Autocrine signals increase Ovine Mesenchymal Stem Cells migration through Aquaporin-1 and CXCR4 overexpression (659 views)
J Cell Physiol (ISSN: 1097-4652electronic, 0021-9541linking), 2018 Jan 18; 233(8): 6241-6249.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.546, 5-year impact factor: 0
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045976063&doi=10.1002%2fjcp.26493&partnerID=40&md5=8babff8395896975f5e6fbf07f9133b3
Keywords: Aqp1, Cxcr4, Ovine Mesenchymal Stem Cells, Aquaporin 1, Chemokine Receptor Cxcr4, Focal Adhesion Kinase, Mitogen Activated Protein Kinase, Animal Cell, Article, Autocrine Effect, Cell Differentiation, Cell Migration, Cell Proliferation, Controlled Study, Intracellular Signaling, Nonhuman, Paracrine Signaling, Priority Journal, Protein Expression, Regenerative Medicine, Sheep,
Affiliations:
*** IBB - CNR ***
Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy., Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy., Osteoarticolar Regeneration Laboratory, Rizzoli Orthopedic Institute, Bologna, Italy.,
References:
Adamzyk, C., Kachel, P., Hoss, M., Gremse, F., Modabber, A., Hölzle, F., Lethaus, B., Bone tissue engineering using polyetherketoneketone scaffolds combined with autologous mesenchymal stem cells in a sheep calvarial defect model (2016) Journal of Cranio-Maxillofacial Surgery, 44, pp. 985-99
Al Faqeh, H., Nor Hamdan, B.M., Chen, H.C., Aminuddin, B.S., Ruszymah, B.H., The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model (2012) Experimental Gerontology, 47, pp. 658-664
Angoulvant, D., Ivanes, F., Ferrera, R., Matthews, P.G., Nataf, S., Ovize, M., Mesenchymal stem cell conditioned media attenuates in vitro and ex vivo myocardial reperfusion injury (2011) The Journal of Heart and Lung Transplantation, 30, pp. 95-102
Boos, A.M., Loew, J.S., Deschler, G., Arkudas, A., Bleiziffer, O., Gulle, H., Beier, J.P., Directly auto-transplanted mesenchymal stem cells induce bone formation in a ceramic bone substitute in an ectopic sheep model (2011) Journal of Cellular and Molecular Medicine, 15, pp. 1364-1378
Burk, J., Glauchea, S.M., Brehma, W., Crovaced, A., Francioso, E., Hillmann, A., Lacitignola, L., Characterisation and intracellular labelling of mesenchymal stromal cells derived from synovial fluid of horses and sheep (2017) Veterinary Journal, 222, pp. 1-8
Camorani, S., Hill, B.S., Fontanella, R., Greco, A., Gramanzini, M., Auletta, L., Zannetti, A., Inhibition of bone marrow-Derived mesenchymal stem cells homing towards triple-Negative Breast cancer microenvironment using an anti-PDGFRβ aptamer (2017) Theranostics, 7, pp. 3595-3607
Cashen, A.F., Nervi, B., Di Persio, J., AMD3100: CXCR4 antagonist and rapid stem cell-mobilizing agent (2007) Future Oncology, 3, pp. 19-27
Chang, W., Kim, R., Park, S.I., Jung, Y.J., Ham, O., Lee, J., Maeng, L.S., Enhanched healing of rat calvarial bone defects hypoxic conditioned medium from mesenchymal stem cells through increased endogenous stem cell migration via regulation of ICAM-1 targeted-microRNA-221 (2015) Molecules and Cells, 38, pp. 643-650
Cibelli, J., Emborg, M.E., Prockop, D.J., Roberts, M., Schatten, G., Rao, M., Mirochnitchenko, O., Strategies for improving animal models for regenerative medicine (2013) Cell Stem Cell, 12, pp. 271-274
Conner, M.T., Conner, A.C., Bland, C.E., Taylor, L.H., Brown, J.E., Parri, R.H., Bill, R.M., Rapid aquaporin translocation regulates cellular water flow: Mechanism of hypotonicity-induced subcellular localization of aquaporin 1 water channel (2012) The Journal of Biological Chemistry, 287, pp. 11516-11525
Dalal, J., Gandy, K., Domen, J., Role of mesenchymal stem cell therapy in Crohn's disease (2012) Pediatric Research, 71, pp. 445-451
Delling, U., Brehma, W., Ludewigb, E., Winterc, K., Jülkec, H., Longitudinal evaluation of effects of intraarticular mesenchymal stromal cell administration for the treatment of osteoarthritis in an ovine model (2015) Cell Transplantation, 24, pp. 2391-2407. , https://doi.org./10.3727/096368915×686193
Desantis, S., Accogli, G., Zizza, S., Mastrodonato, M., Blasi, A., Francioso, E., Resta, L., Ultrastructural study of cultured ovine bone marrow-derived mesenchymal stromal cells (2015) Annals of Anatomy, 201, pp. 43-49
Di Bella, C., Aldini, N.N., Lucarelli, E., Dozza, B., Frisoni, T., Martini, L., Donati, D., Osteogenic protein-1associated with mesenchymal stem cells promote bone allograft integration (2010) Tissue Engineering Part A, 16, pp. 2967-2976
Ding, F., Zhang, G., Liu, L., Jiang, L., Wang, R., Zheng, Y., Duan, Y., Involvement of cationic channels in proliferation and migration of human mesenchymal stem cells (2012) Tissue and Cell, 44, pp. 358-364
Dozza, B., Di Bella, C., Lucarelli, E., Giavaresi, G., Fini, M., Tazzari, P.L., Donati, D., Mesenchymal stem cell and platelet lysate in fibrin or collagen scaffold promote non cemented hip prothesis integration (2011) Journal of Orthopaedic Research, 29, pp. 961-968
Dozza, B., Lesci, I.G., Duchi, S., Della Bella, E., Martini, L., Salamanna, F., Donati, D., When size matters: Differences in demineralized bone matrix particles affect collagen structure, mesenchymal stem cell behavior, and osteogenic potential (2017) Journal of Biomedical Materials Research, 105, pp. 1019-1033
Fontanella, R., Pelagalli, A., Nardelli, A., D'Alterio, C., Ierano’, C., Cerchia, L., Zannetti, A., A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (2016) Cancer Letters, 370, pp. 100-107
Ganju, R.K., Brubaker, S.A., Meyer, J., Dutt, P., Yang, Y., Qin, S., Groopma, J.E., The α-chemokine, stromal cell-derived factor-1α, binds to the transmembrane G protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways (1998) The Journal of Biological Chemistry, 273, pp. 23169-23175
Gebak, T., Schulz, M.M.P., Koumoutsakos, P., Detmar, M., Tscratch: A novel and simple software tool for automated analysis of monolayer wound healing assays (2009) Short Technical Report, 46, pp. 265-274
Gnecchi, M., Danieli, P., Cervio, E., Mesenchymal stem cell therapy for heart disease (2012) Vascular Pharmacology, 57, pp. 48-55
Guo, X., Wang, C., Duan, C., Descamps, M., Zhao, Q., Dong, L., Song, Y.Q., Repair of osteochondral defects with autologous chondrocytes seeded onto bioceramic scaffold in sheep (2004) Tissue Engineering, 10, pp. 1830-1840
Harding, J., Roberts, R.M., Mirochnitchenko, O., Large animal models for stem cell therapy (2013) Stem Cell Research and Therapy, 4, pp. 1-9
Hayashi, H., Tsuchiya, Y., Nakayama, K., Takayuki, S., Nishida, E., Down-regulation of the PI3-kinase/Akt pathway by ERK MAP kinase in growth factor signaling (2008) Genes to Cells, 13, pp. 941-947
Hill, B.S., Pelagalli, A., Passaro, N., Zannetti, A., Tumor-educated mesenchymal stem cells promote pro-metastatic phenotype (2017) Oncotarget, 8 (42), pp. 73296-73311. , https://doi.org./org/10.18632/oncotarget
Hu, J., Verkman, A.S., Increased migration and metastatic potential of tumor cells expressing aquaporin water channels (2006) The FASEB Journal, 20, pp. 1892-1894
Huang, W., Lv, B., Zeng, H., Shi, D., Liu, Y., Chen, F., Jiang, X., Paracrine factors secreted by MSCs promote astrocyte survival associated with GFAP downregulation after ischemic stroke via p38 MAPK and JNK (2015) Journal of Cellular Physiology, 230, pp. 2461-2475
Jiang, Y., Aquaporin-1 activity of plasma membrane affects HT20 colon cancer cell migration (2009) IUBMB Life, 61, pp. 1001-1009
Kalaszczynska, I., Ruminski, S., Platek, A.E., Bissenik, I., Zakrzewski, P., Noszczyk, M., Lewandowska-Szumiel, M., Substantial differences between human and ovine mesenchymal stem cells in response to osteogenic media: How to explain and how to manage (2013) Bio Research, 2, pp. 356-363
Kang, K., Ma, R., Cai, W., Huang, W., Paul, C., Liang, J., Wang, Y., Exosomes secreted from cxcr4 overexpressing mesenchymal stem cells promote cardioprotection via akt signaling pathway following myocardial infarction (2015) Stem Cells International, 2015, p. 659890. , https://doi.org./10.1155/2015/659890
Kim, H.O., Choi, S.M., Kim, H.S., Mesenchymal stem cell-derived secretome and microvescicles as a cell-free therapeutics for neurodegenerative disorders (2013) Tissue Engineering and Regenerative Medicine, 10, pp. 93-101
Li, X., Luo, Q., Sun, J., Conditioned medium from mesenchymal stem cells enhances the migration of hepatoma cells through CXCR4 up-regulation and F-actin remodeling (2015) Biotechnology Letters, 37, pp. 511-521
Liu, B., Shu, S., Kenny, T.P., Chang, C., Leung, P.S., Stem cell therapy in autoimmune rheumatic diseases: A comprehensive review (2014) Clinical Reviews in Allergy and Immunology, 47, pp. 244-257
Lucarelli, E., Fini, M., Beccheroni, A., Giavaresi, G., Di Bella, C., Aldini, N.N., Donati, D., Stromal stem cells and platelet-rich plasma improve bone allograft integration (2005) Clinical Orthopaedics and Related Research, 435, pp. 62-68
Lyahyai, J., Mediano, D.R., Ranera, B., Sanz, A., Remacha, A.R., Bolea, R., Martín-Burriel, I., Isolation and characterization of ovine mesenchymal stem cells derived from peripheral blood (2012) BMC Veterinary Research, 8, p. 169
Müller, E.M., Hub, J.S., Grubmüller, H., de Groot, B.L., Is TEA an inhibitor for human Aquaporin-1 (2008) European Journal of Physiology, 456, pp. 663-669
McCarty, R.C., Gronthos, S., Zannettino, A.C., Foster, B.K., Xian, C.J., Characterization and developmental potential of ovine bone marrow derived mesenchymal stem cells (2009) Journal of Cellular Physiology, 219, pp. 324-333
McCarty, R.C., Xian, C.J., Gronthos, S., Zannettino, A.C., William, A.C., Foster, B.K., Application of autologous bone4 marrow derived mesenchymal stem cells to an ovine model of growth plate cartilage injury (2010) The Open Orthopaedics Journal, 4, pp. 204-210
Meng, F., Rui, Y., Xu, L., Wan, C., Jiang, X., Li, G., AQP1 enhances migration of bone marrow mesenchymal stem cells through regulation of FAK and ß-catenin (2014) Stem Cells and Development, 23, pp. 66-71
Mognetti, B., La Montagna, G., Perrelli, M.G., Pagliaro, P., Penna, C., Bone marrow mesenchymal stem cells increase motility of prostate cancer cells via production of stromal cell-derived factor-1α (2013) Journal of Cellular and Molecular Medicine, 17, pp. 287-292
Monzani, E., Shtil, A.A., La Porta, C.A., The water channels, new druggable targets to combat cancer cell survival, invasiveness and metastasis (2007) Current Drug Targets, 8, pp. 1132-1137
Mrozik, K.M., Zilm, P.S., Bagley, C.J., Hack, S., Hoffmann, P., Gronthos, S., Bartold, P.M., Proteomic characterization of mesenchymal stem cell-like populations derived from ovine periodontal ligament, dental pulp, and bone marrow: Analysis of differentially expressed proteins (2010) Stem Cells and Development, 19, pp. 1485-1499
Mrugala, D., Bony, C., Neves, N., Caillot, L., Fabre, S., Moukoko, D., Noel, D., Phenotypic and functional characterization of ovine mesenchymal stem cells: Application to a cartilage defect model (2008) Annals of the Rheumatic Diseases, 67, pp. 288-295
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J Cell Physiol (ISSN: 1097-4652electronic, 0021-9541linking), 2018 Jan 18; 233(8): 6241-6249.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.546, 5-year impact factor: 0
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045976063&doi=10.1002%2fjcp.26493&partnerID=40&md5=8babff8395896975f5e6fbf07f9133b3
Keywords: Aqp1, Cxcr4, Ovine Mesenchymal Stem Cells, Aquaporin 1, Chemokine Receptor Cxcr4, Focal Adhesion Kinase, Mitogen Activated Protein Kinase, Animal Cell, Article, Autocrine Effect, Cell Differentiation, Cell Migration, Cell Proliferation, Controlled Study, Intracellular Signaling, Nonhuman, Paracrine Signaling, Priority Journal, Protein Expression, Regenerative Medicine, Sheep,
Affiliations:
*** IBB - CNR ***
Department of Advanced Biomedical Sciences, University of Naples "Federico II", Naples, Italy., Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy., Osteoarticolar Regeneration Laboratory, Rizzoli Orthopedic Institute, Bologna, Italy.,
References:
Adamzyk, C., Kachel, P., Hoss, M., Gremse, F., Modabber, A., Hölzle, F., Lethaus, B., Bone tissue engineering using polyetherketoneketone scaffolds combined with autologous mesenchymal stem cells in a sheep calvarial defect model (2016) Journal of Cranio-Maxillofacial Surgery, 44, pp. 985-99
Al Faqeh, H., Nor Hamdan, B.M., Chen, H.C., Aminuddin, B.S., Ruszymah, B.H., The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model (2012) Experimental Gerontology, 47, pp. 658-664
Angoulvant, D., Ivanes, F., Ferrera, R., Matthews, P.G., Nataf, S., Ovize, M., Mesenchymal stem cell conditioned media attenuates in vitro and ex vivo myocardial reperfusion injury (2011) The Journal of Heart and Lung Transplantation, 30, pp. 95-102
Boos, A.M., Loew, J.S., Deschler, G., Arkudas, A., Bleiziffer, O., Gulle, H., Beier, J.P., Directly auto-transplanted mesenchymal stem cells induce bone formation in a ceramic bone substitute in an ectopic sheep model (2011) Journal of Cellular and Molecular Medicine, 15, pp. 1364-1378
Burk, J., Glauchea, S.M., Brehma, W., Crovaced, A., Francioso, E., Hillmann, A., Lacitignola, L., Characterisation and intracellular labelling of mesenchymal stromal cells derived from synovial fluid of horses and sheep (2017) Veterinary Journal, 222, pp. 1-8
Camorani, S., Hill, B.S., Fontanella, R., Greco, A., Gramanzini, M., Auletta, L., Zannetti, A., Inhibition of bone marrow-Derived mesenchymal stem cells homing towards triple-Negative Breast cancer microenvironment using an anti-PDGFRβ aptamer (2017) Theranostics, 7, pp. 3595-3607
Cashen, A.F., Nervi, B., Di Persio, J., AMD3100: CXCR4 antagonist and rapid stem cell-mobilizing agent (2007) Future Oncology, 3, pp. 19-27
Chang, W., Kim, R., Park, S.I., Jung, Y.J., Ham, O., Lee, J., Maeng, L.S., Enhanched healing of rat calvarial bone defects hypoxic conditioned medium from mesenchymal stem cells through increased endogenous stem cell migration via regulation of ICAM-1 targeted-microRNA-221 (2015) Molecules and Cells, 38, pp. 643-650
Cibelli, J., Emborg, M.E., Prockop, D.J., Roberts, M., Schatten, G., Rao, M., Mirochnitchenko, O., Strategies for improving animal models for regenerative medicine (2013) Cell Stem Cell, 12, pp. 271-274
Conner, M.T., Conner, A.C., Bland, C.E., Taylor, L.H., Brown, J.E., Parri, R.H., Bill, R.M., Rapid aquaporin translocation regulates cellular water flow: Mechanism of hypotonicity-induced subcellular localization of aquaporin 1 water channel (2012) The Journal of Biological Chemistry, 287, pp. 11516-11525
Dalal, J., Gandy, K., Domen, J., Role of mesenchymal stem cell therapy in Crohn's disease (2012) Pediatric Research, 71, pp. 445-451
Delling, U., Brehma, W., Ludewigb, E., Winterc, K., Jülkec, H., Longitudinal evaluation of effects of intraarticular mesenchymal stromal cell administration for the treatment of osteoarthritis in an ovine model (2015) Cell Transplantation, 24, pp. 2391-2407. , https://doi.org./10.3727/096368915×686193
Desantis, S., Accogli, G., Zizza, S., Mastrodonato, M., Blasi, A., Francioso, E., Resta, L., Ultrastructural study of cultured ovine bone marrow-derived mesenchymal stromal cells (2015) Annals of Anatomy, 201, pp. 43-49
Di Bella, C., Aldini, N.N., Lucarelli, E., Dozza, B., Frisoni, T., Martini, L., Donati, D., Osteogenic protein-1associated with mesenchymal stem cells promote bone allograft integration (2010) Tissue Engineering Part A, 16, pp. 2967-2976
Ding, F., Zhang, G., Liu, L., Jiang, L., Wang, R., Zheng, Y., Duan, Y., Involvement of cationic channels in proliferation and migration of human mesenchymal stem cells (2012) Tissue and Cell, 44, pp. 358-364
Dozza, B., Di Bella, C., Lucarelli, E., Giavaresi, G., Fini, M., Tazzari, P.L., Donati, D., Mesenchymal stem cell and platelet lysate in fibrin or collagen scaffold promote non cemented hip prothesis integration (2011) Journal of Orthopaedic Research, 29, pp. 961-968
Dozza, B., Lesci, I.G., Duchi, S., Della Bella, E., Martini, L., Salamanna, F., Donati, D., When size matters: Differences in demineralized bone matrix particles affect collagen structure, mesenchymal stem cell behavior, and osteogenic potential (2017) Journal of Biomedical Materials Research, 105, pp. 1019-1033
Fontanella, R., Pelagalli, A., Nardelli, A., D'Alterio, C., Ierano’, C., Cerchia, L., Zannetti, A., A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (2016) Cancer Letters, 370, pp. 100-107
Ganju, R.K., Brubaker, S.A., Meyer, J., Dutt, P., Yang, Y., Qin, S., Groopma, J.E., The α-chemokine, stromal cell-derived factor-1α, binds to the transmembrane G protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways (1998) The Journal of Biological Chemistry, 273, pp. 23169-23175
Gebak, T., Schulz, M.M.P., Koumoutsakos, P., Detmar, M., Tscratch: A novel and simple software tool for automated analysis of monolayer wound healing assays (2009) Short Technical Report, 46, pp. 265-274
Gnecchi, M., Danieli, P., Cervio, E., Mesenchymal stem cell therapy for heart disease (2012) Vascular Pharmacology, 57, pp. 48-55
Guo, X., Wang, C., Duan, C., Descamps, M., Zhao, Q., Dong, L., Song, Y.Q., Repair of osteochondral defects with autologous chondrocytes seeded onto bioceramic scaffold in sheep (2004) Tissue Engineering, 10, pp. 1830-1840
Harding, J., Roberts, R.M., Mirochnitchenko, O., Large animal models for stem cell therapy (2013) Stem Cell Research and Therapy, 4, pp. 1-9
Hayashi, H., Tsuchiya, Y., Nakayama, K., Takayuki, S., Nishida, E., Down-regulation of the PI3-kinase/Akt pathway by ERK MAP kinase in growth factor signaling (2008) Genes to Cells, 13, pp. 941-947
Hill, B.S., Pelagalli, A., Passaro, N., Zannetti, A., Tumor-educated mesenchymal stem cells promote pro-metastatic phenotype (2017) Oncotarget, 8 (42), pp. 73296-73311. , https://doi.org./org/10.18632/oncotarget
Hu, J., Verkman, A.S., Increased migration and metastatic potential of tumor cells expressing aquaporin water channels (2006) The FASEB Journal, 20, pp. 1892-1894
Huang, W., Lv, B., Zeng, H., Shi, D., Liu, Y., Chen, F., Jiang, X., Paracrine factors secreted by MSCs promote astrocyte survival associated with GFAP downregulation after ischemic stroke via p38 MAPK and JNK (2015) Journal of Cellular Physiology, 230, pp. 2461-2475
Jiang, Y., Aquaporin-1 activity of plasma membrane affects HT20 colon cancer cell migration (2009) IUBMB Life, 61, pp. 1001-1009
Kalaszczynska, I., Ruminski, S., Platek, A.E., Bissenik, I., Zakrzewski, P., Noszczyk, M., Lewandowska-Szumiel, M., Substantial differences between human and ovine mesenchymal stem cells in response to osteogenic media: How to explain and how to manage (2013) Bio Research, 2, pp. 356-363
Kang, K., Ma, R., Cai, W., Huang, W., Paul, C., Liang, J., Wang, Y., Exosomes secreted from cxcr4 overexpressing mesenchymal stem cells promote cardioprotection via akt signaling pathway following myocardial infarction (2015) Stem Cells International, 2015, p. 659890. , https://doi.org./10.1155/2015/659890
Kim, H.O., Choi, S.M., Kim, H.S., Mesenchymal stem cell-derived secretome and microvescicles as a cell-free therapeutics for neurodegenerative disorders (2013) Tissue Engineering and Regenerative Medicine, 10, pp. 93-101
Li, X., Luo, Q., Sun, J., Conditioned medium from mesenchymal stem cells enhances the migration of hepatoma cells through CXCR4 up-regulation and F-actin remodeling (2015) Biotechnology Letters, 37, pp. 511-521
Liu, B., Shu, S., Kenny, T.P., Chang, C., Leung, P.S., Stem cell therapy in autoimmune rheumatic diseases: A comprehensive review (2014) Clinical Reviews in Allergy and Immunology, 47, pp. 244-257
Lucarelli, E., Fini, M., Beccheroni, A., Giavaresi, G., Di Bella, C., Aldini, N.N., Donati, D., Stromal stem cells and platelet-rich plasma improve bone allograft integration (2005) Clinical Orthopaedics and Related Research, 435, pp. 62-68
Lyahyai, J., Mediano, D.R., Ranera, B., Sanz, A., Remacha, A.R., Bolea, R., Martín-Burriel, I., Isolation and characterization of ovine mesenchymal stem cells derived from peripheral blood (2012) BMC Veterinary Research, 8, p. 169
Müller, E.M., Hub, J.S., Grubmüller, H., de Groot, B.L., Is TEA an inhibitor for human Aquaporin-1 (2008) European Journal of Physiology, 456, pp. 663-669
McCarty, R.C., Gronthos, S., Zannettino, A.C., Foster, B.K., Xian, C.J., Characterization and developmental potential of ovine bone marrow derived mesenchymal stem cells (2009) Journal of Cellular Physiology, 219, pp. 324-333
McCarty, R.C., Xian, C.J., Gronthos, S., Zannettino, A.C., William, A.C., Foster, B.K., Application of autologous bone4 marrow derived mesenchymal stem cells to an ovine model of growth plate cartilage injury (2010) The Open Orthopaedics Journal, 4, pp. 204-210
Meng, F., Rui, Y., Xu, L., Wan, C., Jiang, X., Li, G., AQP1 enhances migration of bone marrow mesenchymal stem cells through regulation of FAK and ß-catenin (2014) Stem Cells and Development, 23, pp. 66-71
Mognetti, B., La Montagna, G., Perrelli, M.G., Pagliaro, P., Penna, C., Bone marrow mesenchymal stem cells increase motility of prostate cancer cells via production of stromal cell-derived factor-1α (2013) Journal of Cellular and Molecular Medicine, 17, pp. 287-292
Monzani, E., Shtil, A.A., La Porta, C.A., The water channels, new druggable targets to combat cancer cell survival, invasiveness and metastasis (2007) Current Drug Targets, 8, pp. 1132-1137
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Autocrine signals increase Ovine Mesenchymal Stem Cells migration through Aquaporin-1 and CXCR4 overexpression
Sheep is a relevant large animal model that is frequently used to test innovative tissue engineering (TE) approaches especially for bone reconstruction. Mesenchymal stem cells (MSCs) are used in TE applications because they represent key component of adult tissue repair. Importantly, MSCs from different species show similar characteristics, which facilitated their application in translational studies using animal models. Nowadays, many researches are focusing on the use of ovine mesenchymal stem cells (oMSCs) in orthopedic preclinical settings for regenerative medicine purposes. Therefore, there is a need to amplify our knowledge on the mechanisms underlying the behaviour of these cells. Recently, several studies have shown that MSC function is largely dependent on factors that MSCs release in the environment as well as in conditioned medium (CM). It has been demonstrated that MSCs through autocrine and paracrine signals are able to stimulate proliferation, migration and differentiation of different type of cells including themselves. In this study, we investigated the effects of the CM produced by oMSCs on oMSCs themselves and we explored the signal pathways involved. We observed that CM caused an enhancement of oMSC migration. Furthermore, we found that CM increased levels of two membrane proteins involved in cell migration, Aquaporin 1 (AQP1) and C-X-C chemokine receptor type 4 (CXCR4), and activated Akt and Erk intracellular signal pathways. In conclusion, taken together our results suggest the high potential of autologous CM as a promising tool to modulate behaviour of MSCs thus improving their use in therapeutically approaches. This article is protected by copyright. All rights reserved.
Sheep is a relevant large animal model that is frequently used to test innovative tissue engineering (TE) approaches especially for bone reconstruction. Mesenchymal stem cells (MSCs) are used in TE applications because they represent key component of adult tissue repair. Importantly, MSCs from different species show similar characteristics, which facilitated their application in translational studies using animal models. Nowadays, many researches are focusing on the use of ovine mesenchymal stem cells (oMSCs) in orthopedic preclinical settings for regenerative medicine purposes. Therefore, there is a need to amplify our knowledge on the mechanisms underlying the behaviour of these cells. Recently, several studies have shown that MSC function is largely dependent on factors that MSCs release in the environment as well as in conditioned medium (CM). It has been demonstrated that MSCs through autocrine and paracrine signals are able to stimulate proliferation, migration and differentiation of different type of cells including themselves. In this study, we investigated the effects of the CM produced by oMSCs on oMSCs themselves and we explored the signal pathways involved. We observed that CM caused an enhancement of oMSC migration. Furthermore, we found that CM increased levels of two membrane proteins involved in cell migration, Aquaporin 1 (AQP1) and C-X-C chemokine receptor type 4 (CXCR4), and activated Akt and Erk intracellular signal pathways. In conclusion, taken together our results suggest the high potential of autologous CM as a promising tool to modulate behaviour of MSCs thus improving their use in therapeutically approaches. This article is protected by copyright. All rights reserved.
Autocrine signals increase Ovine Mesenchymal Stem Cells migration through Aquaporin-1 and CXCR4 overexpression
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Autocrine signals increase Ovine Mesenchymal Stem Cells migration through Aquaporin-1 and CXCR4 overexpression
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Lamagna B, Ciaramella P, Lamagna F, Di Loria A, Brunetti A, Pelagalli A
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Impact Factor: 4.112
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Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G
* Cancer-selective targeting of the NF-kappaB survival pathway with GADD45beta/MKK7 inhibitors (623 views)
Cancer Cell (ISSN: 1535-6108), 2014 Oct 13; 26(4): 495-508.
Impact Factor: 23.523
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D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
* A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (440 views)
Int J Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
Impact Factor: 5.085
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Portella L, Vitale R, De Luca S, D'Alterio C, Ieranò C, Napolitano M, Riccio A, Polimeno MN, Monfregola L, Barbieri A, Luciano A, Ciarmiello A, Arra C, Castello G, Amodeo P, Scala S
* Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases (503 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Sep 13; 8(9): N/D-N/D.
Impact Factor: 3.534
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Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio PL, Marasco D, Albanesi C
* Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses (584 views)
Eur J Immunol (ISSN: 0014-2980), 2013 Jul; 43(7): 1883-1895.
Impact Factor: 4.518
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Galdiero S, Falanga A, Cantisani M, Tarallo R, della Pepa ME, D'Oriano V, Galdiero M
* Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins (629 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 843-854.
Impact Factor: 2.326
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Galdiero S, Vitiello M, Finamore E, Mansi R, Galdiero M, Morelli G, Tesauro D
* Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens (419 views)
Molecular Biosystems (ISSN: 1742-206x), 2012; 8(12): 3166-3177.
Impact Factor: 3.35
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Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (517 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
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Cantisani M, Vitiello M, Falanga A, Finamore E, Galdiero M, Galdiero S
* Peptides complementary to the active loop of porin P2 from Haemophilus influenzae modulate its activity (510 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2012; 7: 2361-2371.
Impact Factor: 3.463
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Lusso P, Vangelista L, Cimbro R, Secchi M, Sironi F, Longhi R, Faiella M, Maglio O, Pavone V
* Molecular engineering of RANTES peptide mimetics with potent anti-HIV-1 activity (568 views)
Faseb J (ISSN: 0892-6638, 0892-6638linking), 2011 Apr; 25(4): 1230-1243.
Impact Factor: 5.712
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Gautier B, Goncalves V, Diana D, Di Stasi R, Teillet F, Lenoir C, Huguenot F, Garbay C, Fattorusso R, D'Andrea LD, Vidal M, Inguimbert N
* Biochemical and Structural Analysis of the Binding Determinants of a Vascular Endothelial Growth Factor Receptor Peptidic Antagonist (511 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jun 10; 53(11): 4428-4440.
Impact Factor: 5.207
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Alfieri A, Pasanisi F, Salzano S, Esposito L, Martone D, Tafuri D, Daniele A, Contaldo F, Sacchetti L, Zagari A, Buono P
* Functional analysis of melanocortin-4-receptor mutants identified in severely obese subjects living in Southern Italy (395 views)
Gene (ISSN: 0378-1119), 2010 Jun 1; 457(1-2): 35-41.
Impact Factor: 2.266
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Napolitano M, Ottaiano A, Mauro F, Ieranò C, Satriano R, Pacelli R, Franco R, De Angelis V, Castello G, Scala S
* CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients (373 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 2010 Apr; 59(4): 511-517.
Impact Factor: 4.293
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Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
* Viral fusion peptides induce several signal transduction pathway activations that are essential for interleukin-10 and beta-interferon production (476 views)
Intervirology (ISSN: 1423-0100, 0300-5526), 2010; 53(6): 381-389.
Impact Factor: 1.756
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Illario M, Monaco S, Cavallo AL, Esposito I, Formisano P, D'Andrea LD, Cipolletta E, Trimarco B, Fenzi G, Rossi G, Vitale M
* Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake (385 views)
Cell Signal (ISSN: 0898-6568), 2009 May; 21(5): 786-792.
Impact Factor: 4.094
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Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
* A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (394 views)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Impact Factor: 4.087
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Tornatore L, Montil SM, Marasco D, Dathan N, Vitale RM, Benedetti E, Pedone C, Papa S, Franzoso G, Ruvo M
* Gadd45beta dimerization does not affect MKK7 binding (360 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 367-368.
Impact Factor: 2.02
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Tornatore L, Marasco D, Dathan N, Vitale RM, Benedetti E, Papa S, Franzoso G, Ruvo M, Monti SM
* Gadd45 beta forms a homodimeric complex that binds tightly to MKK7 (467 views)
J Mol Biol (ISSN: 0022-2836, 0022-2283, 1089-8638), 2008 Apr 18; 378(1): 97-111.
Impact Factor: 5.673
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Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (489 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jun 29; 282(26): 19029-19041.
Impact Factor: 5.581
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Galdiero S, Vitiello M, Amodeo P, D'Isanto M, Cantisani M, Pedone C, Galdiero M
* Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae (514 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Apr 11; 45(14): 4491-4501.
Impact Factor: 3.633
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Iaccarino G, Izzo R, Trimarco V, Cipolletta E, Lanni F, Sorriento D, Iovino GL, Rozza F, De Luca N, Priante O, Di Renzo G, Trimarco B
* β 2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension (381 views)
Clin Pharmacol Ther Clinical Pharmacology And Therapeutics (ISSN: 0009-9236), 2006; 80(6): 633-645.
Impact Factor: 8.066
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Palladino P, Tizzano B, Pedone C, Ragone R, Rossi F, Saviano G, Tancredi T, Benedetti E
* Structural determinants of unexpected agonist activity in a retro-peptide analogue of the SDF-1α N-terminus (377 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 Oct 10; 579(24): 5293-5298.
Impact Factor: 3.415
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (380 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
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Galdiero S, Vitiello M, D'Isanto M, Di Niola E, Peluso L, Raieta K, Pedone C, Galdiero M, Benedetti E
* Induction of signaling pathways by herpes simplex virus type 1 through glycoprotein H peptides (589 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 494-502.
Impact Factor: 2.863
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Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (475 views)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
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Galdiero S, Capasso D, Vitiello M, D'Isanto M, Pedone C, Galdiero M
* Protein P2 from Haemophilus influenzae: The role of its surface exposed loops on the mitogen-activated protein kinase cascade (376 views)
Infection And Immunity (ISSN: 0019-9567), 2003 May; 71(5): 2798-2809.
Impact Factor: 3.875
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Palladino P, Pedone C, Ragone R, Rossi F, Saviano M, Benedetti E
* A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor (350 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2003 Apr; 10(2): 133-138.
Impact Factor: 0.46
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Palladino P, De Capua A, Pedone C, Ragone R, Rossi F, Limatola C, Ragozzino D, Benedetti E
* A simplified model of the interaction between SDF-1 chemokine and the CXCR4 receptor (383 views)
Peptide Revolution, 2003 Apr; 10(2): 133-138.
Impact Factor: 4.659
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Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
* Fusion in Coq (479 views)
Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2001; 2178LNCS: 583-596.
Impact Factor: 0.415
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36 Records (33 excluding Abstracts).
Total impact factor: 166.588 (151.337 excluding Abstracts).
Total 5 year impact factor: 166.995 (152.203 excluding Abstracts).
Total impact factor: 166.588 (151.337 excluding Abstracts).
Total 5 year impact factor: 166.995 (152.203 excluding Abstracts).
659 views. Last view on Sunday 19 March 2023, 20:58:08
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