A new therapeutic approach to erectile dysfunction: urotensin-II receptor high affinity agonist ligands (476 views)
Asian J Androl (ISSN: 1008-682x), 2015 Jan; 17(1): 81-85.
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Paper type: Journal Article,
Impact factor: 2.644, 5-year impact factor: 2.579
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84920484346&partnerID=40&md5=aa9aafb6905edf4e905afcb91f2eef47
Keywords: Erectile Dysfunction, Intracavernous Pressure, Urotensin-Ii, Urotensin-Ii Ligands, Cyclopeptide, Unclassified Drug, Upg 84, Urotensin Ii, Agonist, Animal Cell, Animal Experiment, Animal Model, Article, Binding Affinity, Controlled Study, Dose Response, Drug Effect, Drug Efficacy, Drug Receptor Binding, Nonhuman,
Affiliations:
*** IBB - CNR ***
Department of Pharmacy, University of Naples, Federico II, Via D. Montesano 49, Naples, Italy
Interdepartmental Centre for Sexual Medicine, University of Naples, Federico II, Via S. Pansini 5, Naples, Italy
Department of Neurosciences, Human Reproduction and Odontostomatology, University of Naples Federico II, Via S. Pansini 5, Naples, Italy
References:
Vaudry, H., Do Rego, J.C., Le Mevel, J.C., Chatenet, D., Tostivint, H., Urotensin II, from fish to human (2010) Ann N y Acad Sci, 1200, pp. 53-6
Conlon, J.M., Yano, K., Waugh, D., Hazon, N., Distribution and molecular forms of urotensin II and its role in cardiovascular regulation in vertebrates (1996) J Exp Zool, 275, pp. 226-238
Ames, R.S., Sarau, H.M., Chambers, J.K., Willette, R.N., Aiyar, N.V., Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14 (1999) Nature, 401, pp. 282-286
Grieco, P., Franco, R., Bozzuto, G., Toccacieli, L., Sgambato, A., Urotensin II receptor predicts the clinical outcome of prostate cancer patients and is involved in the regulation of motility of prostate adenocarcinoma cells (2011) J Cell Biochem, 112, pp. 341-353
D'Emmanuele Di Villa Bianca, R., Cirino, G., Mitidieri, E., Coletta, C., Grassia, G., Urotensin II: A novel target in human corpus cavernosum (2010) J Sex Med, 7, pp. 1778-1786
Ong, K.L., Lam, K.S., Cheung, B.M., Urotensin II: Its function in health and its role in disease (2005) Cardiovasc Drugs Ther, 19, pp. 65-75
Douglas, S.A., Ohlstein, E.H., Human urotensin-II, the most potent mammalian vasoconstrictor identified to date, as a therapeutic target for the management of cardiovascular disease (2000) Trends Cardiovasc Med, 10, pp. 229-237
Camarda, V., Rizzi, A., Calò, G., Gendron, G., Perron, S.I., Effects of human urotensin II in isolated vessels of various species
Comparison with other vasoactive agents (2002) Naunyn Schmiedebergs Arch Pharmacol, 365, pp. 141-149
Maguire, J.J., Kuc, R.E., Davenport, A.P., Orphan-receptor ligand human urotensin II: Receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1 (2000) Br J Pharmacol, 131, pp. 441-446
Yoshimoto, T., Matsushita, M., Hirata, Y., Role of urotensin II in peripheral tissue as an autocrine/paracrine growth factor (2004) Peptides, 25, pp. 1775-1781
Bottrill, F.E., Douglas, S.A., Hiley, C.R., White, R., Human urotensin-II is an endothelium-dependent vasodilator in rat small arteries (2000) Br J Pharmacol, 130, pp. 1865-1870
Gray, G.A., Jones, M.R., Sharif, I., Human urotensin II increases coronary perfusion pressure in the isolated rat heart: Potentiation by nitric oxide synthase and cyclooxygenase inhibition (2001) Life Sci, 69, pp. 175-180
Gardiner, S.M., March, J.E., Kemp, P.A., Maguire, J.J., Kuc, R.E., Regional heterogeneity in the haemodynamic responses to urotensin II infusion in relation to UT receptor localisation (2006) Br J Pharmacol, 147, pp. 612-621
Ishihata, A., Ogaki, T., Aita, T., Katano, Y., Role of prostaglandins in urotensin II-induced vasodilatation in the coronary arteries of aged rats (2005) Eur J Pharmacol, 523, pp. 119-126
Katano, Y., Ishihata, A., Aita, T., Ogaki, T., Horie, T., Vasodilator effect of urotensin II, one of the most potent vasoconstricting factors, on rat coronary arteries (2000) Eur J Pharmacol, 402, pp. R5-7
Lacza, Z., Busija D, W., Urotensin-II is a nitric oxide-dependent vasodilator in the pial arteries of the newborn pig (2006) Life Sci, 78, pp. 2763-2766
Zhang, A.Y., Chen, Y.F., Zhang, D.X., Yi, F.X., Qi, J., Urotensin II is a nitric oxide-dependent vasodilator and natriuretic peptide in the rat kidney (2003) Am J Physiol Renal Physiol, 285, pp. F792-F798
Chen, Z.W., Yang, Q., Huang, Y., Fan, L., Li, X.W., Human urotensin II in internal mammary and radial arteries of patients undergoing coronary surgery (2010) Vascul Pharmacol, 52, pp. 70-76
Grieco, P., Carotenuto, A., Campiglia, P., Gomez-Monterrey, I., Auriemma, L., New insight into the binding mode of peptide ligands at Urotensin-II receptor: Structure-activity relationships study on P5U and urantide (2009) J Med Chem, 52, pp. 3927-3940
Merlino, F., Di Maro, S., Munaim Yousif, A., Caraglia, M., Grieco, P., Urotensin-II ligands: An overview from peptide to nonpeptide structures (2013) J Amino Acids, 2013, p. 979016
Cheng, Y., Prusoff, W.H., Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction (1973) Biochem Pharmacol, 22, pp. 3099-3108
Caliendo, G., Perissutti, E., Santagada, V., Fiorino, F., Severino, B., Synthesis and vasorelaxant activity of new 1, 4-benzoxazine derivatives potassium channel openers (2002) Bioorg Med Chem, 10, pp. 2663-2669
Russell, F.D., Emerging roles of urotensin-II in cardiovascular disease (2004) Pharmacol Ther, 103, pp. 223-243
Stirrat, A., Gallagher, M., Douglas, S.A., Ohlstein, E.H., Berry, C., Potent vasodilator responses to human urotensin-II in human pulmonary and abdominal resistance arteries (2001) Am J Physiol Heart Circ Physiol, 280, pp. H925-H928
Cirino, G., Fusco, F., Imbimbo, C., Mirone, V., Pharmacology of erectile dysfunction in man (2006) Pharmacol Ther, 111, pp. 400-423
Hurt, K.J., Sezen, S.F., Lagoda, G.F., Musicki, B., Rameau, G.A., Cyclic AMP-dependent phosphorylation of neuronal nitric oxide synthase mediates penile erection (2012) Proc Natl Acad Sci USA, 109, pp. 16624-16629
Asian J Androl (ISSN: 1008-682x), 2015 Jan; 17(1): 81-85.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.644, 5-year impact factor: 2.579
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84920484346&partnerID=40&md5=aa9aafb6905edf4e905afcb91f2eef47
Keywords: Erectile Dysfunction, Intracavernous Pressure, Urotensin-Ii, Urotensin-Ii Ligands, Cyclopeptide, Unclassified Drug, Upg 84, Urotensin Ii, Agonist, Animal Cell, Animal Experiment, Animal Model, Article, Binding Affinity, Controlled Study, Dose Response, Drug Effect, Drug Efficacy, Drug Receptor Binding, Nonhuman,
Affiliations:
*** IBB - CNR ***
Department of Pharmacy, University of Naples, Federico II, Via D. Montesano 49, Naples, Italy
Interdepartmental Centre for Sexual Medicine, University of Naples, Federico II, Via S. Pansini 5, Naples, Italy
Department of Neurosciences, Human Reproduction and Odontostomatology, University of Naples Federico II, Via S. Pansini 5, Naples, Italy
References:
Vaudry, H., Do Rego, J.C., Le Mevel, J.C., Chatenet, D., Tostivint, H., Urotensin II, from fish to human (2010) Ann N y Acad Sci, 1200, pp. 53-6
Conlon, J.M., Yano, K., Waugh, D., Hazon, N., Distribution and molecular forms of urotensin II and its role in cardiovascular regulation in vertebrates (1996) J Exp Zool, 275, pp. 226-238
Ames, R.S., Sarau, H.M., Chambers, J.K., Willette, R.N., Aiyar, N.V., Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14 (1999) Nature, 401, pp. 282-286
Grieco, P., Franco, R., Bozzuto, G., Toccacieli, L., Sgambato, A., Urotensin II receptor predicts the clinical outcome of prostate cancer patients and is involved in the regulation of motility of prostate adenocarcinoma cells (2011) J Cell Biochem, 112, pp. 341-353
D'Emmanuele Di Villa Bianca, R., Cirino, G., Mitidieri, E., Coletta, C., Grassia, G., Urotensin II: A novel target in human corpus cavernosum (2010) J Sex Med, 7, pp. 1778-1786
Ong, K.L., Lam, K.S., Cheung, B.M., Urotensin II: Its function in health and its role in disease (2005) Cardiovasc Drugs Ther, 19, pp. 65-75
Douglas, S.A., Ohlstein, E.H., Human urotensin-II, the most potent mammalian vasoconstrictor identified to date, as a therapeutic target for the management of cardiovascular disease (2000) Trends Cardiovasc Med, 10, pp. 229-237
Camarda, V., Rizzi, A., Calò, G., Gendron, G., Perron, S.I., Effects of human urotensin II in isolated vessels of various species
Comparison with other vasoactive agents (2002) Naunyn Schmiedebergs Arch Pharmacol, 365, pp. 141-149
Maguire, J.J., Kuc, R.E., Davenport, A.P., Orphan-receptor ligand human urotensin II: Receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1 (2000) Br J Pharmacol, 131, pp. 441-446
Yoshimoto, T., Matsushita, M., Hirata, Y., Role of urotensin II in peripheral tissue as an autocrine/paracrine growth factor (2004) Peptides, 25, pp. 1775-1781
Bottrill, F.E., Douglas, S.A., Hiley, C.R., White, R., Human urotensin-II is an endothelium-dependent vasodilator in rat small arteries (2000) Br J Pharmacol, 130, pp. 1865-1870
Gray, G.A., Jones, M.R., Sharif, I., Human urotensin II increases coronary perfusion pressure in the isolated rat heart: Potentiation by nitric oxide synthase and cyclooxygenase inhibition (2001) Life Sci, 69, pp. 175-180
Gardiner, S.M., March, J.E., Kemp, P.A., Maguire, J.J., Kuc, R.E., Regional heterogeneity in the haemodynamic responses to urotensin II infusion in relation to UT receptor localisation (2006) Br J Pharmacol, 147, pp. 612-621
Ishihata, A., Ogaki, T., Aita, T., Katano, Y., Role of prostaglandins in urotensin II-induced vasodilatation in the coronary arteries of aged rats (2005) Eur J Pharmacol, 523, pp. 119-126
Katano, Y., Ishihata, A., Aita, T., Ogaki, T., Horie, T., Vasodilator effect of urotensin II, one of the most potent vasoconstricting factors, on rat coronary arteries (2000) Eur J Pharmacol, 402, pp. R5-7
Lacza, Z., Busija D, W., Urotensin-II is a nitric oxide-dependent vasodilator in the pial arteries of the newborn pig (2006) Life Sci, 78, pp. 2763-2766
Zhang, A.Y., Chen, Y.F., Zhang, D.X., Yi, F.X., Qi, J., Urotensin II is a nitric oxide-dependent vasodilator and natriuretic peptide in the rat kidney (2003) Am J Physiol Renal Physiol, 285, pp. F792-F798
Chen, Z.W., Yang, Q., Huang, Y., Fan, L., Li, X.W., Human urotensin II in internal mammary and radial arteries of patients undergoing coronary surgery (2010) Vascul Pharmacol, 52, pp. 70-76
Grieco, P., Carotenuto, A., Campiglia, P., Gomez-Monterrey, I., Auriemma, L., New insight into the binding mode of peptide ligands at Urotensin-II receptor: Structure-activity relationships study on P5U and urantide (2009) J Med Chem, 52, pp. 3927-3940
Merlino, F., Di Maro, S., Munaim Yousif, A., Caraglia, M., Grieco, P., Urotensin-II ligands: An overview from peptide to nonpeptide structures (2013) J Amino Acids, 2013, p. 979016
Cheng, Y., Prusoff, W.H., Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction (1973) Biochem Pharmacol, 22, pp. 3099-3108
Caliendo, G., Perissutti, E., Santagada, V., Fiorino, F., Severino, B., Synthesis and vasorelaxant activity of new 1, 4-benzoxazine derivatives potassium channel openers (2002) Bioorg Med Chem, 10, pp. 2663-2669
Russell, F.D., Emerging roles of urotensin-II in cardiovascular disease (2004) Pharmacol Ther, 103, pp. 223-243
Stirrat, A., Gallagher, M., Douglas, S.A., Ohlstein, E.H., Berry, C., Potent vasodilator responses to human urotensin-II in human pulmonary and abdominal resistance arteries (2001) Am J Physiol Heart Circ Physiol, 280, pp. H925-H928
Cirino, G., Fusco, F., Imbimbo, C., Mirone, V., Pharmacology of erectile dysfunction in man (2006) Pharmacol Ther, 111, pp. 400-423
Hurt, K.J., Sezen, S.F., Lagoda, G.F., Musicki, B., Rameau, G.A., Cyclic AMP-dependent phosphorylation of neuronal nitric oxide synthase mediates penile erection (2012) Proc Natl Acad Sci USA, 109, pp. 16624-16629
A new therapeutic approach to erectile dysfunction: urotensin-II receptor high affinity agonist ligands
Urotensin-II (U-II) is a cyclic peptide that acts through a G protein-coupled receptor (urotensin-II receptor [UTR]) mainly involved in cardiovascular function in humans. The urotensinergic system is also implicated in the urogenital tract. Indeed, U-II relaxes human corpus cavernosum strips and causes an increase in intracavernous pressure (ICP) in rats. In light of this, the U-II/UTR pathway can be considered a new target for the treatment of erectile dysfunction. On this hypothesis, herein we report on two new UTR high affinity-agonists, P5U (H-Asp-c[Pen-Phe-Trp-Lys-Tyr-Cys]-Val-OH) and UPG84(H-Asp-c[Pen-Phe-DTrp-Orn-(pNH 2 ) Phe-Cys]-Val-OH). The effects of P5U and UPG84 were each compared separately with U-II by monitoring the ICP in anesthetized rats. Intracavernous injection of U-II (0.03-1 nmol), P5U (0.03-1 nmol) or UPG84 (0.03-1 nmol) caused an increase in ICP. P5U, in particular, elicited a significant increase in ICP as compared to U-II. The observed effect by using P5U at a dose of 0.1 nmol per rat was comparable to the effect elicited by U-II at a dose of 0.3 nmol. Moreover, UPG84 at the lowest dose (0.03 nmol) showed an effect similar to the highest dose of U-II (1 nmol). Furthermore, UPG84 was found to be more effective than P5U. Indeed, while the lowest dose of P5U (0.03 nmol) did not affect the ICP, UPG84, at the same dose, induced a prominent penile erection in rat. These compounds did not modify the blood pressure, which indicates a good safety profile. In conclusion, UPG84 and P5U may open new perspectives for the management of erectile dysfunction.
Urotensin-II (U-II) is a cyclic peptide that acts through a G protein-coupled receptor (urotensin-II receptor [UTR]) mainly involved in cardiovascular function in humans. The urotensinergic system is also implicated in the urogenital tract. Indeed, U-II relaxes human corpus cavernosum strips and causes an increase in intracavernous pressure (ICP) in rats. In light of this, the U-II/UTR pathway can be considered a new target for the treatment of erectile dysfunction. On this hypothesis, herein we report on two new UTR high affinity-agonists, P5U (H-Asp-c[Pen-Phe-Trp-Lys-Tyr-Cys]-Val-OH) and UPG84(H-Asp-c[Pen-Phe-DTrp-Orn-(pNH 2 ) Phe-Cys]-Val-OH). The effects of P5U and UPG84 were each compared separately with U-II by monitoring the ICP in anesthetized rats. Intracavernous injection of U-II (0.03-1 nmol), P5U (0.03-1 nmol) or UPG84 (0.03-1 nmol) caused an increase in ICP. P5U, in particular, elicited a significant increase in ICP as compared to U-II. The observed effect by using P5U at a dose of 0.1 nmol per rat was comparable to the effect elicited by U-II at a dose of 0.3 nmol. Moreover, UPG84 at the lowest dose (0.03 nmol) showed an effect similar to the highest dose of U-II (1 nmol). Furthermore, UPG84 was found to be more effective than P5U. Indeed, while the lowest dose of P5U (0.03 nmol) did not affect the ICP, UPG84, at the same dose, induced a prominent penile erection in rat. These compounds did not modify the blood pressure, which indicates a good safety profile. In conclusion, UPG84 and P5U may open new perspectives for the management of erectile dysfunction.
A new therapeutic approach to erectile dysfunction: urotensin-II receptor high affinity agonist ligands
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A new therapeutic approach to erectile dysfunction: urotensin-II receptor high affinity agonist ligands
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Specific interaction between bovine cyclophilin A and synthetic analogues of cyclolinopeptide (393 views)
Journal Of Biochemistry (ISSN: 0021-924x), 1998 Nov; 124(5): 880-885.
Impact Factor: 2.189
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Zanotti G, Saviano M, Saviano G, Tancredi T, Rossi F, Pedone C, Benedetti E
Structure of cyclic peptides: the crystal and solution conformation of cyclo(Phe-Phe-Aib-Leu-Pro) (721 views)
Journal Of Peptide Research (ISSN: 1397-002x), 1998 Jun; 51(6): 460-466.
Impact Factor: 1.125
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Lombardi A, D'Agostino B, Nastri F, D'Andrea LD, Filippelli A, Falciani M, Rossi F, Pavone V
A novel super-potent neurokinin A receptor antagonist containing dehydroalanine (463 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894xprint, 0960-894xlinking), 1998 May 19; 8(10): 1153-1156.
Impact Factor: 1.5
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Lombardi A, D'Auria G, Maglio O, Nastri F, Quartara L, Pedone C, Pavone V
A novel rigid β-turn molecular scaffold (456 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 1998; 120(24): 5879-5886.
Impact Factor: 5.725
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Bonomo RP, Impellizzeri G, Pappalardo G, Purrello R, Rizzarelli E, Tabbì G
Co-ordinating properties of cyclopeptides. Thermodynamic and spectroscopic study on the formation of copper(II) complexes with cyclo(Gly-His)4 and cyclo(Gly-His-Gly)2 and their superoxide dismutase-like activity (452 views)
Journal Of The Chemical Society Dalton Transactions (ISSN: 0300-9246), 1998; (22): 3851-3857.
Impact Factor: 2.507
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D'Andrea LD, Mazzeo M, Isernia C, Rossi F, Saviano M, Gallo P, Paolillo L, Pedone C
Solution conformational preferences of a peptidic analogue of a natural macrolide (382 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(3): 349-361.
Impact Factor: 2.425
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Lombardi A, Saviano M, Nastri F, Maglio O, Mazzeo M, Pedone C, Isernia C, Pavone V
Unusual conformational preferences of β-alanine containing cyclic peptides. VII (456 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1996 Jun; 38(6): 683-691.
Impact Factor: 2.425
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Saviano M, Rossi F, Filizola M, Isernia C, Di Blasio B, Benedetti E, Pedone C, Siemion IZ, Pedyczak A
Bioactive peptides: conformational studies of [Tyr4] cyclolinopeptide (406 views)
Biopolymers (ISSN: 0006-3525print, 0006-3525linking, 1097-0282electronic), 1995 Oct; 26(12): 453-460.
Impact Factor: 2.572
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Mazzeo M, Isernia C, Rossi F, Saviano M, Pedone C, Paolillo L, Benedetti E, Pavone V
Conformational Behaviour of a Cyclolinopeptide A Analogue: Two-dimensional NMR study of cyclo(Pro(1)-Pro-Phe-Phe-Ac(6)c-Ile-ala-Val(8)) (320 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 1995 Sep; 1(5): 330-340.
Impact Factor: 1.311
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Gallo P, Saviano M, Rossi F, Pavone V, Pedone C, Ragone R, Stiuso P, Colonna G
SPECIFIC INTERACTION BETWEEN CYCLOPHILIN AND CYCLIC-PEPTIDES (484 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995 Sep; 36(3): 273-281.
Impact Factor: 2.425
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Saviano M, Rossi F, Filizola M, Di Blasio B, Pedone C
[Aib5, 6-D-Ala8]-cyclolinopeptide A, grown from a benzene/acetonitrile mixture (324 views)
Acta Crystallogr Sect C Cryst Struct Commun (ISSN: 0108-2701), 1995 Apr 15; 51: Pt-Pt.
Impact Factor: 0.459
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Fattorusso R, Morelli G, Lombardi A, Nastri F, maglio O, D'Auria G, Pedone C, Pavone V
Design of metal ion binding peptides (614 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995; 37(6): 401-410.
Impact Factor: 2.425
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Pavone V, Lombardi A, Saviano M, Nastri F, Fattorusso R, Maglio O, Isernia C, Paolillo L, Pedone C
β-alanine containing cyclic peptides with turned structure: The 'pseudo type II β-turn. ' VI (463 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Nov; 34(11): 1517-1526.
Impact Factor: 2.425
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Rossi F, Saviano M, Di Blasio B, Zanotti G, Maione AM, Tancredi T, Pedone C
BIOACTIVE PEPTIDES - SOLID-STATE, SOLUTION AND MOLECULAR-DYNAMICS STUDIES OF A CYCLOLINOPEPTIDE-A RELATED CYSTINYL CYCLOPENTAPEPTIDE (455 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Feb; 34(2): 273-284.
Impact Factor: 2.425
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Di Blasio B, Lombardi A, D'Auria G, Saviano M, Isernia C, Maglio O, Paolillo L, Pedone C, Pavone V
Beta-Alanine Containing Peptides: Gamma-Turns In Cyclotetrapeptides (560 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1993 Apr; 31(10): 621-631.
Impact Factor: 2.425
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DIBLASIO B, ROSSI F, BENEDETTI E, PAVONE V, SAVIANO M, PEDONE C, ZANOTTI G, TANCREDI T
BIOACTIVE PEPTIDES - X-RAY AND NMR CONFORMATIONAL STUDY OF [AIB(5, 6)-D-ALA(8)]CYCLOLINOPEPTIDE-A (441 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 1992 Oct 7; 114(21): 8277-8283.
Impact Factor: 5.65
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Tancredi T, Benedetti E, Grimaldi M, Pedone C, Rossi F, Saviano M, Temussi PA, Zanotti G
Ion binding of cyclolinopeptide A: An NMR and CD conformational study (633 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1991 May; 31(6): 761-767.
Impact Factor: 2.425
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Cucinotta V, D'Alessandro F, Impellizzeri G, Pappalardo G, Rizzarelli E, Vecchio G
Cyclopeptide Functionalized beta-Cyclodextrin. A New Class of Potentially Enzyme Mimicking Compound with Two Recognition Sites (268 views)
Chem Commun, 1991; N/D: 293-294.
Impact Factor: 0
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Tancredi T, Zanotti G, Rossi F, Benedetti E, Pedone C, Temussi PA
Comparison of the conformations of cyclolinopeptide A in the solid state and in solution (423 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1989 Jan; 28(1): 513-523.
Impact Factor: 2.425
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Arena G, Impellizzeri G, Maccarrone G, Pappalardo G, Sciotto D, Rizzarelli E
Non-Covalent Interactions in Cyclopeptide Proton Complex Formation in Aqueous Solution (308 views)
Thermochim Acta, 1989; 154: 97-106.
Impact Factor: 0
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* Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases (834 views)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Feb 12; 25(4): 525-539.
Impact Factor: 3.249
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Calvanese L, Caporale A, Focà G, Iaccarino E, Sandomenico A, Doti N, Apicella I, Incisivo GM, De Falco S, Falcigno L, D’auria G, Ruvo M
* Targeting VEGF receptors with non-neutralizing cyclopeptides for imaging applications (512 views)
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Impact Factor: 2.906
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Merlino F, Brancaccio D, Yousif AM, Piras L, Campiglia P, Gomez-monterrey I, Santicioli P, Meini S, Maggi CA, Novellino E, Carotenuto A, Grieco P
* Structure-Activity Study of the Peptides P5U and Urantide by the Development of Analogues Containing Uncoded Amino Acids at Position9 (378 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7179linking), 2016; N/D: N/D-N/D.
Impact Factor: 3.225
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Brancaccio D, Merlino F, Limatola A, Yousif AM, Gomez-Monterrey I, Campiglia P, Novellino E, Grieco P, Carotenuto A
* An investigation into the origin of the biased agonism associated with the urotensin II receptor activation (481 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015 Feb 19; 21(5): 392-399.
Impact Factor: 1.951
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Carotenuto A, Auriemma L, Merlino F, Yousif AM, Marasco D, Limatola A, Campiglia P, Gomez-Monterrey I, Santicioli P, Meini S, Maggi CA, Novellino E, Grieco P
* Lead Optimization of P5U and Urantide: Discovery of Novel Potent Ligands at the Urotensin-II Receptor (683 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2014 Jul 24; 57(14): 5965-5974.
Impact Factor: 5.447
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Federico A, Zappavigna S, Romano M, Grieco P, Luce A, Marra M, Gravina AG, Stiuso P, D'Armiento FP, Vitale G, Tuccillo C, Novellino E, Loguercio C, Caraglia M
* Urotensin-II receptor is over-expressed in colon cancer cell lines and in colon carcinoma in humans (444 views)
Eur J Clin Invest (ISSN: 0014-2972, 1365-2362, 0014-2972linking), 2014 Mar; 44(3): 285-294.
Impact Factor: 2.734
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De Rosa L, Diana D, Basile A, Russomanno A, Isernia C, Turco MC, Fattorusso R, D'Andrea LD
* Design, Structural And Biological Characterization Of A Vegf Inhibitor Beta-Hairpin-Constrained Peptide (510 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014; 73: 210-216.
Impact Factor: 3.447
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Portella L, Vitale R, De Luca S, D'Alterio C, Ieranò C, Napolitano M, Riccio A, Polimeno MN, Monfregola L, Barbieri A, Luciano A, Ciarmiello A, Arra C, Castello G, Amodeo P, Scala S
* Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases (505 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Sep 13; 8(9): N/D-N/D.
Impact Factor: 3.534
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Carotenuto A, Auriemma L, Merlino F, Limatola A, Campiglia P, Gomez-monterrey I, Di Villa Bianca R, Brancaccio D, Santicioli P, Meini S, Maggi CA, Novellino E, Grieco P
* New insight into the binding mode of peptides at urotensin-II receptor by Trp-constrained analogues of P5U and urantide (519 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387electronic, 1075-2617linking), 2013 May; 19(5): 293-300.
Impact Factor: 1.862
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Carotenuto A, Cipolletta E, Gomez-Monterrey I, Sala M, Vernieri E, Limatola A, Bertamino A, Musella S, Sorriento D, Grieco P, Trimarco B, Novellino E, Iaccarino G, Campiglia P
* Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors (575 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013; 69: 384-392.
Impact Factor: 3.432
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Saviano M, Del Gatto A, De Simone M, De Paola I, Saviano M, Zaccaro L
* Investigation of the Best Conditions to Obtain c(RGDfK) Peptide on Solid Phase (508 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2011 Mar; 17(1): 39-45.
Impact Factor: 0.986
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (508 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
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Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (511 views)
J Transl Med (ISSN: 1479-5876electronic), 2011 Jan 13; 9: 7-7.
Impact Factor: 3.474
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Barile E, Leone M, Barile E, Dahl R, Pellecchia M
* Design and NMR Studies of Cyclic Peptides Targeting the N-Terminal Domain of the Protein Tyrosine Phosphatase YopH (2193 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2011 Jan; 77(1): 12-19.
Impact Factor: 2.282
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Gautier B, Goncalves V, Diana D, Di Stasi R, Teillet F, Lenoir C, Huguenot F, Garbay C, Fattorusso R, D'Andrea LD, Vidal M, Inguimbert N
* Biochemical and Structural Analysis of the Binding Determinants of a Vascular Endothelial Growth Factor Receptor Peptidic Antagonist (573 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jun 10; 53(11): 4428-4440.
Impact Factor: 5.207
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Kaczmarek K, Farina B, Zubrzak P, Jankowski S, Zimecki M, Suder P, Benedetti E, Fattorusso R, Saviano M, Zabrocki J
* Synthesis, conformational analysis and immunological activity of β3Phe-substituted Cyclolinopeptide A analogues (478 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 166-174.
Impact Factor: 1.807
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De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
* Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor (398 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Sep 1; 15(17): 5845-5853.
Impact Factor: 2.662
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Galdiero S, Vitiello M, Amodeo P, D'Isanto M, Cantisani M, Pedone C, Galdiero M
* Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae (560 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Apr 11; 45(14): 4491-4501.
Impact Factor: 3.633
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Cozzolino R, Palladino P, Rossi F, Cali G, Benedetti E, Laccetti P
* Antineoplastic cyclic astin analogues kill tumour cells via caspase-mediated induction of apoptosis (524 views)
Carcinogenesis (ISSN: 0143-3334), 2005 Apr; 26(4): 733-739.
Impact Factor: 5.108
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
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De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
Impact Factor: 3.992
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Saviano G, Rossi F, Benedetti E, Pedone C, Mierke DF, Maione A, Zanotti G, Tancredi T, Saviano M
* Structural consequences of metal complexation of cyclo[Pro-Phe-Phe-Ala-Xaa]2 decapeptides (448 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2001 Mar 16; 7(6): 1176-1183.
Impact Factor: 4.614
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Monti SM, Gallo M, Ferracane R, Borrelli RC, Ritieni A, Greco ML, Graniti A, Fogliano V
* Analysis of bacterial lipodepsipeptides by matrix-assisted laser desorption/ionisation time-of-flight and high-performance liquid chromatography with electrospray mass spectrometry (437 views)
Rapid Commun Mass Sp (ISSN: 0951-4198, 1097-0231electronic), 2001; 15(8): 623-628.
Impact Factor: 2.478
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Gallo P, Rossi F, Saviano M, Pedone C, Colonna G, Ragone R
Specific interaction between bovine cyclophilin A and synthetic analogues of cyclolinopeptide (393 views)
Journal Of Biochemistry (ISSN: 0021-924x), 1998 Nov; 124(5): 880-885.
Impact Factor: 2.189
View Export to BibTeX Export to EndNote
Zanotti G, Saviano M, Saviano G, Tancredi T, Rossi F, Pedone C, Benedetti E
Structure of cyclic peptides: the crystal and solution conformation of cyclo(Phe-Phe-Aib-Leu-Pro) (721 views)
Journal Of Peptide Research (ISSN: 1397-002x), 1998 Jun; 51(6): 460-466.
Impact Factor: 1.125
View Export to BibTeX Export to EndNote
Lombardi A, D'Agostino B, Nastri F, D'Andrea LD, Filippelli A, Falciani M, Rossi F, Pavone V
A novel super-potent neurokinin A receptor antagonist containing dehydroalanine (463 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894xprint, 0960-894xlinking), 1998 May 19; 8(10): 1153-1156.
Impact Factor: 1.5
View Export to BibTeX Export to EndNote
Lombardi A, D'Auria G, Maglio O, Nastri F, Quartara L, Pedone C, Pavone V
A novel rigid β-turn molecular scaffold (456 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 1998; 120(24): 5879-5886.
Impact Factor: 5.725
View Export to BibTeX Export to EndNote
Bonomo RP, Impellizzeri G, Pappalardo G, Purrello R, Rizzarelli E, Tabbì G
Co-ordinating properties of cyclopeptides. Thermodynamic and spectroscopic study on the formation of copper(II) complexes with cyclo(Gly-His)4 and cyclo(Gly-His-Gly)2 and their superoxide dismutase-like activity (452 views)
Journal Of The Chemical Society Dalton Transactions (ISSN: 0300-9246), 1998; (22): 3851-3857.
Impact Factor: 2.507
View Export to BibTeX Export to EndNote
D'Andrea LD, Mazzeo M, Isernia C, Rossi F, Saviano M, Gallo P, Paolillo L, Pedone C
Solution conformational preferences of a peptidic analogue of a natural macrolide (382 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(3): 349-361.
Impact Factor: 2.425
View Export to BibTeX Export to EndNote
Lombardi A, Saviano M, Nastri F, Maglio O, Mazzeo M, Pedone C, Isernia C, Pavone V
Unusual conformational preferences of β-alanine containing cyclic peptides. VII (456 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1996 Jun; 38(6): 683-691.
Impact Factor: 2.425
View Export to BibTeX Export to EndNote
Saviano M, Rossi F, Filizola M, Isernia C, Di Blasio B, Benedetti E, Pedone C, Siemion IZ, Pedyczak A
Bioactive peptides: conformational studies of [Tyr4] cyclolinopeptide (406 views)
Biopolymers (ISSN: 0006-3525print, 0006-3525linking, 1097-0282electronic), 1995 Oct; 26(12): 453-460.
Impact Factor: 2.572
View Export to BibTeX Export to EndNote
Mazzeo M, Isernia C, Rossi F, Saviano M, Pedone C, Paolillo L, Benedetti E, Pavone V
Conformational Behaviour of a Cyclolinopeptide A Analogue: Two-dimensional NMR study of cyclo(Pro(1)-Pro-Phe-Phe-Ac(6)c-Ile-ala-Val(8)) (320 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 1995 Sep; 1(5): 330-340.
Impact Factor: 1.311
View Export to BibTeX Export to EndNote
Gallo P, Saviano M, Rossi F, Pavone V, Pedone C, Ragone R, Stiuso P, Colonna G
SPECIFIC INTERACTION BETWEEN CYCLOPHILIN AND CYCLIC-PEPTIDES (484 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995 Sep; 36(3): 273-281.
Impact Factor: 2.425
View Export to BibTeX Export to EndNote
Saviano M, Rossi F, Filizola M, Di Blasio B, Pedone C
[Aib5, 6-D-Ala8]-cyclolinopeptide A, grown from a benzene/acetonitrile mixture (324 views)
Acta Crystallogr Sect C Cryst Struct Commun (ISSN: 0108-2701), 1995 Apr 15; 51: Pt-Pt.
Impact Factor: 0.459
View Export to BibTeX Export to EndNote
Fattorusso R, Morelli G, Lombardi A, Nastri F, maglio O, D'Auria G, Pedone C, Pavone V
Design of metal ion binding peptides (614 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995; 37(6): 401-410.
Impact Factor: 2.425
View Export to BibTeX Export to EndNote
Pavone V, Lombardi A, Saviano M, Nastri F, Fattorusso R, Maglio O, Isernia C, Paolillo L, Pedone C
β-alanine containing cyclic peptides with turned structure: The 'pseudo type II β-turn. ' VI (463 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Nov; 34(11): 1517-1526.
Impact Factor: 2.425
View Export to BibTeX Export to EndNote
Rossi F, Saviano M, Di Blasio B, Zanotti G, Maione AM, Tancredi T, Pedone C
BIOACTIVE PEPTIDES - SOLID-STATE, SOLUTION AND MOLECULAR-DYNAMICS STUDIES OF A CYCLOLINOPEPTIDE-A RELATED CYSTINYL CYCLOPENTAPEPTIDE (455 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Feb; 34(2): 273-284.
Impact Factor: 2.425
View Export to BibTeX Export to EndNote
Di Blasio B, Lombardi A, D'Auria G, Saviano M, Isernia C, Maglio O, Paolillo L, Pedone C, Pavone V
Beta-Alanine Containing Peptides: Gamma-Turns In Cyclotetrapeptides (560 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1993 Apr; 31(10): 621-631.
Impact Factor: 2.425
View Export to BibTeX Export to EndNote
DIBLASIO B, ROSSI F, BENEDETTI E, PAVONE V, SAVIANO M, PEDONE C, ZANOTTI G, TANCREDI T
BIOACTIVE PEPTIDES - X-RAY AND NMR CONFORMATIONAL STUDY OF [AIB(5, 6)-D-ALA(8)]CYCLOLINOPEPTIDE-A (441 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 1992 Oct 7; 114(21): 8277-8283.
Impact Factor: 5.65
View Export to BibTeX Export to EndNote
Tancredi T, Benedetti E, Grimaldi M, Pedone C, Rossi F, Saviano M, Temussi PA, Zanotti G
Ion binding of cyclolinopeptide A: An NMR and CD conformational study (633 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1991 May; 31(6): 761-767.
Impact Factor: 2.425
View Export to BibTeX Export to EndNote
Cucinotta V, D'Alessandro F, Impellizzeri G, Pappalardo G, Rizzarelli E, Vecchio G
Cyclopeptide Functionalized beta-Cyclodextrin. A New Class of Potentially Enzyme Mimicking Compound with Two Recognition Sites (268 views)
Chem Commun, 1991; N/D: 293-294.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Tancredi T, Zanotti G, Rossi F, Benedetti E, Pedone C, Temussi PA
Comparison of the conformations of cyclolinopeptide A in the solid state and in solution (423 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1989 Jan; 28(1): 513-523.
Impact Factor: 2.425
View Export to BibTeX Export to EndNote
Arena G, Impellizzeri G, Maccarrone G, Pappalardo G, Sciotto D, Rizzarelli E
Non-Covalent Interactions in Cyclopeptide Proton Complex Formation in Aqueous Solution (308 views)
Thermochim Acta, 1989; 154: 97-106.
Impact Factor: 0
View Export to BibTeX Export to EndNote
43 Records (40 excluding Abstracts).
Total impact factor: 116.344 (110.4 excluding Abstracts).
Total 5 year impact factor: 123.887 (117.513 excluding Abstracts).
Total impact factor: 116.344 (110.4 excluding Abstracts).
Total 5 year impact factor: 123.887 (117.513 excluding Abstracts).
476 views. Last view on Saturday 14 January 2023, 18:02:46
ibb.cnr.it
