Peripheral neurostimulation breaks the shuffling steps patterns in Parkinsonian gait: a double blind randomized longitudinal study with Automated Mechanical Peripheral Stimulation
Peripheral neurostimulation breaks the shuffling steps patterns in Parkinsonian gait: a double blind randomized longitudinal study with Automated Mechanical Peripheral Stimulation(313 views) Galli M, Vicidomini C, Rozin Kleiner AF, Vacca L, Cimolin V, Condoluci C, Stocchi F, De Pandis MF
Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy - manuela.galli@polimi.it.
Biostructure and Bioimaging Institute (IBB), National Research Council (CNR), Naples, Italy.
San Raffaele Cassino Hospital, Tosinvest Sanità, Cassino, Italy.
Casa Cura Policlinico (CCP), Milan, Italy.
IRCCS San Raffaele Pisana, Tosinvest Sanità, Rome, Italy.
References: Not available.
Peripheral neurostimulation breaks the shuffling steps patterns in Parkinsonian gait: a double blind randomized longitudinal study with Automated Mechanical Peripheral Stimulation
BACKGROUND:
The shuffling steps pattern is a
typical feature of gait in patients affected by Parkinson's Disease
(PD), which progressively reduces their quality of life, being related
to the risk of falls in this population. Recently, Automated Mechanical
Peripheral Stimulation (AMPS) was presented as an integrative
rehabilitative treatment based on peripheral stimulation able to improve
the gait spatiotemporal parameters in PD patients.
AIM:
To evaluate the effects of AMPS on shuffling steps pattern by analyzing the kinematic and spatio-temporal gait parameters.
DESIGN:
Double blind randomized longitudinal study.
SETTING:
Outpatients.
POPULATION:
PD patients.
METHODS:
In
this double blind randomized longitudinal study, 14 patients with PD
were treated with effective-AMPS (AMPS Group), while 14 PD patients were
treated with placebo-AMPS (SHAM Group); 32 healthy subjects were deemed
the control group (CG). A dedicated medical device (GondolaTM Medical
Technologies, Switzerland) was used to deliver both stimulations. Each
treatment session lasted about 15 minutes, including preparation
(approx. 10 to 13 minutes) and stimulation (approx. 2 minutes). All PD
patients were given six AMPS/SHAM treatments sessions, twice a week,
delivered during the off-levodopa phase, having withdrawn from
dopaminergic medication overnight. We evaluated spatio-temporal and
kinematic variables of gait with quantitative 3D-Gait Analysis as
follows: before and after the first intervention (acute phase), then
after the sixth session (long term phase).
RESULTS:
We
detected differences in all gait variables immediately after the first
session of AMPS treatment and again after the sixth stimulation session.
CONCLUSIONS:
AMPS
treatment changes the shuffling steps pattern that is typical of PD
subjects, increasing the ROM of hip, knee and ankle joints during the
gait cycle.
CLINICAL REHABILITATION IMPACT:
This data
present further evidence that a rehabilitative approach based on the
AMPS treatment can induce improvements in the gait pattern of patients
affected by PD.
Peripheral neurostimulation breaks the shuffling steps patterns in Parkinsonian gait: a double blind randomized longitudinal study with Automated Mechanical Peripheral Stimulation
Peripheral neurostimulation breaks the shuffling steps patterns in Parkinsonian gait: a double blind randomized longitudinal study with Automated Mechanical Peripheral Stimulation
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ * Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer(667 views) N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756. Impact Factor:59.558 ViewExport to BibTeXExport to EndNote