Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (323 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.662, 5-year impact factor: 3.644
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84948823181&doi=10.1021%2facs.jnatprod.5b00621&partnerID=40&md5=5888f4cb204268bac659d6e8042fab6f
Keywords: 5 Methoxyflavone, Amyloid Beta Protein[1-42], Cyclin A2, Dna Directed Dna Polymerase Beta, Flavone Derivative, Neuroprotective Agent, Nucleotidyltransferase Inhibitor, Oleanolic Acid, Unclassified Drug, Zalcitabine, 5-Methoxyflavone, Enzyme Inhibitor, Apoptosis, Article, Cell Cycle G2 Phase, Cell Cycle Progression, Cell Cycle S Phase, Cell Viability, Conformational Transition, Controlled Study, Dna Replication, Embryo, Enzyme Inhibition, Human, Human Cell, Hydrogen Bond, Hydrophobicity, In Vitro Study, Molecular Docking, Mouse, Nerve Cell Culture, Nerve Cell Necrosis, Nonhuman, Protein Expression, Alzheimer Disease, Antagonists And Inhibitors, Cell Death, Cell Division, Chemical Structure, Chemistry, Drug Effects, Metabolism, Parkinson Disease, Pathology, Molecular Structure,
Affiliations:
*** IBB - CNR ***
Department of Biomedical and Biotechnological Sciences, Catania, Italy
Department of Drug Sciences, University of Catania, Catania, Italy
Institute of Biostructure and Bioimaging, National Research Council (CNR), Catania, Italy
References:
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Walsh, D.M., Selkoe, D.J., (2007) J. Neurochem., 101, pp. 1172-1184
Copani, A., Guccione, S., Giurato, L., Caraci, F., Calafiore, M., Sortino, M.A., Nicoletti, F., (2008) Curr. Med. Chem., 15, pp. 2420-2432
Lopes, J.P., Oliveira, C.R., Agostinho, P., (2009) Curr. Alzheimer Res., 6, pp. 205-212
Herrup, K., Neve, R., Ackerman, S.L., Copani, A., (2004) J. Neurosci., 24, pp. 9232-9239
Arendt, T., (2012) Mol. Neurobiol., 46, pp. 125-135
Zhang, Z., Zhang, Z., Wang, H., Zhang, G., Hu, D., Xiong, J., Xiong, N., Mao, L., (2014) PLoS One, 9, p. e106669
Hoglinger, G.U., Breunig, J.J., Depboylu, C., Rouaux, C., Michel, P.P., Alvarez-Fischer, D., Boutillier, A.L., Hunot, S., (2007) Proc. Natl. Acad. Sci. U. S. A., 104, pp. 3585-3590
Husseman, J.W., Nochlin, D., Vincent, I., (2000) Neurobiol. Aging, 21, pp. 815-828
Ranganathan, S., Scudiere, S., Bowser, R., (2001) J. Alzheimers Dis., 3, pp. 377-385
Nagy, Z., Esiri, M.M., (1998) Exp. Neurol., 150, pp. 240-247
Busser, J., Geldmacher, D.S., Herrup, K., (1998) J. Neurosci., 18, pp. 2801-2807
Yang, Y., Varvel, N.H., Lamb, B.T., Herrup, K., (2006) J. Neurosci., 26, pp. 775-784
Esteras, N., Bartolome, F., Alquezar, C., Antequera, D., Munoz, U., Carro, E., Martin-Requero, A., (2012) Eur. J. Neurosci., 36, pp. 2609-2618
Copani, A., Melchiorri, D., Caricasole, A., Martini, F., Sale, P., Carnevale, R., Gradini, R., Nicoletti, F., (2002) J. Neurosci., 22, pp. 3963-3968
Giovanni, A., Wirtz-Brugger, F., Keramaris, E., Slack, R., Park, D.S., (1999) J. Biol. Chem., 274, pp. 19011-19016
Sweasy, J.B., Loeb, L.A., (1992) J. Biol. Chem., 267, pp. 1407-1410
Siegel, R.L., Kalf, G.F., (1982) J. Biol. Chem., 257, pp. 1785-1790
Copani, A., Sortino, M.A., Caricasole, A., Chiechio, S., Chisari, M., Battaglia, G., Giuffrida-Stella, A.M., Nicoletti, F., (2002) FASEB J., 16, pp. 2006-2008
Copani, A., Hoozemans, J.J., Caraci, F., Calafiore, M., Van Haastert, E.S., Veerhuis, R., Rozemuller, A.J., Nicoletti, F., (2006) J. Neurosci., 26, pp. 10949-10957
Barakat, K.H., Gajewski, M.M., Tuszynski, J.A., (2012) Drug Discovery Today, 17, pp. 913-920
Vinter, J.G., (1994) J. Comput.-Aided Mol. Des., 8, pp. 653-668
Hu, H.Y., Horton, J.K., Gryk, M.R., Prasad, R., Naron, J.M., Sun, D.A., Hecht, S.M., Mullen, G.P., (2004) J. Biol. Chem., 279, pp. 39736-39744
Gao, Z., Maloney, D.J., Dedkova, L.M., Hecht, S.M., (2008) Bioorg. Med. Chem., 16, pp. 4331-4340
Mizushina, Y., Ohkubo, T., Sugawara, F., Sakaguchi, K., (2000) Biochemistry, 39, pp. 12606-12613
Lambert, M.P., Barlow, A.K., Chromy, B.A., Edwards, C., Freed, R., Liosatos, M., Morgan, T.E., Klein, W.L., (1998) Proc. Natl. Acad. Sci. U. S. A., 95, pp. 6448-6453
Cho, S.O., Ban, J.Y., Kim, J.Y., Jeong, H.Y., Lee, I.S., Song, K.-S., Bae, K., Seong, Y.H., (2009) J. Pharmacol. Sci., 111, pp. 22-32
Singh, M., Kaur, M., Silakari, O., (2014) Eur. J. Med. Chem., 84, pp. 206-239
Yam, C.H., Fung, T.K., Poon, R.Y., (2002) Cell. Mol. Life Sci., 59, pp. 1317-1326
Sheaff, R., Ilsley, D., Kuchta, R., (1991) Biochemistry, 30, pp. 8590-8597
Marcaurelle, L.A., Johannes, C.W., (2008) Cell. Mol. Life Sci., 66 (187), pp. 189-216
Dajas, F., Andres, A.C., Florencia, A., Carolina, E., Felicia, R.M., (2013) Cent. Nerv. Syst. Agents Med. Chem., 13, pp. 30-35
Walle, T., Ta, N., Kawamori, T., Wen, X., Tsuji, P.A., Walle, U.K., (2007) Biochem. Pharmacol., 73, pp. 1288-1296
Vauzour, D., Vafeiadou, K., Rodriguez-Mateos, A., Rendeiro, C., Spencer, J.P., (2008) Genes Nutr., 3, pp. 115-126
Wudtiwai, B., Sripanidkulchai, B., Kongtawelert, P., Banjerdpongchai, R., (2011) J. Hematol. Oncol., 4, p. 52
Calderone, V., Chericoni, S., Martinelli, C., Testai, L., Nardi, A., Morelli, I., Breschi, M.C., Martinotti, E., (2004) Naunyn-Schmiedeberg's Arch. Pharmacol., 370, pp. 290-298
Ares, J.J., Outt, P.E., Randall, J.L., Murray, P.D., Weisshaar, P.S., O'Brien, L.M., Ems, B.L., Kershaw, W.C., (1995) J. Med. Chem., 38, pp. 4937-4943
Blank, M.A., Ems, B.L., O'Brien, L.M., Weisshaar, P.S., Ares, J.J., Abel, P.W., McCafferty, D.M., Wallace, J.L., (1997) Digestion, 58, pp. 147-154
Haddad, A.Q., Venkateswaran, V., Viswanathan, L., Teahan, S.J., Fleshner, N.E., Klotz, L.H., (2006) Prostate Cancer Prostatic Dis., 9, pp. 68-76
Goellner, E.M., Svilar, D., Almeida, K.H., Sobol, R.W., (2012) Curr. Mol. Pharmacol., 5, pp. 68-87
Luo, Q., Lai, Y., Liu, S., Wu, M., Liu, Y., Zhang, Z., (2012) Environ. Mol. Mutagen., 53, pp. 325-333
Sykora, P., Misiak, M., Wang, Y., Ghosh, S., Leandro, G.S., Liu, D., Tian, J., Bohr, V.A., (2015) Nucleic Acids Res., 43, pp. 943-959
Garcia-Diaz, M., Bebenek, K., Sabariegos, R., Dominguez, O., Rodriguez, J., Kirchhoff, T., Garcia-Palomero, E., Blanco, L., (2002) J. Biol. Chem., 277, pp. 13184-13191
Sobol, R.W., (2007) DNA Repair, 6, pp. 3-7
Cheeseright, T., MacKey, M., Rose, S., Vinter, A., (2006) J. Chem. Inf. Model., 46, pp. 665-676
Irwin, J.J., Shoichet, B.K., (2005) J. Chem. Inf. Model., 45, pp. 177-182
Thomsen, R., Christensen, M.H., (2006) J. Med. Chem., 49, pp. 3315-3321
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., (1999) FASEB J., 13, pp. 2225-2234
Sobol, R.W., Horton, J.K., Kuhn, R., Gu, H., Singhal, R.K., Prasad, R., Rajewsky, K., Wilson, S.H., (1996) Nature, 379, pp. 183-186
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.662, 5-year impact factor: 3.644
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84948823181&doi=10.1021%2facs.jnatprod.5b00621&partnerID=40&md5=5888f4cb204268bac659d6e8042fab6f
Keywords: 5 Methoxyflavone, Amyloid Beta Protein[1-42], Cyclin A2, Dna Directed Dna Polymerase Beta, Flavone Derivative, Neuroprotective Agent, Nucleotidyltransferase Inhibitor, Oleanolic Acid, Unclassified Drug, Zalcitabine, 5-Methoxyflavone, Enzyme Inhibitor, Apoptosis, Article, Cell Cycle G2 Phase, Cell Cycle Progression, Cell Cycle S Phase, Cell Viability, Conformational Transition, Controlled Study, Dna Replication, Embryo, Enzyme Inhibition, Human, Human Cell, Hydrogen Bond, Hydrophobicity, In Vitro Study, Molecular Docking, Mouse, Nerve Cell Culture, Nerve Cell Necrosis, Nonhuman, Protein Expression, Alzheimer Disease, Antagonists And Inhibitors, Cell Death, Cell Division, Chemical Structure, Chemistry, Drug Effects, Metabolism, Parkinson Disease, Pathology, Molecular Structure,
Affiliations:
*** IBB - CNR ***
Department of Biomedical and Biotechnological Sciences, Catania, Italy
Department of Drug Sciences, University of Catania, Catania, Italy
Institute of Biostructure and Bioimaging, National Research Council (CNR), Catania, Italy
References:
Selkoe, D.J., (2001) Physiol. Rev., 81, pp. 741-76
Walsh, D.M., Selkoe, D.J., (2007) J. Neurochem., 101, pp. 1172-1184
Copani, A., Guccione, S., Giurato, L., Caraci, F., Calafiore, M., Sortino, M.A., Nicoletti, F., (2008) Curr. Med. Chem., 15, pp. 2420-2432
Lopes, J.P., Oliveira, C.R., Agostinho, P., (2009) Curr. Alzheimer Res., 6, pp. 205-212
Herrup, K., Neve, R., Ackerman, S.L., Copani, A., (2004) J. Neurosci., 24, pp. 9232-9239
Arendt, T., (2012) Mol. Neurobiol., 46, pp. 125-135
Zhang, Z., Zhang, Z., Wang, H., Zhang, G., Hu, D., Xiong, J., Xiong, N., Mao, L., (2014) PLoS One, 9, p. e106669
Hoglinger, G.U., Breunig, J.J., Depboylu, C., Rouaux, C., Michel, P.P., Alvarez-Fischer, D., Boutillier, A.L., Hunot, S., (2007) Proc. Natl. Acad. Sci. U. S. A., 104, pp. 3585-3590
Husseman, J.W., Nochlin, D., Vincent, I., (2000) Neurobiol. Aging, 21, pp. 815-828
Ranganathan, S., Scudiere, S., Bowser, R., (2001) J. Alzheimers Dis., 3, pp. 377-385
Nagy, Z., Esiri, M.M., (1998) Exp. Neurol., 150, pp. 240-247
Busser, J., Geldmacher, D.S., Herrup, K., (1998) J. Neurosci., 18, pp. 2801-2807
Yang, Y., Varvel, N.H., Lamb, B.T., Herrup, K., (2006) J. Neurosci., 26, pp. 775-784
Esteras, N., Bartolome, F., Alquezar, C., Antequera, D., Munoz, U., Carro, E., Martin-Requero, A., (2012) Eur. J. Neurosci., 36, pp. 2609-2618
Copani, A., Melchiorri, D., Caricasole, A., Martini, F., Sale, P., Carnevale, R., Gradini, R., Nicoletti, F., (2002) J. Neurosci., 22, pp. 3963-3968
Giovanni, A., Wirtz-Brugger, F., Keramaris, E., Slack, R., Park, D.S., (1999) J. Biol. Chem., 274, pp. 19011-19016
Sweasy, J.B., Loeb, L.A., (1992) J. Biol. Chem., 267, pp. 1407-1410
Siegel, R.L., Kalf, G.F., (1982) J. Biol. Chem., 257, pp. 1785-1790
Copani, A., Sortino, M.A., Caricasole, A., Chiechio, S., Chisari, M., Battaglia, G., Giuffrida-Stella, A.M., Nicoletti, F., (2002) FASEB J., 16, pp. 2006-2008
Copani, A., Hoozemans, J.J., Caraci, F., Calafiore, M., Van Haastert, E.S., Veerhuis, R., Rozemuller, A.J., Nicoletti, F., (2006) J. Neurosci., 26, pp. 10949-10957
Barakat, K.H., Gajewski, M.M., Tuszynski, J.A., (2012) Drug Discovery Today, 17, pp. 913-920
Vinter, J.G., (1994) J. Comput.-Aided Mol. Des., 8, pp. 653-668
Hu, H.Y., Horton, J.K., Gryk, M.R., Prasad, R., Naron, J.M., Sun, D.A., Hecht, S.M., Mullen, G.P., (2004) J. Biol. Chem., 279, pp. 39736-39744
Gao, Z., Maloney, D.J., Dedkova, L.M., Hecht, S.M., (2008) Bioorg. Med. Chem., 16, pp. 4331-4340
Mizushina, Y., Ohkubo, T., Sugawara, F., Sakaguchi, K., (2000) Biochemistry, 39, pp. 12606-12613
Lambert, M.P., Barlow, A.K., Chromy, B.A., Edwards, C., Freed, R., Liosatos, M., Morgan, T.E., Klein, W.L., (1998) Proc. Natl. Acad. Sci. U. S. A., 95, pp. 6448-6453
Cho, S.O., Ban, J.Y., Kim, J.Y., Jeong, H.Y., Lee, I.S., Song, K.-S., Bae, K., Seong, Y.H., (2009) J. Pharmacol. Sci., 111, pp. 22-32
Singh, M., Kaur, M., Silakari, O., (2014) Eur. J. Med. Chem., 84, pp. 206-239
Yam, C.H., Fung, T.K., Poon, R.Y., (2002) Cell. Mol. Life Sci., 59, pp. 1317-1326
Sheaff, R., Ilsley, D., Kuchta, R., (1991) Biochemistry, 30, pp. 8590-8597
Marcaurelle, L.A., Johannes, C.W., (2008) Cell. Mol. Life Sci., 66 (187), pp. 189-216
Dajas, F., Andres, A.C., Florencia, A., Carolina, E., Felicia, R.M., (2013) Cent. Nerv. Syst. Agents Med. Chem., 13, pp. 30-35
Walle, T., Ta, N., Kawamori, T., Wen, X., Tsuji, P.A., Walle, U.K., (2007) Biochem. Pharmacol., 73, pp. 1288-1296
Vauzour, D., Vafeiadou, K., Rodriguez-Mateos, A., Rendeiro, C., Spencer, J.P., (2008) Genes Nutr., 3, pp. 115-126
Wudtiwai, B., Sripanidkulchai, B., Kongtawelert, P., Banjerdpongchai, R., (2011) J. Hematol. Oncol., 4, p. 52
Calderone, V., Chericoni, S., Martinelli, C., Testai, L., Nardi, A., Morelli, I., Breschi, M.C., Martinotti, E., (2004) Naunyn-Schmiedeberg's Arch. Pharmacol., 370, pp. 290-298
Ares, J.J., Outt, P.E., Randall, J.L., Murray, P.D., Weisshaar, P.S., O'Brien, L.M., Ems, B.L., Kershaw, W.C., (1995) J. Med. Chem., 38, pp. 4937-4943
Blank, M.A., Ems, B.L., O'Brien, L.M., Weisshaar, P.S., Ares, J.J., Abel, P.W., McCafferty, D.M., Wallace, J.L., (1997) Digestion, 58, pp. 147-154
Haddad, A.Q., Venkateswaran, V., Viswanathan, L., Teahan, S.J., Fleshner, N.E., Klotz, L.H., (2006) Prostate Cancer Prostatic Dis., 9, pp. 68-76
Goellner, E.M., Svilar, D., Almeida, K.H., Sobol, R.W., (2012) Curr. Mol. Pharmacol., 5, pp. 68-87
Luo, Q., Lai, Y., Liu, S., Wu, M., Liu, Y., Zhang, Z., (2012) Environ. Mol. Mutagen., 53, pp. 325-333
Sykora, P., Misiak, M., Wang, Y., Ghosh, S., Leandro, G.S., Liu, D., Tian, J., Bohr, V.A., (2015) Nucleic Acids Res., 43, pp. 943-959
Garcia-Diaz, M., Bebenek, K., Sabariegos, R., Dominguez, O., Rodriguez, J., Kirchhoff, T., Garcia-Palomero, E., Blanco, L., (2002) J. Biol. Chem., 277, pp. 13184-13191
Sobol, R.W., (2007) DNA Repair, 6, pp. 3-7
Cheeseright, T., MacKey, M., Rose, S., Vinter, A., (2006) J. Chem. Inf. Model., 46, pp. 665-676
Irwin, J.J., Shoichet, B.K., (2005) J. Chem. Inf. Model., 45, pp. 177-182
Thomsen, R., Christensen, M.H., (2006) J. Med. Chem., 49, pp. 3315-3321
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., (1999) FASEB J., 13, pp. 2225-2234
Sobol, R.W., Horton, J.K., Kuhn, R., Gu, H., Singhal, R.K., Prasad, R., Rajewsky, K., Wilson, S.H., (1996) Nature, 379, pp. 183-186
Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity
Cell-cycle reactivation is a core feature of degenerating neurons in Alzheimer's disease (AD) and Parkinson's disease (PD). A variety of stressors, including β-amyloid (Aβ) in the case of AD, can force neurons to leave quiescence and to initiate an ectopic DNA replication process, leading to neuronal death rather than division. As the primary polymerase (pol) involved in neuronal DNA replication, DNA pol-β contributes to neuronal death, and DNA pol-β inhibitors may prove to be effective neuroprotective agents. Currently, specific and highly active DNA pol-β inhibitors are lacking. Nine putative DNA pol-β inhibitors were identified in silico by querying the ZINC database, containing more than 35 million purchasable compounds. Following pharmacological evaluation, only 5-methoxyflavone (1) was validated as an inhibitor of DNA pol-β activity. Cultured primary neurons are a useful model to investigate the neuroprotective effects of potential DNA pol-β inhibitors, since these neurons undergo DNA replication and death when treated with Aβ. Consistent with the inhibition of DNA pol-β, 5-methoxyflavone (1) reduced the number of S-phase neurons and the ensuing apoptotic death triggered by Aβ. 5-Methoxyflavone (1) is the first flavonoid compound able to halt neurodegeneration via a definite molecular mechanism rather than through general antioxidant and anti-inflammatory properties. © 2015 The American Chemical Society and American Society of Pharmacognosy.
Cell-cycle reactivation is a core feature of degenerating neurons in Alzheimer's disease (AD) and Parkinson's disease (PD). A variety of stressors, including β-amyloid (Aβ) in the case of AD, can force neurons to leave quiescence and to initiate an ectopic DNA replication process, leading to neuronal death rather than division. As the primary polymerase (pol) involved in neuronal DNA replication, DNA pol-β contributes to neuronal death, and DNA pol-β inhibitors may prove to be effective neuroprotective agents. Currently, specific and highly active DNA pol-β inhibitors are lacking. Nine putative DNA pol-β inhibitors were identified in silico by querying the ZINC database, containing more than 35 million purchasable compounds. Following pharmacological evaluation, only 5-methoxyflavone (1) was validated as an inhibitor of DNA pol-β activity. Cultured primary neurons are a useful model to investigate the neuroprotective effects of potential DNA pol-β inhibitors, since these neurons undergo DNA replication and death when treated with Aβ. Consistent with the inhibition of DNA pol-β, 5-methoxyflavone (1) reduced the number of S-phase neurons and the ensuing apoptotic death triggered by Aβ. 5-Methoxyflavone (1) is the first flavonoid compound able to halt neurodegeneration via a definite molecular mechanism rather than through general antioxidant and anti-inflammatory properties. © 2015 The American Chemical Society and American Society of Pharmacognosy.
Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity
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Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity
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Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
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Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (597 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
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Saccà F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Perrotta G, Carotenuto B, Marsili A, Palma V, De Michele G, Brunetti A, Brescia Morra V, Filla A, Salvatore M
* A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results (793 views)
J Neurol (ISSN: 1432-1459, 0340-5354, 1432-1459electronic), 2012 Jan; 259(1): 132-138.
Impact Factor: 3.578
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (1289 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (765 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (805 views)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
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De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (698 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Impact Factor: 1.807
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Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (1615 views)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (440 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (454 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (1014 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (517 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (504 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (579 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (585 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (711 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (808 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (722 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
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* Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain (17 views)
Eur J Med Chem (ISSN: 0223-5234linking), 2022 Jan 5; 227: 113956-113956.
Impact Factor: 7.088
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Marasco D, Vicidomini C, Krupa P, Cioffi F, Pham DQH, Li MS, Florio D, Broersen K, De Pandis MF, Roviello GN
* Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine based compounds on β-amyloid aggregation (145 views)
Chem Biol Interact (ISSN: 0009-2797linking), 2021 Jan 25; 334: 109300-109301.
Impact Factor: 5.192
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Monti A, Sturlese M, Caporale A, Roger JA, Mascanzoni F, Ruvo M, Doti N
* Design, synthesis, structural analysis and biochemical studies of stapled AIF(370-394) analogues as ligand of CypA (87 views)
Bba-Gen Subjects (ISSN: 0304-4165linking, 0005-2728, 0006-3002print), 2020 Dec; 1864(12): 129717-129717.
Impact Factor: 3.422
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Fusco FA, Fiorentino G, Pedone E, Contursi P, Bartolucci S, Limauro D
* Biochemical characterization of a novel thermostable beta-glucosidase from Dictyoglomus turgidum (1313 views)
Int J Biol Macromol (ISSN: 1879-0003electronic, 0141-8130linking), 2018 Jul 1; 113: 783-791.
Impact Factor: 4.784
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Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (291 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
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Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (806 views)
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
Impact Factor: 2.73
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Tabbì G, Magrì A, Giuffrida A, Lanza V, Pappalardo G, Naletova I, Nicoletti VG, Attanasio F, Rizzarelli E
* Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity (487 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015 Jan; 142: 39-46.
Impact Factor: 3.205
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Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
* Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (595 views)
J Pharmacol Exp Ther (ISSN: 0022-3565, 1521-0103), 2014 Sep; 350(2): 273-289.
Impact Factor: 3.972
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Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C
* Mitochondrial Small Conductance SK2 Channels Prevent Glutamate-induced Oxytosis and Mitochondrial Dysfunction (599 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2013 Apr 12; 288(15): 10792-10804.
Impact Factor: 4.6
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (838 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
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Attanasio F, De Bona P, Cataldo S, Sciacca MFM, Milardi D, Pignataro B, Pappalardo G
* Copper(II) and zinc(II) dependent effects on A beta 42 aggregation: a CD, Th-T and SFM study (457 views)
New J Chem (ISSN: 1144-0546), 2013; 37(4): 1206-1215.
Impact Factor: 3.159
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Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (647 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
View Export to BibTeX Export to EndNote
Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (597 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
View Export to BibTeX Export to EndNote
Saccà F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Perrotta G, Carotenuto B, Marsili A, Palma V, De Michele G, Brunetti A, Brescia Morra V, Filla A, Salvatore M
* A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results (793 views)
J Neurol (ISSN: 1432-1459, 0340-5354, 1432-1459electronic), 2012 Jan; 259(1): 132-138.
Impact Factor: 3.578
View Export to BibTeX Export to EndNote
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (1289 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
View Export to BibTeX Export to EndNote
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (765 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
View Export to BibTeX Export to EndNote
Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (805 views)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
View Export to BibTeX Export to EndNote
De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (698 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Impact Factor: 1.807
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (1615 views)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (440 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
View Export to BibTeX Export to EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (454 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
View Export to BibTeX Export to EndNote
Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (1014 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
View Export to BibTeX Export to EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (517 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
View Export to BibTeX Export to EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (504 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
View Export to BibTeX Export to EndNote
Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (579 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
View Export to BibTeX Export to EndNote
Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (585 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
View Export to BibTeX Export to EndNote
Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (711 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
View Export to BibTeX Export to EndNote
Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (808 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
View Export to BibTeX Export to EndNote
Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (722 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
View Export to BibTeX Export to EndNote
29 Records (29 excluding Abstracts).
Total impact factor: 128.666 (128.666 excluding Abstracts).
Total 5 year impact factor: 124.465 (124.465 excluding Abstracts).
Total impact factor: 128.666 (128.666 excluding Abstracts).
Total 5 year impact factor: 124.465 (124.465 excluding Abstracts).
323 views. Last view on Saturday 14 January 2023, 18:30:41
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