European Institute for Molecular Imaging (EIMI), Westfalische Wilhelms University Munster, Munster, Germany., Paris Centre de Recherche Cardiovasculaire (PARC), Paris, France., Department of Clinical Radiology of the University Hospital, Westfalische Wilhelms University Munster, Munster, Germany., Department of Nuclear Medicine of the University Hospital, Westfalische Wilhelms University Munster, Munster, Germany., Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), Westfalische Wilhelms University Munster, Munster, Germany., Service Hospitalier Frederic Joliot, Institut d'Imagerie BioMedicale, CEA, Orsay, France., Institute of Biostructure and Bioimaging, CNR, Naples, Italy., Institut d'Investigacions Biomediques de Barcelona, Consejo Superior de Investigaciones Cientificas (CSIC), Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Institute of Physiological Chemistry and Pathobiochemistry, Westfalische Wilhelms University Munster, Munster, Germany., Department of Geriatrics, Johanniter Hospital, Evangelische Kliniken, Bonn, Germany.,
References: Not available.
Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke
Stroke is the most common cause of death and disability from neurologic disease in humans. Activation of microglia and matrix metalloproteinases (MMPs) is involved in positively and negatively affecting stroke outcome. Novel, noninvasive, multimodal imaging methods visualizing microglial and MMP alterations were employed. The spatio-temporal dynamics of these parameters were studied in relation to blood flow changes. Micro positron emission tomography (muPET) using [(18)F]BR-351 showed MMP activity within the first days after transient middle cerebral artery occlusion (tMCAo), followed by increased [(18)F]DPA-714 uptake as a marker for microglia activation with a maximum at 14 days after tMCAo. The inflammatory response was spatially located in the infarct core and in adjacent (penumbral) tissue. For the first time, multimodal imaging based on PET, single photon emission computed tomography, and magnetic resonance imaging revealed insight into the spatio-temporal distribution of critical parameters of poststroke inflammation. This allows further evaluation of novel treatment paradigms targeting the postischemic inflammation.
Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G * CaMK4 gene deletion induces hypertension(410 views) J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D. Impact Factor:2.882 ViewExport to BibTeXExport to EndNote
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(897 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote