Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (1129 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.268, 5-year impact factor: 3.571
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33847264869&partnerID=40&md5=347e83a5d413fa371eeae7868a1fe6c2
Keywords: β-Amyloid, Alzheimer, S Disease, Copper, Fibrils, Folding, Amyloid Beta Protein[25-35], Trace Metal, Amyloid Beta Protein (25 35), Amyloid Beta-Protein (25-35), Neurotoxin, Peptide Fragment, Unclassified Drug, Alzheimer Disease, Amino Terminal Sequence, Animal Cell, Article, Controlled Study, Electron Spin Resonance, Electrospray Mass Spectrometry, Neurotoxicity, Nonhuman, Oligomerization, Priority Journal, Protein Structure, Protein Synthesis, Scanning Force Microscopy, Animal Model, Atomic Force Microscopy, Brain Cortex, Chemistry, Circular Dichroism, Drug Effect, Nerve Cell, Pathology, Protein Conformation, Cerebral Cortex, Electron Spin Resonance Spectroscopy, Electrospray Ionization, Amyloid Beta Protein [25-35],
Affiliations:
*** IBB - CNR ***
PhD Program in Neurobiology, Faculty of Medicine, University of Catania, Catania, Italy
I.B.B., CNR, Catania, Italy
I.B.B., CNR, Napoli, Italy
Department of Physical-Chemistry (F. Accascina), University of Palermo, Palermo, Italy
Consorzio Catania Ricerche, Catania, Italy
Department of Pharmaceutical Sciences, University of Catania, Catania, Italy
Department of Chemical Sciences, University of Catania, Catania, Italy
I. B. B., CNR, Catania, Italy
I. B. B., CNR, Napoli, Italy
References:
Not available.
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.268, 5-year impact factor: 3.571
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33847264869&partnerID=40&md5=347e83a5d413fa371eeae7868a1fe6c2
Keywords: β-Amyloid, Alzheimer, S Disease, Copper, Fibrils, Folding, Amyloid Beta Protein[25-35], Trace Metal, Amyloid Beta Protein (25 35), Amyloid Beta-Protein (25-35), Neurotoxin, Peptide Fragment, Unclassified Drug, Alzheimer Disease, Amino Terminal Sequence, Animal Cell, Article, Controlled Study, Electron Spin Resonance, Electrospray Mass Spectrometry, Neurotoxicity, Nonhuman, Oligomerization, Priority Journal, Protein Structure, Protein Synthesis, Scanning Force Microscopy, Animal Model, Atomic Force Microscopy, Brain Cortex, Chemistry, Circular Dichroism, Drug Effect, Nerve Cell, Pathology, Protein Conformation, Cerebral Cortex, Electron Spin Resonance Spectroscopy, Electrospray Ionization, Amyloid Beta Protein [25-35],
Affiliations:
*** IBB - CNR ***
PhD Program in Neurobiology, Faculty of Medicine, University of Catania, Catania, Italy
I.B.B., CNR, Catania, Italy
I.B.B., CNR, Napoli, Italy
Department of Physical-Chemistry (F. Accascina), University of Palermo, Palermo, Italy
Consorzio Catania Ricerche, Catania, Italy
Department of Pharmaceutical Sciences, University of Catania, Catania, Italy
Department of Chemical Sciences, University of Catania, Catania, Italy
I. B. B., CNR, Catania, Italy
I. B. B., CNR, Napoli, Italy
References:
Not available.
Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity
The toxic properties of P-amyloid protein, A beta (1-42), the major component of senile plaques in Alzheimer's disease, depend on nucleation-dependent oligomerization and aggregation. In addition, A beta (1-42) toxicity is favored by the presence of trace metals, which affect the secondary structure of the peptide. A peptide comprising 11 residues within A beta (1-42) [A beta (25-35)] aggregates and retains the neurotoxic activity of A beta (1-42). We have used both A beta (25-35) and its C-amidated or N-acetylated/C-amidated derivatives to investigate the role of copper (II) in modulating the conformation and aggregation state as well as the neurotoxic properties of amyloid peptides. Electrospray ionization mass spectrometry (ESI-MS) and electron paramagnetic resonance (EPR) measurements were performed to verify the formation of copper (II) /A beta (25-35) complexes and to determine the coordination mode, respectively. A beta (2535) and its derivatives were analyzed by circular dichroism spectroscopy to assess their secondary structure, subjected to thioflavine-T (Th-T) binding assay to reveal beta-sheet structured aggregates formation, and imaged by scanning force microscopy. Toxicity was assessed on mature cultures of rat cortical neurons. We found that beta-sheet-structured species of A beta (25-35) were neurotoxic, whereas the random-coil-structured derivatives were devoid of effect. Interestingly, copper promoted the random-coiI/beta-sheet transition of A beta (25-35), with ensuing peptide toxicity, but it induced the toxicity of the N-acetylated/C-amidated derivative without affecting peptide folding. Moreover, copper did not influence either the folding or the activity of the C-amidated A beta (25-35), suggesting that blockade of the C-terminus of A beta peptides might be sufficient to prevent A beta toxicity. (c) 2006 Wiley-Liss, Inc
The toxic properties of P-amyloid protein, A beta (1-42), the major component of senile plaques in Alzheimer's disease, depend on nucleation-dependent oligomerization and aggregation. In addition, A beta (1-42) toxicity is favored by the presence of trace metals, which affect the secondary structure of the peptide. A peptide comprising 11 residues within A beta (1-42) [A beta (25-35)] aggregates and retains the neurotoxic activity of A beta (1-42). We have used both A beta (25-35) and its C-amidated or N-acetylated/C-amidated derivatives to investigate the role of copper (II) in modulating the conformation and aggregation state as well as the neurotoxic properties of amyloid peptides. Electrospray ionization mass spectrometry (ESI-MS) and electron paramagnetic resonance (EPR) measurements were performed to verify the formation of copper (II) /A beta (25-35) complexes and to determine the coordination mode, respectively. A beta (2535) and its derivatives were analyzed by circular dichroism spectroscopy to assess their secondary structure, subjected to thioflavine-T (Th-T) binding assay to reveal beta-sheet structured aggregates formation, and imaged by scanning force microscopy. Toxicity was assessed on mature cultures of rat cortical neurons. We found that beta-sheet-structured species of A beta (25-35) were neurotoxic, whereas the random-coil-structured derivatives were devoid of effect. Interestingly, copper promoted the random-coiI/beta-sheet transition of A beta (25-35), with ensuing peptide toxicity, but it induced the toxicity of the N-acetylated/C-amidated derivative without affecting peptide folding. Moreover, copper did not influence either the folding or the activity of the C-amidated A beta (25-35), suggesting that blockade of the C-terminus of A beta peptides might be sufficient to prevent A beta toxicity. (c) 2006 Wiley-Liss, Inc
Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity
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Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
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View Export to BibTeX Export to EndNote
* Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine based compounds on β-amyloid aggregation (715 views)
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Impact Factor: 5.192
View Export to BibTeX Export to EndNote
Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F
* The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice (1460 views)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic), 2016 Apr; 106: 10-20.
Impact Factor: 4.48
View Export to BibTeX Export to EndNote
Palladino P, Aura AM, Spoto G
* Surface plasmon resonance for the label-free detection of Alzheimer's β-amyloid peptide aggregation (1069 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2016; 408(3): 849-854.
Impact Factor: 3.431
View Export to BibTeX Export to EndNote
Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (2403 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
View Export to BibTeX Export to EndNote
Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (952 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
View Export to BibTeX Export to EndNote
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (3131 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
View Export to BibTeX Export to EndNote
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (1048 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
View Export to BibTeX Export to EndNote
Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (973 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
View Export to BibTeX Export to EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (936 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
View Export to BibTeX Export to EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (1174 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
View Export to BibTeX Export to EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (1157 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
View Export to BibTeX Export to EndNote
Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (1136 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
View Export to BibTeX Export to EndNote
Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (1063 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
View Export to BibTeX Export to EndNote
Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (1224 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
View Export to BibTeX Export to EndNote
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (841 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
View Export to BibTeX Export to EndNote
15 Records (15 excluding Abstracts).
Total impact factor: 56.271 (56.271 excluding Abstracts).
Total 5 year impact factor: 56.473 (56.473 excluding Abstracts).
Total impact factor: 56.271 (56.271 excluding Abstracts).
Total 5 year impact factor: 56.473 (56.473 excluding Abstracts).
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