Prevalence and prognostic value of hepatic histological alterations in patients with Crohn's disease (397 views)
Scand J Gastroentero (ISSN: 0036-5521, 0036-5521linking), 2015; 50(12): 1463-1468.
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Paper type: Journal Article,
Impact factor: 2.199, 5-year impact factor: 2.311
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Keywords: Crohn, S Disease, Bowel Resection, Liver Biopsy, Liver Disease, Liver Elastography,
Affiliations:
*** IBB - CNR ***
Department of Gastroenterology and Hepatology, Citta della Salute e della Scienza-Molinette Hospital , Turin , Italy.,
References:
Not available.
Scand J Gastroentero (ISSN: 0036-5521, 0036-5521linking), 2015; 50(12): 1463-1468.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.199, 5-year impact factor: 2.311
Url: Not available.
Keywords: Crohn, S Disease, Bowel Resection, Liver Biopsy, Liver Disease, Liver Elastography,
Affiliations:
*** IBB - CNR ***
Department of Gastroenterology and Hepatology, Citta della Salute e della Scienza-Molinette Hospital , Turin , Italy.,
References:
Not available.
Prevalence and prognostic value of hepatic histological alterations in patients with Crohn's disease
Variable degrees of liver histological changes in patients with Crohn's disease (CD) have been reported. OBJECTIVE: To evaluate the liver histological alterations and their prognostic significance in patients affected by CD without abnormalities of liver biochemical parameters and ultrasound features. MATERIAL AND METHODS: A prospective, single-blind study, including 35 consecutive patients with CD that underwent bowel resection with a contemporary performance of liver biopsy from 1992 to 2003. EXCLUSION CRITERIA: the presence of standard causes of liver disease, such as alcohol consumption exceeding 20 g/day, primary sclerosing cholangitis, viral infections, celiac disease, metabolic syndrome and alterations of the metabolism. Patients were followed up with regular evaluation of hepatic cytolysis, cholestasis, synthesis and ultrasound performance. After a mean interval of 14 years (from May to December 2013), liver fibrosis was assessed by Fibroscan(R). RESULTS: Histological alterations were shown in 60% of patients, without serious liver injuries (no case of inflammation or significant fibrosis). Fibroscan(R) was performed in 33 subjects and no significant changes were observed (mean value of liver stiffness: 5.2 +/- 1.2 kPa). The minimal microscopic damage did not evolve either in patients with a normal histology or in those with an altered histology at baseline (p = 0.9). Only patients who took azathioprine had a statistically significant increase of liver stiffness values (5.7 +/- 1.5 kPa vs 4.7 +/- 1.3 kPa, p = 0.017). CONCLUSIONS: Patients with CD do not need additional examinations compared to the general population, unless clinical or biochemical abnormalities are found.
Variable degrees of liver histological changes in patients with Crohn's disease (CD) have been reported. OBJECTIVE: To evaluate the liver histological alterations and their prognostic significance in patients affected by CD without abnormalities of liver biochemical parameters and ultrasound features. MATERIAL AND METHODS: A prospective, single-blind study, including 35 consecutive patients with CD that underwent bowel resection with a contemporary performance of liver biopsy from 1992 to 2003. EXCLUSION CRITERIA: the presence of standard causes of liver disease, such as alcohol consumption exceeding 20 g/day, primary sclerosing cholangitis, viral infections, celiac disease, metabolic syndrome and alterations of the metabolism. Patients were followed up with regular evaluation of hepatic cytolysis, cholestasis, synthesis and ultrasound performance. After a mean interval of 14 years (from May to December 2013), liver fibrosis was assessed by Fibroscan(R). RESULTS: Histological alterations were shown in 60% of patients, without serious liver injuries (no case of inflammation or significant fibrosis). Fibroscan(R) was performed in 33 subjects and no significant changes were observed (mean value of liver stiffness: 5.2 +/- 1.2 kPa). The minimal microscopic damage did not evolve either in patients with a normal histology or in those with an altered histology at baseline (p = 0.9). Only patients who took azathioprine had a statistically significant increase of liver stiffness values (5.7 +/- 1.5 kPa vs 4.7 +/- 1.3 kPa, p = 0.017). CONCLUSIONS: Patients with CD do not need additional examinations compared to the general population, unless clinical or biochemical abnormalities are found.
Prevalence and prognostic value of hepatic histological alterations in patients with Crohn's disease
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Prevalence and prognostic value of hepatic histological alterations in patients with Crohn's disease
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Impact Factor: 3.018
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Di Lorenzo G, Imbimbo M, Leopardo D, Marciano R, Federico P, Buonerba C, Salvatore B, Marinelli A, Palmieri G. A
* A long-lasting response to sorafenib treatment in an advanced hepatocellular carcinoma patient (450 views)
Int J Immunopathol Pharmacol (ISSN: 0394-6320), 2010 Jul; 23(3): 951-954.
Impact Factor: 2.685
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Gentile I, Viola C, Graf M, Liuzzi R, Quarto M, Cerini R, Piazza M, Borgia G
* A simple noninvasive score predicts gastroesophageal varices in patients with chronic viral hepatitis (511 views)
J Clin Gastroenterol (ISSN: 0192-0790), 2009 Jan; 43(1): 81-87.
Impact Factor: 2.207
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Mainenti PP, Cantalupo T, Nicotra S, Camera L, Imbriaco M, Di Vizio D, Insabato L, Salvatore M
* Systemic amyloidosis: The CT sign of splenic hypoperfusion (382 views)
Amyloid (ISSN: 1350-6129), 2004 Dec; 11(4): 281-282.
Impact Factor: 1.886
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Mainenti PP, D'Agostino L, Soscia E, Romano M, Salvatore M
* Hepatic and splenic amyloidosis: Dual-phase spiral CT findings (507 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2003 Sep; 28(5): 688-690.
Impact Factor: 0.996
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Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS
Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease (702 views)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026.
Impact Factor: 0.913
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30 Records (30 excluding Abstracts).
Total impact factor: 73.825 (73.825 excluding Abstracts).
Total 5 year impact factor: 56.709 (56.709 excluding Abstracts).
Total impact factor: 73.825 (73.825 excluding Abstracts).
Total 5 year impact factor: 56.709 (56.709 excluding Abstracts).
397 views. Last view on Friday 13 September 2024, 4:57:47
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