Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-beta-OTX2-SNAIL via PTEN inhibition (1273 views)
Brain (ISSN: 1460-2156electronic, 0006-8950linking), 2018 May 1; 141(5): 1300-1319.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 9.915, 5-year impact factor: 10.87
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047083488&doi=10.1093%2fbrain%2fawy039&partnerID=40&md5=71c6ed3662dcc138b64ddaf9e7b67ac4
Keywords: Genetic Network, Medulloblastoma, Metastatic Cns Tumour, Molecular Genetics, Oncology, Nme1 Protein, Phosphatidylinositol 3, 5 Trisphosphate 3 Phosphatase, Prune1 Protein, Pyrimidine Derivative, Transcription Factor Otx2, Transcription Factor Snail, Transforming Growth Factor Beta, Unclassified Drug, Adolescent, Animal Experiment, Animal Tissue, Article, Cancer Cell, Cancer Growth, Cell Migration, Cell Proliferation, Child, Clinical Article, Complex Formation, Controlled Study, Female, Gene Expression, Gene Repression, Genetic Predisposition, Genetic Variability, Hek293t Cell Line, Human, Human Cell, Immunocompetent Cell, In Vivo Study, Infant, Luciferase Assay, Medulloblastoma Cell Line, Metastasis, Next Generation Sequencing, Nonhuman, Pediatrics, Primary Tumor, Priority Journal, Protein Binding, Protein Degradation, Protein Expression, Protein Interaction, Signal Transduction, Upregulation, Whole Exome Sequencing,
Affiliations:
*** IBB - CNR ***
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, Naples, Italy., CEINGE Biotecnologie Avanzate, Naples, Italy., European School of Molecular Medicine (SEMM), Milan, Italy., Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Ontario, Canada., Dipartimento di Farmacia, Universita degli Studi di Napoli Federico II, Naples, Italy., Department of Veterinary Medicine and Animal Productions, Universita degli Studi di Napoli Federico II, Naples, Italy., Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale della Ricerca, Naples, Italy., Dipartimento di Scienze Biomediche Avanzate, Universita degli Studi di Napoli Federico II, Naples, Italy., Division of Clinical Studies, The Institute of Cancer Research, London SM2 5NG, UK., Paediatric Neurosurgery, Ospedale Santobono-Pausilipon, Naples, Italy., Pathology Unit, Ospedale Santobono-Pausilipon, Naples, Italy., Genetic Control of Development-URT, Institute of Cell Biology and Neurobiology, National Research Council, Fondazione Santa Lucia, Rome, Italy., Dipartimento di Onco-Ematologia, IRCCS Ospedale Pediatrico Bambino Gesu, Rome, Italy., Dipartimento di Scienze Radiologiche, Oncologiche e Anatomo Patologiche, Universita La Sapienza, Rome, Italy., IRCCS Neuromed, Pozzilli, Italy., German Cancer Consortium (DKTK), Department of Paediatric Oncology, Haematology, and Clinical Immunology, University Hospital Dusseldorf, Dusseldorf, Germany., Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto ON, Canada., PSL Research University, Inserm U830, Equipe Labellis?Ligue contre le Cancer, Institut Curie, Paris, France., Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Caserta, Italy., DAI-Medicina Trasfusionale-Azienda Ospedaliera Universitaria Federico<
References:
Adamson, D.C., Shi, Q., Wortham, M., Northcott, P.A., Di, C., Duncan, C.G., OTX2 is critical for the maintenance and progression of Shhindependent medulloblastomas (2010) Cancer Res, 70, pp. 181-19
Alimonti, A., Carracedo, A., Clohessy, J.G., Trotman, L.C., Nardella, C., Egia, A., Subtle variations in Pten dose determine cancer susceptibility (2010) Nat Genet, 42, pp. 454-458
Asadzadeh, F., Ferrucci, V., De Antonellis, P., Zollo, M., In vivo bioluminescence imaging (BLI) using orthotopic xenografts towards patient's derived-xenograft (PDX) Medulloblastoma models (2017) Q J Nucl Med Mol Imaging, 61, pp. 95-101
Asuthkar, S., Nalla, A.K., Gondi, C.S., Dinh, D.H., Gujrati, M., Mohanam, S., Gadd45a sensitizes medulloblastoma cells to irradiation and suppresses MMP-9-mediated EMT (2011) Neuro Oncol, 13, pp. 1059-1073
Bai, R.Y., Staedtke, V., Lidov, H.G., Eberhart, C.G., Riggins, G.J., OTX2 represses myogenic and neuronal differentiation in medulloblastoma cells (2012) Cancer Res, 72, pp. 5988-6001
Batlle, R., Alba-Castellon, L., Loubat-Casanovas, J., Armenteros, E., Franci, C., Stanisavljevic, J., Snail1 controls TGF-beta responsiveness and differentiation of mesenchymal stem cells (2013) Oncogene, 32, pp. 3381-3389
Boulay, G., Awad, M.E., Riggi, N., Archer, T.C., Iyer, S., Boonseng, W.E., OTX2 Activity at distal regulatory elements shapes the chromatin landscape of group 3 medulloblastoma (2017) Cancer Discov, 7, pp. 288-301
Bunt, J., Hasselt, N.A., Zwijnenburg, D.A., Koster, J., Versteeg, R., Kool, M., OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels (2013) Acta Neuropathol, 125, pp. 385-394
Carotenuto, M., De Antonellis, P., Chiarolla, C.M., Attanasio, C., Damiani, V., Boffa, I., A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction (2015) Naunyn Schmiedeberg's Arch Pharmacol, 388, pp. 257-269
Carotenuto, M., Pedone, E., Diana, D., De Antonellis, P., Dzeroski, S., Marino, N., Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction (2013) Sci Rep, 3, p. 1351
Carotenuto, P., Marino, N., Bello, A.M., D'Angelo, A., Di Porzio, U., Lombardi, D., PRUNE and NM23-M1 expression in embryonic and adult mouse brain (2006) J Bioenerg Biomembr, 38, pp. 233-246
Cavalli, F.M.G., Remke, M., Rampasek, L., Peacock, J., Shih, D.J.H., Luu, B., Intertumoral heterogeneity within medulloblastoma subgroups (2017) Cancer Cell, 31, pp. 737-754e6
Cho, Y.J., Tsherniak, A., Tamayo, P., Santagata, S., Ligon, A., Greulich, H., Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome (2011) J Clin Oncol, 29, pp. 1424-1430
Contos, J.J., Ye, X., Sah, V.P., Chun, J., Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/ Edg6) gene (2002) FEBS Lett, 531, pp. 99-102
Dai, G., Yu, H., Kruse, M., Traynor-Kaplan, A., Hille, B., Osmoregulatory inositol transporter SMIT1 modulates electrical activity by adjusting PI(4, 5)P2 levels (2016) Proc Natl Acad Sci USA, 113, pp. E3290-E3299
Dai, W., Zheng, H., Cheung, A.K., Tang, C.S., Ko, J.M., Wong, B.W., Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma (2016) Proc Natl Acad Sci USA, 113, pp. 3317-3322
D'Angelo, A., Garzia, L., Andre, A., Carotenuto, P., Aglio, V., Guardiola, O., Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis (2004) Cancer Cell, 5, pp. 137-149
Diana, D., Smaldone, G., De Antonellis, P., Pirone, L., Carotenuto, M., Alonzi, A., Mapping functional interaction sites of human prune C-terminal domain by NMR spectroscopy in human cell lysates (2013) Chemistry, 19, pp. 12217-12220
Escriva, M., Peiro, S., Herranz, N., Villagrasa, P., Dave, N., Montserrat-Sentis, B., Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis (2008) Mol Cell Biol, 28, pp. 1528-1540
Ferrucci, V., Francesco Paolo Pennino, F., Siciliano, R., Asadzadeh, F., Zollo, M., A competitive cell-permeable peptide (CPP) to impair the Nme-1 (NDPK-A) and Prune-1 interaction for therapeutic applications in cancer (2018) Lab Invest, , PMID: 29449633
Forus, A., D'Angelo, A., Henriksen, J., Merla, G., Maelandsmo, G.M., Florenes, V.A., Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity (2001) Oncogene, 20, pp. 6881-6890
Gajjar, A., Hernan, R., Kocak, M., Fuller, C., Lee, Y., McKinnon, P.J., Clinical, histopathologic, and molecular markers of prognosis: Toward a new disease risk stratification system for medulloblastoma (2004) J Clin Oncol, 22, pp. 984-993
Galasso, A., Zollo, M., The Nm23-H1-h-Prune complex in cellular physiology: A 'tip of the iceberg' protein network perspective (2009) Mol Cell Biochem, 329, pp. 149-159
Garzia, L., D'Angelo, A., Amoresano, A., Knauer, S.K., Cirulli, C., Campanella, C., Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility (2008) Oncogene, 27, pp. 1853-1864
Gibson, P., Tong, Y., Robinson, G., Thompson, M.C., Currle, D.S., Eden, C., Subtypes of medulloblastoma have distinct developmental origins (2010) Nature, 468, pp. 1095-1099
Goldberg-Stern, H., Gadoth, N., Stern, S., Cohen, I.J., Zaizov, R., Sandbank, U., The prognostic significance of glial fibrillary acidic protein staining in medulloblastoma (1991) Cancer, 68, pp. 568-573
Hashimoto, M., Kobayashi, T., Tashiro, H., Arihiro, K., Kikuchi, A., Ohdan, H., H-Prune is associated with poor prognosis and epithelial-mesenchymal transition in patients with colorectal liver metastases (2016) Int J Cancer, 139, pp. 812-823
Ivanov, D.P., Walker, D.A., Coyle, B., Grabowska, A.M., Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines (2016) Data Brief, 9, pp. 696-698
Jia, S., Wu, D., Xing, C., Meng, A., Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafish (2009) Dev Biol, 333, pp. 273-284
Jin, G., Klika, A., Callahan, M., Faga, B., Danzig, J., Jiang, Z., Identification of a human NF-kappaB-activating protein, TAB3 (2004) Proc Natl Acad Sci USA, 101, pp. 2028-2033
Kool, M., Koster, J., Bunt, J., Hasselt, N.E., Lakeman, A., Van Sluis, P., Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features (2008) PLoS One, 3, p. e3088
Kubo, A., Suzuki, N., Yuan, X., Nakai, K., Satoh, N., Imai, K.S., Genomic cis-regulatory networks in the early Ciona intestinalis embryo (2010) Development, 137, pp. 1613-1623
Lamouille, S., Xu, J., Derynck, R., Molecular mechanisms of epithelialmesenchymal transition (2014) Nat Rev Mol Cell Biol, 15, pp. 178-196
Lee, S.J., Kang, W.Y., Yoon, Y., Jin, J.Y., Song, H.J., Her, J.H., Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain (2015) BMC Cancer, 15, p. 1011
Li, P., Du, F., Yuelling, L.W., Lin, T., Muradimova, R.E., Tricarico, R., A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity (2013) Nat Neurosci, 16, pp. 1737-1744
Long, M., Simpson, J.C., Rho GTPases operating at the Golgi complex: Implications for membrane traffic and cancer biology (2017) Tissue Cell, 49, pp. 163-169
Long, N.P., Lee, W.J., Huy, N.T., Lee, S.J., Park, J.H., Kwon, S.W., Novel biomarker candidates for colorectal cancer metastasis: A meta-analysis of in vitro studies (2016) Cancer Inform, 15, pp. 11-17
Louis, D.N., Perry, A., Burger, P., Ellison, D.W., Reifenberger, G., Von Deimling, A., International Society of Neuropathology- Haarlem consensus guidelines for nervous system tumor classification and grading (2014) Brain Pathol, 24, pp. 429-435
Luo, S., Li, Y., Ma, R., Liu, J., Xu, P., Zhang, H., Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma (2017) Oncogene, 36, pp. 3609-3617
Ma, X., Guan, L., Wu, W., Zhang, Y., Zheng, W., Gao, Y.T., Wholeexome sequencing identifies OR2W3 mutation as a cause of autosomal dominant retinitis pigmentosa (2015) Sci Rep, 5, p. 9236
Mack, J.T., Brown, C.B., Tew, K.D., ABCA2 as a therapeutic target in cancer and nervous system disorders (2008) Expert Opin Ther Targets, 12, pp. 491-504
Malnic, B., Godfrey, P.A., Buck, L.B., The human olfactory receptor gene family (2004) Proc Natl Acad Sci USA, 101, pp. 2584-2589
Massague, J., TGFbeta in cancer (2008) Cell, 134, pp. 215-230
Massimino, M., Biassoni, V., Gandola, L., Garre, M.L., Gatta, G., Giangaspero, F., Childhood medulloblastoma (2016) Crit Rev Oncol Hematol, 105, pp. 35-51
McCloy, R.A., Rogers, S., Caldon, C.E., Lorca, T., Castro, A., Burgess, A., Partial inhibition of Cdk1 in G 2 phase overrides the SAC and decouples mitotic events (2014) Cell Cycle, 13, pp. 1400-1412
Metcalfe, C., Alicke, B., Crow, A., Lamoureux, M., Dijkgraaf, G.J., Peale, F., PTEN loss mitigates the response of medulloblastoma to Hedgehog pathway inhibition (2013) Cancer Res, 73, pp. 7034-7042
Morikawa, M., Koinuma, D., Miyazono, K., Heldin, C.H., Genome-wide mechanisms of Smad binding (2013) Oncogene, 32, pp. 1609-1615
Nagano, H., Noguchi, T., Inagaki, K., Yoon, S., Matozaki, T., Itoh, H., Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma (2003) Oncogene, 22, pp. 4656-4663
Noguchi, T., Oue, N., Wada, S., Sentani, K., Sakamoto, N., Kikuchi, A., H-Prune is an independent prognostic marker for survival in esophageal squamous cell carcinoma (2009) Ann Surg Oncol, 16, pp. 1390-1396
Neesen, J., Kirschner, R., Ochs, M., Schmiedl, A., Habermann, B., Mueller, C., Disruption of an inner arm dynein heavy chain gene results in asthenozoospermia and reduced ciliary beat frequency (2001) Hum Mol Genet, 10, pp. 1117-1128
Northcott, P.A., Korshunov, A., Witt, H., Hielscher, T., Eberhart, C.G., Mack, S., Medulloblastoma comprises four distinct molecular variants (2011) J Clin Oncol, 29, pp. 1408-1414
Oue, N., Yoshida, K., Noguchi, T., Sentani, K., Kikuchi, A., Yasui, W., Increased expression of h-prune is associated with tumor progression and poor survival in gastric cancer (2007) Cancer Sci, 98, pp. 1198-1205
Paternoster, L., Standl, M., Chen, C.M., Ramasamy, A., Bønnelykke, K., Duijts, L., Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis (2011) Nat Genet, 44, pp. 187-192
Pickup, M., Novitskiy, S., Moses, H.L., The roles of TGFbeta in the tumour microenvironment (2013) Nat Rev Cancer, 13, pp. 788-799
Quatromoni, J.G., Suzuki, E., Okusanya, O., Judy, B.F., Bhojnagarwala, P., Venegas, O., The timing of TGF-beta inhibition affects the generation of antigen-specific CD8+ T cells (2013) BMC Immunol, 14, p. 30
Rausch, T., Jones, D.T., Zapatka, M., Stutz, A.M., Zichner, T., Weischenfeldt, J., Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations (2012) Cell, 148, pp. 59-71
Remke, M., Hielscher, T., Northcott, P.A., Witt, H., Ryzhova, M., Wittmann, A., Adult medulloblastoma comprises three major molecular variants (2011) J Clin Oncol, 29, pp. 2717-2723
Rieken, S., Rieber, J., Brons, S., Habermehl, D., Rief, H., Orschiedt, L., Radiation-induced motility alterations in medulloblastoma cells (2015) J Radiat Res, 56, pp. 430-436
Sakai, L.Y., Keene, D.R., Renard, M., De Backer, J., FBN1: The diseasecausing gene for Marfan syndrome and other genetic disorders (2016) Gene, 591, pp. 279-291
Shao, S., Brown, A., Santhanam, B., Hegde, R.S., Structure and assembly pathway of the ribosome quality control complex (2015) Mol Cell, 57, pp. 433-444
Slowicka, K., Vereecke, L., Mc Guire, C., Sze, M., Maelfait, J., Kolpe, A., Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF--B signaling (2016) Eur J Immunol, 46, pp. 971-980
Solovieff, N., Milton, J.N., Hartley, S.W., Sherva, R., Sebastiani, P., Dworkis, D.A., Fetal hemoglobin in sickle cell anemia: Genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster (2010) Blood, 115, pp. 1815-1822
Stavraka, C., Blagden, S., The La-related proteins, a family with connections to cancer (2015) Biomolecules, 5, pp. 2701-2722
Stedman, H.H., Kozyak, B.W., Nelson, A., Thesier, D.M., Su, L.T., Low, D.W., Myosin gene mutation correlates with anatomical changes in the human lineage (2004) Nature, 428, pp. 415-418
Tammenkoski, M., Koivula, K., Cusanelli, E., Zollo, M., Steegborn, C., Baykov, A.A., Human metastasis regulator protein H-prune is a short-chain exopolyphosphatase (2008) Biochemistry, 47, pp. 9707-9713
Tarbell, N.J., Friedman, H., Polkinghorn, W.R., Yock, T., Zhou, T., Chen, Z., High-risk medulloblastoma: A pediatric oncology group randomized trial of chemotherapy before or after radiation therapy (POG 9031) (2013) J Clin Oncol, 31, pp. 2936-2941
Tsang, H.T., Connell, J.W., Brown, S.E., Thompson, A., Reid, E., Sanderson, C.M., A systematic analysis of human CHMP protein interactions: Additional mit domain-containing proteins bind to multiple components of the human ESCRT III complex (2006) Genomics, 88, pp. 333-346
Vaibhava, V., Nagabhushana, A., Chalasani, M.L., Sudhakar, C., Kumari, A., Swarup, G., Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17 (2012) J Cell Sci, 125, pp. 5026-5039
Virgilio, A., Spano, D., Esposito, V., Di Dato, V., Citarella, G., Marino, N., Novel pyrimidopyrimidine derivatives for inhibition of cellular proliferation and motility induced by h-prune in breast cancer (2012) Eur J Med Chem, 57, pp. 41-50
Van Rooij, E., Quiat, D., Johnson, B.A., Sutherland, L.B., Qi, X., Richardson, J.A., A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance (2009) Dev Cell, 17, pp. 662-673
Von Bueren, A.O., Kortmann, R.D., Von Hoff, K., Friedrich, C., Mynarek, M., Muller, K., Treatment of children and adolescents with metastatic medulloblastoma and prognostic relevance of clinical and biologic parameters (2016) J Clin Oncol, 34, pp. 4151-4160
Yang, L., Pang, Y., Moses, H.L., TGF-beta and immune cells: An important regulatory axis in the tumor microenvironment and progression (2010) Trends Immunol, 31, pp. 220-227
Zhao, R., Gong, L., Li, L., Guo, L., Zhu, D., Wu, Z., Nm23-H1 is a negative regulator of TGF-beta1-dependent induction of epithelialmesenchymal transition (2013) Exp Cell Res, 319, pp. 740-749
Zhu, G., Rankin, S.L., Larson, J.D., Zhu, X., Chow, L.M., Qu, C., PTEN Signaling in the postnatal perivascular progenitor niche drives medulloblastoma formation (2017) Cancer Res, 77, pp. 123-133
Zollo, M., Genetics of recurrent medulloblastoma (2013) Lancet Oncol, 14, pp. 1147-1148
Zollo, M., Ahmed, M., Ferrucci, V., Salpietro, V., Asadzadeh, F., Carotenuto, M., PRUNE is crucial for normal brain development and mutated in microcephaly with neurodevelopmental impairment (2017) Brain, 140, pp. 940-952
Zollo, M., Andre, A., Cossu, A., Sini, M.C., D'Angelo, A., Marino, N., Overexpression of h-prune in breast cancer is correlated with advanced disease status (2005) Clin Cancer Res, 11, pp. 199-205
Brain (ISSN: 1460-2156electronic, 0006-8950linking), 2018 May 1; 141(5): 1300-1319.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 9.915, 5-year impact factor: 10.87
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047083488&doi=10.1093%2fbrain%2fawy039&partnerID=40&md5=71c6ed3662dcc138b64ddaf9e7b67ac4
Keywords: Genetic Network, Medulloblastoma, Metastatic Cns Tumour, Molecular Genetics, Oncology, Nme1 Protein, Phosphatidylinositol 3, 5 Trisphosphate 3 Phosphatase, Prune1 Protein, Pyrimidine Derivative, Transcription Factor Otx2, Transcription Factor Snail, Transforming Growth Factor Beta, Unclassified Drug, Adolescent, Animal Experiment, Animal Tissue, Article, Cancer Cell, Cancer Growth, Cell Migration, Cell Proliferation, Child, Clinical Article, Complex Formation, Controlled Study, Female, Gene Expression, Gene Repression, Genetic Predisposition, Genetic Variability, Hek293t Cell Line, Human, Human Cell, Immunocompetent Cell, In Vivo Study, Infant, Luciferase Assay, Medulloblastoma Cell Line, Metastasis, Next Generation Sequencing, Nonhuman, Pediatrics, Primary Tumor, Priority Journal, Protein Binding, Protein Degradation, Protein Expression, Protein Interaction, Signal Transduction, Upregulation, Whole Exome Sequencing,
Affiliations:
*** IBB - CNR ***
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, Naples, Italy., CEINGE Biotecnologie Avanzate, Naples, Italy., European School of Molecular Medicine (SEMM), Milan, Italy., Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Ontario, Canada., Dipartimento di Farmacia, Universita degli Studi di Napoli Federico II, Naples, Italy., Department of Veterinary Medicine and Animal Productions, Universita degli Studi di Napoli Federico II, Naples, Italy., Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale della Ricerca, Naples, Italy., Dipartimento di Scienze Biomediche Avanzate, Universita degli Studi di Napoli Federico II, Naples, Italy., Division of Clinical Studies, The Institute of Cancer Research, London SM2 5NG, UK., Paediatric Neurosurgery, Ospedale Santobono-Pausilipon, Naples, Italy., Pathology Unit, Ospedale Santobono-Pausilipon, Naples, Italy., Genetic Control of Development-URT, Institute of Cell Biology and Neurobiology, National Research Council, Fondazione Santa Lucia, Rome, Italy., Dipartimento di Onco-Ematologia, IRCCS Ospedale Pediatrico Bambino Gesu, Rome, Italy., Dipartimento di Scienze Radiologiche, Oncologiche e Anatomo Patologiche, Universita La Sapienza, Rome, Italy., IRCCS Neuromed, Pozzilli, Italy., German Cancer Consortium (DKTK), Department of Paediatric Oncology, Haematology, and Clinical Immunology, University Hospital Dusseldorf, Dusseldorf, Germany., Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto ON, Canada., PSL Research University, Inserm U830, Equipe Labellis?Ligue contre le Cancer, Institut Curie, Paris, France., Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Caserta, Italy., DAI-Medicina Trasfusionale-Azienda Ospedaliera Universitaria Federico<
References:
Adamson, D.C., Shi, Q., Wortham, M., Northcott, P.A., Di, C., Duncan, C.G., OTX2 is critical for the maintenance and progression of Shhindependent medulloblastomas (2010) Cancer Res, 70, pp. 181-19
Alimonti, A., Carracedo, A., Clohessy, J.G., Trotman, L.C., Nardella, C., Egia, A., Subtle variations in Pten dose determine cancer susceptibility (2010) Nat Genet, 42, pp. 454-458
Asadzadeh, F., Ferrucci, V., De Antonellis, P., Zollo, M., In vivo bioluminescence imaging (BLI) using orthotopic xenografts towards patient's derived-xenograft (PDX) Medulloblastoma models (2017) Q J Nucl Med Mol Imaging, 61, pp. 95-101
Asuthkar, S., Nalla, A.K., Gondi, C.S., Dinh, D.H., Gujrati, M., Mohanam, S., Gadd45a sensitizes medulloblastoma cells to irradiation and suppresses MMP-9-mediated EMT (2011) Neuro Oncol, 13, pp. 1059-1073
Bai, R.Y., Staedtke, V., Lidov, H.G., Eberhart, C.G., Riggins, G.J., OTX2 represses myogenic and neuronal differentiation in medulloblastoma cells (2012) Cancer Res, 72, pp. 5988-6001
Batlle, R., Alba-Castellon, L., Loubat-Casanovas, J., Armenteros, E., Franci, C., Stanisavljevic, J., Snail1 controls TGF-beta responsiveness and differentiation of mesenchymal stem cells (2013) Oncogene, 32, pp. 3381-3389
Boulay, G., Awad, M.E., Riggi, N., Archer, T.C., Iyer, S., Boonseng, W.E., OTX2 Activity at distal regulatory elements shapes the chromatin landscape of group 3 medulloblastoma (2017) Cancer Discov, 7, pp. 288-301
Bunt, J., Hasselt, N.A., Zwijnenburg, D.A., Koster, J., Versteeg, R., Kool, M., OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels (2013) Acta Neuropathol, 125, pp. 385-394
Carotenuto, M., De Antonellis, P., Chiarolla, C.M., Attanasio, C., Damiani, V., Boffa, I., A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction (2015) Naunyn Schmiedeberg's Arch Pharmacol, 388, pp. 257-269
Carotenuto, M., Pedone, E., Diana, D., De Antonellis, P., Dzeroski, S., Marino, N., Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction (2013) Sci Rep, 3, p. 1351
Carotenuto, P., Marino, N., Bello, A.M., D'Angelo, A., Di Porzio, U., Lombardi, D., PRUNE and NM23-M1 expression in embryonic and adult mouse brain (2006) J Bioenerg Biomembr, 38, pp. 233-246
Cavalli, F.M.G., Remke, M., Rampasek, L., Peacock, J., Shih, D.J.H., Luu, B., Intertumoral heterogeneity within medulloblastoma subgroups (2017) Cancer Cell, 31, pp. 737-754e6
Cho, Y.J., Tsherniak, A., Tamayo, P., Santagata, S., Ligon, A., Greulich, H., Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome (2011) J Clin Oncol, 29, pp. 1424-1430
Contos, J.J., Ye, X., Sah, V.P., Chun, J., Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/ Edg6) gene (2002) FEBS Lett, 531, pp. 99-102
Dai, G., Yu, H., Kruse, M., Traynor-Kaplan, A., Hille, B., Osmoregulatory inositol transporter SMIT1 modulates electrical activity by adjusting PI(4, 5)P2 levels (2016) Proc Natl Acad Sci USA, 113, pp. E3290-E3299
Dai, W., Zheng, H., Cheung, A.K., Tang, C.S., Ko, J.M., Wong, B.W., Whole-exome sequencing identifies MST1R as a genetic susceptibility gene in nasopharyngeal carcinoma (2016) Proc Natl Acad Sci USA, 113, pp. 3317-3322
D'Angelo, A., Garzia, L., Andre, A., Carotenuto, P., Aglio, V., Guardiola, O., Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis (2004) Cancer Cell, 5, pp. 137-149
Diana, D., Smaldone, G., De Antonellis, P., Pirone, L., Carotenuto, M., Alonzi, A., Mapping functional interaction sites of human prune C-terminal domain by NMR spectroscopy in human cell lysates (2013) Chemistry, 19, pp. 12217-12220
Escriva, M., Peiro, S., Herranz, N., Villagrasa, P., Dave, N., Montserrat-Sentis, B., Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis (2008) Mol Cell Biol, 28, pp. 1528-1540
Ferrucci, V., Francesco Paolo Pennino, F., Siciliano, R., Asadzadeh, F., Zollo, M., A competitive cell-permeable peptide (CPP) to impair the Nme-1 (NDPK-A) and Prune-1 interaction for therapeutic applications in cancer (2018) Lab Invest, , PMID: 29449633
Forus, A., D'Angelo, A., Henriksen, J., Merla, G., Maelandsmo, G.M., Florenes, V.A., Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity (2001) Oncogene, 20, pp. 6881-6890
Gajjar, A., Hernan, R., Kocak, M., Fuller, C., Lee, Y., McKinnon, P.J., Clinical, histopathologic, and molecular markers of prognosis: Toward a new disease risk stratification system for medulloblastoma (2004) J Clin Oncol, 22, pp. 984-993
Galasso, A., Zollo, M., The Nm23-H1-h-Prune complex in cellular physiology: A 'tip of the iceberg' protein network perspective (2009) Mol Cell Biochem, 329, pp. 149-159
Garzia, L., D'Angelo, A., Amoresano, A., Knauer, S.K., Cirulli, C., Campanella, C., Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility (2008) Oncogene, 27, pp. 1853-1864
Gibson, P., Tong, Y., Robinson, G., Thompson, M.C., Currle, D.S., Eden, C., Subtypes of medulloblastoma have distinct developmental origins (2010) Nature, 468, pp. 1095-1099
Goldberg-Stern, H., Gadoth, N., Stern, S., Cohen, I.J., Zaizov, R., Sandbank, U., The prognostic significance of glial fibrillary acidic protein staining in medulloblastoma (1991) Cancer, 68, pp. 568-573
Hashimoto, M., Kobayashi, T., Tashiro, H., Arihiro, K., Kikuchi, A., Ohdan, H., H-Prune is associated with poor prognosis and epithelial-mesenchymal transition in patients with colorectal liver metastases (2016) Int J Cancer, 139, pp. 812-823
Ivanov, D.P., Walker, D.A., Coyle, B., Grabowska, A.M., Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines (2016) Data Brief, 9, pp. 696-698
Jia, S., Wu, D., Xing, C., Meng, A., Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafish (2009) Dev Biol, 333, pp. 273-284
Jin, G., Klika, A., Callahan, M., Faga, B., Danzig, J., Jiang, Z., Identification of a human NF-kappaB-activating protein, TAB3 (2004) Proc Natl Acad Sci USA, 101, pp. 2028-2033
Kool, M., Koster, J., Bunt, J., Hasselt, N.E., Lakeman, A., Van Sluis, P., Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features (2008) PLoS One, 3, p. e3088
Kubo, A., Suzuki, N., Yuan, X., Nakai, K., Satoh, N., Imai, K.S., Genomic cis-regulatory networks in the early Ciona intestinalis embryo (2010) Development, 137, pp. 1613-1623
Lamouille, S., Xu, J., Derynck, R., Molecular mechanisms of epithelialmesenchymal transition (2014) Nat Rev Mol Cell Biol, 15, pp. 178-196
Lee, S.J., Kang, W.Y., Yoon, Y., Jin, J.Y., Song, H.J., Her, J.H., Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain (2015) BMC Cancer, 15, p. 1011
Li, P., Du, F., Yuelling, L.W., Lin, T., Muradimova, R.E., Tricarico, R., A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity (2013) Nat Neurosci, 16, pp. 1737-1744
Long, M., Simpson, J.C., Rho GTPases operating at the Golgi complex: Implications for membrane traffic and cancer biology (2017) Tissue Cell, 49, pp. 163-169
Long, N.P., Lee, W.J., Huy, N.T., Lee, S.J., Park, J.H., Kwon, S.W., Novel biomarker candidates for colorectal cancer metastasis: A meta-analysis of in vitro studies (2016) Cancer Inform, 15, pp. 11-17
Louis, D.N., Perry, A., Burger, P., Ellison, D.W., Reifenberger, G., Von Deimling, A., International Society of Neuropathology- Haarlem consensus guidelines for nervous system tumor classification and grading (2014) Brain Pathol, 24, pp. 429-435
Luo, S., Li, Y., Ma, R., Liu, J., Xu, P., Zhang, H., Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma (2017) Oncogene, 36, pp. 3609-3617
Ma, X., Guan, L., Wu, W., Zhang, Y., Zheng, W., Gao, Y.T., Wholeexome sequencing identifies OR2W3 mutation as a cause of autosomal dominant retinitis pigmentosa (2015) Sci Rep, 5, p. 9236
Mack, J.T., Brown, C.B., Tew, K.D., ABCA2 as a therapeutic target in cancer and nervous system disorders (2008) Expert Opin Ther Targets, 12, pp. 491-504
Malnic, B., Godfrey, P.A., Buck, L.B., The human olfactory receptor gene family (2004) Proc Natl Acad Sci USA, 101, pp. 2584-2589
Massague, J., TGFbeta in cancer (2008) Cell, 134, pp. 215-230
Massimino, M., Biassoni, V., Gandola, L., Garre, M.L., Gatta, G., Giangaspero, F., Childhood medulloblastoma (2016) Crit Rev Oncol Hematol, 105, pp. 35-51
McCloy, R.A., Rogers, S., Caldon, C.E., Lorca, T., Castro, A., Burgess, A., Partial inhibition of Cdk1 in G 2 phase overrides the SAC and decouples mitotic events (2014) Cell Cycle, 13, pp. 1400-1412
Metcalfe, C., Alicke, B., Crow, A., Lamoureux, M., Dijkgraaf, G.J., Peale, F., PTEN loss mitigates the response of medulloblastoma to Hedgehog pathway inhibition (2013) Cancer Res, 73, pp. 7034-7042
Morikawa, M., Koinuma, D., Miyazono, K., Heldin, C.H., Genome-wide mechanisms of Smad binding (2013) Oncogene, 32, pp. 1609-1615
Nagano, H., Noguchi, T., Inagaki, K., Yoon, S., Matozaki, T., Itoh, H., Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma (2003) Oncogene, 22, pp. 4656-4663
Noguchi, T., Oue, N., Wada, S., Sentani, K., Sakamoto, N., Kikuchi, A., H-Prune is an independent prognostic marker for survival in esophageal squamous cell carcinoma (2009) Ann Surg Oncol, 16, pp. 1390-1396
Neesen, J., Kirschner, R., Ochs, M., Schmiedl, A., Habermann, B., Mueller, C., Disruption of an inner arm dynein heavy chain gene results in asthenozoospermia and reduced ciliary beat frequency (2001) Hum Mol Genet, 10, pp. 1117-1128
Northcott, P.A., Korshunov, A., Witt, H., Hielscher, T., Eberhart, C.G., Mack, S., Medulloblastoma comprises four distinct molecular variants (2011) J Clin Oncol, 29, pp. 1408-1414
Oue, N., Yoshida, K., Noguchi, T., Sentani, K., Kikuchi, A., Yasui, W., Increased expression of h-prune is associated with tumor progression and poor survival in gastric cancer (2007) Cancer Sci, 98, pp. 1198-1205
Paternoster, L., Standl, M., Chen, C.M., Ramasamy, A., Bønnelykke, K., Duijts, L., Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis (2011) Nat Genet, 44, pp. 187-192
Pickup, M., Novitskiy, S., Moses, H.L., The roles of TGFbeta in the tumour microenvironment (2013) Nat Rev Cancer, 13, pp. 788-799
Quatromoni, J.G., Suzuki, E., Okusanya, O., Judy, B.F., Bhojnagarwala, P., Venegas, O., The timing of TGF-beta inhibition affects the generation of antigen-specific CD8+ T cells (2013) BMC Immunol, 14, p. 30
Rausch, T., Jones, D.T., Zapatka, M., Stutz, A.M., Zichner, T., Weischenfeldt, J., Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations (2012) Cell, 148, pp. 59-71
Remke, M., Hielscher, T., Northcott, P.A., Witt, H., Ryzhova, M., Wittmann, A., Adult medulloblastoma comprises three major molecular variants (2011) J Clin Oncol, 29, pp. 2717-2723
Rieken, S., Rieber, J., Brons, S., Habermehl, D., Rief, H., Orschiedt, L., Radiation-induced motility alterations in medulloblastoma cells (2015) J Radiat Res, 56, pp. 430-436
Sakai, L.Y., Keene, D.R., Renard, M., De Backer, J., FBN1: The diseasecausing gene for Marfan syndrome and other genetic disorders (2016) Gene, 591, pp. 279-291
Shao, S., Brown, A., Santhanam, B., Hegde, R.S., Structure and assembly pathway of the ribosome quality control complex (2015) Mol Cell, 57, pp. 433-444
Slowicka, K., Vereecke, L., Mc Guire, C., Sze, M., Maelfait, J., Kolpe, A., Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF--B signaling (2016) Eur J Immunol, 46, pp. 971-980
Solovieff, N., Milton, J.N., Hartley, S.W., Sherva, R., Sebastiani, P., Dworkis, D.A., Fetal hemoglobin in sickle cell anemia: Genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster (2010) Blood, 115, pp. 1815-1822
Stavraka, C., Blagden, S., The La-related proteins, a family with connections to cancer (2015) Biomolecules, 5, pp. 2701-2722
Stedman, H.H., Kozyak, B.W., Nelson, A., Thesier, D.M., Su, L.T., Low, D.W., Myosin gene mutation correlates with anatomical changes in the human lineage (2004) Nature, 428, pp. 415-418
Tammenkoski, M., Koivula, K., Cusanelli, E., Zollo, M., Steegborn, C., Baykov, A.A., Human metastasis regulator protein H-prune is a short-chain exopolyphosphatase (2008) Biochemistry, 47, pp. 9707-9713
Tarbell, N.J., Friedman, H., Polkinghorn, W.R., Yock, T., Zhou, T., Chen, Z., High-risk medulloblastoma: A pediatric oncology group randomized trial of chemotherapy before or after radiation therapy (POG 9031) (2013) J Clin Oncol, 31, pp. 2936-2941
Tsang, H.T., Connell, J.W., Brown, S.E., Thompson, A., Reid, E., Sanderson, C.M., A systematic analysis of human CHMP protein interactions: Additional mit domain-containing proteins bind to multiple components of the human ESCRT III complex (2006) Genomics, 88, pp. 333-346
Vaibhava, V., Nagabhushana, A., Chalasani, M.L., Sudhakar, C., Kumari, A., Swarup, G., Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17 (2012) J Cell Sci, 125, pp. 5026-5039
Virgilio, A., Spano, D., Esposito, V., Di Dato, V., Citarella, G., Marino, N., Novel pyrimidopyrimidine derivatives for inhibition of cellular proliferation and motility induced by h-prune in breast cancer (2012) Eur J Med Chem, 57, pp. 41-50
Van Rooij, E., Quiat, D., Johnson, B.A., Sutherland, L.B., Qi, X., Richardson, J.A., A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance (2009) Dev Cell, 17, pp. 662-673
Von Bueren, A.O., Kortmann, R.D., Von Hoff, K., Friedrich, C., Mynarek, M., Muller, K., Treatment of children and adolescents with metastatic medulloblastoma and prognostic relevance of clinical and biologic parameters (2016) J Clin Oncol, 34, pp. 4151-4160
Yang, L., Pang, Y., Moses, H.L., TGF-beta and immune cells: An important regulatory axis in the tumor microenvironment and progression (2010) Trends Immunol, 31, pp. 220-227
Zhao, R., Gong, L., Li, L., Guo, L., Zhu, D., Wu, Z., Nm23-H1 is a negative regulator of TGF-beta1-dependent induction of epithelialmesenchymal transition (2013) Exp Cell Res, 319, pp. 740-749
Zhu, G., Rankin, S.L., Larson, J.D., Zhu, X., Chow, L.M., Qu, C., PTEN Signaling in the postnatal perivascular progenitor niche drives medulloblastoma formation (2017) Cancer Res, 77, pp. 123-133
Zollo, M., Genetics of recurrent medulloblastoma (2013) Lancet Oncol, 14, pp. 1147-1148
Zollo, M., Ahmed, M., Ferrucci, V., Salpietro, V., Asadzadeh, F., Carotenuto, M., PRUNE is crucial for normal brain development and mutated in microcephaly with neurodevelopmental impairment (2017) Brain, 140, pp. 940-952
Zollo, M., Andre, A., Cossu, A., Sini, M.C., D'Angelo, A., Marino, N., Overexpression of h-prune in breast cancer is correlated with advanced disease status (2005) Clin Cancer Res, 11, pp. 199-205
Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-beta-OTX2-SNAIL via PTEN inhibition
Genetic modifications during development of paediatric groups 3 and 4 medulloblastoma are responsible for their highly metastatic properties and poor patient survival rates. PRUNE1 is highly expressed in metastatic medulloblastoma group 3, which is characterized by TGF-β signalling activation, c-MYC amplification, and OTX2 expression. We describe the process of activation of the PRUNE1 signalling pathway that includes its binding to NME1, TGF-β activation, OTX2 upregulation, SNAIL (SNAI1) upregulation, and PTEN inhibition. The newly identified small molecule pyrimido-pyrimidine derivative AA7.1 enhances PRUNE1 degradation, inhibits this activation network, and augments PTEN expression. Both AA7.1 and a competitive permeable peptide that impairs PRUNE1/NME1 complex formation, impair tumour growth and metastatic dissemination in orthotopic xenograft models with a metastatic medulloblastoma group 3 cell line (D425-Med cells). Using whole exome sequencing technology in metastatic medulloblastoma primary tumour cells, we also define 23 common 'non-synonymous homozygous' deleterious gene variants as part of the protein molecular network of relevance for metastatic processes. This PRUNE1/TGF-β/OTX2/PTEN axis, together with the medulloblastoma-driver mutations, is of relevance for future rational and targeted therapies for metastatic medulloblastoma group 3. 10.1093/brain/awy039-video1 awy039media1 5742053534001 © The Author(s) (2018). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
Genetic modifications during development of paediatric groups 3 and 4 medulloblastoma are responsible for their highly metastatic properties and poor patient survival rates. PRUNE1 is highly expressed in metastatic medulloblastoma group 3, which is characterized by TGF-β signalling activation, c-MYC amplification, and OTX2 expression. We describe the process of activation of the PRUNE1 signalling pathway that includes its binding to NME1, TGF-β activation, OTX2 upregulation, SNAIL (SNAI1) upregulation, and PTEN inhibition. The newly identified small molecule pyrimido-pyrimidine derivative AA7.1 enhances PRUNE1 degradation, inhibits this activation network, and augments PTEN expression. Both AA7.1 and a competitive permeable peptide that impairs PRUNE1/NME1 complex formation, impair tumour growth and metastatic dissemination in orthotopic xenograft models with a metastatic medulloblastoma group 3 cell line (D425-Med cells). Using whole exome sequencing technology in metastatic medulloblastoma primary tumour cells, we also define 23 common 'non-synonymous homozygous' deleterious gene variants as part of the protein molecular network of relevance for metastatic processes. This PRUNE1/TGF-β/OTX2/PTEN axis, together with the medulloblastoma-driver mutations, is of relevance for future rational and targeted therapies for metastatic medulloblastoma group 3. 10.1093/brain/awy039-video1 awy039media1 5742053534001 © The Author(s) (2018). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-beta-OTX2-SNAIL via PTEN inhibition
| ▼ Characterization of the KCTD protein family: key factors in several biological processes |
Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-beta-OTX2-SNAIL via PTEN inhibition
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 0.506
View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Varriale S, Merlino A, Coscia MR, Mazzarella L, Oreste U
* An evolutionary conserved motif is responsible for Immunoglobulin heavy chain packing in the B cell membrane (497 views)
Molecular Phylogenetics And Evolution (ISSN: 1055-7903), 2010 Dec; 57(3): 1238-1244.
Impact Factor: 3.889
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Stanzione F, Esposito L, Paladino A, Pedone C, Morelli G, Vitagliano L
* Role of the conformational versatility of the neurotrophin N-terminal regions in their recognition by Trk receptors (515 views)
Biophysical Journal (ISSN: 1542-0086, 0006-3495), 2010 Oct 6; 99(7): 2273-2278.
Impact Factor: 4.218
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Alterio V, Monti SM, Truppo E, Pedone C, Supuran CT, De Simone G
* The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: The carbonic anhydrase I-topiramate complex (448 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2010 Sep 7; 8(15): 3528-3533.
Impact Factor: 3.451
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Tosco A, Monti MC, Fontanella B, Montefusco S, D'Andrea LD, Ziaco B, Baldantoni D, Rio MC, Marzullo L
* Copper binds the carboxy-terminus of trefoil protein 1 (TFF1), favoring its homodimerization and motogenic activity (1356 views)
Cell Mol Life Sci (ISSN: 1420-9071electronic, 1420-682xlinking), 2010 Jun; 67(11): 1943-1955.
Impact Factor: 7.047
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Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone E, Gallinari P, Giorgi A, Steinkuhler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A
* Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation (688 views)
Nature Cell Biol Nature Cell Biology (ISSN: 1476-4679, 1465-7392), 2010 Feb; 12(2): 132-142.
Impact Factor: 19.407
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Palmieri G, Langella E, Gogliettino M, Saviano M, Pocsfalvi G, Rossi M
* A novel class of protease targets of phosphatidylethanolamine-binding proteins (PEBP): A study of the acylpeptide hydrolase and the PEBP inhibitor from the archaeon Sulfolobus solfataricus (378 views)
Mol Biosyst (ISSN: 1742-206x), 2010; 6(12): 2498-2507.
Impact Factor: 3.825
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Scir A, Pedone E, Ausili A, Saviano M, Baldassarre M, Bertoli E, Bartolucci S, Tanfani F
* High hydrostatic pressure-induced conformational changes in protein disulfide oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus. A Fourier-transform infrared spectroscopic study (347 views)
Molecular Biosystems (ISSN: 1742-206x), 2010; 6(10): 2015-2022.
Impact Factor: 3.825
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Faiella M, Andreozzi C, de Rosales RT, Pavone V, Maglio O, Nastri F, DeGrado WF, Lombardi A
* An artificial di-iron oxo-protein with phenol oxidase activity (433 views)
Nat Chem Biol (ISSN: 1552-4450), 2009 Dec; 5(12): 882-884.
Impact Factor: 16.058
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Damante CA, Osz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* Metal Loading Capacity Of Abeta N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Zinc (ii) Complexes With Abeta (1-16), Its Short Or Mutated Peptide Fragments And Its Polyethylene Glycol-Ylated Analogue (611 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 Nov 2; 48(21): 10405-10415.
Impact Factor: 4.657
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Marasco D, Stilo R, Sandomenico A, Monti SM, Tizzano B, De Capua A, Varricchio E, Liguoro D, Zotti T, Formisano S, Ruvo M, Vito P
* Generation And Functional Characterization Of A Bcl10-Inhibitory Peptide That Represses Nf-Kappa B Activation (602 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2009 Sep 15; 422(3): 553-561.
Impact Factor: 5.155
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Pietropaolo A, Muccioli L, Zannoni C, Rizzarelli E
* Conformational preferences of the full chicken prion protein in solution and its differences with respect to mammals (407 views)
Chemphyschem (ISSN: 1439-7641, 1439-4235, 1439-7641electronic), 2009 Jul 13; 10(9-10): 1500-1510.
Impact Factor: 3.453
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Ruggiero A, Lanzotti MA, Ruocco MR, Grimaldi P, Marasco D, Arcari P, Masullo M, Zagari A, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of two dimeric hyperthermostable thioredoxins isolated from Sulfolobus solfataricus (337 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2009 Jun; 65: 604-607.
Impact Factor: 0.551
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Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Del Vecchio L, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M
* MicroRNA-199b-5p Impairs Cancer Stem Cells through Negative Regulation of HES1 in Medulloblastoma (442 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Mar 24; 4(3): e4998-e4998.
Impact Factor: 4.351
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Calvanese L, Saporito A, Oliva R, D'Auria G, Pedone C, Paolillo L, Ruvo M, Marasco D, Falcigno L
* Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor (489 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 175-183.
Impact Factor: 1.807
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Palmieri G, Catara G, Saviano M, Langella E, Gogliettino M, Rossi M
* First archaeal PEPB-serine protease inhibitor from sulfolobus solfataricus with noncanonical amino acid sequence in the reactive-site loop (399 views)
J Proteome Res (ISSN: 1535-3893), 2009 Jan; 8(1): 327-334.
Impact Factor: 5.132
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Viparelli F, Doti N, Monti SM, Marasco D, Dathan N, Pedone C, Miele C, Formisano P, Beguinot F, Ruvo M
* Peptide antagonists of the PED-hPLD1 binding (354 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print, 0065-2598linking), 2009; 611: 445-446.
Impact Factor: 2.02
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Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (562 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
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Galdiero S, Vitiello M, D'Isanto M, Falanga A, Cantisani M, Browne H, Pedone C, Galdiero M
* The identification and characterization of fusogenic domains in herpes virus glycoprotein B molecules (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2008 Mar 25; 9(5): 758-767.
Impact Factor: 3.322
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Hilvo M, Innocenti A, Monti SM, De Simone G, Supuran CT, Parkkila S
* Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV (497 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008; 14(7): 672-678.
Impact Factor: 4.399
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Diana D, Ziaco B, Colombo G, Scarabelli G, Romanelli A, Fedone C, Fattorusso R, D'Andrea LD
* Structural determinants of the unusual helix stability of a de novo engineered vascular endothelial growth factor (VEGF) mimicking peptide (470 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2008; 14(14): 4164-4166.
Impact Factor: 5.454
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Malgieri G, Russo L, Esposito S, Baglivo I, Zaccaro L, Pedone EM, Di Blasio B, Isernia C, Pedone PV, Fattorusso R
* The Prokaryotic Cys2his2 Zinc Finger Domain Adopts A Novel Fold As Revealed By The Solution Structure Of Agrobacterium Tumefaciens Ros Dna Binding Domain (480 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2007 Oct 30; 104(44): 17341-17346.
Impact Factor: 9.598
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Ruggiero A, Tizzano B, Geerlof A, Pedone E, Pedone C, Wilmanns M, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis (389 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2007 Oct 1; 63(10): 870-873.
Impact Factor: 0.645
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Galdiero S, Falanga A, Vitiello M, D'Isanto M, Collins C, Orrei V, Browne H, Pedone C, Galdiero M
* Evidence for a role of the membrane-proximal region of herpes simplex virus type 1 glycoprotein H in membrane fusion and virus inhibition (617 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 885-895.
Impact Factor: 3.446
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De Pinto V, Tomasello F, Messina A, Guarino F, Benz R, La Mendola D, Magrì A, Milardi D, Pappalardo G
* Determination of the conformation of the human VDAC1 N-terminal peptide, a protein moiety essential for the functional properties of the pore (555 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 7; 8(7): 744-756.
Impact Factor: 3.446
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Bonomo RP, Pappalardo G, Rizzarelli E, Santoro AM, Tabbì G, Vagliasindi LI
* Nitrogen oxide interaction with copper complexes formed by small peptides belonging to the prion protein octa-repeat region (592 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2007 Apr 14; (14): 1400-1408.
Impact Factor: 3.212
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Pappalardo G, Milardi D, Magrì A, Attanasio F, Impellizzeri G, La Rosa C, Grasso D, Rizzarelli E
* Environmental factors differently affect human and rat IAPP: Conformational preferences and membrane interactions of IAPP17-29 peptide derivatives (655 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2007; 13(36): 10204-10215.
Impact Factor: 5.33
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Grasso D, Grasso G, Guantieri V, Impellizzeri G, La Rosa C, Milardi D, Micera G, Osz K, Pappalardo G, Rizzarelli E, Sanna D, Sovago I
* Environmental effects on a prion's helix II domain: copper(II) and membrane interactions with PrP180-193 and its analogues (432 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2005 Dec 23; 12(2): 537-547.
Impact Factor: 4.907
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Di Natale G, Grasso G, Impellizzeri G, La Mendola D, Micera G, Mihala N, Nagy Z, Osz K, Pappalardo G, Rigó V, Rizzarelli E, Sanna D, Sóvágó I
* Copper(II) interaction with unstructured prion domain outside the octarepeat region: Speciation, stability, and binding details of copper(II) complexes with PrP106-126 peptides (4139 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2005 Oct 3; 44(20): 7214-7225.
Impact Factor: 3.851
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Cucinotta V, Giuffrida A, Maccarrone G, Messina M, Puglisi A, Rizzarelli E, Vecchio G
* Coordination properties of 3-functionalized β-cyclodextrins. Thermodynamic stereoselectivity of copper(II) complexes of the A, B-diamino derivative and its exploitation in LECE (356 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2005 Sep 21; (16): 2731-2736.
Impact Factor: 3.003
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Rivieccio V, Mannini R, Concilio L, D'Auria S, Pedone C, Grimaldi G
* Expression, purification and partial characterization of the Krüppel-associated box (KRAB) from the human ZNF2 protein (362 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2005; 12(6): 527-532.
Impact Factor: 0.84
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Miralbell R, Lomax A, Cella L, Schneider U
* Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors (262 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2002 Nov 1; 54(3): 824-829.
Impact Factor: 3.756
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Menchise V, Corbier C, Didierjean C, Saviano M, Benedetti E, Jacquot JP, Aubry A
* Crystal structure of the wild-type and D30A mutant thioredoxin h of Chlamydomonas reinhardtii and implications for the catalytic mechanism (454 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2001 Oct 1; 359(1): 65-75.
Impact Factor: 4.326
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De Falco S, Ruvoletto MG, Verdoliva A, Ruvo M, Raucci A, Marino M, Senatore S, Cassani G, Alberti A, Pontisso P, Fassina G
* Cloning and Expression of a Novel Hepatitis B Virus-binding Protein from HepG2 Cells (626 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2001 Sep 28; 276(39): 36613-36623.
Impact Factor: 7.258
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Monti SM, Gallo M, Ferracane R, Borrelli RC, Ritieni A, Greco ML, Graniti A, Fogliano V
* Analysis of bacterial lipodepsipeptides by matrix-assisted laser desorption/ionisation time-of-flight and high-performance liquid chromatography with electrospray mass spectrometry (437 views)
Rapid Commun Mass Sp (ISSN: 0951-4198, 1097-0231electronic), 2001; 15(8): 623-628.
Impact Factor: 2.478
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Berisio R, Vitagliano L, Sorrentino G, Carotenuto L, Piccolo C, Mazzarella L, Zagari A
Effects of microgravity on the crystal quality of a collagen-like polypeptide (523 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2000 Jan; 56(1): 55-61.
Impact Factor: 3.067
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Aime S, Dastrù W, Gobetto R, Viale A
An NMR study of H(μ-H)Os3(CO)11 (371 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2000; 39(11): 2422-2425.
Impact Factor: 2.712
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Bonomo RP, Marchelli R, Tabbì G
Study of H2O2 interaction with copper(II) complexes with diamino-diamide type ligands, diastereoisomeric dipeptides, and tripeptides (513 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Nov 15; 60(3): 205-218.
Impact Factor: 1.342
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Saviano M, Rossi F, Filizola M, Di Blasio B, Pedone C
[Aib5, 6-D-Ala8]-cyclolinopeptide A, grown from a benzene/acetonitrile mixture (324 views)
Acta Crystallogr Sect C Cryst Struct Commun (ISSN: 0108-2701), 1995 Apr 15; 51: Pt-Pt.
Impact Factor: 0.459
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* gH625: A milestone in understanding the many roles of membranotropic peptides (530 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2015 Jan; 1848(PA): 16-25.
Impact Factor: 5.158
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Caporale A, Selis F, Pain D, Sandomenico A, Jotti S, Tonon G, Ruvo M
* The LQSP tetrapeptide is a new highly efficient substrate of microbial transglutaminase for the site-specific derivatization of peptides and proteins (683 views)
Biotechnol J (ISSN: 1860-6768), 2015 Jan; 10(1): 154-161.
Impact Factor: 3.781
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Ruggiero A, Dattelbaum JD, Staiano M, Berisio R, D'Auria S, Vitagliano L
* A loose domain swapping organization confers a remarkable stability to the dimeric structure of the arginine binding protein from Thermotoga maritima (444 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 May 15; 9(5): e96560-e96560.
Impact Factor: 3.234
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Cefalo G, Massimino M, Ruggiero A, Barone G, Ridola V, Spreafico F, Potepan P, Abate ME, Mascarin M, Garrè ML, Perilongo G, Madon E, Colosimo C, Riccardi R
* Temozolomide is an active agent in children with recurrent medulloblastoma/primitive neuroectodermal tumor: An Italian multi-institutional phase II trial (369 views)
Neuro-Oncology (ISSN: 1522-8517), 2014 May; 16(5): 748-753.
Impact Factor: 6.776
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Limauro D, De Simone G, Pirone L, Bartolucci S, D'Ambrosio K, Pedone E
* Sulfolobus solfataricus thiol redox puzzle: characterization of an atypical protein disulfide oxidoreductase (430 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2014 Mar; 18(2): 219-228.
Impact Factor: 2.306
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Antoniali G, Lirussi L, D'Ambrosio C, Dal Piaz F, Vascotto C, Casarano E, Marasco D, Scaloni A, Fogolari F, Tell G
* SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements (548 views)
Mol Biol Cell (ISSN: 1059-1524), 2014 Feb 15; 25(4): 532-547.
Impact Factor: 4.466
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Dathan NA, Alterio V, Troiano E, Vullo D, Ludwig M, De Simone G, Supuran CT, Monti SM
* Biochemical Characterization Of The Chloroplastic β-Carbonic Anhydrase From Flaveria Bidentis (l. ) "kuntze" (517 views)
J Enzym Inhib Med Ch (ISSN: 1475-6366, 1475-6374electronic, 1475-6366linking), 2014; 29(4): 500-504.
Impact Factor: 2.332
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Calce E, Sandomenico A, Saviano M, Ruvo M, De Luca S
* Cysteine Co-Oxidation Process Driven By Native Peptide Folding: An Example On Her2 Receptor Model System (371 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2014; 46(5): 1197-1206.
Impact Factor: 3.293
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Bellia F, GrassoG
* The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme (579 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2014; 49(4): 274-279.
Impact Factor: 2.379
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Correale S, Esposito C, Pirone L, Vitagliano L, Di Gaetano S, Pedone E
* A biophysical characterization of the folded domains of KCTD12: insights into interaction with the GABA(B2) receptor (392 views)
Journal Of Molecular Recognition (ISSN: 0952-3499, 0952-2349), 2013 Oct; 26(10): 488-495.
Impact Factor: 2.337
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Balasco N, Esposito L, De Simone A, Vitagliano L
* Role of loops connecting secondary structure elements in the stabilization of proteins isolated from thermophilic organisms (353 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2013 Jul; 22(7): 1016-1023.
Impact Factor: 2.861
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Pennacchio A, Sannino V, Sorrentino G, Rossi M, Raia CA, Esposito L
* Biochemical and structural characterization of recombinant short-chain NAD(H)-dependent dehydrogenase/reductase from Sulfolobus acidocaldarius highly enantioselective on diaryl diketone benzil (393 views)
Appl Microbiol Biot (ISSN: 0175-7598), 2013 May; 97(9): 1-16.
Impact Factor: 3.811
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Carotenuto M, Pedone E, Diana D, de Antonellis P, Džeroski S, Marino N, Navas L, Di Dato V, Scoppettuolo MN, Cimmino F, Correale S, Pirone L, Monti SM, Bruder E, Zenko B, Slavkov I, Pastorino F, Ponzoni M, Schulte JH, Schramm A, Eggert A, Westermann F, Arrigoni G, Accordi B, Basso G, Saviano M, Fattorusso R, Zollo M
* Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction (507 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2013 Mar 1; 3: 1351-1351.
Impact Factor: 5.078
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Balasco N, Esposito L, De Simone A, Vitagliano L
* FOR the RECORD: Role of loops connecting secondary structure elements in the stabilization of proteins isolated from thermophilic organisms (620 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2013; 22(7): 1016-1023.
Impact Factor: 2.861
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Tamburino R, Severino V, Sandomenico A, Ruvo M, Parente A, Chambery A, Di Maro A
* De novo sequencing and characterization of a novel Bowman-Birk inhibitor from Lathyrus sativus L. seeds by electrospray mass spectrometry (385 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051linking, 1742-2051electronic), 2012 Oct 30; 8(12): 3232-3241.
Impact Factor: 3.35
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Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G
* Multiple binding modes of inhibitors to carbonic anhydrases: How to design specific drugs targeting 15 different isoforms? (462 views)
Chem Rev (ISSN: 0009-2665), 2012 Sep; 112(8): 4421-4468.
Impact Factor: 41.298
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Monfregola L, Leone M, Calce E, de Luca S
* Postsynthetic modification of peptides via chemoselective N-alkylation of their side chains (468 views)
Org Lett (ISSN: 1523-7060, 1523-7052, 1523-7052electronic), 2012 Apr 6; 14(7): 1664-1667.
Impact Factor: 6.142
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Andreotti G, Citro V, De Crescenzo A, Orlando P, Cammisa M, Correra A, Cubellis MV
* Therapy of Fabry disease with pharmacological chaperones: from in silico predictions to in vitro tests (1698 views)
Orphanet Journal Of Rare Diseases (ISSN: 1750-1172), 2011 Oct 17; 6: 66-66.
Impact Factor: 5.074
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Kállay C, Dávid A, Timári S, Nagy EM, Sanna D, Garribba E, Micera G, De Bona P, Pappalardo G, Rizzarelli E, Sóvágó I
* Copper(II) complexes of rat amylin fragments (360 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2011 Oct 14; 40(38): 9711-9721.
Impact Factor: 3.838
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Correale S, Pirone L, Di Marcotullio L, De Smaele E, Greco A, Mazzà D, Moretti M, Alterio V, Vitagliano L, Di Gaetano S, Gulino A, Pedone E
* Molecular organization of the cullin E3 ligase adaptor KCTD11 (568 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Apr; 93(4): 715-724.
Impact Factor: 3.022
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Travaglia A, Arena G, Fattorusso R, Isernia C, La Mendola D, Malgieri G, Nicoletti VG, Rizzarelli E
* The inorganic perspective of nerve growth factor: interactions of Cu2+ and Zn2+ with the N-terminus fragment of nerve growth factor encompassing the recognition domain of the TrkA receptor (499 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Mar 21; 17(13): 3726-3738.
Impact Factor: 5.925
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Ruggiero A, Squeglia F, Pirone L, Correale S, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a major fragment of the resuscitation-promoting factor RpfB from Mycobacterium tuberculosis (408 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2011 Jan 1; 67(1): 164-168.
Impact Factor: 0.506
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Milardi D, Sciacca MFM, Pappalardo M, Grasso DM, La Rosa C
* The Role Of Aromatic Side-Chains In Amyloid Growth And Membrane Interaction Of The Islet Amyloid Polypeptide Fragment Lanflvh (458 views)
Eur Biophys J, 2011 Jan; 40(1): 1-12.
Impact Factor: 3.832
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Castellano I, Di Salle A, Merlino A, Rossi M, La Cara F
* Gene cloning and protein expression of γ-glutamyltranspeptidases from Thermus thermophilus and Deinococcus radiodurans: Comparison of molecular and structural properties with mesophilic counterparts (347 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2011; 15(2): 259-270.
Impact Factor: 2.941
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Varriale S, Merlino A, Coscia MR, Mazzarella L, Oreste U
* An evolutionary conserved motif is responsible for Immunoglobulin heavy chain packing in the B cell membrane (497 views)
Molecular Phylogenetics And Evolution (ISSN: 1055-7903), 2010 Dec; 57(3): 1238-1244.
Impact Factor: 3.889
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Stanzione F, Esposito L, Paladino A, Pedone C, Morelli G, Vitagliano L
* Role of the conformational versatility of the neurotrophin N-terminal regions in their recognition by Trk receptors (515 views)
Biophysical Journal (ISSN: 1542-0086, 0006-3495), 2010 Oct 6; 99(7): 2273-2278.
Impact Factor: 4.218
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Alterio V, Monti SM, Truppo E, Pedone C, Supuran CT, De Simone G
* The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: The carbonic anhydrase I-topiramate complex (448 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2010 Sep 7; 8(15): 3528-3533.
Impact Factor: 3.451
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Tosco A, Monti MC, Fontanella B, Montefusco S, D'Andrea LD, Ziaco B, Baldantoni D, Rio MC, Marzullo L
* Copper binds the carboxy-terminus of trefoil protein 1 (TFF1), favoring its homodimerization and motogenic activity (1356 views)
Cell Mol Life Sci (ISSN: 1420-9071electronic, 1420-682xlinking), 2010 Jun; 67(11): 1943-1955.
Impact Factor: 7.047
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Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone E, Gallinari P, Giorgi A, Steinkuhler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A
* Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation (688 views)
Nature Cell Biol Nature Cell Biology (ISSN: 1476-4679, 1465-7392), 2010 Feb; 12(2): 132-142.
Impact Factor: 19.407
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Palmieri G, Langella E, Gogliettino M, Saviano M, Pocsfalvi G, Rossi M
* A novel class of protease targets of phosphatidylethanolamine-binding proteins (PEBP): A study of the acylpeptide hydrolase and the PEBP inhibitor from the archaeon Sulfolobus solfataricus (378 views)
Mol Biosyst (ISSN: 1742-206x), 2010; 6(12): 2498-2507.
Impact Factor: 3.825
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Scir A, Pedone E, Ausili A, Saviano M, Baldassarre M, Bertoli E, Bartolucci S, Tanfani F
* High hydrostatic pressure-induced conformational changes in protein disulfide oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus. A Fourier-transform infrared spectroscopic study (347 views)
Molecular Biosystems (ISSN: 1742-206x), 2010; 6(10): 2015-2022.
Impact Factor: 3.825
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Faiella M, Andreozzi C, de Rosales RT, Pavone V, Maglio O, Nastri F, DeGrado WF, Lombardi A
* An artificial di-iron oxo-protein with phenol oxidase activity (433 views)
Nat Chem Biol (ISSN: 1552-4450), 2009 Dec; 5(12): 882-884.
Impact Factor: 16.058
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Damante CA, Osz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* Metal Loading Capacity Of Abeta N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Zinc (ii) Complexes With Abeta (1-16), Its Short Or Mutated Peptide Fragments And Its Polyethylene Glycol-Ylated Analogue (611 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 Nov 2; 48(21): 10405-10415.
Impact Factor: 4.657
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Marasco D, Stilo R, Sandomenico A, Monti SM, Tizzano B, De Capua A, Varricchio E, Liguoro D, Zotti T, Formisano S, Ruvo M, Vito P
* Generation And Functional Characterization Of A Bcl10-Inhibitory Peptide That Represses Nf-Kappa B Activation (602 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2009 Sep 15; 422(3): 553-561.
Impact Factor: 5.155
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Pietropaolo A, Muccioli L, Zannoni C, Rizzarelli E
* Conformational preferences of the full chicken prion protein in solution and its differences with respect to mammals (407 views)
Chemphyschem (ISSN: 1439-7641, 1439-4235, 1439-7641electronic), 2009 Jul 13; 10(9-10): 1500-1510.
Impact Factor: 3.453
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Ruggiero A, Lanzotti MA, Ruocco MR, Grimaldi P, Marasco D, Arcari P, Masullo M, Zagari A, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of two dimeric hyperthermostable thioredoxins isolated from Sulfolobus solfataricus (337 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2009 Jun; 65: 604-607.
Impact Factor: 0.551
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Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Del Vecchio L, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M
* MicroRNA-199b-5p Impairs Cancer Stem Cells through Negative Regulation of HES1 in Medulloblastoma (442 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Mar 24; 4(3): e4998-e4998.
Impact Factor: 4.351
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Calvanese L, Saporito A, Oliva R, D'Auria G, Pedone C, Paolillo L, Ruvo M, Marasco D, Falcigno L
* Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor (489 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 175-183.
Impact Factor: 1.807
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Palmieri G, Catara G, Saviano M, Langella E, Gogliettino M, Rossi M
* First archaeal PEPB-serine protease inhibitor from sulfolobus solfataricus with noncanonical amino acid sequence in the reactive-site loop (399 views)
J Proteome Res (ISSN: 1535-3893), 2009 Jan; 8(1): 327-334.
Impact Factor: 5.132
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Viparelli F, Doti N, Monti SM, Marasco D, Dathan N, Pedone C, Miele C, Formisano P, Beguinot F, Ruvo M
* Peptide antagonists of the PED-hPLD1 binding (354 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print, 0065-2598linking), 2009; 611: 445-446.
Impact Factor: 2.02
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Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (562 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
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Galdiero S, Vitiello M, D'Isanto M, Falanga A, Cantisani M, Browne H, Pedone C, Galdiero M
* The identification and characterization of fusogenic domains in herpes virus glycoprotein B molecules (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2008 Mar 25; 9(5): 758-767.
Impact Factor: 3.322
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Hilvo M, Innocenti A, Monti SM, De Simone G, Supuran CT, Parkkila S
* Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV (497 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008; 14(7): 672-678.
Impact Factor: 4.399
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Diana D, Ziaco B, Colombo G, Scarabelli G, Romanelli A, Fedone C, Fattorusso R, D'Andrea LD
* Structural determinants of the unusual helix stability of a de novo engineered vascular endothelial growth factor (VEGF) mimicking peptide (470 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2008; 14(14): 4164-4166.
Impact Factor: 5.454
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Malgieri G, Russo L, Esposito S, Baglivo I, Zaccaro L, Pedone EM, Di Blasio B, Isernia C, Pedone PV, Fattorusso R
* The Prokaryotic Cys2his2 Zinc Finger Domain Adopts A Novel Fold As Revealed By The Solution Structure Of Agrobacterium Tumefaciens Ros Dna Binding Domain (480 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2007 Oct 30; 104(44): 17341-17346.
Impact Factor: 9.598
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Ruggiero A, Tizzano B, Geerlof A, Pedone E, Pedone C, Wilmanns M, Berisio R
* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis (389 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2007 Oct 1; 63(10): 870-873.
Impact Factor: 0.645
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Galdiero S, Falanga A, Vitiello M, D'Isanto M, Collins C, Orrei V, Browne H, Pedone C, Galdiero M
* Evidence for a role of the membrane-proximal region of herpes simplex virus type 1 glycoprotein H in membrane fusion and virus inhibition (617 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 885-895.
Impact Factor: 3.446
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De Pinto V, Tomasello F, Messina A, Guarino F, Benz R, La Mendola D, Magrì A, Milardi D, Pappalardo G
* Determination of the conformation of the human VDAC1 N-terminal peptide, a protein moiety essential for the functional properties of the pore (555 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 7; 8(7): 744-756.
Impact Factor: 3.446
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Bonomo RP, Pappalardo G, Rizzarelli E, Santoro AM, Tabbì G, Vagliasindi LI
* Nitrogen oxide interaction with copper complexes formed by small peptides belonging to the prion protein octa-repeat region (592 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2007 Apr 14; (14): 1400-1408.
Impact Factor: 3.212
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Pappalardo G, Milardi D, Magrì A, Attanasio F, Impellizzeri G, La Rosa C, Grasso D, Rizzarelli E
* Environmental factors differently affect human and rat IAPP: Conformational preferences and membrane interactions of IAPP17-29 peptide derivatives (655 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2007; 13(36): 10204-10215.
Impact Factor: 5.33
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Grasso D, Grasso G, Guantieri V, Impellizzeri G, La Rosa C, Milardi D, Micera G, Osz K, Pappalardo G, Rizzarelli E, Sanna D, Sovago I
* Environmental effects on a prion's helix II domain: copper(II) and membrane interactions with PrP180-193 and its analogues (432 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2005 Dec 23; 12(2): 537-547.
Impact Factor: 4.907
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Di Natale G, Grasso G, Impellizzeri G, La Mendola D, Micera G, Mihala N, Nagy Z, Osz K, Pappalardo G, Rigó V, Rizzarelli E, Sanna D, Sóvágó I
* Copper(II) interaction with unstructured prion domain outside the octarepeat region: Speciation, stability, and binding details of copper(II) complexes with PrP106-126 peptides (4139 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2005 Oct 3; 44(20): 7214-7225.
Impact Factor: 3.851
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Cucinotta V, Giuffrida A, Maccarrone G, Messina M, Puglisi A, Rizzarelli E, Vecchio G
* Coordination properties of 3-functionalized β-cyclodextrins. Thermodynamic stereoselectivity of copper(II) complexes of the A, B-diamino derivative and its exploitation in LECE (356 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2005 Sep 21; (16): 2731-2736.
Impact Factor: 3.003
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Rivieccio V, Mannini R, Concilio L, D'Auria S, Pedone C, Grimaldi G
* Expression, purification and partial characterization of the Krüppel-associated box (KRAB) from the human ZNF2 protein (362 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2005; 12(6): 527-532.
Impact Factor: 0.84
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Miralbell R, Lomax A, Cella L, Schneider U
* Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors (262 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2002 Nov 1; 54(3): 824-829.
Impact Factor: 3.756
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Menchise V, Corbier C, Didierjean C, Saviano M, Benedetti E, Jacquot JP, Aubry A
* Crystal structure of the wild-type and D30A mutant thioredoxin h of Chlamydomonas reinhardtii and implications for the catalytic mechanism (454 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2001 Oct 1; 359(1): 65-75.
Impact Factor: 4.326
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De Falco S, Ruvoletto MG, Verdoliva A, Ruvo M, Raucci A, Marino M, Senatore S, Cassani G, Alberti A, Pontisso P, Fassina G
* Cloning and Expression of a Novel Hepatitis B Virus-binding Protein from HepG2 Cells (626 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2001 Sep 28; 276(39): 36613-36623.
Impact Factor: 7.258
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Monti SM, Gallo M, Ferracane R, Borrelli RC, Ritieni A, Greco ML, Graniti A, Fogliano V
* Analysis of bacterial lipodepsipeptides by matrix-assisted laser desorption/ionisation time-of-flight and high-performance liquid chromatography with electrospray mass spectrometry (437 views)
Rapid Commun Mass Sp (ISSN: 0951-4198, 1097-0231electronic), 2001; 15(8): 623-628.
Impact Factor: 2.478
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Berisio R, Vitagliano L, Sorrentino G, Carotenuto L, Piccolo C, Mazzarella L, Zagari A
Effects of microgravity on the crystal quality of a collagen-like polypeptide (523 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2000 Jan; 56(1): 55-61.
Impact Factor: 3.067
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Aime S, Dastrù W, Gobetto R, Viale A
An NMR study of H(μ-H)Os3(CO)11 (371 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2000; 39(11): 2422-2425.
Impact Factor: 2.712
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Bonomo RP, Marchelli R, Tabbì G
Study of H2O2 interaction with copper(II) complexes with diamino-diamide type ligands, diastereoisomeric dipeptides, and tripeptides (513 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Nov 15; 60(3): 205-218.
Impact Factor: 1.342
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Saviano M, Rossi F, Filizola M, Di Blasio B, Pedone C
[Aib5, 6-D-Ala8]-cyclolinopeptide A, grown from a benzene/acetonitrile mixture (324 views)
Acta Crystallogr Sect C Cryst Struct Commun (ISSN: 0108-2701), 1995 Apr 15; 51: Pt-Pt.
Impact Factor: 0.459
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62 Records (58 excluding Abstracts).
Total impact factor: 295.309 (280.347 excluding Abstracts).
Total 5 year impact factor: 317.158 (301.085 excluding Abstracts).
Total impact factor: 295.309 (280.347 excluding Abstracts).
Total 5 year impact factor: 317.158 (301.085 excluding Abstracts).
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