Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity(341 views) Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
Keywords: 5 Methoxyflavone, Amyloid Beta Protein[1-42], Cyclin A2, Dna Directed Dna Polymerase Beta, Flavone Derivative, Neuroprotective Agent, Nucleotidyltransferase Inhibitor, Oleanolic Acid, Unclassified Drug, Zalcitabine, 5-Methoxyflavone, Enzyme Inhibitor, Apoptosis, Article, Cell Cycle G2 Phase, Cell Cycle Progression, Cell Cycle S Phase, Cell Viability, Conformational Transition, Controlled Study, Dna Replication, Embryo, Enzyme Inhibition, Human, Human Cell, Hydrogen Bond, Hydrophobicity, In Vitro Study, Molecular Docking, Mouse, Nerve Cell Culture, Nerve Cell Necrosis, Nonhuman, Protein Expression, Alzheimer Disease, Antagonists And Inhibitors, Cell Death, Cell Division, Chemical Structure, Chemistry, Drug Effects, Metabolism, Parkinson Disease, Pathology, Molecular Structure,
Affiliations: *** IBB - CNR ***
Department of Biomedical and Biotechnological Sciences, Catania, Italy
Department of Drug Sciences, University of Catania, Catania, Italy
Institute of Biostructure and Bioimaging, National Research Council (CNR), Catania, Italy
References: Not available.
Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity