Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention? (1088 views)
Mutagenesismutagenesis (ISSN: 0267-8357, 1464-3804electronic, 0267-8357linking), 2013 Mar; 28(2): 127-134.
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Paper type: Journal Article, Research Support, N. I. H. , Extramural, Non-U. S. Gov'T, Review,
Impact factor: 3.497, 5-year impact factor: 3.798
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84874326742&partnerID=40&md5=5ae6ac4d25d17f51a0bad409f3fc20c6
Keywords: Ebselen, Selenite, Selenomethionine, Selenoprotein, Sodium Selenite, Aberrant Crypt Focus, Bladder Cancer, Cancer Incidence, Cancer Mortality, Cancer Prevention, Carcinogenesis, Chemoprophylaxis, Controlled Clinical Trial (topic), Dna Damage, Dna Repair, Drug Efficacy, Drug Mechanism, Human, Lung Cancer, Nonhuman, Priority Journal, Prostate Cancer, Review, Animals, Chemoprevention, Dietary Supplements, Dna Adducts, Glutathione Peroxidase, Models, Neoplasms, Thioredoxin-Disulfide Reductase, Drug Effects, Metabolism, Administration, Dosage, Dna Adducts Drug Effects , Dna Repair Drug Effects , Glutathione Peroxidase Metabolism , Neoplasms Prevention, Selenium Administration, Selenoproteins Metabolism , Thioredoxin-Disulfide Reductase Metabolism,
Affiliations:
*** IBB - CNR ***
Department of Pathology, University of Illinois at Chicago, Chicago, IL, United States
Université Joseph Fourier, Grenoble 1, CEA, INAC, SCIB, Laboratoire Lésions des Acides Nucléiques, 17 rue des Martyrs, F-38054 Grenoble Cedex 9, France
Istituto di Biostrutture e Bioimmagini, CNR, Via De Amicis 95 Naples, Italy
References:
Not available.
Mutagenesismutagenesis (ISSN: 0267-8357, 1464-3804electronic, 0267-8357linking), 2013 Mar; 28(2): 127-134.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, N. I. H. , Extramural, Non-U. S. Gov'T, Review,
Impact factor: 3.497, 5-year impact factor: 3.798
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84874326742&partnerID=40&md5=5ae6ac4d25d17f51a0bad409f3fc20c6
Keywords: Ebselen, Selenite, Selenomethionine, Selenoprotein, Sodium Selenite, Aberrant Crypt Focus, Bladder Cancer, Cancer Incidence, Cancer Mortality, Cancer Prevention, Carcinogenesis, Chemoprophylaxis, Controlled Clinical Trial (topic), Dna Damage, Dna Repair, Drug Efficacy, Drug Mechanism, Human, Lung Cancer, Nonhuman, Priority Journal, Prostate Cancer, Review, Animals, Chemoprevention, Dietary Supplements, Dna Adducts, Glutathione Peroxidase, Models, Neoplasms, Thioredoxin-Disulfide Reductase, Drug Effects, Metabolism, Administration, Dosage, Dna Adducts Drug Effects , Dna Repair Drug Effects , Glutathione Peroxidase Metabolism , Neoplasms Prevention, Selenium Administration, Selenoproteins Metabolism , Thioredoxin-Disulfide Reductase Metabolism,
Affiliations:
*** IBB - CNR ***
Department of Pathology, University of Illinois at Chicago, Chicago, IL, United States
Université Joseph Fourier, Grenoble 1, CEA, INAC, SCIB, Laboratoire Lésions des Acides Nucléiques, 17 rue des Martyrs, F-38054 Grenoble Cedex 9, France
Istituto di Biostrutture e Bioimmagini, CNR, Via De Amicis 95 Naples, Italy
References:
Not available.
Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention?
The trace element selenium is an essential micronutrient that has received considerable attention for its potential use in the prevention of cancer. In spite of this interest, the mechanism(s) by which selenium might function as a chemopreventive remain to be determined. Considerable experimental evidence indicates that one possible mechanism by which selenium supplementation may exert its benefits is by enhancing the DNA damage repair response, and this includes data obtained using cultured cells, animal models as well as in human clinical studies. In these studies, selenium supplementation has been shown to be beneficial in reducing the frequency of DNA adducts and chromosome breaks, consequentially reducing the likelihood of detrimental mutations that ultimately contribute to carcinogenesis. The benefits of selenium can be envisioned as being due, at least in part, to it being a critical constituent of selenoproteins such as glutathione peroxidases and thioredoxin reductases, proteins that play important roles in antioxidant defence and maintaining the cellular reducing environment. Selenium, therefore, may be protective by preventing DNA damage from occurring as well as by increasing the activity of repair enzymes such as DNA glycosylases and DNA damage repair pathways that involve p53, BRCA1 and Gadd45. An improved understanding of the mechanism of selenium's impact on DNA repair processes may help to resolve the apparently contradicting data obtained from decades of animal work, human epidemiology and more recently, clinical supplementation studies. © The Author 2012. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved.
The trace element selenium is an essential micronutrient that has received considerable attention for its potential use in the prevention of cancer. In spite of this interest, the mechanism(s) by which selenium might function as a chemopreventive remain to be determined. Considerable experimental evidence indicates that one possible mechanism by which selenium supplementation may exert its benefits is by enhancing the DNA damage repair response, and this includes data obtained using cultured cells, animal models as well as in human clinical studies. In these studies, selenium supplementation has been shown to be beneficial in reducing the frequency of DNA adducts and chromosome breaks, consequentially reducing the likelihood of detrimental mutations that ultimately contribute to carcinogenesis. The benefits of selenium can be envisioned as being due, at least in part, to it being a critical constituent of selenoproteins such as glutathione peroxidases and thioredoxin reductases, proteins that play important roles in antioxidant defence and maintaining the cellular reducing environment. Selenium, therefore, may be protective by preventing DNA damage from occurring as well as by increasing the activity of repair enzymes such as DNA glycosylases and DNA damage repair pathways that involve p53, BRCA1 and Gadd45. An improved understanding of the mechanism of selenium's impact on DNA repair processes may help to resolve the apparently contradicting data obtained from decades of animal work, human epidemiology and more recently, clinical supplementation studies. © The Author 2012. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved.
Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention?
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Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention?
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