Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (613 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.268, 5-year impact factor: 3.571
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33847264869&partnerID=40&md5=347e83a5d413fa371eeae7868a1fe6c2
Keywords: β-Amyloid, Alzheimer, S Disease, Copper, Fibrils, Folding, Amyloid Beta Protein[25-35], Trace Metal, Amyloid Beta Protein (25 35), Amyloid Beta-Protein (25-35), Neurotoxin, Peptide Fragment, Unclassified Drug, Alzheimer Disease, Amino Terminal Sequence, Animal Cell, Article, Controlled Study, Electron Spin Resonance, Electrospray Mass Spectrometry, Neurotoxicity, Nonhuman, Oligomerization, Priority Journal, Protein Structure, Protein Synthesis, Scanning Force Microscopy, Animal Model, Atomic Force Microscopy, Brain Cortex, Chemistry, Circular Dichroism, Drug Effect, Nerve Cell, Pathology, Protein Conformation, Cerebral Cortex, Electron Spin Resonance Spectroscopy, Electrospray Ionization, Amyloid Beta Protein [25-35],
Affiliations:
*** IBB - CNR ***
PhD Program in Neurobiology, Faculty of Medicine, University of Catania, Catania, Italy
I.B.B., CNR, Catania, Italy
I.B.B., CNR, Napoli, Italy
Department of Physical-Chemistry (F. Accascina), University of Palermo, Palermo, Italy
Consorzio Catania Ricerche, Catania, Italy
Department of Pharmaceutical Sciences, University of Catania, Catania, Italy
Department of Chemical Sciences, University of Catania, Catania, Italy
I. B. B., CNR, Catania, Italy
I. B. B., CNR, Napoli, Italy
References:
Atwood, C.S., Moir, R.D., Huang, X., Scarpa, R.C., Bacarra, N.M., Hartshom, M.A., Tanzi, R.E., Bush, A.I., Drammatic aggregation of Alzheimer Abeta by Cu(II) is induced by condition representing physiological acidosis (1998) J Biol Chem, 273, pp. 12817-1282
Barrow, C.J., Yasuda, A., Kenny, P.T., Zagorski, M.G., Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra (1992) J Mol Biol, 225, pp. 1075-1093
Behl, C., Davis, J.B., Lesley, R., Schubert, D., Hydrogen peroxide mediates amyloid-β protein toxicity (1994) Cell, 77, pp. 817-827
Bondy, S.C., Guo-Ross, S.X., Truong, A.T., Promotion of transition metal-induced reactive oxygen species formation by beta-amyloid (1998) Brain Res, 799, pp. 91-96
Butterfield, D.A., Amyloid beta peptide (1-42) induced oxidative stress and neurotoxicity: Implication for neurodegeneration in Alzheimer's disease brain [review] (2002) Free Radic Res, 36, pp. 1307-1313
Cherny, R.A., Barnham, K.J., Bush, A.I., Cappai, R., Gautier Elisabeth, C.L., Masters, C.L., Carrington, D., Kok, G.B., PBT2, a novel MPAC for the treatment of Alzheimer's disease (2006) 10th International Conference on Alzheimer's Disease (ICAD), pp. P4-435
Copani, A., Condorelli, F., Caruso, A., Cancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signalling by beta-amyloid causes neuronal death (1999) FASEB J, 13, pp. 2225-2234
Curtain, C.C., Ali, F., Volitakis, I., Chemy, R.A., Norton, R.S., Beyreuther, K., Barrow, C.J., Barnham, K.J., Alzheimer's disease amyloid β binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits (2001) J Biol Chem, 276, pp. 20466-20473
Deibel, M.A., Ehmann, W.D., Markesbery, W.R., Copper, iron and zinc imbalance in severely degenerated brain regions in Alzheimer's disease: Possible relation to oxidative stress (1996) J Neurol Sci, 143, pp. 137-142
Eckman, E.A., Reed, D.K., Eckman, C.B., Degradation of the Alzheimer's beta peptide by endothelin-converting enzyme (2001) J Biol Chem, 276, pp. 24540-24548
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxy-carbonil amin acids (1990) Int J Pept Prot Res, 35, pp. 161-214
Garcia, V.J., Martinez, L., Briceño-Valero, J.M., Schilling, C.M., Dimensional metrology of nanometric spherical particles using AFM (1997) Probe Microsc, 1, p. 107
Gotz, J., Chen, F., van Dorpe, J., Nitsch, R.M., Formation of neurofibrillary tangles in P3011 tau transgenic mice induced by Abeta 42 fibrils (2001) Science, 293, pp. 1491-1495
Hardy, J., Selkoe, D.J., The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics (2002) Science, 297, pp. 353-356
Hou, L., Kang, I., Marchant, R.E., Zagorski, M.G., Methionine 35 oxidation reduces fibril assembly of the amyloid Aβ(1-42) peptide of Alzheimer's disease (2002) J Biol Chem, 43, pp. 40173-40176
Joachim, C.L., Selkoe, D.J., The seminal role of β-amyloid in the pathogenesis of Alzheimer disease (1992) Alzheimer Dis Assoc Disord, 6, pp. 7-34
Kang, J., Lemaire, H., Unterbeck, A., Salbaum, J.M., Master, C.L., Grzeeschik, K., Multhaup, G., Muller-Hill, B., The precursor of Alzheimer's disease amyloid A4 protein resembles a cell surface receptor (1987) Nature, 325, pp. 733-736
Kohno, T., Kobayashi, K., Maeda, T., Sato, K., Takashima, A., Three-dimensional structures of the amyloid beta peptide (25-35) in membrane-mimicking environment (1996) Biochemistry, 35, pp. 16094-16104
LeVine, H., Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution (1993) Prot Sci, 2, pp. 76-83
Lewis, J., Dickson, D.W., Lin, W.L., Chisholm, L., Corral, A., Jones, G., Yen, S.H., McGowan, E., Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP (2001) Science, 293, pp. 1487-1491
Loo, D.T., Copani, A., Pike, C.J., Whittemore, E.R., Walencewicz, A.J., Cotman, C.W., Apoptosis is induced by β-amyloid in cultured central nervous system neurons (1993) Proc Natl Acad Sci U S A, 90, pp. 7951-7955
Moir, R.D., Atwood, C.S., Romano, D.M., Laurans, M.H., Huang, X., Bush, A.I., Smith, J.D., Tanzi, R.E., Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations (1999) Biochemistry, 38, pp. 4595-4603
Molnár, Z.S., Kovács, P., Laczkó, I., Soós, K., Fülöp, L., Penke, B., Lengyel, I., Enhanced G-protein activation by a mixture of Aβ(25-35), Aβ(1-40/42) and zinc (2004) J Neurochem, 89, pp. 1215-1223
Niemeyer, C., Adler, M., Pignataro, B., Chi, L., Fuchs, H., Blohm, D., Self-assembly of DNA-streptavidin nanostructures and their use as reagents in immuno-PCR (1999) Nucleic Acids Res, 27, pp. 4553-4561
Oddo, S., Billings, L., Kesslak, J.P., Cribbs, D.H., La Ferla, F.M., Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome (2004) Neuron, 43, pp. 321-332
Opazo, C., Huang, X., Cherny, R.A., Moir, R.D., Roher, A.E., White, A.R., Cappai, R., Bush, A.I., Metalloenzyme-like activity of Alzheimer's disease β-amyloid. Cu-dependent catalytic conversion of dopamine cholesterol, and biological reducing agents to neurotoxic H 2O2 (2002) J Biol Chem, 277, pp. 40302-40308
Pike, C.J., Burdick, D., Walencewicz, A.J., Glabe, C.G., Cotman, C.W., Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state (1993) J Neurosci, 13, pp. 1676-1687
Pike, C.J., Walencewicz-Wasserman, A.J., Kosmoski, J., Cribbs, D.H., Glabe, C.G., Cotman, C.W., Structure-activity analyses of beta-amyloid peptides: Contributions of the beta 25-35 region to aggregation and neurotoxicity (1995) J. Neurochem, 64, pp. 253-255
Rae, T.D., Schmidt, P.J., Pufhal, R.A., Culotta, V.C., O' Halloran, T.V., Undetectable intracellular free copper: The requirement of a copper chaperone for superoxide dismutase (1999) Science, 284, pp. 805-808
Ritchie, C.W., Bush, A.I., Mackinnon, A., Macfarlane, S., Mastwyk, M., Macgregor, L., Kiers, L., Masters, C.L., Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: A pilot phase 2 clinical trial (2003) Arch Neurol, 60, pp. 1685-1691
Saido, T.C., Yamao-Harigaya, W., Iwatsubo, T., Kawashima, S., Amino- and carboxyl-terminal heterogeneity of β-amyloid peptides deposited in human brain (1996) Neurosci Lett, 215, pp. 173-176
Selkoe, D.J., Normal and abnormal biology of the β-amyloid precursor protein (1994) Annu Rev Neurosci, 17, pp. 489-517
Selkoe, D.J., Translating cell biology into therapeutic advances in Alzheimer's disease [review] (1999) Nature, 399, pp. A23-A31
Simmons, M.A., Schneider, C.R., Amyloid β-peptides act directly on single neurons (1993) Neurosci Lett, 150, pp. 133-136
Smith, D.P., Smith, D.G., Curtain, C.G., Boas, J., Pilbrow, J.R., Ciccotosto, G.D., Lau, T.L., Barnham, K.J., Copper-mediated amyloid-β toxicity is associated with an intermolecular histidine bridge (2006) J Biol Chem, 281, pp. 15145-15154
Soto, C., Kindy Mark, S., Baumann, M., Frangione, B., Inhibition of Alzheimer's amyloidosis by peptides that prevents β-sheet conformations (1996) Biochem Biophys Res Commun, 226, pp. 672-680
Squitti, R., Barbati, G., Rossi, L., Ventriglia, M., Dal Forno, G., Cesaretti, S., Moffa, F., Rossini, P.M., Excess of nonceruloplasmin serum copper in AD correlates with MMSE, CSF [beta]-amyloid, and h-tau (2006) Neurology, 67, pp. 76-82
Terzi, E., Hölzemann, G., Seelig, J., Reversible random coil-β-sheet transition of the β-amyloid fragment (25-35) (1994) Biochemistry, 33, pp. 1345-1350
Valentine, J.S., Gralla, E.B., Delivering copper inside yeast and human cells (1997) Science, 278, pp. 817-818
Walsh, D.M., Hartley, D.M., Kusumoto, Y., Fezoui, Y., Condron, M.M., Lomakin, A., Benedek, G.B., Teplow, D.B., Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates (1999) J Biol Chem, 274, pp. 25945-25952
White, A.R., Barnham, K.J., Bush, A.I., Metal homeostasis in Alzheimer's disease [review] (2006) Expert Rev Neurother, 6, pp. 711-722
Yankner, B.A., Duffy, L.K., Kirschner, D.A., Neurotrophic and neurotoxic effects of amyloid β-protein: Reversal by tachykinin neuropeptides (1990) Science, 25, pp. 279-282
Zbilut, J.P., Colosimo, A., Conti, F., Colafranceschi, M., Manetti, C., Valerio, M., Webber Jr, C.L., Giuliani, A., Protein aggregation/folding: The role of deterministic singularities of sequence hydrophobicity as determined by nonlinear signal analysis of acylphosphatase and Aβ (1-40) (2003) Biophys J, 85, pp. 3544-3557
Atwood, C. S., Moir, R. D., Huang, X., Scarpa, R. C., Bacarra, N. M., Hartshom, M. A., Tanzi, R. E., Bush, A. I., Drammatic aggregation of Alzheimer Abeta by Cu (II) is induced by condition representing physiological acidosis (1998) J Biol Chem, 273, pp. 12817-1282
Barrow, C. J., Yasuda, A., Kenny, P. T., Zagorski, M. G., Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra (1992) J Mol Biol, 225, pp. 1075-1093
Bondy, S. C., Guo-Ross, S. X., Truong, A. T., Promotion of transition metal-induced reactive oxygen species formation by beta-amyloid (1998) Brain Res, 799, pp. 91-96
Butterfield, D. A., Amyloid beta peptide (1-42) induced oxidative stress and neurotoxicity: Implication for neurodegeneration in Alzheimer's disease brain [review] (2002) Free Radic Res, 36, pp. 1307-1313
Cherny, R. A., Barnham, K. J., Bush, A. I., Cappai, R., Gautier Elisabeth, C. L., Masters, C. L., Carrington, D., Kok, G. B., PBT2, a novel MPAC for the treatment of Alzheimer's disease (2006) 10th International Conference on Alzheimer's Disease (ICAD), pp. P4-435
Curtain, C. C., Ali, F., Volitakis, I., Chemy, R. A., Norton, R. S., Beyreuther, K., Barrow, C. J., Barnham, K. J., Alzheimer's disease amyloid binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits (2001) J Biol Chem, 276, pp. 20466-20473
Deibel, M. A., Ehmann, W. D., Markesbery, W. R., Copper, iron and zinc imbalance in severely degenerated brain regions in Alzheimer's disease: Possible relation to oxidative stress (1996) J Neurol Sci, 143, pp. 137-142
Eckman, E. A., Reed, D. K., Eckman, C. B., Degradation of the Alzheimer's beta peptide by endothelin-converting enzyme (2001) J Biol Chem, 276, pp. 24540-24548
Fields, G. B., Noble, R. L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxy-carbonil amin acids (1990) Int J Pept Prot Res, 35, pp. 161-214
Garcia, V. J., Martinez, L., Brice o-Valero, J. M., Schilling, C. M., Dimensional metrology of nanometric spherical particles using AFM (1997) Probe Microsc, 1, p. 107
Joachim, C. L., Selkoe, D. J., The seminal role of -amyloid in the pathogenesis of Alzheimer disease (1992) Alzheimer Dis Assoc Disord, 6, pp. 7-34
Loo, D. T., Copani, A., Pike, C. J., Whittemore, E. R., Walencewicz, A. J., Cotman, C. W., Apoptosis is induced by -amyloid in cultured central nervous system neurons (1993) Proc Natl Acad Sci U S A, 90, pp. 7951-7955
Moir, R. D., Atwood, C. S., Romano, D. M., Laurans, M. H., Huang, X., Bush, A. I., Smith, J. D., Tanzi, R. E., Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations (1999) Biochemistry, 38, pp. 4595-4603
Moln r, Z. S., Kov cs, P., Laczk, I., So s, K., F l p, L., Penke, B., Lengyel, I., Enhanced G-protein activation by a mixture of A (25-35), A (1-40/42) and zinc (2004) J Neurochem, 89, pp. 1215-1223
Pike, C. J., Burdick, D., Walencewicz, A. J., Glabe, C. G., Cotman, C. W., Neurodegeneration induced by -amyloid peptides in vitro: The role of peptide assembly state (1993) J Neurosci, 13, pp. 1676-1687
Pike, C. J., Walencewicz-Wasserman, A. J., Kosmoski, J., Cribbs, D. H., Glabe, C. G., Cotman, C. W., Structure-activity analyses of beta-amyloid peptides: Contributions of the beta 25-35 region to aggregation and neurotoxicity (1995) J. Neurochem, 64, pp. 253-255
Rae, T. D., Schmidt, P. J., Pufhal, R. A., Culotta, V. C., O' Halloran, T. V., Undetectable intracellular free copper: The requirement of a copper chaperone for superoxide dismutase (1999) Science, 284, pp. 805-808
Ritchie, C. W., Bush, A. I., Mackinnon, A., Macfarlane, S., Mastwyk, M., Macgregor, L., Kiers, L., Masters, C. L., Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: A pilot phase 2 clinical trial (2003) Arch Neurol, 60, pp. 1685-1691
Saido, T. C., Yamao-Harigaya, W., Iwatsubo, T., Kawashima, S., Amino- and carboxyl-terminal heterogeneity of -amyloid peptides deposited in human brain (1996) Neurosci Lett, 215, pp. 173-176
Selkoe, D. J., Normal and abnormal biology of the -amyloid precursor protein (1994) Annu Rev Neurosci, 17, pp. 489-517
Selkoe, D. J., Translating cell biology into therapeutic advances in Alzheimer's disease [review] (1999) Nature, 399, pp. A23-A31
Simmons, M. A., Schneider, C. R., Amyloid -peptides act directly on single neurons (1993) Neurosci Lett, 150, pp. 133-136
Smith, D. P., Smith, D. G., Curtain, C. G., Boas, J., Pilbrow, J. R., Ciccotosto, G. D., Lau, T. L., Barnham, K. J., Copper-mediated amyloid- toxicity is associated with an intermolecular histidine bridge (2006) J Biol Chem, 281, pp. 15145-15154
Terzi, E., H lzemann, G., Seelig, J., Reversible random coil- -sheet transition of the -amyloid fragment (25-35) (1994) Biochemistry, 33, pp. 1345-1350
Valentine, J. S., Gralla, E. B., Delivering copper inside yeast and human cells (1997) Science, 278, pp. 817-818
Walsh, D. M., Hartley, D. M., Kusumoto, Y., Fezoui, Y., Condron, M. M., Lomakin, A., Benedek, G. B., Teplow, D. B., Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates (1999) J Biol Chem, 274, pp. 25945-25952
White, A. R., Barnham, K. J., Bush, A. I., Metal homeostasis in Alzheimer's disease [review] (2006) Expert Rev Neurother, 6, pp. 711-722
Yankner, B. A., Duffy, L. K., Kirschner, D. A., Neurotrophic and neurotoxic effects of amyloid -protein: Reversal by tachykinin neuropeptides (1990) Science, 25, pp. 279-282
Zbilut, J. P., Colosimo, A., Conti, F., Colafranceschi, M., Manetti, C., Valerio, M., Webber Jr, C. L., Giuliani, A., Protein aggregation/folding: The role of deterministic singularities of sequence hydrophobicity as determined by nonlinear signal analysis of acylphosphatase and A (1-40) (2003) Biophys J, 85, pp. 3544-3557
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.268, 5-year impact factor: 3.571
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33847264869&partnerID=40&md5=347e83a5d413fa371eeae7868a1fe6c2
Keywords: β-Amyloid, Alzheimer, S Disease, Copper, Fibrils, Folding, Amyloid Beta Protein[25-35], Trace Metal, Amyloid Beta Protein (25 35), Amyloid Beta-Protein (25-35), Neurotoxin, Peptide Fragment, Unclassified Drug, Alzheimer Disease, Amino Terminal Sequence, Animal Cell, Article, Controlled Study, Electron Spin Resonance, Electrospray Mass Spectrometry, Neurotoxicity, Nonhuman, Oligomerization, Priority Journal, Protein Structure, Protein Synthesis, Scanning Force Microscopy, Animal Model, Atomic Force Microscopy, Brain Cortex, Chemistry, Circular Dichroism, Drug Effect, Nerve Cell, Pathology, Protein Conformation, Cerebral Cortex, Electron Spin Resonance Spectroscopy, Electrospray Ionization, Amyloid Beta Protein [25-35],
Affiliations:
*** IBB - CNR ***
PhD Program in Neurobiology, Faculty of Medicine, University of Catania, Catania, Italy
I.B.B., CNR, Catania, Italy
I.B.B., CNR, Napoli, Italy
Department of Physical-Chemistry (F. Accascina), University of Palermo, Palermo, Italy
Consorzio Catania Ricerche, Catania, Italy
Department of Pharmaceutical Sciences, University of Catania, Catania, Italy
Department of Chemical Sciences, University of Catania, Catania, Italy
I. B. B., CNR, Catania, Italy
I. B. B., CNR, Napoli, Italy
References:
Atwood, C.S., Moir, R.D., Huang, X., Scarpa, R.C., Bacarra, N.M., Hartshom, M.A., Tanzi, R.E., Bush, A.I., Drammatic aggregation of Alzheimer Abeta by Cu(II) is induced by condition representing physiological acidosis (1998) J Biol Chem, 273, pp. 12817-1282
Barrow, C.J., Yasuda, A., Kenny, P.T., Zagorski, M.G., Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra (1992) J Mol Biol, 225, pp. 1075-1093
Behl, C., Davis, J.B., Lesley, R., Schubert, D., Hydrogen peroxide mediates amyloid-β protein toxicity (1994) Cell, 77, pp. 817-827
Bondy, S.C., Guo-Ross, S.X., Truong, A.T., Promotion of transition metal-induced reactive oxygen species formation by beta-amyloid (1998) Brain Res, 799, pp. 91-96
Butterfield, D.A., Amyloid beta peptide (1-42) induced oxidative stress and neurotoxicity: Implication for neurodegeneration in Alzheimer's disease brain [review] (2002) Free Radic Res, 36, pp. 1307-1313
Cherny, R.A., Barnham, K.J., Bush, A.I., Cappai, R., Gautier Elisabeth, C.L., Masters, C.L., Carrington, D., Kok, G.B., PBT2, a novel MPAC for the treatment of Alzheimer's disease (2006) 10th International Conference on Alzheimer's Disease (ICAD), pp. P4-435
Copani, A., Condorelli, F., Caruso, A., Cancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signalling by beta-amyloid causes neuronal death (1999) FASEB J, 13, pp. 2225-2234
Curtain, C.C., Ali, F., Volitakis, I., Chemy, R.A., Norton, R.S., Beyreuther, K., Barrow, C.J., Barnham, K.J., Alzheimer's disease amyloid β binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits (2001) J Biol Chem, 276, pp. 20466-20473
Deibel, M.A., Ehmann, W.D., Markesbery, W.R., Copper, iron and zinc imbalance in severely degenerated brain regions in Alzheimer's disease: Possible relation to oxidative stress (1996) J Neurol Sci, 143, pp. 137-142
Eckman, E.A., Reed, D.K., Eckman, C.B., Degradation of the Alzheimer's beta peptide by endothelin-converting enzyme (2001) J Biol Chem, 276, pp. 24540-24548
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxy-carbonil amin acids (1990) Int J Pept Prot Res, 35, pp. 161-214
Garcia, V.J., Martinez, L., Briceño-Valero, J.M., Schilling, C.M., Dimensional metrology of nanometric spherical particles using AFM (1997) Probe Microsc, 1, p. 107
Gotz, J., Chen, F., van Dorpe, J., Nitsch, R.M., Formation of neurofibrillary tangles in P3011 tau transgenic mice induced by Abeta 42 fibrils (2001) Science, 293, pp. 1491-1495
Hardy, J., Selkoe, D.J., The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics (2002) Science, 297, pp. 353-356
Hou, L., Kang, I., Marchant, R.E., Zagorski, M.G., Methionine 35 oxidation reduces fibril assembly of the amyloid Aβ(1-42) peptide of Alzheimer's disease (2002) J Biol Chem, 43, pp. 40173-40176
Joachim, C.L., Selkoe, D.J., The seminal role of β-amyloid in the pathogenesis of Alzheimer disease (1992) Alzheimer Dis Assoc Disord, 6, pp. 7-34
Kang, J., Lemaire, H., Unterbeck, A., Salbaum, J.M., Master, C.L., Grzeeschik, K., Multhaup, G., Muller-Hill, B., The precursor of Alzheimer's disease amyloid A4 protein resembles a cell surface receptor (1987) Nature, 325, pp. 733-736
Kohno, T., Kobayashi, K., Maeda, T., Sato, K., Takashima, A., Three-dimensional structures of the amyloid beta peptide (25-35) in membrane-mimicking environment (1996) Biochemistry, 35, pp. 16094-16104
LeVine, H., Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution (1993) Prot Sci, 2, pp. 76-83
Lewis, J., Dickson, D.W., Lin, W.L., Chisholm, L., Corral, A., Jones, G., Yen, S.H., McGowan, E., Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP (2001) Science, 293, pp. 1487-1491
Loo, D.T., Copani, A., Pike, C.J., Whittemore, E.R., Walencewicz, A.J., Cotman, C.W., Apoptosis is induced by β-amyloid in cultured central nervous system neurons (1993) Proc Natl Acad Sci U S A, 90, pp. 7951-7955
Moir, R.D., Atwood, C.S., Romano, D.M., Laurans, M.H., Huang, X., Bush, A.I., Smith, J.D., Tanzi, R.E., Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations (1999) Biochemistry, 38, pp. 4595-4603
Molnár, Z.S., Kovács, P., Laczkó, I., Soós, K., Fülöp, L., Penke, B., Lengyel, I., Enhanced G-protein activation by a mixture of Aβ(25-35), Aβ(1-40/42) and zinc (2004) J Neurochem, 89, pp. 1215-1223
Niemeyer, C., Adler, M., Pignataro, B., Chi, L., Fuchs, H., Blohm, D., Self-assembly of DNA-streptavidin nanostructures and their use as reagents in immuno-PCR (1999) Nucleic Acids Res, 27, pp. 4553-4561
Oddo, S., Billings, L., Kesslak, J.P., Cribbs, D.H., La Ferla, F.M., Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome (2004) Neuron, 43, pp. 321-332
Opazo, C., Huang, X., Cherny, R.A., Moir, R.D., Roher, A.E., White, A.R., Cappai, R., Bush, A.I., Metalloenzyme-like activity of Alzheimer's disease β-amyloid. Cu-dependent catalytic conversion of dopamine cholesterol, and biological reducing agents to neurotoxic H 2O2 (2002) J Biol Chem, 277, pp. 40302-40308
Pike, C.J., Burdick, D., Walencewicz, A.J., Glabe, C.G., Cotman, C.W., Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state (1993) J Neurosci, 13, pp. 1676-1687
Pike, C.J., Walencewicz-Wasserman, A.J., Kosmoski, J., Cribbs, D.H., Glabe, C.G., Cotman, C.W., Structure-activity analyses of beta-amyloid peptides: Contributions of the beta 25-35 region to aggregation and neurotoxicity (1995) J. Neurochem, 64, pp. 253-255
Rae, T.D., Schmidt, P.J., Pufhal, R.A., Culotta, V.C., O' Halloran, T.V., Undetectable intracellular free copper: The requirement of a copper chaperone for superoxide dismutase (1999) Science, 284, pp. 805-808
Ritchie, C.W., Bush, A.I., Mackinnon, A., Macfarlane, S., Mastwyk, M., Macgregor, L., Kiers, L., Masters, C.L., Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: A pilot phase 2 clinical trial (2003) Arch Neurol, 60, pp. 1685-1691
Saido, T.C., Yamao-Harigaya, W., Iwatsubo, T., Kawashima, S., Amino- and carboxyl-terminal heterogeneity of β-amyloid peptides deposited in human brain (1996) Neurosci Lett, 215, pp. 173-176
Selkoe, D.J., Normal and abnormal biology of the β-amyloid precursor protein (1994) Annu Rev Neurosci, 17, pp. 489-517
Selkoe, D.J., Translating cell biology into therapeutic advances in Alzheimer's disease [review] (1999) Nature, 399, pp. A23-A31
Simmons, M.A., Schneider, C.R., Amyloid β-peptides act directly on single neurons (1993) Neurosci Lett, 150, pp. 133-136
Smith, D.P., Smith, D.G., Curtain, C.G., Boas, J., Pilbrow, J.R., Ciccotosto, G.D., Lau, T.L., Barnham, K.J., Copper-mediated amyloid-β toxicity is associated with an intermolecular histidine bridge (2006) J Biol Chem, 281, pp. 15145-15154
Soto, C., Kindy Mark, S., Baumann, M., Frangione, B., Inhibition of Alzheimer's amyloidosis by peptides that prevents β-sheet conformations (1996) Biochem Biophys Res Commun, 226, pp. 672-680
Squitti, R., Barbati, G., Rossi, L., Ventriglia, M., Dal Forno, G., Cesaretti, S., Moffa, F., Rossini, P.M., Excess of nonceruloplasmin serum copper in AD correlates with MMSE, CSF [beta]-amyloid, and h-tau (2006) Neurology, 67, pp. 76-82
Terzi, E., Hölzemann, G., Seelig, J., Reversible random coil-β-sheet transition of the β-amyloid fragment (25-35) (1994) Biochemistry, 33, pp. 1345-1350
Valentine, J.S., Gralla, E.B., Delivering copper inside yeast and human cells (1997) Science, 278, pp. 817-818
Walsh, D.M., Hartley, D.M., Kusumoto, Y., Fezoui, Y., Condron, M.M., Lomakin, A., Benedek, G.B., Teplow, D.B., Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates (1999) J Biol Chem, 274, pp. 25945-25952
White, A.R., Barnham, K.J., Bush, A.I., Metal homeostasis in Alzheimer's disease [review] (2006) Expert Rev Neurother, 6, pp. 711-722
Yankner, B.A., Duffy, L.K., Kirschner, D.A., Neurotrophic and neurotoxic effects of amyloid β-protein: Reversal by tachykinin neuropeptides (1990) Science, 25, pp. 279-282
Zbilut, J.P., Colosimo, A., Conti, F., Colafranceschi, M., Manetti, C., Valerio, M., Webber Jr, C.L., Giuliani, A., Protein aggregation/folding: The role of deterministic singularities of sequence hydrophobicity as determined by nonlinear signal analysis of acylphosphatase and Aβ (1-40) (2003) Biophys J, 85, pp. 3544-3557
Atwood, C. S., Moir, R. D., Huang, X., Scarpa, R. C., Bacarra, N. M., Hartshom, M. A., Tanzi, R. E., Bush, A. I., Drammatic aggregation of Alzheimer Abeta by Cu (II) is induced by condition representing physiological acidosis (1998) J Biol Chem, 273, pp. 12817-1282
Barrow, C. J., Yasuda, A., Kenny, P. T., Zagorski, M. G., Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra (1992) J Mol Biol, 225, pp. 1075-1093
Bondy, S. C., Guo-Ross, S. X., Truong, A. T., Promotion of transition metal-induced reactive oxygen species formation by beta-amyloid (1998) Brain Res, 799, pp. 91-96
Butterfield, D. A., Amyloid beta peptide (1-42) induced oxidative stress and neurotoxicity: Implication for neurodegeneration in Alzheimer's disease brain [review] (2002) Free Radic Res, 36, pp. 1307-1313
Cherny, R. A., Barnham, K. J., Bush, A. I., Cappai, R., Gautier Elisabeth, C. L., Masters, C. L., Carrington, D., Kok, G. B., PBT2, a novel MPAC for the treatment of Alzheimer's disease (2006) 10th International Conference on Alzheimer's Disease (ICAD), pp. P4-435
Curtain, C. C., Ali, F., Volitakis, I., Chemy, R. A., Norton, R. S., Beyreuther, K., Barrow, C. J., Barnham, K. J., Alzheimer's disease amyloid binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits (2001) J Biol Chem, 276, pp. 20466-20473
Deibel, M. A., Ehmann, W. D., Markesbery, W. R., Copper, iron and zinc imbalance in severely degenerated brain regions in Alzheimer's disease: Possible relation to oxidative stress (1996) J Neurol Sci, 143, pp. 137-142
Eckman, E. A., Reed, D. K., Eckman, C. B., Degradation of the Alzheimer's beta peptide by endothelin-converting enzyme (2001) J Biol Chem, 276, pp. 24540-24548
Fields, G. B., Noble, R. L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxy-carbonil amin acids (1990) Int J Pept Prot Res, 35, pp. 161-214
Garcia, V. J., Martinez, L., Brice o-Valero, J. M., Schilling, C. M., Dimensional metrology of nanometric spherical particles using AFM (1997) Probe Microsc, 1, p. 107
Joachim, C. L., Selkoe, D. J., The seminal role of -amyloid in the pathogenesis of Alzheimer disease (1992) Alzheimer Dis Assoc Disord, 6, pp. 7-34
Loo, D. T., Copani, A., Pike, C. J., Whittemore, E. R., Walencewicz, A. J., Cotman, C. W., Apoptosis is induced by -amyloid in cultured central nervous system neurons (1993) Proc Natl Acad Sci U S A, 90, pp. 7951-7955
Moir, R. D., Atwood, C. S., Romano, D. M., Laurans, M. H., Huang, X., Bush, A. I., Smith, J. D., Tanzi, R. E., Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations (1999) Biochemistry, 38, pp. 4595-4603
Moln r, Z. S., Kov cs, P., Laczk, I., So s, K., F l p, L., Penke, B., Lengyel, I., Enhanced G-protein activation by a mixture of A (25-35), A (1-40/42) and zinc (2004) J Neurochem, 89, pp. 1215-1223
Pike, C. J., Burdick, D., Walencewicz, A. J., Glabe, C. G., Cotman, C. W., Neurodegeneration induced by -amyloid peptides in vitro: The role of peptide assembly state (1993) J Neurosci, 13, pp. 1676-1687
Pike, C. J., Walencewicz-Wasserman, A. J., Kosmoski, J., Cribbs, D. H., Glabe, C. G., Cotman, C. W., Structure-activity analyses of beta-amyloid peptides: Contributions of the beta 25-35 region to aggregation and neurotoxicity (1995) J. Neurochem, 64, pp. 253-255
Rae, T. D., Schmidt, P. J., Pufhal, R. A., Culotta, V. C., O' Halloran, T. V., Undetectable intracellular free copper: The requirement of a copper chaperone for superoxide dismutase (1999) Science, 284, pp. 805-808
Ritchie, C. W., Bush, A. I., Mackinnon, A., Macfarlane, S., Mastwyk, M., Macgregor, L., Kiers, L., Masters, C. L., Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: A pilot phase 2 clinical trial (2003) Arch Neurol, 60, pp. 1685-1691
Saido, T. C., Yamao-Harigaya, W., Iwatsubo, T., Kawashima, S., Amino- and carboxyl-terminal heterogeneity of -amyloid peptides deposited in human brain (1996) Neurosci Lett, 215, pp. 173-176
Selkoe, D. J., Normal and abnormal biology of the -amyloid precursor protein (1994) Annu Rev Neurosci, 17, pp. 489-517
Selkoe, D. J., Translating cell biology into therapeutic advances in Alzheimer's disease [review] (1999) Nature, 399, pp. A23-A31
Simmons, M. A., Schneider, C. R., Amyloid -peptides act directly on single neurons (1993) Neurosci Lett, 150, pp. 133-136
Smith, D. P., Smith, D. G., Curtain, C. G., Boas, J., Pilbrow, J. R., Ciccotosto, G. D., Lau, T. L., Barnham, K. J., Copper-mediated amyloid- toxicity is associated with an intermolecular histidine bridge (2006) J Biol Chem, 281, pp. 15145-15154
Terzi, E., H lzemann, G., Seelig, J., Reversible random coil- -sheet transition of the -amyloid fragment (25-35) (1994) Biochemistry, 33, pp. 1345-1350
Valentine, J. S., Gralla, E. B., Delivering copper inside yeast and human cells (1997) Science, 278, pp. 817-818
Walsh, D. M., Hartley, D. M., Kusumoto, Y., Fezoui, Y., Condron, M. M., Lomakin, A., Benedek, G. B., Teplow, D. B., Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates (1999) J Biol Chem, 274, pp. 25945-25952
White, A. R., Barnham, K. J., Bush, A. I., Metal homeostasis in Alzheimer's disease [review] (2006) Expert Rev Neurother, 6, pp. 711-722
Yankner, B. A., Duffy, L. K., Kirschner, D. A., Neurotrophic and neurotoxic effects of amyloid -protein: Reversal by tachykinin neuropeptides (1990) Science, 25, pp. 279-282
Zbilut, J. P., Colosimo, A., Conti, F., Colafranceschi, M., Manetti, C., Valerio, M., Webber Jr, C. L., Giuliani, A., Protein aggregation/folding: The role of deterministic singularities of sequence hydrophobicity as determined by nonlinear signal analysis of acylphosphatase and A (1-40) (2003) Biophys J, 85, pp. 3544-3557
Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity
The toxic properties of P-amyloid protein, A beta (1-42), the major component of senile plaques in Alzheimer's disease, depend on nucleation-dependent oligomerization and aggregation. In addition, A beta (1-42) toxicity is favored by the presence of trace metals, which affect the secondary structure of the peptide. A peptide comprising 11 residues within A beta (1-42) [A beta (25-35)] aggregates and retains the neurotoxic activity of A beta (1-42). We have used both A beta (25-35) and its C-amidated or N-acetylated/C-amidated derivatives to investigate the role of copper (II) in modulating the conformation and aggregation state as well as the neurotoxic properties of amyloid peptides. Electrospray ionization mass spectrometry (ESI-MS) and electron paramagnetic resonance (EPR) measurements were performed to verify the formation of copper (II) /A beta (25-35) complexes and to determine the coordination mode, respectively. A beta (2535) and its derivatives were analyzed by circular dichroism spectroscopy to assess their secondary structure, subjected to thioflavine-T (Th-T) binding assay to reveal beta-sheet structured aggregates formation, and imaged by scanning force microscopy. Toxicity was assessed on mature cultures of rat cortical neurons. We found that beta-sheet-structured species of A beta (25-35) were neurotoxic, whereas the random-coil-structured derivatives were devoid of effect. Interestingly, copper promoted the random-coiI/beta-sheet transition of A beta (25-35), with ensuing peptide toxicity, but it induced the toxicity of the N-acetylated/C-amidated derivative without affecting peptide folding. Moreover, copper did not influence either the folding or the activity of the C-amidated A beta (25-35), suggesting that blockade of the C-terminus of A beta peptides might be sufficient to prevent A beta toxicity. (c) 2006 Wiley-Liss, Inc
The toxic properties of P-amyloid protein, A beta (1-42), the major component of senile plaques in Alzheimer's disease, depend on nucleation-dependent oligomerization and aggregation. In addition, A beta (1-42) toxicity is favored by the presence of trace metals, which affect the secondary structure of the peptide. A peptide comprising 11 residues within A beta (1-42) [A beta (25-35)] aggregates and retains the neurotoxic activity of A beta (1-42). We have used both A beta (25-35) and its C-amidated or N-acetylated/C-amidated derivatives to investigate the role of copper (II) in modulating the conformation and aggregation state as well as the neurotoxic properties of amyloid peptides. Electrospray ionization mass spectrometry (ESI-MS) and electron paramagnetic resonance (EPR) measurements were performed to verify the formation of copper (II) /A beta (25-35) complexes and to determine the coordination mode, respectively. A beta (2535) and its derivatives were analyzed by circular dichroism spectroscopy to assess their secondary structure, subjected to thioflavine-T (Th-T) binding assay to reveal beta-sheet structured aggregates formation, and imaged by scanning force microscopy. Toxicity was assessed on mature cultures of rat cortical neurons. We found that beta-sheet-structured species of A beta (25-35) were neurotoxic, whereas the random-coil-structured derivatives were devoid of effect. Interestingly, copper promoted the random-coiI/beta-sheet transition of A beta (25-35), with ensuing peptide toxicity, but it induced the toxicity of the N-acetylated/C-amidated derivative without affecting peptide folding. Moreover, copper did not influence either the folding or the activity of the C-amidated A beta (25-35), suggesting that blockade of the C-terminus of A beta peptides might be sufficient to prevent A beta toxicity. (c) 2006 Wiley-Liss, Inc
Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity
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Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity
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Marasco D, Vicidomini C, Krupa P, Cioffi F, Pham DQH, Li MS, Florio D, Broersen K, De Pandis MF, Roviello GN
* Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine based compounds on β-amyloid aggregation (145 views)
Chem Biol Interact (ISSN: 0009-2797linking), 2021 Jan 25; 334: 109300-109301.
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Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F
* The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice (549 views)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic), 2016 Apr; 106: 10-20.
Impact Factor: 4.48
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Palladino P, Aura AM, Spoto G
* Surface plasmon resonance for the label-free detection of Alzheimer's β-amyloid peptide aggregation (528 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2016; 408(3): 849-854.
Impact Factor: 3.431
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1070 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
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Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (597 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (987 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (748 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (454 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (452 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (481 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (491 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (544 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (584 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (797 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (543 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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* Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine based compounds on β-amyloid aggregation (145 views)
Chem Biol Interact (ISSN: 0009-2797linking), 2021 Jan 25; 334: 109300-109301.
Impact Factor: 5.192
View Export to BibTeX Export to EndNote
Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F
* The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice (549 views)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic), 2016 Apr; 106: 10-20.
Impact Factor: 4.48
View Export to BibTeX Export to EndNote
Palladino P, Aura AM, Spoto G
* Surface plasmon resonance for the label-free detection of Alzheimer's β-amyloid peptide aggregation (528 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2016; 408(3): 849-854.
Impact Factor: 3.431
View Export to BibTeX Export to EndNote
Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1070 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
View Export to BibTeX Export to EndNote
Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (597 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
View Export to BibTeX Export to EndNote
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (987 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
View Export to BibTeX Export to EndNote
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (748 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
View Export to BibTeX Export to EndNote
Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (454 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
View Export to BibTeX Export to EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (452 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
View Export to BibTeX Export to EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (481 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
View Export to BibTeX Export to EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (491 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
View Export to BibTeX Export to EndNote
Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (544 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
View Export to BibTeX Export to EndNote
Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (584 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
View Export to BibTeX Export to EndNote
Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (797 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
View Export to BibTeX Export to EndNote
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (543 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
View Export to BibTeX Export to EndNote
15 Records (15 excluding Abstracts).
Total impact factor: 56.271 (56.271 excluding Abstracts).
Total 5 year impact factor: 56.473 (56.473 excluding Abstracts).
Total impact factor: 56.271 (56.271 excluding Abstracts).
Total 5 year impact factor: 56.473 (56.473 excluding Abstracts).
613 views. Last view on Monday 20 February 2023, 0:20:05
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