New G-quadruplex-forming oligodeoxynucleotides incorporating a bifunctional Double-Ended Linker (DEL): effects of DEL size and ODNs orientation on the topology, stability and molecularity of DEL-G-quadruplexes (394 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2019 Feb 12; 24(3): 654-654.
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Paper type: Research Journal Article,
Impact factor: 3.06, 5-year impact factor: 3.38
Url: https://doi.org/10.3390/molecules24030654
Keywords: G-Quadruplexes, Double-Ended Linkers, Del-Odns, Tel-Odns, Supramolecular G-Quadruplexes, Size-Exclusion Chromatography, Circular Dichroism Methods, Dna Chemistry, Guanosine Chemistry, Magnetic Resonance Spectroscopy Methods, Molecular Weight, Oligodeoxyribonucleotides Chemistry, Oligonucleotides Chemistry, Orientation, Spatial,
Affiliations:
*** IBB - CNR ***
Dipartimento di Farmacia, Universita degli Studi di Napoli Federico II, via Domenico Montesano 49, 80131 Napoli, Italy. maria.marzano@unina.it.
Dipartimento di Chimica, Universita degli Studi di Milano, via Camillo Golgi 19, 20133 Milano, Italy. brunella.pinto87@gmail.com.
Istituto di Biostrutture e Bioimmagini, CNR, Via Tommaso De Amicis 95, 80145 Napoli, Italy. giroviel@unina.it.
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, via Sergio Pansini 5, 80131 Napoli, Italy. golivier@unina.it.
References:
Not available.
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2019 Feb 12; 24(3): 654-654.
Export to BibTeX Export to EndNote
Paper type: Research Journal Article,
Impact factor: 3.06, 5-year impact factor: 3.38
Url: https://doi.org/10.3390/molecules24030654
Keywords: G-Quadruplexes, Double-Ended Linkers, Del-Odns, Tel-Odns, Supramolecular G-Quadruplexes, Size-Exclusion Chromatography, Circular Dichroism Methods, Dna Chemistry, Guanosine Chemistry, Magnetic Resonance Spectroscopy Methods, Molecular Weight, Oligodeoxyribonucleotides Chemistry, Oligonucleotides Chemistry, Orientation, Spatial,
Affiliations:
*** IBB - CNR ***
Dipartimento di Farmacia, Universita degli Studi di Napoli Federico II, via Domenico Montesano 49, 80131 Napoli, Italy. maria.marzano@unina.it.
Dipartimento di Chimica, Universita degli Studi di Milano, via Camillo Golgi 19, 20133 Milano, Italy. brunella.pinto87@gmail.com.
Istituto di Biostrutture e Bioimmagini, CNR, Via Tommaso De Amicis 95, 80145 Napoli, Italy. giroviel@unina.it.
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, via Sergio Pansini 5, 80131 Napoli, Italy. golivier@unina.it.
References:
Not available.
New G-quadruplex-forming oligodeoxynucleotides incorporating a bifunctional Double-Ended Linker (DEL): effects of DEL size and ODNs orientation on the topology, stability and molecularity of DEL-G-quadruplexes
G-quadruplexes (G4s) are unusual secondary structures of DNA occurring
in guanosine-rich oligodeoxynucleotide (ODN) strands that are
extensively studied for their relevance to the biological processes in
which they are involved. In this study, we report the synthesis of a new
kind of G4-forming molecule named double-ended-linker ODN (DEL-ODN), in
which two TG 4 T strands are attached to the two ends of
symmetric, non-nucleotide linkers. Four DEL-ODNs differing for the
incorporation of either a short or long linker and the directionality of
the TG 4 T strands were synthesized, and their ability to form
G4 structures and/or multimeric species was investigated by PAGE,
HPLC–size-exclusion chromatography (HPLC–SEC), circular dichroism (CD),
and NMR studies in comparison with the previously reported monomeric
tetra-ended-linker (TEL) analogues and with the corresponding
tetramolecular species (TG 4 T) 4 . The structural
characterization of DEL-ODNs confirmed the formation of stable,
bimolecular DEL-G4s for all DEL-ODNs, as well as of additional DEL-G4
multimers with higher molecular weights, thus suggesting a way towards
the obtainment of thermally stable DNA nanostructures based on
reticulated DEL-G4s
G-quadruplexes (G4s) are unusual secondary structures of DNA occurring
in guanosine-rich oligodeoxynucleotide (ODN) strands that are
extensively studied for their relevance to the biological processes in
which they are involved. In this study, we report the synthesis of a new
kind of G4-forming molecule named double-ended-linker ODN (DEL-ODN), in
which two TG 4 T strands are attached to the two ends of
symmetric, non-nucleotide linkers. Four DEL-ODNs differing for the
incorporation of either a short or long linker and the directionality of
the TG 4 T strands were synthesized, and their ability to form
G4 structures and/or multimeric species was investigated by PAGE,
HPLC–size-exclusion chromatography (HPLC–SEC), circular dichroism (CD),
and NMR studies in comparison with the previously reported monomeric
tetra-ended-linker (TEL) analogues and with the corresponding
tetramolecular species (TG 4 T) 4 . The structural
characterization of DEL-ODNs confirmed the formation of stable,
bimolecular DEL-G4s for all DEL-ODNs, as well as of additional DEL-G4
multimers with higher molecular weights, thus suggesting a way towards
the obtainment of thermally stable DNA nanostructures based on
reticulated DEL-G4s
New G-quadruplex-forming oligodeoxynucleotides incorporating a bifunctional Double-Ended Linker (DEL): effects of DEL size and ODNs orientation on the topology, stability and molecularity of DEL-G-quadruplexes
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New G-quadruplex-forming oligodeoxynucleotides incorporating a bifunctional Double-Ended Linker (DEL): effects of DEL size and ODNs orientation on the topology, stability and molecularity of DEL-G-quadruplexes
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View Export to BibTeX Export to EndNote
* DNA Binding Mode Analysis of a Core-Extended Naphthalene Diimide as a Conformation-Sensitive Fluorescent Probe of G-Quadruplex Structures (143 views)
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 7.446
View Export to BibTeX Export to EndNote
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Impact Factor: 5.39
View Export to BibTeX Export to EndNote
Martínez-fernández L, Esposito L, Improta R
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Photochem Photobiol Sci (ISSN: 1474-905xlinking), 2020 Apr 15; 19(4): 436-444.
Impact Factor: 2.831
View Export to BibTeX Export to EndNote
Fik-jaskółka MA, Mkrtchyan AF, Saghyan AS, Palumbo R, Belter A, Hayriyan LA, Simonyan H, Roviello V, Roviello GN
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Spectrochim Acta A (ISSN: 1386-1425linking), 2020 Mar 15; 229: 117884-117884.
Impact Factor: 3.232
View Export to BibTeX Export to EndNote
Pelliccia S, Amato J, Capasso D, Di Gaetano S, Massarotti A, Piccolo M, Irace C, Tron GC, Pagano B, Randazzo A, Novellino E, Giustiniano M
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Impact Factor: 6.205
View Export to BibTeX Export to EndNote
Riccardi C, Capasso D, Rozza GM, Platella C, Montesarchio D, Di Gaetano S, Marzo T, Pratesi A, Messori L, Roviello GN, Musumeci D
* Synthesis, DNA binding studies, and antiproliferative activity of novel Pt(II)- complexes with an L-alanyl-based ligand (374 views)
J Chem Res (ISSN: 0162-0134linking, 0162-0134print, 1873-3344), 2020 Feb; 203: 110868-110868.
Impact Factor: 3.224
View Export to BibTeX Export to EndNote
Martinez-fernandez L, Changenet P, Banyasz A, Gustavsson T, Markovitsi D, Improta R
* Comprehensive Study of Guanine Excited State Relaxation and Photoreactivity in G-quadruplexes (118 views)
J Phys Chem Lett (ISSN: 1948-7185linking, 1948-7185electronic), 2019 Nov 7; 10(21): 6873-6877.
Impact Factor: 6.687
View Export to BibTeX Export to EndNote
Martinez-fernandez L, Banyasz A, Markovitsi D, Improta R
* Topology Controls the Electronic Absorption and Delocalization of Electron Holes in Guanine Quadruplexes (537 views)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Oct 12; 24(57): 15185-15189.
Impact Factor: 5.476
View Export to BibTeX Export to EndNote
Deiana M, Mettra B, Martinez-fernandez L, Mazur LM, Pawlik K, Andraud C, Samoc M, Improta R, Monnereau C, Matczyszyn K
* Specific Recognition of G-Quadruplexes Over Duplex-DNA by a Macromolecular NIR Two-Photon Fluorescent Probe (490 views)
J Phys Chem Lett (ISSN: 1948-7185, 1948-7185electronic, 1948-7185linking), 2017 Dec 7; 8(23): 5915-5920.
Impact Factor: 8.709
View Export to BibTeX Export to EndNote
Banyasz A, Martinez-fernandez L, Balty C, Perron M, Douki T, Improta R, Markovitsi D
* Absorption of Low-Energy UV Radiation by Human Telomere G-Quadruplexes Generates Long-Lived Guanine Radical Cations (245 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 0002-7863print), 2017 Aug 2; 139(30): 10561-10568.
Impact Factor: 14.357
View Export to BibTeX Export to EndNote
Platella C, Guida S, Bonmassar L, Aquino A, Bonmassar E, Ravagnan G, Montesarchio D, Roviello GN, Musumeci D, Fuggetta MP
* Antitumour activity of resveratrol on human melanoma cells: a possible mechanism related to its interaction with malignant cell telomerase (406 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2017 Aug 02; 1861(11PtA): 2843-2851.
Impact Factor: 4.28
View Export to BibTeX Export to EndNote
Platella C, Riccardi C, Montesarchio D, Roviello GN, Musumeci D
* G-quadruplex-based aptamers against protein targets in therapy and diagnostics (436 views)
Bba-Gen Subjects (ISSN: 0304-4165, 0006-3002, 1872-8006electronic), 2017 May; 1861(5PtB): 1429-1447.
Impact Factor: 3.679
View Export to BibTeX Export to EndNote
Scognamiglio PL, Di Natale C, Leone M, Poletto M, Vitagliano L, Tell G, Marasco D
* G-quadruplex DNA recognition by nucleophosmin: new insights from protein dissection (738 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2014 Jun; 1840(6): 2050-2059.
Impact Factor: 5.353
View Export to BibTeX Export to EndNote
Sica F, Pica A, Merlino A, Russo Krauss I, Ercole C, Picone D
* The multiple forms of bovine seminal ribonuclease: Structure and stability of a C-terminal swapped dimer (406 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013 Nov 29; 587(23): 3755-3762.
Impact Factor: 3.341
View Export to BibTeX Export to EndNote
Musumeci D, Oliviero G, Roviello GN, Bucci EM, Piccialli G
* G-quadruplex-forming oligonucleotide conjugated to magnetic nanoparticles: Synthesis, characterization, and enzymatic stability assays (1116 views)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812, 1520-4812electronic), 2012 Mar 21; 23(3): 382-391.
Impact Factor: 4.58
View Export to BibTeX Export to EndNote
Haider SM, Autiero I, Neidle S
Surface area accessibility and the preferred topology of telomeric DNA quadruplex-ligand complexes (3 views)
Biochimie (ISSN: 0300-9084linking), 2011 Aug; 93 (8 ): 1275-1279.
Impact Factor:
View Export to BibTeX Export to EndNote
19 Records (18 excluding Abstracts).
Total impact factor: 99.786 (96.107 excluding Abstracts).
Total 5 year impact factor: 94.663 (89.853 excluding Abstracts).
Total impact factor: 99.786 (96.107 excluding Abstracts).
Total 5 year impact factor: 94.663 (89.853 excluding Abstracts).
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