Grape pomace polyphenols improve insulin response to a standard meal in healthy individuals: a pilot study (286 views)
Clin Nutr (ISSN: 0261-5614linking), 2019 Dec; 38(6): 2727-2734.
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Paper type: Journal Article, Randomized Controlled Trial , Research Support, Non-U. S. Gov'T,
Impact factor: 0.5, 5-year impact factor: 4.581
Url: Not available.
Keywords: Adult , Blood Glucose Analysis Drug Effects Metabolism , Cross-Over Studies , Fruit And Vegetable Juices , Gallic Acid Blood , Humans , Insulin Blood Metabolism , Insulin Resistance Physiology , Male , Pilot Projects , Polyphenols Administration, Dosage Pharmacology , Triglycerides Blood Metabolism , Vitis Chemistry , Young Adult , Glucose Metabolism , Grape Polyphenols , Insulin Secretion , Insulin Sensitivity,
Affiliations:
*** IBB - CNR ***
Department of Clinical Medicine and Surgery, Federico II University of Naples, Via S. Pansini 5, 80131, Naples, Italy.
CNR-Institute of Biostructures and Bioimaging, Via Tommaso De Amicis, 95, 80131, Naples, Italy.
Department of Chemical Sciences, Federico II University of Naples, Via Cintia 21, 80126, Naples, Italy.
Metabolic Unit, CNR Institute of Neuroscience, Corso Stati Uniti 4, 35127, Padova, Italy.
Department of Food & Drugs, University of Parma, Via Volturno 39, 43125 Parma, Italy.
Department of Veterinary Science, University of Parma, Via Volturno 39, 43125 Parma, Italy
Microbiome Research Hub, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.
Institute of Food Science, National Research Council, Via Roma 64, 83100 Avellino, Italy.
References:
Not available.
Clin Nutr (ISSN: 0261-5614linking), 2019 Dec; 38(6): 2727-2734.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Randomized Controlled Trial , Research Support, Non-U. S. Gov'T,
Impact factor: 0.5, 5-year impact factor: 4.581
Url: Not available.
Keywords: Adult , Blood Glucose Analysis Drug Effects Metabolism , Cross-Over Studies , Fruit And Vegetable Juices , Gallic Acid Blood , Humans , Insulin Blood Metabolism , Insulin Resistance Physiology , Male , Pilot Projects , Polyphenols Administration, Dosage Pharmacology , Triglycerides Blood Metabolism , Vitis Chemistry , Young Adult , Glucose Metabolism , Grape Polyphenols , Insulin Secretion , Insulin Sensitivity,
Affiliations:
*** IBB - CNR ***
Department of Clinical Medicine and Surgery, Federico II University of Naples, Via S. Pansini 5, 80131, Naples, Italy.
CNR-Institute of Biostructures and Bioimaging, Via Tommaso De Amicis, 95, 80131, Naples, Italy.
Department of Chemical Sciences, Federico II University of Naples, Via Cintia 21, 80126, Naples, Italy.
Metabolic Unit, CNR Institute of Neuroscience, Corso Stati Uniti 4, 35127, Padova, Italy.
Department of Food & Drugs, University of Parma, Via Volturno 39, 43125 Parma, Italy.
Department of Veterinary Science, University of Parma, Via Volturno 39, 43125 Parma, Italy
Microbiome Research Hub, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.
Institute of Food Science, National Research Council, Via Roma 64, 83100 Avellino, Italy.
References:
Not available.
Grape pomace polyphenols improve insulin response to a standard meal in healthy individuals: a pilot study
BACKGROUND & AIMS: Dietary polyphenols have beneficial effects on glucose/lipid metabolism in subjects at high risk to develop type 2 diabetes; however, the underlying mechanisms are not clear. We aimed to evaluate: 1) the acute effects of the consumption of a drink rich in polyphenols from red grape pomace (RGPD) on glucose/insulin and triglyceride responses to a standard meal in healthy individuals, and, 2) the relationship between plasma levels of phenolic metabolites and metabolic parameters. METHODS: Twelve healthy men, aged 20-40 years participated in a randomized, controlled study according to a cross-over design. After a 3-day low-polyphenol diet, all participants consumed, on two different days and separated by a one week interval, after an overnight fast, a drink rich in polyphenols (1.562 g gallic acid equivalents (GAE)) or a control drink (CD, no polyphenols), followed after 3 h by a standard meal (960 kcal, 18% protein, 30% fat, 52% CHO). Blood samples were taken at fasting, 3 h after the drink, over 5 h after the standard meal and at fasting on the next day to measure plasma concentrations of glucose, insulin, triglyceride and phenolic metabolites. RESULTS: Glycemic and triglyceride post-meal responses were similar after both the RGPD and the control drink. In contrast, postprandial insulin incremental area (iAUC(0-5h)) was 31% lower (p < 0.05), insulin secretion index was 18% lower (p < 0.016) and insulin sensitivity (S(I)) index was 36% higher (p = 0.037) after the RGPD compared to CD. Among phenolic metabolites, gallic acid correlated inversely with the insulin response (r = -0.604; p = 0.032) and positively with the S(I) index (r = 0.588, p = 0.037). CONCLUSIONS: RGPD consumption acutely reduced postprandial insulin levels and improved insulin sensitivity. This effect could be likely related to the increase in gallic acid levels. This drink, added to usual diet, could contribute to increase the daily intake of polyphenols, with potential health benefits. CLINICALTRIALS. GOV IDENTIFIER: NCT02865278.
BACKGROUND & AIMS: Dietary polyphenols have beneficial effects on glucose/lipid metabolism in subjects at high risk to develop type 2 diabetes; however, the underlying mechanisms are not clear. We aimed to evaluate: 1) the acute effects of the consumption of a drink rich in polyphenols from red grape pomace (RGPD) on glucose/insulin and triglyceride responses to a standard meal in healthy individuals, and, 2) the relationship between plasma levels of phenolic metabolites and metabolic parameters. METHODS: Twelve healthy men, aged 20-40 years participated in a randomized, controlled study according to a cross-over design. After a 3-day low-polyphenol diet, all participants consumed, on two different days and separated by a one week interval, after an overnight fast, a drink rich in polyphenols (1.562 g gallic acid equivalents (GAE)) or a control drink (CD, no polyphenols), followed after 3 h by a standard meal (960 kcal, 18% protein, 30% fat, 52% CHO). Blood samples were taken at fasting, 3 h after the drink, over 5 h after the standard meal and at fasting on the next day to measure plasma concentrations of glucose, insulin, triglyceride and phenolic metabolites. RESULTS: Glycemic and triglyceride post-meal responses were similar after both the RGPD and the control drink. In contrast, postprandial insulin incremental area (iAUC(0-5h)) was 31% lower (p < 0.05), insulin secretion index was 18% lower (p < 0.016) and insulin sensitivity (S(I)) index was 36% higher (p = 0.037) after the RGPD compared to CD. Among phenolic metabolites, gallic acid correlated inversely with the insulin response (r = -0.604; p = 0.032) and positively with the S(I) index (r = 0.588, p = 0.037). CONCLUSIONS: RGPD consumption acutely reduced postprandial insulin levels and improved insulin sensitivity. This effect could be likely related to the increase in gallic acid levels. This drink, added to usual diet, could contribute to increase the daily intake of polyphenols, with potential health benefits. CLINICALTRIALS. GOV IDENTIFIER: NCT02865278.
Grape pomace polyphenols improve insulin response to a standard meal in healthy individuals: a pilot study
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Grape pomace polyphenols improve insulin response to a standard meal in healthy individuals: a pilot study
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* Effects Of Baked Products Enriched With N-3 Fatty Acids, Folates, β -Glucans, And Tocopherol In Patients With Mild Mixed Hyperlipidemia (679 views)
J Am Coll Nutr (ISSN: 1541-1087, 0731-5724), 2012 Oct; 31(5): 311-319.
Impact Factor: 1.738
View Export to BibTeX Export to EndNote
Giacco R, Clemente G, Cipriano D, Luongo D, Viscovo D, Patti L, Di Marino L, Giacco A, Naviglio D, Bianchi MA, Ciati R, Brighenti F, Rivellese AA, Riccardi G
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Nutrition (ISSN: 0939-4753, 1590-3729electronic), 2010 Mar; 20(3): 186-194.
Impact Factor: 3.438
View Export to BibTeX Export to EndNote
Giacco R, Clemente G, Luongo D, Lasorella G, Fiume I, Brouns F, Bornet F, Patti L, Cipriano P, Rivellese AA, Riccardi G
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Clin Nutr (ISSN: 0261-5614, 0261-5614linking), 2004 Jun; 23(3): 331-340.
Impact Factor: 2.019
View Export to BibTeX Export to EndNote
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Journal Of Hypertension (ISSN: 0263-6352), 1999 Dec; 17(12): 1759-1766.
Impact Factor: 3.039
View Export to BibTeX Export to EndNote
Morisco C, Cuocolo A, Romano M, Nappi A, Iaccarino G, Volpe M, Salvatore M, Trimarco B
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Am J Cardiol (ISSN: 0002-9149), 1996 Mar 1; 77(7): 480-485.
Impact Factor: 2.402
View Export to BibTeX Export to EndNote
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6 Records (5 excluding Abstracts).
Total impact factor: 14.636 (12.636 excluding Abstracts).
Total 5 year impact factor: 29.597 (19.051 excluding Abstracts).
Total impact factor: 14.636 (12.636 excluding Abstracts).
Total 5 year impact factor: 29.597 (19.051 excluding Abstracts).
286 views. Last view on Monday 07 October 2024, 1:45:20
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