Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors
Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors(339 views) Angapelly S, Ramya PVS, Angeli A, Monti SM, Buonanno M, Alvala M, Supuran CT, Arifuddin M
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2017; 25(2): 539-544.
Keywords: Carbonic Anhydrase, Isoform Ca I, Vii, Sulfonamide, β-Lactam, 4 Sulfamoylphenyl Beta Lactam Derivative, Acetazolamide, Benzenesulfonamide Derivative, Carbonate Dehydratase, Carbonate Dehydratase I Inhibitor, Carbonate Dehydratase Ii Inhibitor, Carbonate Dehydratase Inhibitor, Carbonate Dehydratase Iv Inhibitor, Carbonate Dehydratase Vii, Carbonate Dehydratase Vii Inhibitor, Schiff Base, Unclassified Drug, Isoenzyme, Article, Chemical Reaction, Concentration Response, Controlled Study, Drug Potency, Drug Synthesis, Drug Targeting, Edema, Enzyme Inhibition, Eye Disease, Glaucoma, Neuropathic Pain, Protein Function, Retinitis Pigmentosa, Staudinger Cycloaddition Reaction, Structure Activity Relation, Antagonists And Inhibitors, Chemical Structure, Chemistry, Dose Response, Drug Development, Human, Metabolism, Carbonic Anhydrase Inhibitors, Dose-Response Relationship, Drug Discovery, Molecular Structure, Structure-Activity Relationship,
Affiliations: *** IBB - CNR ***
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Department of Pharmaceuticals, Ministry of Chemicals & Fertilizers, Govt of India, Balanagar, Hyderabad, 500037, India
Neurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, Università degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy
Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, Napoli, 80134, Italy
Molecular Modeling Facility, Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Department of Pharmaceuticals, Ministry of Chemicals & Fertilizers, Govt. of India, Balanagar, Hyderabad, 500037, India
References: Not available.
Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors
Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors
Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors