Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (1053 views)
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
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Paper type: Journal Article,
Impact factor: 2.73, 5-year impact factor: 2.749
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84937207623&partnerID=40&md5=5b42687a83402da0b49803f68d34824b
Keywords: Amyloid, Anti-Aggregant Acstivity, Antidepressants, Butyric Acid (pubchem Cid: 264), Neurons, Neuroprotection, Tranylcypromine (pubchem Cid: 19493 Or 26070), Tranylcypromine Acetamide (pubchem Cid: 583384), Anti-Aggregant Activity, Amyloid Beta Protein[1-42], Glial Fibrillary Acidic Protein, Microtubule Associated Protein 2, Tranylcypromine Butyramide, Tranylcypromine Derivative, Unclassified Drug, Alzheimer Disease, Animal Cell, Animal Experiment, Animal Model, Article, Controlled Study, Drug Degradation, Drug Efficacy, Drug Potency, Drug Stability, Drug Synthesis, In Vitro Study, Nerve Cell Necrosis, Nerve Degeneration, Neurotoxicity, Nonhuman, Priority Journal, Protein Aggregation,
Affiliations:
*** IBB - CNR ***
Department of drug Sciences, university of Catania, Catania, Italy; IRCCS Associazione Oasi maria S.S., institute for research on mental Retardation and brain aging, Troina, Italy. Electronic address: Carafil@hotmail.com., National research council, institute of Biostructures and Bioimaging, Catania, Italy., Department of drug Sciences, university of Catania, Catania, Italy., Department of drug Sciences, university of Catania, Catania, Italy; National research council, institute of Biostructures and Bioimaging, Catania, Italy., National research council, institute of Biostructures and Bioimaging, Catania, Italy; PhD Program in Translational Biomedicine, university of Catania., Department of biomedical and Biotechnological Sciences, university of Catania, Catania, Italy.,
References:
Not available.
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.73, 5-year impact factor: 2.749
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84937207623&partnerID=40&md5=5b42687a83402da0b49803f68d34824b
Keywords: Amyloid, Anti-Aggregant Acstivity, Antidepressants, Butyric Acid (pubchem Cid: 264), Neurons, Neuroprotection, Tranylcypromine (pubchem Cid: 19493 Or 26070), Tranylcypromine Acetamide (pubchem Cid: 583384), Anti-Aggregant Activity, Amyloid Beta Protein[1-42], Glial Fibrillary Acidic Protein, Microtubule Associated Protein 2, Tranylcypromine Butyramide, Tranylcypromine Derivative, Unclassified Drug, Alzheimer Disease, Animal Cell, Animal Experiment, Animal Model, Article, Controlled Study, Drug Degradation, Drug Efficacy, Drug Potency, Drug Stability, Drug Synthesis, In Vitro Study, Nerve Cell Necrosis, Nerve Degeneration, Neurotoxicity, Nonhuman, Priority Journal, Protein Aggregation,
Affiliations:
*** IBB - CNR ***
Department of drug Sciences, university of Catania, Catania, Italy; IRCCS Associazione Oasi maria S.S., institute for research on mental Retardation and brain aging, Troina, Italy. Electronic address: Carafil@hotmail.com., National research council, institute of Biostructures and Bioimaging, Catania, Italy., Department of drug Sciences, university of Catania, Catania, Italy., Department of drug Sciences, university of Catania, Catania, Italy; National research council, institute of Biostructures and Bioimaging, Catania, Italy., National research council, institute of Biostructures and Bioimaging, Catania, Italy; PhD Program in Translational Biomedicine, university of Catania., Department of biomedical and Biotechnological Sciences, university of Catania, Catania, Italy.,
References:
Not available.
Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity
Abstract Monoamine oxidase (MAO) enzymes play a central role in the pathogenesis of Alzheimer's disease (AD) and MAO inhibitors (MAOIs) are antidepressant drugs currently studied for their neuroprotective properties in neurodegenerative disorders. In the present work MAOIs such as tranylcypromine [trans-(+)-2-phenylcyclopropanamine, TCP] and its amide derivatives, TCP butyramide (TCP-But) and TCP acetamide (TCP-Ac), were tested for their ability to protect cortical neurons challenged with synthetic amyloid-β (Aβ)-(1-42) oligomers (100 nM) for 48 h. TCP significantly prevented Aβ-induced neuronal death in a concentration-dependent fashion and was maximally protective only at 10 μM. TCP-But was maximally protective in mixed neuronal cultures at 1 μM, a lower concentration compared to TCP, whereas the new derivative, TCP-Ac, was more efficacious than TCP and TCP-But and significantly protected cortical neurons against Aβ toxicity at nanomolar concentrations (100 nM). Experiments carried out with the Thioflavin-T (Th-T) fluorescence assay for fibril formation showed that TCP and its amide derivatives influenced the early events of the Aβ aggregation process in a concentration-dependent manner. TCP-Ac was more effective than TCP-But and TCP in slowing down the Aβ(1-42) aggregates formation through a lengthening at the lag phase. In our experimental model co-incubation of Aβ(1-42) oligomers with TCP-Ac was able to almost completely prevent Aβ-induced neurodegeneration. These results suggest that inhibition of Aβ oligomer-mediated aggregation significantly contributes to the overall neuroprotective activity of TCP-Ac and also raise the possibility that TCP, and in particular the new compound TCP-Ac, might represent new pharmacological tools to yield neuroprotection in AD. © 2015 Elsevier B.V.
Abstract Monoamine oxidase (MAO) enzymes play a central role in the pathogenesis of Alzheimer's disease (AD) and MAO inhibitors (MAOIs) are antidepressant drugs currently studied for their neuroprotective properties in neurodegenerative disorders. In the present work MAOIs such as tranylcypromine [trans-(+)-2-phenylcyclopropanamine, TCP] and its amide derivatives, TCP butyramide (TCP-But) and TCP acetamide (TCP-Ac), were tested for their ability to protect cortical neurons challenged with synthetic amyloid-β (Aβ)-(1-42) oligomers (100 nM) for 48 h. TCP significantly prevented Aβ-induced neuronal death in a concentration-dependent fashion and was maximally protective only at 10 μM. TCP-But was maximally protective in mixed neuronal cultures at 1 μM, a lower concentration compared to TCP, whereas the new derivative, TCP-Ac, was more efficacious than TCP and TCP-But and significantly protected cortical neurons against Aβ toxicity at nanomolar concentrations (100 nM). Experiments carried out with the Thioflavin-T (Th-T) fluorescence assay for fibril formation showed that TCP and its amide derivatives influenced the early events of the Aβ aggregation process in a concentration-dependent manner. TCP-Ac was more effective than TCP-But and TCP in slowing down the Aβ(1-42) aggregates formation through a lengthening at the lag phase. In our experimental model co-incubation of Aβ(1-42) oligomers with TCP-Ac was able to almost completely prevent Aβ-induced neurodegeneration. These results suggest that inhibition of Aβ oligomer-mediated aggregation significantly contributes to the overall neuroprotective activity of TCP-Ac and also raise the possibility that TCP, and in particular the new compound TCP-Ac, might represent new pharmacological tools to yield neuroprotection in AD. © 2015 Elsevier B.V.
Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity
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Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity
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Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (678 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
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Cirillo G, Bianco MR, Colangelo AM, Cavaliere C, Daniele DL, Zaccaro L, Alberghina L, Papa M
* Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor (559 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2011 Mar; 41(3): 630-639.
Impact Factor: 5.403
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (798 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (528 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
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Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (789 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (1554 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
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Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (1896 views)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1536 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Gustavsson T, Banyasz A, Sarkar N, Markovitsi D, Improta R
* Statin: New life for an old drug (503 views)
Pharmacol Res Academic Press, 2008 Jun 23; 350(1-3): 1-2.
Impact Factor: 3.976
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (543 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (543 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (1220 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (768 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (700 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (871 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (907 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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33 Records (32 excluding Abstracts).
Total impact factor: 166.942 (161.928 excluding Abstracts).
Total 5 year impact factor: 154.183 (148.892 excluding Abstracts).
Total impact factor: 166.942 (161.928 excluding Abstracts).
Total 5 year impact factor: 154.183 (148.892 excluding Abstracts).
1053 views. Last view on Sunday 06 October 2024, 9:28:01
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