A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (1071 views) (PDF restricted 305 views)
Cancer Lett (ISSN: 0304-3835), 2015 Oct 27; 370(1): 100-107.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 7.36, 5-year impact factor: 5.174
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84949455030&partnerID=40&md5=63010eee90601e58d27b20329e347084
Keywords: Bone Marrow-Derived Mesenchymal Stem Cells (bm-Mscs), Chemokine Receptor Type 4 (cxcr4), Novel Cxcr4 Inhibitor, Tumor Invasion, Chemokine Receptor Cxcr4, Chemokine Receptor Cxcr4 Antagonist, Mitogen Activated Protein Kinase, Peptide R, Plerixafor, Unclassified Drug, Antineoplastic Activity, Article, Bone Marrow Derived Mesenchymal Stem Cell, Cancer Growth, Carcinogenesis, Cell Function, Cell Interaction, Cell Invasion, Cell Proliferation, Controlled Study, Hepatocellular Carcinoma Cell Line, Human, Human Cell, In Vitro Study, Liver Cell Carcinoma, Metastasis Potential, Migration Inhibition, Osteosarcoma, Priority Journal, Protein Phosphorylation, Signal Transduction, Snu 398 Cell Line, U2os Cell Line, Bone Neoplasms, Drug Therapy, Pathology, Cell Movement, Epithelial-Mesenchymal Transition, Extracellular Signal-Regulated Map Kinases, Metabolism, Liver Neoplasms, Mesenchymal Stromal Cells, Physiology, Neoplasm Invasiveness, Proto-Oncogene Proteins C-Akt, Wound Healing,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy., Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy; Dipartimento di Scienze Biomediche Avanzate, Universita degli Studi di Napoli "Federico II", Naples, Italy., Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale", IRCCS, Naples, Italy., Istituto per l'Endocrinologia e l'Oncologia Sperimentale "G. Salvatore", CNR, Naples, Italy., Istituto Ortopedico Rizzoli, Bologna, Italy., Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy. Electronic address: antonella.zannetti@cnr.it.,
References:
Not available.
Cancer Lett (ISSN: 0304-3835), 2015 Oct 27; 370(1): 100-107.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 7.36, 5-year impact factor: 5.174
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84949455030&partnerID=40&md5=63010eee90601e58d27b20329e347084
Keywords: Bone Marrow-Derived Mesenchymal Stem Cells (bm-Mscs), Chemokine Receptor Type 4 (cxcr4), Novel Cxcr4 Inhibitor, Tumor Invasion, Chemokine Receptor Cxcr4, Chemokine Receptor Cxcr4 Antagonist, Mitogen Activated Protein Kinase, Peptide R, Plerixafor, Unclassified Drug, Antineoplastic Activity, Article, Bone Marrow Derived Mesenchymal Stem Cell, Cancer Growth, Carcinogenesis, Cell Function, Cell Interaction, Cell Invasion, Cell Proliferation, Controlled Study, Hepatocellular Carcinoma Cell Line, Human, Human Cell, In Vitro Study, Liver Cell Carcinoma, Metastasis Potential, Migration Inhibition, Osteosarcoma, Priority Journal, Protein Phosphorylation, Signal Transduction, Snu 398 Cell Line, U2os Cell Line, Bone Neoplasms, Drug Therapy, Pathology, Cell Movement, Epithelial-Mesenchymal Transition, Extracellular Signal-Regulated Map Kinases, Metabolism, Liver Neoplasms, Mesenchymal Stromal Cells, Physiology, Neoplasm Invasiveness, Proto-Oncogene Proteins C-Akt, Wound Healing,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy., Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy; Dipartimento di Scienze Biomediche Avanzate, Universita degli Studi di Napoli "Federico II", Naples, Italy., Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale", IRCCS, Naples, Italy., Istituto per l'Endocrinologia e l'Oncologia Sperimentale "G. Salvatore", CNR, Naples, Italy., Istituto Ortopedico Rizzoli, Bologna, Italy., Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy. Electronic address: antonella.zannetti@cnr.it.,
References:
Not available.
A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion
Recent findings suggest that bone marrow-derived mesenchymal stem cells (BM-MSCs) are recruited into the microenvironment of developing tumors, where they contribute to metastatic processes. The aim of this study was to investigate the role of BM-MSCs in promoting osteosarcoma and hepatocellular carcinoma cell progression in vitro and the possible mechanisms involved in these processes. U2OS and SNU-398 are osteosarcoma and hepatocellular carcinoma cell lines, respectively, that can be induced to proliferate when cultured in the presence of BM-MSCs. To determine the effect of BM-MSCs on U2OS and SNU-398 cells, the AKT and ERK signaling pathways were investigated, and increases were observed in active P-Akt and P-Erk forms. Moreover, BM-MSCs caused an increase in tumor cell migration and invasion that was derived from the enhancement of CXCR4 levels.Thus, when tumor cells were treated with the CXCR4 antagonist AMD3100, a reduction in their migration and invasion was observed. Furthermore, a new CXCR4 inhibitor, Peptide R, which was recently developed as an anticancer agent, was used to inhibit BM-MSC-mediated tumor invasion and to overcome AMD3100 toxicity. Taken together, these results suggest that inhibiting CXCR4 impairs the cross-talk between tumor cells and BM-MSCs, resulting in reduced metastatic potential in osteosarcoma and hepatocellular carcinoma cells. © 2015 Elsevier Ireland Ltd.
Recent findings suggest that bone marrow-derived mesenchymal stem cells (BM-MSCs) are recruited into the microenvironment of developing tumors, where they contribute to metastatic processes. The aim of this study was to investigate the role of BM-MSCs in promoting osteosarcoma and hepatocellular carcinoma cell progression in vitro and the possible mechanisms involved in these processes. U2OS and SNU-398 are osteosarcoma and hepatocellular carcinoma cell lines, respectively, that can be induced to proliferate when cultured in the presence of BM-MSCs. To determine the effect of BM-MSCs on U2OS and SNU-398 cells, the AKT and ERK signaling pathways were investigated, and increases were observed in active P-Akt and P-Erk forms. Moreover, BM-MSCs caused an increase in tumor cell migration and invasion that was derived from the enhancement of CXCR4 levels.Thus, when tumor cells were treated with the CXCR4 antagonist AMD3100, a reduction in their migration and invasion was observed. Furthermore, a new CXCR4 inhibitor, Peptide R, which was recently developed as an anticancer agent, was used to inhibit BM-MSC-mediated tumor invasion and to overcome AMD3100 toxicity. Taken together, these results suggest that inhibiting CXCR4 impairs the cross-talk between tumor cells and BM-MSCs, resulting in reduced metastatic potential in osteosarcoma and hepatocellular carcinoma cells. © 2015 Elsevier Ireland Ltd.
A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion
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A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion
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View Export to BibTeX Export to EndNote
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Impact Factor: 5.085
View Export to BibTeX Export to EndNote
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Impact Factor: 3.534
View Export to BibTeX Export to EndNote
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Impact Factor: 5.333
View Export to BibTeX Export to EndNote
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Impact Factor: 5.712
View Export to BibTeX Export to EndNote
Napolitano M, Ottaiano A, Mauro F, Ieranò C, Satriano R, Pacelli R, Franco R, De Angelis V, Castello G, Scala S
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Impact Factor: 4.293
View Export to BibTeX Export to EndNote
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Impact Factor: 4.087
View Export to BibTeX Export to EndNote
Palladino P, Tizzano B, Pedone C, Ragone R, Rossi F, Saviano G, Tancredi T, Benedetti E
* Structural determinants of unexpected agonist activity in a retro-peptide analogue of the SDF-1α N-terminus (577 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 Oct 10; 579(24): 5293-5298.
Impact Factor: 3.415
View Export to BibTeX Export to EndNote
Palladino P, Pedone C, Ragone R, Rossi F, Saviano M, Benedetti E
* A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor (443 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2003 Apr; 10(2): 133-138.
Impact Factor: 0.46
View Export to BibTeX Export to EndNote
Palladino P, De Capua A, Pedone C, Ragone R, Rossi F, Limatola C, Ragozzino D, Benedetti E
* A simplified model of the interaction between SDF-1 chemokine and the CXCR4 receptor (574 views)
Peptide Revolution, 2003 Apr; 10(2): 133-138.
Impact Factor: 4.659
View Export to BibTeX Export to EndNote
17 Records (14 excluding Abstracts).
Total impact factor: 64.099 (54.597 excluding Abstracts).
Total 5 year impact factor: 60.167 (50.244 excluding Abstracts).
Total impact factor: 64.099 (54.597 excluding Abstracts).
Total 5 year impact factor: 60.167 (50.244 excluding Abstracts).
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