAZIONE?] (360 views)
G Mal Infett Parassit (ISSN: 0017-0321), 1992; 44: 65-68.
Impact Factor: 0
View Export to BibTeX Export to EndNote
* An IgE receptor mimetic peptide (PepE) protects mice from IgE mediated anaphylaxis (492 views)
Molecular Biosystems (ISSN: 1742-206x), 2013 Nov; 9(11): 2853-2859.
Impact Factor: 3.183
View Export to BibTeX Export to EndNote
Sandomenico A, Monti SM, Palumbo R, Ruvo M
* A New Fc Epsilon Ri Receptor-Mimetic Peptide (pepe) That Blocks Ige Binding To Its High Affinity Receptor And Prevents Mediator Release From Rbl 2h3 Cells (651 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Sep; 17(9): 604-609.
Impact Factor: 1.799
View Export to BibTeX Export to EndNote
Ruvo M, Sandomenico A, Tudisco L, De Falco S
* Branched peptides for the modulation of protein-protein interactions: More arms are better than one? (532 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2011 Jun; 18(16): 2429-2437.
Impact Factor: 4.859
View Export to BibTeX Export to EndNote
Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M
* A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (501 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2005 Jul; 6(7): 1242-1253.
Impact Factor: 3.94
View Export to BibTeX Export to EndNote
Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (399 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
View Export to BibTeX Export to EndNote
Perrella O, Liguori G, Cattaneo D, Morelli L, Precchia E, Morisco E, Fonti R, Marinelli P
Ig antibody levels to Helicobacter pylori and histology of antral gastritis and duodenal ulcer: What is the correlation? (254 views)
G Mal Infett Parassit (ISSN: 0017-0321), 1992; 44(1): 65-68.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Perrella O, Liguori G, Cattaneo D, Morelli L, Precchia E, Morisco E, Fonti R, Marinelli P
Ig antibody levels to Helicobacter pylori and histology of antral gastritis and duodenal ulcer: What is the correlation? [LIVELLI DI IG AD ISOTIPO DIVERSO E QUADRO ISTOLOGICO NELLA PATOLOGIA GASTRICA ASSOCIATA ALL'HELICOBACTER PYLORI: QUALE CORRELAZIONE?] (360 views)
G Mal Infett Parassit (ISSN: 0017-0321), 1992; 44: 65-68.
Impact Factor: 0
View Export to BibTeX Export to EndNote
7 Records (7 excluding Abstracts).
Total impact factor: 17.378 (17.378 excluding Abstracts).
Total 5 year impact factor: 16.744 (16.744 excluding Abstracts).
Total impact factor: 17.378 (17.378 excluding Abstracts).
Total 5 year impact factor: 16.744 (16.744 excluding Abstracts).
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