Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis(332 views) Ciccarelli M, Rusciano MR, Sorriento D, Maione AS, Soprano M, Iaccarino G, Illario M
Journal Of Cancer Therapy (ISSN: 2151-1934), 2015 Feb 11; 6: 199-212.
Department of Medicine and Surgery, University of Salerno, Salerno, Italy
Department of Clinical and Translational Medicine, Federico II University, Napoli, Italy
IBB, CNR, Napoli, Italy
IOS e Coleman, Napoli, Italy
References: Not available.
Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis
Cancer is a multistep process encompassing the transformation of normal epithelial cells to thestromal invasion and metastasis, with these last considered the final stage of the disease. Tumorinvasiveness is based on creation of a specific peri-tumoral environment which on turn dependsupon epithelial-stromal interactions, degradation of extracellular matrix and reorganization of fibrillarcomponents. Even though several aspects of the stromal and cellular remodeling have beenelucidated and described, such as the epithelial-mesenchymal transition (EMT) and extracellularmatrix degradation, all the underlying molecular mechanism are far to be elucidated in their complexity.In this review we focused on new actors such as microRNAs, G protein coupled receptorkinases (GRKs) and Calcium/calmodulin-dependent protein kinase (CaMKs) known to be involvedin several important physiological processes like development, cell differentiation and cell signaling,and more recently linked to tumor progression and invasion.
Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis
Bogdanovich S, Kim Y, Mizutani T, Yasuma R, Tudisco L, Cicatiello V, Bastos-carvalho A, Kerur N, Hirano Y, Baffi JZ, Tarallo V, Li S, Yasuma T, Arpitha P, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ruvo M, Sandomenico A, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Ambati BK, Leusen JH, Langdon WY, Clark MR, Armour KL, Bruhns P, Verbeek JS, Gelfand BD, De Falco S, Ambati J * Human IgG1 antibodies suppress angiogenesis in a target-independent manner(682 views) Signal Transduct Target Ther (ISSN: 2059-3635print), 2016; 1: N/D-N/D. Impact Factor:0 ViewExport to BibTeXExport to EndNote
Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G * CaMK4 gene deletion induces hypertension(428 views) J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D. Impact Factor:2.882 ViewExport to BibTeXExport to EndNote
Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A * Tumor Imaging(471 views) Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309. Impact Factor:1.148 ViewExport to BibTeXExport to EndNote