Sleep disordered breathing and airway disease in primary ciliary dyskinesia(760 views) Santamaria F, Esposito M, Montella S, Cantone E, Mollica C, De Stefano S, Mirra V, Carotenuto M
Department of Translational Medical Sciences, Reproductive and Odontostomatologic Sciences, Unit of Ear, Nose and Throat and Molecular and Cellular Biology and Pathology, Federico II University, Via Sergio Pansini, 5-80131 Naples, Italy
Department of Neurosciences, Reproductive and Odontostomatologic Sciences, Unit of Ear, Nose and Throat and Molecular and Cellular Biology and Pathology, Federico II University, Naples, Italy
Biostructure and Bioimaging Institute, National Research Council, Naples, Italy
Clinic of Child and Adolescent Neuropsychiatry, Department of Mental and Physical Health, and Preventive Medicine, Second University of Naples, Naples, Italy
References: Not available.
Sleep disordered breathing and airway disease in primary ciliary dyskinesia
Background and objective Sleep-disordered breathing (SDB) may develop in primary ciliary dyskinesia (PCD), leading to these diseases worsening one another. Methods Sixteen stable PCD patients (4. 9-17. 2 years) and 42 controls underwent overnight respiratory polysomnography (rPSG) and Sleep Disturbances Scale for Children (SDSC). In PCD we assessed nasal endoscopy, pulmonary function tests and chest high-resolution computed tomography (HRCT). Results Compared with controls, PCD had higher obstructive apnoea (4. 7 vs 0. 2, P < 0. 001), central apnoea (0. 8 vs 0. 2, P < 0. 001), hypopnoea (1. 8 vs 0. 2, P < 0. 001), apnoea-hypopnoea (7. 8 vs 0. 6, P < 0. 001), oxygen desaturation indexes (ODI; 0. 7 vs 0. 2, P = 0. 002), and mean oxygen desaturation (4% vs 1%, P < 0. 001), while mean and nadir oxygen saturation (97. 1% vs 98. 1, P < 0. 001) (93% vs 97. 2%, P < 0. 001) were lower, respectively. In PCD, SDSC was unrelated to rPSG (P > 0. 05), with total score and subscores of disorders in initiating and maintaining sleep, and sleep-wake transition lower than controls. PCD patients had chronic rhinosinusitis (100%) and adenoidal hypertrophy (50%). Total HRCT score was 7 (range 0-14). ODI correlated with functional residual capacity (r = 0. 8, P = 0. 02), total HRCT (r = 0. 6, P = 0. 03) and peribronchial thickening scores (r = 0. 7, P = 0. 02). Oxygen saturation was associated with bronchiectasis severity score (r = -0. 6, P = 0. 02). Conclusions PCD's parents may underestimate SDB. As nocturnal desaturation is associated with lung function and structure abnormalities, SDB may significantly contribute to pulmonary morbidity. 2014 The Authors. Respirology 2014 Asian Pacific Society of Respirology
Sleep disordered breathing and airway disease in primary ciliary dyskinesia
No results.
Sleep disordered breathing and airway disease in primary ciliary dyskinesia