Striatonigral involvement in Fabry Disease: A quantitative and volumetric Magnetic Resonance Imaging study(244 views) Russo C, Pontillo G, Pisani A, Saccà F, Riccio E, Macera A, Rusconi G, Stanzione A, Borrelli P, Brescia Morra V, Tedeschi E, Brunetti A, Cocozza S, Palma G
Department of Advanced Biomedical Sciences, University "Federico II", Naples, Italy.
Department of Public Health, Nephrology Unit, University "Federico II", Naples, Italy.
Department of Neurosciences and Reproductive and Odontostomatological Sciences, University "Federico II", Naples, Italy.
IRCCS SDN, Naples, Italy.
Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy.
References: Not available.
Striatonigral involvement in Fabry Disease: A quantitative and volumetric Magnetic Resonance Imaging study
INTRODUCTION:
Aim of this study is to elucidate possible
mechanisms of extrapyramidal damage in Fabry Disease (FD), a condition
in which involvement of the motor system has been recently suggested, by
simultaneously assessing morphometric and susceptibility changes of
striatonigral pathway and their possible correlations with clinical
variables.
METHODS:
In this cross-sectional study, we
investigated possible differences in terms of Quantitative
Susceptibility Mapping (QSM) values and volumes of different
extrapyramidal relays, including striatum and substantia nigra (SN), in
30 FD patients (M/F = 11/19, mean age 42.6 ± 12.2) and 37 healthy
controls (HC) (M/F = 16/21, mean age 43.2 ± 14.6). Patients underwent a
clinical examination for the study of different motor functions, and the
relationship between MRI and clinical variables was tested using the
Spearman's coefficient.
RESULTS:
Compared to HC, FD
patients showed an increase in susceptibility values of the SN
(p < 0.001) and striatum (p = 0.001), while no difference emerged for
the other tested extrapyramidal structures, suggesting their relative
sparing. The increased susceptibility was coupled to a reduced volume of
the SN (p < 0.001), but not of the striatum (p = 0.34). Finally, no
significant correlation emerged when probing the relationship between
these modifications and the clinical variables.
CONCLUSION:
In
FD patients, susceptibility and volumetric alterations are present
throughout the extrapyramidal pathway, with the SN being particularly
affected by these changes. Such results are in line with the subtle
extrapyramidal involvement recently suggested in FD, and could further
contribute to the understanding of the physiopathological bases of
cerebral involvement in FD.
Striatonigral involvement in Fabry Disease: A quantitative and volumetric Magnetic Resonance Imaging study
Antonini A, Vitale C, Barone P, Cilia R, Righini A, Bonuccelli U, Abbruzzese G, Ramat S, Petrone A, Quatrale R, Marconi R, Ceravolo R, Stefani A, Lopiano L, Zappia M, Capus L, Morgante L, Tamma F, Tinazzi M, Colosimo C, Guerra UP, Valzania F, Fagioli G, Distefano A, Bagnato A, Feggi L, Anna S, Maria Teresa Rosaria De Cr, Nobili F, Mazzuca N, Baldari S, Eleopra R, Bestetti A, Benti R, Varrone A, Volterrani D, Massa R, Stocchi F, Schillaci O, Dore F, Zibetti M, Castellano G, Battista SG, Giorgetti G * The relationship between cerebral vascular disease and parkinsonism: The VADO study(602 views) Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2012; 18(6): 775-780. Impact Factor:3.274 ViewExport to BibTeXExport to EndNote
Malvindi MA, Greco A, Conversano F, Figuerola A, Corti M, Bonora M, Lascialfari A, Doumari HA, Moscardini M, Cingolani R, Gigli G, Casciaro S, Pellegrino T, Ragusa A * MR Contrast Agents(384 views) Small Animal Imaging, 2011 Jul 8; 21(13): 2548-2555. Impact Factor:1.784 ViewExport to BibTeXExport to EndNote
Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A * Tumor Imaging(446 views) Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309. Impact Factor:1.148 ViewExport to BibTeXExport to EndNote
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(896 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote