In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET (736 views) (PDF restricted 263 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 2015 Mar; 42(3): 309-316.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.429, 5-year impact factor: 2.299
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84922883622&partnerID=40&md5=11ee166d047d6864c454e3bd3601bcfd
Keywords: Biodistribution, Microglia, Neuroinflammation, Pet, Tspo, [18f]dpa-714, Benzodiazepine Receptor, N Diethyl 2 [2 [4 (2 Fluoroethoxy)phenyl] 5, 7 Dimethylpyrazolo[1, 5 A]pyrimidin 3 Yl]acetamide F 18, Radiopharmaceutical Agent, Translocator Protein 18, Unclassified Drug, Animal Experiment, Article, Brain, Competitive Inhibition, Controlled Study, Heart, High Performance Liquid Chromatography, In Vivo Study, Mouse, Nonhuman, Pet-Ct Scanner, Positron Emission Tomography, Radioactivity, Spleen, Tissue Distribution, [(18)f]dpa-714, 4 Aminobutyric Acid Receptor, Bzrp Protein, Fluorine, Isoquinoline Derivative, Ligand, N Sec Butyl 1 (2 Chlorophenyl) N Methyl 3 Isoquinolinecarboxamide, N-Diethyl-2-(2-(4-(2-Fluoroethoxy)phenyl)-5, 7-Dimethylpyrazolo(1, 5-A)pyrimidin-3-Yl)acetamide, Pyrazole Derivative, Pyrimidine Derivative, Binding Competition, Computer Assisted Tomography, Diagnostic Use, Drug Effects, Metabolism, Radiography, Scintiscanning, Fluorine Radioisotopes, Positron-Emission Tomography, X-Ray Computed,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, CNRNaples, Italy
Department of Advanced Biomedical Sciences, Federico II UniversityNaples, Italy
CEINGE, Biotecnologie Avanzate, s.c.a.r.l.Naples, Italy
Inserm U970, PARCC, Université Paris Descartes, Hôpital Européen Georges PompidouParis, France
CEA, I2BM, Service Hospitalier Frédéric JoliotOrsay, France
References:
Papadopoulos, V., Baraldi, M., Guilarte, T.R., Knudsen, T.B., Lacapere, J.J., Lindemann, P., Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function (2006) Trends Pharmacol Sci, 27, pp. 402-40
Venneti, S., Lopresti, B.J., Wiley, C.A., Molecular imaging of microglia/macrophages in the brain (2013) Glia, 61, pp. 10-23
Jacobs, A.H., Tavitian, B., Noninvasive molecular imaging of neuroinflammation (2012) J Cereb Blood Flow Metab, 32, pp. 1393-1415
Chen, M.K., Guilarte, T.R., Translocator protein 18kDa (TSPO): molecular sensor of brain injury and repair (2008) Pharmacol Ther, 118, pp. 1-17
Yasuno, F., Kosaka, J., Ota, M., Higuchi, M., Ito, H., Fujimura, Y., Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment-dementia converters measured by positron emission tomography with [(1)(1)C]DAA1106 (2012) Psychiatry Res, 203, pp. 67-74
Politis, M., Su, P., Piccini, P., Imaging of microglia in patients with neurodegenerative disorders (2012) Front Pharmacol, 3, p. 96
Papadopoulos, V., Lecanu, L., Translocator protein (18kDa) TSPO: an emerging therapeutic target in neurotrauma (2009) Exp Neurol, 219, pp. 53-57
Harberts, E., Datta, D., Chen, S., Wohler, J.E., Oh, U., Jacobson, S., Translocator protein 18kDa (TSPO) expression in multiple sclerosis patients (2013) J Neuroimmune Pharmacol, 8, pp. 51-57
Gavish, M., Bachman, I., Shoukrun, R., Katz, Y., Veenman, L., Weisinger, G., Enigma of the peripheral benzodiazepine receptor (1999) Pharmacol Rev, 51, pp. 629-650
Camsonne, R., Crouzel, C., Comar, D., Mazière, M., Prenant, C., Sastre, J., Synthesis of N-(11C) methyl, N-(methyl-1 propyl), (chloro-2 phenyl)-1 isoquinoleine carboxamide-3 (PK 11195): A new ligand for peripheral benzodiazepine receptors (1984) J Label Compd Radiopharm, 21, pp. 985-991
Dolle, F., Luus, C., Reynolds, A., Kassiou, M., Radiolabelled molecules for imaging the translocator protein (18kDa) using positron emission tomography (2009) Curr Med Chem, 16, pp. 2899-2923
Chauveau, F., Boutin, H., Van Camp, N., Dolle, F., Tavitian, B., Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers (2008) Eur J Nucl Med Mol Imaging, 35, pp. 2304-2319
Brown, A.K., Fujita, M., Fujimura, Y., Liow, J.S., Stabin, M., Ryu, Y.H., Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: a PET radioligand to image inflammation (2007) J Nucl Med, 48, pp. 2072-2079
Trapani, A., Palazzo, C., de Candia, M., Lasorsa, F.M., Trapani, G., Targeting of the translocator protein 18kDa (TSPO): a valuable approach for nuclear and optical imaging of activated microglia (2013) Bioconjug Chem, 24, pp. 1415-1428
Scarf, A.M., Kassiou, M., The translocator protein (2011) J Nucl Med, 52, pp. 677-680
Owen, D.R., Matthews, P.M., Imaging brain microglial activation using positron emission tomography and translocator protein-specific radioligands (2011) Int Rev Neurobiol, 101, pp. 19-39
Doorduin, J., de Vries, E.F., Dierckx, R.A., Klein, H.C., PET imaging of the peripheral benzodiazepine receptor: monitoring disease progression and therapy response in neurodegenerative disorders (2008) Curr Pharm Des, 14, pp. 3297-3315
Cagnin, A., Kassiou, M., Meikle, S.R., Banati, R.B., Positron emission tomography imaging of neuroinflammation (2007) Neurotherapeutics, 4, pp. 443-452
James, M.L., Fulton, R.R., Vercoullie, J., Henderson, D.J., Garreau, L., Chalon, S., DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization (2008) J Nucl Med, 49, pp. 814-822
Damont, A., Hinnen, F., Kuhnast, B., Schöllhorn-Peyronneau, M.A., James, M., Luus, C., Radiosynthesis of [18F]DPA-714, a selective radioligand for imaging the translocator protein (18kDa) with PET (2008) J Label Compd Radiopharm, 51, pp. 286-292
Arlicot, N., Vercouillie, J., Ribeiro, M.J., Tauber, C., Venel, Y., Baulieu, J.L., Initial evaluation in healthy humans of [18F]DPA-714, a potential PET biomarker for neuroinflammation (2012) Nucl Med Biol, 39, pp. 570-578
Martin, A., Boisgard, R., Theze, B., Van Camp, N., Kuhnast, B., Damont, A., Evaluation of the PBR/TSPO radioligand [(18)F]DPA-714 in a rat model of focal cerebral ischemia (2010) J Cereb Blood Flow Metab, 30, pp. 230-241
Doorduin, J., Klein, H.C., Dierckx, R.A., James, M., Kassiou, M., de Vries, E.F., [11C]-DPA-713 and [18F]-DPA-714 as new PET tracers for TSPO: a comparison with [11C]-(R)-PK11195 in a rat model of herpes encephalitis (2009) Mol Imaging Biol, 11, pp. 386-398
Chauveau, F., Van Camp, N., Dolle, F., Kuhnast, B., Hinnen, F., Damont, A., Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation (2009) J Nucl Med, 50, pp. 468-476
Boutin, H., Prenant, C., Maroy, R., Galea, J., Greenhalgh, A.D., Smigova, A., [18F]DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats (2013) PLoS One, 8, p. e56441
Peyronneau, M.A., Saba, W., Goutal, S., Damont, A., Dolle, F., Kassiou, M., Metabolism and quantification of [(18)F]DPA-714, a new TSPO positron emission tomography radioligand (2013) Drug Metab Dispos, 41, pp. 122-131
Harhausen, D., Sudmann, V., Khojasteh, U., Muller, J., Zille, M., Graham, K., Specific imaging of inflammation with the 18kDa translocator protein ligand DPA-714 in animal models of epilepsy and stroke (2013) PLoS One, 8, p. e69529
Gent, Y.Y., Weijers, K., Molthoff, C.F., Windhorst, A.D., Huisman, M.C., Kassiou, M., Promising potential of new generation translocator protein tracers providing enhanced contrast of arthritis imaging by positron emission tomography in a rat model of arthritis (2014) Arthritis Res Ther, 16, p. R70
Yanamoto, K., Kumata, K., Fujinaga, M., Nengaki, N., Takei, M., Wakizaka, H., In vivo imaging and quantitative analysis of TSPO in rat peripheral tissues using small-animal PET with [18F]FEDAC (2010) Nucl Med Biol, 37, pp. 853-860
Hashimoto, K., Inoue, O., Suzuki, K., Yamasaki, T., Kojima, M., Synthesis and evaluation of 11C-PK 11195 for in vivo study of peripheral-type benzodiazepine receptors using positron emission tomography (1989) Ann Nucl Med, 3, pp. 63-71
Fookes, C.J., Pham, T.Q., Mattner, F., Greguric, I., Loc'h, C., Liu, X., Synthesis and biological evaluation of substituted [18F]imidazo[1,2-a]pyridines and [18F]pyrazolo[1,5-a]pyrimidines for the study of the peripheral benzodiazepine receptor using positron emission tomography (2008) J Med Chem, 51, pp. 3700-3712
Mattner, F., Mardon, K., Katsifis, A., Pharmacological evaluation of [123I]-CLINDE: a radioiodinated imidazopyridine-3-acetamide for the study of peripheral benzodiazepine binding sites (PBBS) (2008) Eur J Nucl Med Mol Imaging, 35, pp. 779-789
Boutin, H., Chauveau, F., Thominiaux, C., Gregoire, M.C., James, M.L., Trebossen, R., 11C-DPA-713: a novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation (2007) J Nucl Med, 48, pp. 573-581
Bribes, E., Carriere, D., Goubet, C., Galiegue, S., Casellas, P., Simony-Lafontaine, J., Immunohistochemical assessment of the peripheral benzodiazepine receptor in human tissues (2004) J Histochem Cytochem, 52, pp. 19-28
Papadopoulos, V., Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function (1993) Endocr Rev, 14, pp. 222-240
Maeda, J., Suhara, T., Zhang, M.R., Okauchi, T., Yasuno, F., Ikoma, Y., Novel peripheral benzodiazepine receptor ligand [11C]DAA1106 for PET: an imaging tool for glial cells in the brain (2004) Synapse, 52, pp. 283-291
Zhang, M.R., Kumata, K., Maeda, J., Yanamoto, K., Hatori, A., Okada, M., 11C-AC-5216: a novel PET ligand for peripheral benzodiazepine receptors in the primate brain (2007) J Nucl Med, 48, pp. 1853-1861
Edison, P., Archer, H.A., Gerhard, A., Hinz, R., Pavese, N., Turkheimer, F.E., Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study (2008) Neurobiol Dis, 32, pp. 412-419
Pavese, N., Gerhard, A., Tai, Y.F., Ho, A.K., Turkheimer, F., Barker, R.A., Microglial activation correlates with severity in Huntington disease: a clinical and PET study (2006) Neurology, 66, pp. 1638-1643
Messmer, K., Reynolds, G.P., Increased peripheral benzodiazepine binding sites in the brain of patients with Huntington's disease (1998) Neurosci Lett, 241, pp. 53-56
Ouchi, Y., Yoshikawa, E., Sekine, Y., Futatsubashi, M., Kanno, T., Ogusu, T., Microglial activation and dopamine terminal loss in early Parkinson's disease (2005) Ann Neurol, 57, pp. 168-175
Turner, M.R., Cagnin, A., Turkheimer, F.E., Miller, C.C., Shaw, C.E., Brooks, D.J., Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study (2004) Neurobiol Dis, 15, pp. 601-609
Cagnin, A., Rossor, M., Sampson, E.L., Mackinnon, T., Banati, R.B., In vivo detection of microglial activation in frontotemporal dementia (2004) Ann Neurol, 56, pp. 894-897
Versijpt, J., Debruyne, J.C., Van Laere, K.J., De Vos, F., Keppens, J., Strijckmans, K., Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study (2005) Mult Scler, 11, pp. 127-134
Vowinckel, E., Reutens, D., Becher, B., Verge, G., Evans, A., Owens, T., PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis (1997) J Neurosci Res, 50, pp. 345-353
Gerhard, A., Schwarz, J., Myers, R., Wise, R., Banati, R.B., Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study (2005) Neuroimage, 24, pp. 591-595
Cosenza-Nashat, M., Zhao, M.L., Suh, H.S., Morgan, J., Natividad, R., Morgello, S., Expression of the translocator protein of 18kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain (2009) Neuropathol Appl Neurobiol, 35, pp. 306-328
Han, Z., Slack, R.S., Li, W., Papadopoulos, V., Expression of peripheral benzodiazepine receptor (PBR) in human tumors: relationship to breast, colorectal, and prostate tumor progression (2003) J Recept Signal Transduct Res, 23, pp. 225-238
Vlodavsky, E., Soustiel, J.F., Immunohistochemical expression of peripheral benzodiazepine receptors in human astrocytomas and its correlation with grade of malignancy, proliferation, apoptosis and survival (2007) J Neurooncol, 81, pp. 1-7
Gaemperli, O., Shalhoub, J., Owen, D.R., Lamare, F., Johansson, S., Fouladi, N., Imaging intraplaque inflammation in carotid atherosclerosis with 11C-PK11195 positron emission tomography/computed tomography (2012) Eur Heart J, 33, pp. 1902-1910
Varrone, A., Mattsson, P., Forsberg, A., Takano, A., Nag, S., Gulyas, B., In vivo imaging of the 18-kDa translocator protein (TSPO) with [18F]FEDAA1106 and PET does not show increased binding in Alzheimer's disease patients (2013) Eur J Nucl Med Mol Imaging, 40, pp. 921-931
Takano, A., Piehl, F., Hillert, J., Varrone, A., Nag, S., Gulyas, B., In vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [18F]FEDAA1106 (2013) EJNMMI Res, 3, p. 30
Rupprecht, R., Papadopoulos, V., Rammes, G., Baghai, T.C., Fan, J., Akula, N., Translocator protein (18kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders (2010) Nat Rev Drug Discov, 9, pp. 971-988
Daugherty, D.J., Selvaraj, V., Chechneva, O.V., Liu, X.B., Pleasure, D.E., Deng, W., A TSPO ligand is protective in a mouse model of multiple sclerosis (2013) EMBO Mol Med, 5, pp. 891-903
Fafalios, A., Akhavan, A., Parwani, A.V., Bies, R.R., McHugh, K.J., Pflug, B.R., Translocator protein blockade reduces prostate tumor growth (2009) Clin Cancer Res, 15, pp. 6177-6184
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Guo, Q., Owen, D.R., Rabiner, E.A., Turkheimer, F.E., Gunn, R.N., Identifying improved TSPO PET imaging probes through biomathematics: the impact of multiple TSPO binding sites in vivo (2012) Neuroimage, 60, pp. 902-910
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 2015 Mar; 42(3): 309-316.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.429, 5-year impact factor: 2.299
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84922883622&partnerID=40&md5=11ee166d047d6864c454e3bd3601bcfd
Keywords: Biodistribution, Microglia, Neuroinflammation, Pet, Tspo, [18f]dpa-714, Benzodiazepine Receptor, N Diethyl 2 [2 [4 (2 Fluoroethoxy)phenyl] 5, 7 Dimethylpyrazolo[1, 5 A]pyrimidin 3 Yl]acetamide F 18, Radiopharmaceutical Agent, Translocator Protein 18, Unclassified Drug, Animal Experiment, Article, Brain, Competitive Inhibition, Controlled Study, Heart, High Performance Liquid Chromatography, In Vivo Study, Mouse, Nonhuman, Pet-Ct Scanner, Positron Emission Tomography, Radioactivity, Spleen, Tissue Distribution, [(18)f]dpa-714, 4 Aminobutyric Acid Receptor, Bzrp Protein, Fluorine, Isoquinoline Derivative, Ligand, N Sec Butyl 1 (2 Chlorophenyl) N Methyl 3 Isoquinolinecarboxamide, N-Diethyl-2-(2-(4-(2-Fluoroethoxy)phenyl)-5, 7-Dimethylpyrazolo(1, 5-A)pyrimidin-3-Yl)acetamide, Pyrazole Derivative, Pyrimidine Derivative, Binding Competition, Computer Assisted Tomography, Diagnostic Use, Drug Effects, Metabolism, Radiography, Scintiscanning, Fluorine Radioisotopes, Positron-Emission Tomography, X-Ray Computed,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, CNRNaples, Italy
Department of Advanced Biomedical Sciences, Federico II UniversityNaples, Italy
CEINGE, Biotecnologie Avanzate, s.c.a.r.l.Naples, Italy
Inserm U970, PARCC, Université Paris Descartes, Hôpital Européen Georges PompidouParis, France
CEA, I2BM, Service Hospitalier Frédéric JoliotOrsay, France
References:
Papadopoulos, V., Baraldi, M., Guilarte, T.R., Knudsen, T.B., Lacapere, J.J., Lindemann, P., Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function (2006) Trends Pharmacol Sci, 27, pp. 402-40
Venneti, S., Lopresti, B.J., Wiley, C.A., Molecular imaging of microglia/macrophages in the brain (2013) Glia, 61, pp. 10-23
Jacobs, A.H., Tavitian, B., Noninvasive molecular imaging of neuroinflammation (2012) J Cereb Blood Flow Metab, 32, pp. 1393-1415
Chen, M.K., Guilarte, T.R., Translocator protein 18kDa (TSPO): molecular sensor of brain injury and repair (2008) Pharmacol Ther, 118, pp. 1-17
Yasuno, F., Kosaka, J., Ota, M., Higuchi, M., Ito, H., Fujimura, Y., Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment-dementia converters measured by positron emission tomography with [(1)(1)C]DAA1106 (2012) Psychiatry Res, 203, pp. 67-74
Politis, M., Su, P., Piccini, P., Imaging of microglia in patients with neurodegenerative disorders (2012) Front Pharmacol, 3, p. 96
Papadopoulos, V., Lecanu, L., Translocator protein (18kDa) TSPO: an emerging therapeutic target in neurotrauma (2009) Exp Neurol, 219, pp. 53-57
Harberts, E., Datta, D., Chen, S., Wohler, J.E., Oh, U., Jacobson, S., Translocator protein 18kDa (TSPO) expression in multiple sclerosis patients (2013) J Neuroimmune Pharmacol, 8, pp. 51-57
Gavish, M., Bachman, I., Shoukrun, R., Katz, Y., Veenman, L., Weisinger, G., Enigma of the peripheral benzodiazepine receptor (1999) Pharmacol Rev, 51, pp. 629-650
Camsonne, R., Crouzel, C., Comar, D., Mazière, M., Prenant, C., Sastre, J., Synthesis of N-(11C) methyl, N-(methyl-1 propyl), (chloro-2 phenyl)-1 isoquinoleine carboxamide-3 (PK 11195): A new ligand for peripheral benzodiazepine receptors (1984) J Label Compd Radiopharm, 21, pp. 985-991
Dolle, F., Luus, C., Reynolds, A., Kassiou, M., Radiolabelled molecules for imaging the translocator protein (18kDa) using positron emission tomography (2009) Curr Med Chem, 16, pp. 2899-2923
Chauveau, F., Boutin, H., Van Camp, N., Dolle, F., Tavitian, B., Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers (2008) Eur J Nucl Med Mol Imaging, 35, pp. 2304-2319
Brown, A.K., Fujita, M., Fujimura, Y., Liow, J.S., Stabin, M., Ryu, Y.H., Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: a PET radioligand to image inflammation (2007) J Nucl Med, 48, pp. 2072-2079
Trapani, A., Palazzo, C., de Candia, M., Lasorsa, F.M., Trapani, G., Targeting of the translocator protein 18kDa (TSPO): a valuable approach for nuclear and optical imaging of activated microglia (2013) Bioconjug Chem, 24, pp. 1415-1428
Scarf, A.M., Kassiou, M., The translocator protein (2011) J Nucl Med, 52, pp. 677-680
Owen, D.R., Matthews, P.M., Imaging brain microglial activation using positron emission tomography and translocator protein-specific radioligands (2011) Int Rev Neurobiol, 101, pp. 19-39
Doorduin, J., de Vries, E.F., Dierckx, R.A., Klein, H.C., PET imaging of the peripheral benzodiazepine receptor: monitoring disease progression and therapy response in neurodegenerative disorders (2008) Curr Pharm Des, 14, pp. 3297-3315
Cagnin, A., Kassiou, M., Meikle, S.R., Banati, R.B., Positron emission tomography imaging of neuroinflammation (2007) Neurotherapeutics, 4, pp. 443-452
James, M.L., Fulton, R.R., Vercoullie, J., Henderson, D.J., Garreau, L., Chalon, S., DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization (2008) J Nucl Med, 49, pp. 814-822
Damont, A., Hinnen, F., Kuhnast, B., Schöllhorn-Peyronneau, M.A., James, M., Luus, C., Radiosynthesis of [18F]DPA-714, a selective radioligand for imaging the translocator protein (18kDa) with PET (2008) J Label Compd Radiopharm, 51, pp. 286-292
Arlicot, N., Vercouillie, J., Ribeiro, M.J., Tauber, C., Venel, Y., Baulieu, J.L., Initial evaluation in healthy humans of [18F]DPA-714, a potential PET biomarker for neuroinflammation (2012) Nucl Med Biol, 39, pp. 570-578
Martin, A., Boisgard, R., Theze, B., Van Camp, N., Kuhnast, B., Damont, A., Evaluation of the PBR/TSPO radioligand [(18)F]DPA-714 in a rat model of focal cerebral ischemia (2010) J Cereb Blood Flow Metab, 30, pp. 230-241
Doorduin, J., Klein, H.C., Dierckx, R.A., James, M., Kassiou, M., de Vries, E.F., [11C]-DPA-713 and [18F]-DPA-714 as new PET tracers for TSPO: a comparison with [11C]-(R)-PK11195 in a rat model of herpes encephalitis (2009) Mol Imaging Biol, 11, pp. 386-398
Chauveau, F., Van Camp, N., Dolle, F., Kuhnast, B., Hinnen, F., Damont, A., Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation (2009) J Nucl Med, 50, pp. 468-476
Boutin, H., Prenant, C., Maroy, R., Galea, J., Greenhalgh, A.D., Smigova, A., [18F]DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats (2013) PLoS One, 8, p. e56441
Peyronneau, M.A., Saba, W., Goutal, S., Damont, A., Dolle, F., Kassiou, M., Metabolism and quantification of [(18)F]DPA-714, a new TSPO positron emission tomography radioligand (2013) Drug Metab Dispos, 41, pp. 122-131
Harhausen, D., Sudmann, V., Khojasteh, U., Muller, J., Zille, M., Graham, K., Specific imaging of inflammation with the 18kDa translocator protein ligand DPA-714 in animal models of epilepsy and stroke (2013) PLoS One, 8, p. e69529
Gent, Y.Y., Weijers, K., Molthoff, C.F., Windhorst, A.D., Huisman, M.C., Kassiou, M., Promising potential of new generation translocator protein tracers providing enhanced contrast of arthritis imaging by positron emission tomography in a rat model of arthritis (2014) Arthritis Res Ther, 16, p. R70
Yanamoto, K., Kumata, K., Fujinaga, M., Nengaki, N., Takei, M., Wakizaka, H., In vivo imaging and quantitative analysis of TSPO in rat peripheral tissues using small-animal PET with [18F]FEDAC (2010) Nucl Med Biol, 37, pp. 853-860
Hashimoto, K., Inoue, O., Suzuki, K., Yamasaki, T., Kojima, M., Synthesis and evaluation of 11C-PK 11195 for in vivo study of peripheral-type benzodiazepine receptors using positron emission tomography (1989) Ann Nucl Med, 3, pp. 63-71
Fookes, C.J., Pham, T.Q., Mattner, F., Greguric, I., Loc'h, C., Liu, X., Synthesis and biological evaluation of substituted [18F]imidazo[1,2-a]pyridines and [18F]pyrazolo[1,5-a]pyrimidines for the study of the peripheral benzodiazepine receptor using positron emission tomography (2008) J Med Chem, 51, pp. 3700-3712
Mattner, F., Mardon, K., Katsifis, A., Pharmacological evaluation of [123I]-CLINDE: a radioiodinated imidazopyridine-3-acetamide for the study of peripheral benzodiazepine binding sites (PBBS) (2008) Eur J Nucl Med Mol Imaging, 35, pp. 779-789
Boutin, H., Chauveau, F., Thominiaux, C., Gregoire, M.C., James, M.L., Trebossen, R., 11C-DPA-713: a novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation (2007) J Nucl Med, 48, pp. 573-581
Bribes, E., Carriere, D., Goubet, C., Galiegue, S., Casellas, P., Simony-Lafontaine, J., Immunohistochemical assessment of the peripheral benzodiazepine receptor in human tissues (2004) J Histochem Cytochem, 52, pp. 19-28
Papadopoulos, V., Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function (1993) Endocr Rev, 14, pp. 222-240
Maeda, J., Suhara, T., Zhang, M.R., Okauchi, T., Yasuno, F., Ikoma, Y., Novel peripheral benzodiazepine receptor ligand [11C]DAA1106 for PET: an imaging tool for glial cells in the brain (2004) Synapse, 52, pp. 283-291
Zhang, M.R., Kumata, K., Maeda, J., Yanamoto, K., Hatori, A., Okada, M., 11C-AC-5216: a novel PET ligand for peripheral benzodiazepine receptors in the primate brain (2007) J Nucl Med, 48, pp. 1853-1861
Edison, P., Archer, H.A., Gerhard, A., Hinz, R., Pavese, N., Turkheimer, F.E., Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study (2008) Neurobiol Dis, 32, pp. 412-419
Pavese, N., Gerhard, A., Tai, Y.F., Ho, A.K., Turkheimer, F., Barker, R.A., Microglial activation correlates with severity in Huntington disease: a clinical and PET study (2006) Neurology, 66, pp. 1638-1643
Messmer, K., Reynolds, G.P., Increased peripheral benzodiazepine binding sites in the brain of patients with Huntington's disease (1998) Neurosci Lett, 241, pp. 53-56
Ouchi, Y., Yoshikawa, E., Sekine, Y., Futatsubashi, M., Kanno, T., Ogusu, T., Microglial activation and dopamine terminal loss in early Parkinson's disease (2005) Ann Neurol, 57, pp. 168-175
Turner, M.R., Cagnin, A., Turkheimer, F.E., Miller, C.C., Shaw, C.E., Brooks, D.J., Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study (2004) Neurobiol Dis, 15, pp. 601-609
Cagnin, A., Rossor, M., Sampson, E.L., Mackinnon, T., Banati, R.B., In vivo detection of microglial activation in frontotemporal dementia (2004) Ann Neurol, 56, pp. 894-897
Versijpt, J., Debruyne, J.C., Van Laere, K.J., De Vos, F., Keppens, J., Strijckmans, K., Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study (2005) Mult Scler, 11, pp. 127-134
Vowinckel, E., Reutens, D., Becher, B., Verge, G., Evans, A., Owens, T., PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis (1997) J Neurosci Res, 50, pp. 345-353
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Cosenza-Nashat, M., Zhao, M.L., Suh, H.S., Morgan, J., Natividad, R., Morgello, S., Expression of the translocator protein of 18kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain (2009) Neuropathol Appl Neurobiol, 35, pp. 306-328
Han, Z., Slack, R.S., Li, W., Papadopoulos, V., Expression of peripheral benzodiazepine receptor (PBR) in human tumors: relationship to breast, colorectal, and prostate tumor progression (2003) J Recept Signal Transduct Res, 23, pp. 225-238
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Gaemperli, O., Shalhoub, J., Owen, D.R., Lamare, F., Johansson, S., Fouladi, N., Imaging intraplaque inflammation in carotid atherosclerosis with 11C-PK11195 positron emission tomography/computed tomography (2012) Eur Heart J, 33, pp. 1902-1910
Varrone, A., Mattsson, P., Forsberg, A., Takano, A., Nag, S., Gulyas, B., In vivo imaging of the 18-kDa translocator protein (TSPO) with [18F]FEDAA1106 and PET does not show increased binding in Alzheimer's disease patients (2013) Eur J Nucl Med Mol Imaging, 40, pp. 921-931
Takano, A., Piehl, F., Hillert, J., Varrone, A., Nag, S., Gulyas, B., In vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [18F]FEDAA1106 (2013) EJNMMI Res, 3, p. 30
Rupprecht, R., Papadopoulos, V., Rammes, G., Baghai, T.C., Fan, J., Akula, N., Translocator protein (18kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders (2010) Nat Rev Drug Discov, 9, pp. 971-988
Daugherty, D.J., Selvaraj, V., Chechneva, O.V., Liu, X.B., Pleasure, D.E., Deng, W., A TSPO ligand is protective in a mouse model of multiple sclerosis (2013) EMBO Mol Med, 5, pp. 891-903
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In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET
Introduction: The translocator protein 18kDa (TSPO), a biochemical marker of neuroinflammation, is highly expressed in the brain activated microglia and it is also expressed by peripheral inflammatory cells and normal peripheral tissues. Thus, development of radioligands for the TSPO may contribute to further understanding the in vivo TSPO function in central and peripheral inflammatory processes and other pathologies. Here, we report the biodistribution, the specific binding and the radiometabolites of [18F]DPA-714, a promising fluorinated PET radiotracer, in normal mice using a microPET/CT scanner. Methods: The in vivo biodistribution and kinetics of [18F]DPA-714 were measured in mice brain and peripheral tissues. Specific binding to TSPO sites was assessed using pharmacological competitive studies by means of saturation experiments performed by i.v. injection of 1mg/kg of unlabeled DPA-714 or 3mg/kg of unlabeled PK11195. A region of interest analysis was performed to generate time-activity curves in the brain, heart, lung, kidney, spleen and liver. Metabolites assay was performed in the plasma and peripheral organs by radio-HPLC. Results: [18F]DPA-714 reached high concentration in lung, heart, kidney and spleen, tissues well known to be rich in TSPO sites. [18F]DPA-714 kinetics were faster in the lung and slower in the kidney. Pre-injection of unlabeled DPA-714 or PK11195 inhibited about 80% of [18F]DPA-714 uptake in the lung and heart (p<0.0005). The percentage of inhibition in the kidney was lower and achieved at later times only with DPA-714 (p<0.05) but not with PK11195. Sixty minutes after radiotracer injection only unmetabolized radioligand was found in the brain, lung, heart and spleen. Conclusion: These results suggest that [18F]DPA-714 is a suitable PET ligand for imaging in mice brain and peripheral tissues since it binds with high specificity TSPO binding sites and it is almost unchanged at 60minutes after radiotracer injection in the brain and TSPO-rich regions. © 2014 Elsevier Inc.
Introduction: The translocator protein 18kDa (TSPO), a biochemical marker of neuroinflammation, is highly expressed in the brain activated microglia and it is also expressed by peripheral inflammatory cells and normal peripheral tissues. Thus, development of radioligands for the TSPO may contribute to further understanding the in vivo TSPO function in central and peripheral inflammatory processes and other pathologies. Here, we report the biodistribution, the specific binding and the radiometabolites of [18F]DPA-714, a promising fluorinated PET radiotracer, in normal mice using a microPET/CT scanner. Methods: The in vivo biodistribution and kinetics of [18F]DPA-714 were measured in mice brain and peripheral tissues. Specific binding to TSPO sites was assessed using pharmacological competitive studies by means of saturation experiments performed by i.v. injection of 1mg/kg of unlabeled DPA-714 or 3mg/kg of unlabeled PK11195. A region of interest analysis was performed to generate time-activity curves in the brain, heart, lung, kidney, spleen and liver. Metabolites assay was performed in the plasma and peripheral organs by radio-HPLC. Results: [18F]DPA-714 reached high concentration in lung, heart, kidney and spleen, tissues well known to be rich in TSPO sites. [18F]DPA-714 kinetics were faster in the lung and slower in the kidney. Pre-injection of unlabeled DPA-714 or PK11195 inhibited about 80% of [18F]DPA-714 uptake in the lung and heart (p<0.0005). The percentage of inhibition in the kidney was lower and achieved at later times only with DPA-714 (p<0.05) but not with PK11195. Sixty minutes after radiotracer injection only unmetabolized radioligand was found in the brain, lung, heart and spleen. Conclusion: These results suggest that [18F]DPA-714 is a suitable PET ligand for imaging in mice brain and peripheral tissues since it binds with high specificity TSPO binding sites and it is almost unchanged at 60minutes after radiotracer injection in the brain and TSPO-rich regions. © 2014 Elsevier Inc.
In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET
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In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET
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Coda AR, Anzilotti S, Boscia F, Greco A, Panico M, Gargiulo S, Gramanzini M, Zannetti A, Albanese S, Pignataro G, Annunziato L, Salvatore M, Brunetti A, De Berardinis P, Quarantelli M, Palma G, Pappata S
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Rendina A, Drongitis D, Donizetti A, Fucci L, Milan G, Tripodi F, Giustezza F, Postiglione A, Pappata S, Ferrari R, Bossù P, Angiolillo A, Di Costanzo A, Caiazzo M, Vitale E
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Perani D, Iaccarino L, Lammertsma AA, Windhorst AD, Edison P, Boellaard R, Hansson O, Nordberg A, Jacobs AH, Bottlaender M, Brooks D, Carroll MA, Chalon S, Gee A, Gerhard A, Halldin C, Herholz K, Herth MM, Hinz R, Knudsen GM, Kuhnast B, López-picón F, Moresco RM, Pappata S, Rinne JO, Rodriguez-vieitez E, Santiago-ribeiro MJ, Turkheimer FE, Van Laere K, Varrone A, Vercouillie J, Winkeler A
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Perani D, Iaccarino L, Jacobs AH, Lammertsma AA, Nordberg A, Windhorst AD, Gerhard A, Winkeler A, Jacobs AH, Gee A, Kuhnast B, Halldin C, Perani D, Brooks D, Rodriguez-vieitez E, Turkheimer FE, López-picón F, Knudsen GM, Vercouillie J, Rinne JO, Herholz K, Van Laere K, Santiago-ribeiro MJ, Herth MM, Carroll MA, Bottlaender M, Hansson O, Edison P, Hinz R, Boellaard R, Moresco RM, Pappata S
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Ugga L, Romeo V, Tedeschi E, Brunetti A, Quarantelli M
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Garello F, Pagoto A, Arena F, Buffo A, Blasi F, Alberti D, Terreno E
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Pontillo G, Cocozza S, Lanzillo R, Borrelli P, De Rosa A, Brescia Morra V, Tedeschi E, PalmaG
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Impact Factor: 3.508
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Gargiulo S, Coda AR, Panico M, Gramanzini M, Moresco RM, Chalon S, Pappata S
* Molecular imaging of neuroinflammation in preclinical rodent models using positron emission tomography (324 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 60-75.
Impact Factor: 2.368
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Quarantelli M
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Impact Factor: 0
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Jacobs AH, Tavitian B, TheInmindG, Pappata S, Quarantelli M
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Impact Factor: 5.398
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Takano A, Gulyas B, Varrone A, Karlsson P, Sjoholm N, Larsson S, Jonsson C, Odh R, Sparks R, Al Tawil N, Hoffmann A, Zimmermann T, Thiele A, Halldin C
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Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Nov; 38(11): 2058-2065.
Impact Factor: 4.991
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Varrone A, Stepanov V, Nakao R, Toth M, Gulyas B, Emond P, Deloye JB, Vercouillie J, Stabin MG, Jonsson C, Guilloteau D, Halldin C
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J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2011 Sep 1; 52(8): 1313-1321.
Impact Factor: 6.381
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Gulyas B, Vas A, Toth M, Takano A, Varrone A, Cselenyi Z, Schain M, Mattsson P, Halldin C
* Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine (596 views)
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Pappata S, Varrone A, Vicidomini C, Milan G, De Falco C, Sansone V, Iavarone A, Comerci M, Loré E, Panico M, Quarantelli M, Postiglione A, Salvatore M
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Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jun; 37(6): 1156-1163.
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Odano I, Halldin C, Karlsson P, Varrone A, Airaksinen AJ, Krasikova RN, Farde L
* [18F]Flumazenil binding to central benzodiazepine receptor studies by PET. - Quantitative analysis and comparisons with [11C]flumazenil (307 views)
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Impact Factor: 5.739
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Vergote J, Chalon S, Emond P, Vercouillie J, Pappata S, Guilloteau D
* New SPECT and PET dementia tracers (358 views)
Med Nucl (ISSN: 0928-1258), 2009 Mar; 33(3): 137-141.
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Takano A, Halldin C, Varrone A, Karlsson P, Sjoholm N, Stubbs JB, Schou M, Airaksinen AJ, Tauscher J, Gulyas B
* Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S, S)-[18F]FMeNER-D2: A human whole-body PET study (357 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Mar; 35(3): 630-636.
Impact Factor: 4.532
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Fonti R, Cheung N-KV, Bridger GJ, Guo H-F, Abrams MJ, Larson SM
99mTc-monoclonal antibody radiolabeled via hydrazino nicotinamide derivative for imaging disialoganglioside G(D2)-positive tumors (394 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999; 26(6): 681-686.
Impact Factor: 1.623
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Varrone A, Soricelli A, Postiglione A, Salvatore M, Lassen N
Benzodiazepine receptor distribution in Alzheimer's disease with (123)I-iomazenil by SPECT (286 views)
Textbook Of Spect In Neurology And Psychiatry, 1997; N/D: N/D-N/D.
Impact Factor: 0
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Soricelli A, Postiglione A, GrivetFojaja M, Mainenti PP, Discepolo A, Varrone A, Salvatore M, Lassen N
Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses (417 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1996 Oct; 23(10): 1323-1328.
Impact Factor: 2.692
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* In vivo imaging of CNS microglial activation/macrophage infiltration with combined [(18)F]DPA-714-PET and SPIO-MRI in a mouse model of relapsing remitting experimental autoimmune encephalomyelitis (150 views) (PDF 60 views)
Eur J Nucl Med (ISSN: 1619-7070linking, 1619-7089electronic, 1619-7070print), 2021 Jan; 48(1): 40-52.
Impact Factor: 7.18
View Export to BibTeX Export to EndNote
Rendina A, Drongitis D, Donizetti A, Fucci L, Milan G, Tripodi F, Giustezza F, Postiglione A, Pappata S, Ferrari R, Bossù P, Angiolillo A, Di Costanzo A, Caiazzo M, Vitale E
* CD33 and SIGLECL1 Immunoglobulin Superfamily Involved in Dementia (94 views)
J Neuropathol Exp Neurol (ISSN: 0022-3069linking), 2020 Jul 10; 79(8): 891-901.
Impact Factor: 3.51
View Export to BibTeX Export to EndNote
Perani D, Iaccarino L, Lammertsma AA, Windhorst AD, Edison P, Boellaard R, Hansson O, Nordberg A, Jacobs AH, Bottlaender M, Brooks D, Carroll MA, Chalon S, Gee A, Gerhard A, Halldin C, Herholz K, Herth MM, Hinz R, Knudsen GM, Kuhnast B, López-picón F, Moresco RM, Pappata S, Rinne JO, Rodriguez-vieitez E, Santiago-ribeiro MJ, Turkheimer FE, Van Laere K, Varrone A, Vercouillie J, Winkeler A
* A new perspective for advanced positron emission tomography-based molecular imaging in neurodegenerative proteinopathies (206 views)
Alzheimers Dement (ISSN: 1552-5260linking), 2019 Jun 20; N/D: N/D-N/D.
Impact Factor: 14.43
View Export to BibTeX Export to EndNote
Perani D, Iaccarino L, Jacobs AH, Lammertsma AA, Nordberg A, Windhorst AD, Gerhard A, Winkeler A, Jacobs AH, Gee A, Kuhnast B, Halldin C, Perani D, Brooks D, Rodriguez-vieitez E, Turkheimer FE, López-picón F, Knudsen GM, Vercouillie J, Rinne JO, Herholz K, Van Laere K, Santiago-ribeiro MJ, Herth MM, Carroll MA, Bottlaender M, Hansson O, Edison P, Hinz R, Boellaard R, Moresco RM, Pappata S
* Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies (253 views)
Alzheimers Dement (ISSN: 2352-8729print), 2019 Apr 16; 11: 327-332.
Impact Factor: 14.423
View Export to BibTeX Export to EndNote
Ugga L, Romeo V, Tedeschi E, Brunetti A, Quarantelli M
* Superparamagnetic iron oxide nanocolloids in MRI studies of neuroinflammation (438 views)
J Neurosci Methods (ISSN: 0165-0270linking, 1872-678xelectronic), 2018 Jun 18; 310: 12-23.
Impact Factor: 2.668
View Export to BibTeX Export to EndNote
Garello F, Pagoto A, Arena F, Buffo A, Blasi F, Alberti D, Terreno E
* MRI visualization of neuroinflammation using VCAM-1 targeted paramagnetic micelles (231 views)
Nanomedicine (ISSN: 1549-9634, 1549-9642), 2017 Nov 8; N/D: N/D-N/D.
Impact Factor: 6.5
View Export to BibTeX Export to EndNote
Pontillo G, Cocozza S, Lanzillo R, Borrelli P, De Rosa A, Brescia Morra V, Tedeschi E, PalmaG
* Brain Susceptibility Changes in a Patient with Natalizumab-Related Progressive Multifocal Leukoencephalopathy: A Longitudinal Quantitative Susceptibility Mapping and Relaxometry Study (232 views)
Front Neurol (ISSN: 1664-2295, 1664-2295linking, 1664-2295print), 2017 Jun 19; 8: 294-294.
Impact Factor: 3.508
View Export to BibTeX Export to EndNote
Gargiulo S, Coda AR, Panico M, Gramanzini M, Moresco RM, Chalon S, Pappata S
* Molecular imaging of neuroinflammation in preclinical rodent models using positron emission tomography (324 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 60-75.
Impact Factor: 2.368
View Export to BibTeX Export to EndNote
Quarantelli M
* MRI/MRS in neuroinflammation: methodology and applications (296 views)
Clin Transl Imaging (ISSN: 2281-5872print, 2281-5872linking), 2015; 3: 475-489.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Jacobs AH, Tavitian B, TheInmindG, Pappata S, Quarantelli M
* Noninvasive molecular imaging of neuroinflammation (335 views) (PDF 196 views)
J Cereb Blood Flow Metab (ISSN: 0271-678x, 1559-7016electronic), 2012 Jul; 32(7): 1393-1415.
Impact Factor: 5.398
View Export to BibTeX Export to EndNote
Takano A, Gulyas B, Varrone A, Karlsson P, Sjoholm N, Larsson S, Jonsson C, Odh R, Sparks R, Al Tawil N, Hoffmann A, Zimmermann T, Thiele A, Halldin C
* Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [ 18F]FEDAA1106: A human whole-body PET study (419 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Nov; 38(11): 2058-2065.
Impact Factor: 4.991
View Export to BibTeX Export to EndNote
Varrone A, Stepanov V, Nakao R, Toth M, Gulyas B, Emond P, Deloye JB, Vercouillie J, Stabin MG, Jonsson C, Guilloteau D, Halldin C
* Imaging of the striatal and extrastriatal dopamine transporter with 18F-LBT-999: Quantification, biodistribution, and radiation dosimetry in nonhuman primates (517 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2011 Sep 1; 52(8): 1313-1321.
Impact Factor: 6.381
View Export to BibTeX Export to EndNote
Gulyas B, Vas A, Toth M, Takano A, Varrone A, Cselenyi Z, Schain M, Mattsson P, Halldin C
* Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine (596 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2011 Jun 1; 56(3): 1111-1121.
Impact Factor: 5.895
View Export to BibTeX Export to EndNote
Pappata S, Varrone A, Vicidomini C, Milan G, De Falco C, Sansone V, Iavarone A, Comerci M, Loré E, Panico M, Quarantelli M, Postiglione A, Salvatore M
* SPECT imaging of GABAA/benzodiazepine receptors and cerebral perfusion in mild cognitive impairment (504 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jun; 37(6): 1156-1163.
Impact Factor: 5.036
View Export to BibTeX Export to EndNote
Odano I, Halldin C, Karlsson P, Varrone A, Airaksinen AJ, Krasikova RN, Farde L
* [18F]Flumazenil binding to central benzodiazepine receptor studies by PET. - Quantitative analysis and comparisons with [11C]flumazenil (307 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2009 Apr 15; 45(3): 891-902.
Impact Factor: 5.739
View Export to BibTeX Export to EndNote
Vergote J, Chalon S, Emond P, Vercouillie J, Pappata S, Guilloteau D
* New SPECT and PET dementia tracers (358 views)
Med Nucl (ISSN: 0928-1258), 2009 Mar; 33(3): 137-141.
Impact Factor: 0.155
View Export to BibTeX Export to EndNote
Takano A, Halldin C, Varrone A, Karlsson P, Sjoholm N, Stubbs JB, Schou M, Airaksinen AJ, Tauscher J, Gulyas B
* Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S, S)-[18F]FMeNER-D2: A human whole-body PET study (357 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Mar; 35(3): 630-636.
Impact Factor: 4.532
View Export to BibTeX Export to EndNote
Fonti R, Cheung N-KV, Bridger GJ, Guo H-F, Abrams MJ, Larson SM
99mTc-monoclonal antibody radiolabeled via hydrazino nicotinamide derivative for imaging disialoganglioside G(D2)-positive tumors (394 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999; 26(6): 681-686.
Impact Factor: 1.623
View Export to BibTeX Export to EndNote
Varrone A, Soricelli A, Postiglione A, Salvatore M, Lassen N
Benzodiazepine receptor distribution in Alzheimer's disease with (123)I-iomazenil by SPECT (286 views)
Textbook Of Spect In Neurology And Psychiatry, 1997; N/D: N/D-N/D.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Soricelli A, Postiglione A, GrivetFojaja M, Mainenti PP, Discepolo A, Varrone A, Salvatore M, Lassen N
Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses (417 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1996 Oct; 23(10): 1323-1328.
Impact Factor: 2.692
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20 Records (19 excluding Abstracts).
Total impact factor: 97.029 (97.029 excluding Abstracts).
Total 5 year impact factor: 66.285 (66.285 excluding Abstracts).
Total impact factor: 97.029 (97.029 excluding Abstracts).
Total 5 year impact factor: 66.285 (66.285 excluding Abstracts).
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