Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (504 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Export to BibTeX Export to EndNote
Paper type: Letter, Journal Article,
Impact factor: 2.117, 5-year impact factor: 3.236
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33751071588&partnerID=40&md5=504be2a1d2372d1d6d8f44e08a844bbe
Keywords: β-Amyloid, Ape-1 Ref-1, Dna Polymerase-β, Dna Repair, Dna Replication, Methoxyamine, Amyloid Beta Protein, Dna Directed Dna Polymerase Beta, Dna Primase, Endonuclease, Nucleoprotein, Alzheimer Disease, Animal Model, Apoptosis, Article, Cell Cycle, Cell Division, Dna Synthesis, Embryo, Excision Repair, Immunoprecipitation, Nerve Conduction, Nonhuman, Priority Journal, Adult, Aged, 80 And Over, Amyloid Beta-Protein, Brain, Cultured, Female, Gene Expression Regulation, Enzymologic, Middle Aged, Neurons, Retinoblastoma Protein, ß-Amyloid, Contrast Medium, Contrast Enhancement, Diagnostic Procedure, Letter, Multidetector Computed Tomography, Pancreas Tumor, Spiral Computer Assisted Tomography,
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Catania, 95125 Catania, Italy
Department of Experimental and Clinical Pharmacology, University of Catania, 95125 Catania, Italy
Institute of Biostructure and Bioimaging, National Research Council, 95125 Catania, Italy
Department of Human Physiology and Pharmacology, University of Rome La Sapienza, 00185 Rome, Italy
Mediterranean Neurological Institute Neuromed, 86077 Pozzilli, Italy
Department of Neuropathology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, Netherlands
Departments of Psychiatry, Pathology, and Clinical Chemistry, Alzheimer Center, Vrije University Medical Center, 1007 MB Amsterdam, Netherlands
University Federico II, Naples, Italy
References:
Aparicio, O.M., Stout, A.M., Bell, S.P., Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication (1999) Proc Natl Acad Sci USA, 96, pp. 9130-913
Becker, E.B., Bonni, A., Cell cycle regulation of neuronal apoptosis in development and disease (2004) Progr Neurobiol, 72, pp. 1-25
Braak, H., Braak, E., Staging of Alzheimer's disease-related neurofibrillary changes (1995) Neurobiol Aging, 16, pp. 271-278
Busser, J., Geldmacher, D.S., Herrup, K., Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain (1998) J Neurosci, 18, pp. 2801-2807
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signaling by beta amyloid causes neuronal death (1999) FASEB J, 13, pp. 2225-2234
Copani, A., Uberti, D., Sortimo, M.A., Bruno, V., Nicoletti, F., Memo, M., Activation of cell-cycle-associated proteins in neuronal death: A mandatory or dispensable path? (2001) Trends Neurosci, 24, pp. 25-31
Copani, A., Sortino, M.A., Caricasole, A., Chiechio, S., Chisari, M., Battaglia, G., Giuffrida-Stella, A.M., Nicoletti, F., Erratic expression of DNA polymerases by beta-amyloid causes neuronal death (2002) FASEB J, 16, pp. 2006-2008
Giovanni, A., Wirtz-Brugger, F., Keramaris, E., Slack, R., Park, D.S., Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F·DP, in β-amyloid-induced neuronal death (1999) J Biol Chem, 274, pp. 19011-19016
Giovanni, A., Keramaris, E., Morris, E.J., Hou, S.T., O'Hare, M., Dyson, N., Robertson, G.S., Park, D.S., E2F1 mediates death of β-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3 (2000) J Biol Chem, 275, pp. 11553-11560
Göhring, F., Fackelmayer, F.O., The scaffold/matrix attachment region binding protein hmRNP-U (SAF-A) is directly bound to chromosomal DNA in vivo: A chemical cross-linking study (1997) Biochemistry, 35, pp. 8276-8283
Guyton, K.Z., Liu, Y., Gorospe, M., Xu, Q., Holbrook, N.J., Activation of mitogen-activated protein kinase by H2O 2 (1996) J Biol Chem, 271, pp. 4138-4142
Hardy, J., Selkoe, D.J., The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics (2002) Science, 297, pp. 353-356
Heim, M.M., Eberhardt, W., Seeber, S., Muller, M.R., Differential modulation of chemosensitivity to alkylating agents and platinum compounds by DNA repair modulators in human lung cancer cell lines (2000) J Cancer Res Clin Oncol, 126, pp. 198-204
Herrup, K., Neve, R., Ackerman, S.L., Copani, A., Divide and die: Cell cycle events as triggers of nerve cell death (2004) J Neurosci, 24, pp. 9232-9239
Hoozemans, J.J., Veerhuis, R., Rozemuller, A.J., Arendt, T., Eikelenboom, P., Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex (2004) Neurobiol Dis, 15, pp. 492-499
Huang, Z., Zang, K., Reichardt, L.F., The origin recognition core complex regulates dendrite and spine development in postmitotic neurons (2005) J Cell Biol, 170, pp. 527-535
Kayed, R., Head, E., Thompson, J.L., McIntire, T.M., Milton, S.C., Cotman, C.W., Glabe, C.G., Common structure of soluble amyloid oligomers implies common mechanisms of pathogenesis (2003) Science, 300, pp. 486-489
Kelly, T.J., Brown, G.W., Regulation of chromosome replication (2000) Annu Rev Biochem, 69, pp. 829-880
Madhusudan, S., Middleton, M.R., The emerging role of DNA repair proteins as predictive, prognostic, and therapeutic targets in cancer (2005) Cancer Treat Rev, 31, pp. 603-617
Mimura, S., Masuda, T., Matsui, T., Takisawa, H., Central role for Cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts (2000) Genes Cells, 5, pp. 439-452
Pollok, S., Stoepel, J., Bauerschmidt, C., Kremmer, E., Nasheuer, H.-P., Regulation of eukaryotic DNA replication at the initiation step (2003) Biochem Soc Trans, 31, pp. 266-269
Reisberg, B., Ferris, S.H., De Leon, M.J., Crook, T., The global deterioration scale for assessment of primary degenerative dementia (1982) Am J Psychiatry, 139, pp. 1136-1139
Siegel, R.L., Kalf, G.F., DNA polymerase β involvement in DNA endoreduplication in rat giant trophoblast cells (1982) J Biol Chem, 257, pp. 1785-1790
Sobol, R., Horton, J., Kuhn, R., Gu, H., Prasad, R., Rajewsky, K., Wilson, S.H., Requirement of mammalian DNA polymerase-β in base-excision repair (1996) Nature, 379, pp. 183-186
Sweasy, J., Loeb, L., Mammalian DNA polymerase β can substitute for DNA polymerase I during DNA replication in Escherichia coli (1992) J Biol Chem, 267, pp. 1407-1410
Tan, Z., Sun, N., Schreiber, S.S., Immunohistochemical localization of redox factor-1 (Ref-1) in Alzheimer's hippocampus (1998) NeuroReport, 9, pp. 2749-2752
Vasko, M.R., Guo, C., Kelley, M.R., The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress (2005) DNA Repair, 4, pp. 367-379. , (Amst)
Wong, D., Demple, B., Modulation of 5′-deoxyribose-5-phosphate lyase and DNA synthesis activities of mammalian DNA polymerase-β by apurinic/apyrimidinic endonuclease (2004) J Biol Chem, 279, pp. 25368-25375
Yamaguchi, H., Haga, C., Hirai, S., Nakazato, Y., Kosaka, K., Distinctive, rapid, and easy labeling of diffuse plaques in the Alzheimer brains by a new methenamine silver stain (1990) Acta Neuropathol, 79, pp. 569-572. , (Berl)
Yang, Y., Geldmacher, D.S., Herrup, K., DNA replication precedes neuronal cell death in Alzheimer's disease (2001) J Neurosci, 21, pp. 2661-2668
Yang, Y., Mufson, E.J., Herrup, K., Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease (2003) J Neurosci, 23, pp. 2557-2563
Yu, H.M., Zhi, J.L., Cui, Y., Tang, E.H., Sun, S.N., Feng, J.Q., Chen, P.X., Role of the JAK-STAT pathway in protection of hydrogen peroxide preconditioning against apoptosis induced by oxidative stress in PC12 cells (2006) Apoptosis, 11, pp. 931-941
Imbriaco, M., Megibow, A. J., Ragozzino, A., Value of the single-phase technique in MDCT assessment of pancreatic tumors (2005) AJR, 184, pp. 1111-111
Lu, D. S. K., Vedantham, S., Krasny, R. M., Kadell, B., Berger, W. L., Reber, H. A., Two-phase helical CT for pancreatic tumors: Pancreatic versus hepatic phase enhancement of tumor, pancreas and vascular structures (1996) Radiology, 199, pp. 697-701
Tublin, M. E., Tessler, F. N., Cheng, S. L., Peters, T. L., McGovern, P. C., Effect of injection rate of contrast medium on pancreatic and hepatic helical CT (1999) Radiology, 210, pp. 97-101
Camera, L., Danlele, S., Di Giacomo, A., Soscia, E., Salvatore, M., (2002) Abstract book of the 40th Conference of the Italian Society of Radiology, 103 (SUPPL. 3), p. 318
Kim, T., Murakami, T., Takahashi, S., Pancreatic CT imaging: Effects of different injection rates and doses of contrast material (1999) Radiology, 212, pp. 219-225
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Export to BibTeX Export to EndNote
Paper type: Letter, Journal Article,
Impact factor: 2.117, 5-year impact factor: 3.236
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33751071588&partnerID=40&md5=504be2a1d2372d1d6d8f44e08a844bbe
Keywords: β-Amyloid, Ape-1 Ref-1, Dna Polymerase-β, Dna Repair, Dna Replication, Methoxyamine, Amyloid Beta Protein, Dna Directed Dna Polymerase Beta, Dna Primase, Endonuclease, Nucleoprotein, Alzheimer Disease, Animal Model, Apoptosis, Article, Cell Cycle, Cell Division, Dna Synthesis, Embryo, Excision Repair, Immunoprecipitation, Nerve Conduction, Nonhuman, Priority Journal, Adult, Aged, 80 And Over, Amyloid Beta-Protein, Brain, Cultured, Female, Gene Expression Regulation, Enzymologic, Middle Aged, Neurons, Retinoblastoma Protein, ß-Amyloid, Contrast Medium, Contrast Enhancement, Diagnostic Procedure, Letter, Multidetector Computed Tomography, Pancreas Tumor, Spiral Computer Assisted Tomography,
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Catania, 95125 Catania, Italy
Department of Experimental and Clinical Pharmacology, University of Catania, 95125 Catania, Italy
Institute of Biostructure and Bioimaging, National Research Council, 95125 Catania, Italy
Department of Human Physiology and Pharmacology, University of Rome La Sapienza, 00185 Rome, Italy
Mediterranean Neurological Institute Neuromed, 86077 Pozzilli, Italy
Department of Neuropathology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, Netherlands
Departments of Psychiatry, Pathology, and Clinical Chemistry, Alzheimer Center, Vrije University Medical Center, 1007 MB Amsterdam, Netherlands
University Federico II, Naples, Italy
References:
Aparicio, O.M., Stout, A.M., Bell, S.P., Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication (1999) Proc Natl Acad Sci USA, 96, pp. 9130-913
Becker, E.B., Bonni, A., Cell cycle regulation of neuronal apoptosis in development and disease (2004) Progr Neurobiol, 72, pp. 1-25
Braak, H., Braak, E., Staging of Alzheimer's disease-related neurofibrillary changes (1995) Neurobiol Aging, 16, pp. 271-278
Busser, J., Geldmacher, D.S., Herrup, K., Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain (1998) J Neurosci, 18, pp. 2801-2807
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signaling by beta amyloid causes neuronal death (1999) FASEB J, 13, pp. 2225-2234
Copani, A., Uberti, D., Sortimo, M.A., Bruno, V., Nicoletti, F., Memo, M., Activation of cell-cycle-associated proteins in neuronal death: A mandatory or dispensable path? (2001) Trends Neurosci, 24, pp. 25-31
Copani, A., Sortino, M.A., Caricasole, A., Chiechio, S., Chisari, M., Battaglia, G., Giuffrida-Stella, A.M., Nicoletti, F., Erratic expression of DNA polymerases by beta-amyloid causes neuronal death (2002) FASEB J, 16, pp. 2006-2008
Giovanni, A., Wirtz-Brugger, F., Keramaris, E., Slack, R., Park, D.S., Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F·DP, in β-amyloid-induced neuronal death (1999) J Biol Chem, 274, pp. 19011-19016
Giovanni, A., Keramaris, E., Morris, E.J., Hou, S.T., O'Hare, M., Dyson, N., Robertson, G.S., Park, D.S., E2F1 mediates death of β-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3 (2000) J Biol Chem, 275, pp. 11553-11560
Göhring, F., Fackelmayer, F.O., The scaffold/matrix attachment region binding protein hmRNP-U (SAF-A) is directly bound to chromosomal DNA in vivo: A chemical cross-linking study (1997) Biochemistry, 35, pp. 8276-8283
Guyton, K.Z., Liu, Y., Gorospe, M., Xu, Q., Holbrook, N.J., Activation of mitogen-activated protein kinase by H2O 2 (1996) J Biol Chem, 271, pp. 4138-4142
Hardy, J., Selkoe, D.J., The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics (2002) Science, 297, pp. 353-356
Heim, M.M., Eberhardt, W., Seeber, S., Muller, M.R., Differential modulation of chemosensitivity to alkylating agents and platinum compounds by DNA repair modulators in human lung cancer cell lines (2000) J Cancer Res Clin Oncol, 126, pp. 198-204
Herrup, K., Neve, R., Ackerman, S.L., Copani, A., Divide and die: Cell cycle events as triggers of nerve cell death (2004) J Neurosci, 24, pp. 9232-9239
Hoozemans, J.J., Veerhuis, R., Rozemuller, A.J., Arendt, T., Eikelenboom, P., Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex (2004) Neurobiol Dis, 15, pp. 492-499
Huang, Z., Zang, K., Reichardt, L.F., The origin recognition core complex regulates dendrite and spine development in postmitotic neurons (2005) J Cell Biol, 170, pp. 527-535
Kayed, R., Head, E., Thompson, J.L., McIntire, T.M., Milton, S.C., Cotman, C.W., Glabe, C.G., Common structure of soluble amyloid oligomers implies common mechanisms of pathogenesis (2003) Science, 300, pp. 486-489
Kelly, T.J., Brown, G.W., Regulation of chromosome replication (2000) Annu Rev Biochem, 69, pp. 829-880
Madhusudan, S., Middleton, M.R., The emerging role of DNA repair proteins as predictive, prognostic, and therapeutic targets in cancer (2005) Cancer Treat Rev, 31, pp. 603-617
Mimura, S., Masuda, T., Matsui, T., Takisawa, H., Central role for Cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts (2000) Genes Cells, 5, pp. 439-452
Pollok, S., Stoepel, J., Bauerschmidt, C., Kremmer, E., Nasheuer, H.-P., Regulation of eukaryotic DNA replication at the initiation step (2003) Biochem Soc Trans, 31, pp. 266-269
Reisberg, B., Ferris, S.H., De Leon, M.J., Crook, T., The global deterioration scale for assessment of primary degenerative dementia (1982) Am J Psychiatry, 139, pp. 1136-1139
Siegel, R.L., Kalf, G.F., DNA polymerase β involvement in DNA endoreduplication in rat giant trophoblast cells (1982) J Biol Chem, 257, pp. 1785-1790
Sobol, R., Horton, J., Kuhn, R., Gu, H., Prasad, R., Rajewsky, K., Wilson, S.H., Requirement of mammalian DNA polymerase-β in base-excision repair (1996) Nature, 379, pp. 183-186
Sweasy, J., Loeb, L., Mammalian DNA polymerase β can substitute for DNA polymerase I during DNA replication in Escherichia coli (1992) J Biol Chem, 267, pp. 1407-1410
Tan, Z., Sun, N., Schreiber, S.S., Immunohistochemical localization of redox factor-1 (Ref-1) in Alzheimer's hippocampus (1998) NeuroReport, 9, pp. 2749-2752
Vasko, M.R., Guo, C., Kelley, M.R., The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress (2005) DNA Repair, 4, pp. 367-379. , (Amst)
Wong, D., Demple, B., Modulation of 5′-deoxyribose-5-phosphate lyase and DNA synthesis activities of mammalian DNA polymerase-β by apurinic/apyrimidinic endonuclease (2004) J Biol Chem, 279, pp. 25368-25375
Yamaguchi, H., Haga, C., Hirai, S., Nakazato, Y., Kosaka, K., Distinctive, rapid, and easy labeling of diffuse plaques in the Alzheimer brains by a new methenamine silver stain (1990) Acta Neuropathol, 79, pp. 569-572. , (Berl)
Yang, Y., Geldmacher, D.S., Herrup, K., DNA replication precedes neuronal cell death in Alzheimer's disease (2001) J Neurosci, 21, pp. 2661-2668
Yang, Y., Mufson, E.J., Herrup, K., Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease (2003) J Neurosci, 23, pp. 2557-2563
Yu, H.M., Zhi, J.L., Cui, Y., Tang, E.H., Sun, S.N., Feng, J.Q., Chen, P.X., Role of the JAK-STAT pathway in protection of hydrogen peroxide preconditioning against apoptosis induced by oxidative stress in PC12 cells (2006) Apoptosis, 11, pp. 931-941
Imbriaco, M., Megibow, A. J., Ragozzino, A., Value of the single-phase technique in MDCT assessment of pancreatic tumors (2005) AJR, 184, pp. 1111-111
Lu, D. S. K., Vedantham, S., Krasny, R. M., Kadell, B., Berger, W. L., Reber, H. A., Two-phase helical CT for pancreatic tumors: Pancreatic versus hepatic phase enhancement of tumor, pancreas and vascular structures (1996) Radiology, 199, pp. 697-701
Tublin, M. E., Tessler, F. N., Cheng, S. L., Peters, T. L., McGovern, P. C., Effect of injection rate of contrast medium on pancreatic and hepatic helical CT (1999) Radiology, 210, pp. 97-101
Camera, L., Danlele, S., Di Giacomo, A., Soscia, E., Salvatore, M., (2002) Abstract book of the 40th Conference of the Italian Society of Radiology, 103 (SUPPL. 3), p. 318
Kim, T., Murakami, T., Takahashi, S., Pancreatic CT imaging: Effects of different injection rates and doses of contrast material (1999) Radiology, 212, pp. 219-225
Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid
Cultured neurons exposed to synthetic β-amyloid (Aβ) fragments reenter the cell cycle and initiate a pathway of DNA replication that involves the repair enzyme DNA polymerase-β (DNA pol-β) before undergoing apoptotic death. In this study, by performing coimmunoprecipitation experiments on cross-linked nucleoprotein fragments from Aβ-treated neurons, we demonstrate that DNA pol-β coimmunoprecipitates with cell division cycle 45 (Cdc45) and with DNA primase in short nucleoprotein fragments. This indicates that DNA pol-β is loaded into neuronal DNA replication forks after Aβ treatment. In response to Aβ the canonical DNA-synthesizing enzyme DNA pol-δ also was loaded into neuronal replication forks, but at later times than DNA pol-β. Methoxyamine, an inhibitor of the apurinic/apyrimidinic endonuclease that allows for the recruitment of DNA pol-β during the process of base excision repair (BER), failed to affect coimmunoprecipitation between DNA pol-β and Cdc45, indicating that DNA pol-β loading to the replication forks is independent of DNA breaks. However, methoxyamine reduced DNA replication and ensuing apoptosis in neurons exposed to Aβ, suggesting that an efficient BER process allows DNA replication to proceed up to the threshold for death. These data demonstrate that DNA pol-β is an essential component of the DNA replication machinery in Aβ-treated neurons and additionally support the hypothesis of a close association of cell cycle events with neuronal death in Alzheimer's disease (AD). Accordingly, by investigating the neuronal expression of DNA pol-β, along with phosphorylated retinoblastoma protein and neurofibrillary changes in AD brain, we show an early involvement of DNA pol-β in the pathogenesis of AD. Copyright © 2006 Society for Neuroscience.
Cultured neurons exposed to synthetic β-amyloid (Aβ) fragments reenter the cell cycle and initiate a pathway of DNA replication that involves the repair enzyme DNA polymerase-β (DNA pol-β) before undergoing apoptotic death. In this study, by performing coimmunoprecipitation experiments on cross-linked nucleoprotein fragments from Aβ-treated neurons, we demonstrate that DNA pol-β coimmunoprecipitates with cell division cycle 45 (Cdc45) and with DNA primase in short nucleoprotein fragments. This indicates that DNA pol-β is loaded into neuronal DNA replication forks after Aβ treatment. In response to Aβ the canonical DNA-synthesizing enzyme DNA pol-δ also was loaded into neuronal replication forks, but at later times than DNA pol-β. Methoxyamine, an inhibitor of the apurinic/apyrimidinic endonuclease that allows for the recruitment of DNA pol-β during the process of base excision repair (BER), failed to affect coimmunoprecipitation between DNA pol-β and Cdc45, indicating that DNA pol-β loading to the replication forks is independent of DNA breaks. However, methoxyamine reduced DNA replication and ensuing apoptosis in neurons exposed to Aβ, suggesting that an efficient BER process allows DNA replication to proceed up to the threshold for death. These data demonstrate that DNA pol-β is an essential component of the DNA replication machinery in Aβ-treated neurons and additionally support the hypothesis of a close association of cell cycle events with neuronal death in Alzheimer's disease (AD). Accordingly, by investigating the neuronal expression of DNA pol-β, along with phosphorylated retinoblastoma protein and neurofibrillary changes in AD brain, we show an early involvement of DNA pol-β in the pathogenesis of AD. Copyright © 2006 Society for Neuroscience.
Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid
| ▼ Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events |
Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid
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J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Mar; 19(3): 148-158.
Impact Factor: 1.862
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1516 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
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Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (461 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
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Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G
* Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells (790 views)
Mol Biol Cell (ISSN: 1059-1524), 2012 Oct 15; 23(20): 4079-4096.
Impact Factor: 4.803
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Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
* Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (364 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 24; 7(5): N/D-N/D.
Impact Factor: 3.73
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Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (597 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
View Export to BibTeX Export to EndNote
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (1289 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
View Export to BibTeX Export to EndNote
De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (848 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
View Export to BibTeX Export to EndNote
Palmieri D, Valentino T, D'Angelo D, De Martino I, Postiglione I, Pacelli R, Croce CM, Fedele M, Fusco A
* HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents (887 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
Impact Factor: 6.373
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (765 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
View Export to BibTeX Export to EndNote
De Rosa V, Alan D, Alain F, Thierry D, Walid R
* The anticancer effect of selenium: study of its role in DNA repair activity and resistance to oxidative stress (250 views)
Bulletin Du Cancer (ISSN: 0007-4551), 2009 Mar; 96: N/D-N/D.
Impact Factor: 0.792
View Export to BibTeX Export to EndNote
Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (455 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
View Export to BibTeX Export to EndNote
Prato S, Vitale RM, Contursi P, Lipps G, Saviano M, Rossi M, Bartolucci S
* Molecular modeling and functional characterization of the monomeric primase-polymerase domain from the Sulfolobus solfataricus plasmid pIT3 (400 views)
Febs J (ISSN: 1742-464x), 2008; 275(17): 4389-4402.
Impact Factor: 3.139
View Export to BibTeX Export to EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (454 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
View Export to BibTeX Export to EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (501 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
View Export to BibTeX Export to EndNote
Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (629 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
View Export to BibTeX Export to EndNote
Messere A, Fabbri E, Borgatti M, Gambari R, Di Blasio B, Pedone C, Romanelli A
* Antiproliferative activity of Pt(II) and Pd(II) phosphine complexes with thymine and thymidine (308 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2007 Feb; 101(2): 254-260.
Impact Factor: 3.663
View Export to BibTeX Export to EndNote
Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (555 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
View Export to BibTeX Export to EndNote
Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (585 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
View Export to BibTeX Export to EndNote
Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (808 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
View Export to BibTeX Export to EndNote
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (552 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
View Export to BibTeX Export to EndNote
Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (408 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
View Export to BibTeX Export to EndNote
Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (502 views)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
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* Biochemical and Structural Insights into the Winged Helix Domain of P150, the Largest Subunit of the Chromatin Assembly Factor (10 views)
Int J Mol Sci (ISSN: 1422-0067linking), 2022 Feb 15; 23(4): 2160-2160.
Impact Factor: 6.208
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Marasco D, Vicidomini C, Krupa P, Cioffi F, Pham DQH, Li MS, Florio D, Broersen K, De Pandis MF, Roviello GN
* Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine based compounds on β-amyloid aggregation (145 views)
Chem Biol Interact (ISSN: 0009-2797linking), 2021 Jan 25; 334: 109300-109301.
Impact Factor: 5.192
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Esposito MV, Minopoli G, Esposito L, D'Argenio V, Di Maggio F, Sasso E, D'Aiuto M, Zambrano N, Salvatore F
* A Functional Analysis of the Unclassified Pro2767Ser BRCA2 Variant Reveals Its Potential Pathogenicity that Acts by Hampering DNA Binding and Homology-Mediated DNA Repair (142 views)
Cancers (ISSN: 2072-6694linking), 2019 Sep 28; 11(10): N/D-N/D.
Impact Factor: 6.102
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Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F
* The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice (641 views)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic), 2016 Apr; 106: 10-20.
Impact Factor: 4.48
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Palladino P, Aura AM, Spoto G
* Surface plasmon resonance for the label-free detection of Alzheimer's β-amyloid peptide aggregation (528 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2016; 408(3): 849-854.
Impact Factor: 3.431
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Forestier A, Douki T, De Rosa V, Beal D, Rachidi W
* Combination of Abeta Secretion and Oxidative Stress in an Alzheimer-Like Cell Line Leads to the Over-Expression of the Nucleotide Excision Repair Proteins DDB2 and XPC (353 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015 Jul 30; 16(8): 17422-17444.
Impact Factor: 3.257
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Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (323 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
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Galdiero E, Maselli V, Falanga A, Gesuele R, Galdiero S, Fulgione D, Guida M
* Integrated analysis of the ecotoxicological and genotoxic effects of the antimicrobial peptide melittin on Daphnia magna and Pseudokirchneriella subcapitata (615 views)
Environ Pollut (ISSN: 0269-7491), 2015; 203: 145-152.
Impact Factor: 4.839
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Morra F, Luise C, Visconti R, Staibano S, Merolla F, Ilardi G, Guggino G, Paladino S, Sarnataro D, Franco R, Monaco R, Zitomarino F, Pacelli R, Monaco G, Rocco G, Cerrato A, Linardopoulos S, Muller MT, Celetti A
* New therapeutic perspectives in CCDC6 deficient lung cancer cells (462 views)
Int J Cancer (ISSN: 0020-7136), 2015; 136(9): 2146-2157.
Impact Factor: 5.531
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Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (524 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
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Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
* Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells (491 views)
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2013 Sep 19; 20(5): 633-647.
Impact Factor: 4.907
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Bera S, De Rosa V, Rachidi W, Diamond AM
* Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention? (759 views)
Mutagenesismutagenesis (ISSN: 0267-8357, 1464-3804electronic, 0267-8357linking), 2013 Mar; 28(2): 127-134.
Impact Factor: 3.497
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Galdiero S, Falanga A, Tarallo R, Russo L, Galdiero E, Cantisani M, Morelli G, Galdiero M
* Peptide inhibitors against herpes simplex virus infections (1074 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Mar; 19(3): 148-158.
Impact Factor: 1.862
View Export to BibTeX Export to EndNote
Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1516 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
View Export to BibTeX Export to EndNote
Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (461 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
View Export to BibTeX Export to EndNote
Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G
* Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells (790 views)
Mol Biol Cell (ISSN: 1059-1524), 2012 Oct 15; 23(20): 4079-4096.
Impact Factor: 4.803
View Export to BibTeX Export to EndNote
Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
* Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (364 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 24; 7(5): N/D-N/D.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (597 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
View Export to BibTeX Export to EndNote
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (1289 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
View Export to BibTeX Export to EndNote
De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (848 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
View Export to BibTeX Export to EndNote
Palmieri D, Valentino T, D'Angelo D, De Martino I, Postiglione I, Pacelli R, Croce CM, Fedele M, Fusco A
* HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents (887 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
Impact Factor: 6.373
View Export to BibTeX Export to EndNote
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (765 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
View Export to BibTeX Export to EndNote
De Rosa V, Alan D, Alain F, Thierry D, Walid R
* The anticancer effect of selenium: study of its role in DNA repair activity and resistance to oxidative stress (250 views)
Bulletin Du Cancer (ISSN: 0007-4551), 2009 Mar; 96: N/D-N/D.
Impact Factor: 0.792
View Export to BibTeX Export to EndNote
Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (455 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
View Export to BibTeX Export to EndNote
Prato S, Vitale RM, Contursi P, Lipps G, Saviano M, Rossi M, Bartolucci S
* Molecular modeling and functional characterization of the monomeric primase-polymerase domain from the Sulfolobus solfataricus plasmid pIT3 (400 views)
Febs J (ISSN: 1742-464x), 2008; 275(17): 4389-4402.
Impact Factor: 3.139
View Export to BibTeX Export to EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (454 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
View Export to BibTeX Export to EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (501 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
View Export to BibTeX Export to EndNote
Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (629 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
View Export to BibTeX Export to EndNote
Messere A, Fabbri E, Borgatti M, Gambari R, Di Blasio B, Pedone C, Romanelli A
* Antiproliferative activity of Pt(II) and Pd(II) phosphine complexes with thymine and thymidine (308 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2007 Feb; 101(2): 254-260.
Impact Factor: 3.663
View Export to BibTeX Export to EndNote
Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (555 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
View Export to BibTeX Export to EndNote
Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (585 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
View Export to BibTeX Export to EndNote
Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (808 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
View Export to BibTeX Export to EndNote
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (552 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
View Export to BibTeX Export to EndNote
Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (408 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
View Export to BibTeX Export to EndNote
Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (502 views)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
View Export to BibTeX Export to EndNote
35 Records (34 excluding Abstracts).
Total impact factor: 132.161 (128.431 excluding Abstracts).
Total 5 year impact factor: 126.237 (121.993 excluding Abstracts).
Total impact factor: 132.161 (128.431 excluding Abstracts).
Total 5 year impact factor: 126.237 (121.993 excluding Abstracts).
504 views. Last view on Sunday 28 May 2023, 16:01:15
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