Quantification of hydroxyl exchange of D-Glucose at physiological conditions for optimization of glucoCEST MRI at 3, 7 and 9. 4 Tesla (236 views)
Nmr Biomed (ISSN: 0952-3480linking, 1099-1492electronic), 2019 Sep; 32(9): e4113-e4113.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.983, 5-year impact factor: 3.372
Url: Not available.
Keywords: Bloch-Mcconell, D-Glucose, Chemical Exchange Saturation Transfer, Dynamic Glucose Enhancement, Endogenous Contrast Methods, Glucocest, Glucose Proton Exchange, Animals , Computer Simulation , Female , Glucose Analysis Chemistry , Heterografts , Hydrogen-Ion Concentration , Hydroxyl Radical Analysis , Magnetic Resonance Imaging , Inbred Balb C,
Affiliations:
*** IBB - CNR ***
High-field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tubingen, Germany., Molecular Imaging Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy., Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Institute of Biostructures and Bioimaging (IBB), Italian National Research Council (CNR), Torino, Italy., School of Chemisty, Tel-Aviv University, Tel-Aviv, Israel., Institute of Neurology, University College London, London, UK., Department of Biomedical Magnetic Resonance, Eberhard-Karls University Tubingen, Tubingen, Germany.,
Molecular Imaging Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Institute of Biostructures and Bioimaging (IBB), Italian National Research Council (CNR), Torino, Italy.
School of Chemisty, Tel-Aviv University, Tel-Aviv, Israel.
Institute of Neurology, University College London, London, UK.
Department of Biomedical Magnetic Resonance, Eberhard-Karls University Tübingen, Tübingen, Germany.
References:
Not available.
Nmr Biomed (ISSN: 0952-3480linking, 1099-1492electronic), 2019 Sep; 32(9): e4113-e4113.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.983, 5-year impact factor: 3.372
Url: Not available.
Keywords: Bloch-Mcconell, D-Glucose, Chemical Exchange Saturation Transfer, Dynamic Glucose Enhancement, Endogenous Contrast Methods, Glucocest, Glucose Proton Exchange, Animals , Computer Simulation , Female , Glucose Analysis Chemistry , Heterografts , Hydrogen-Ion Concentration , Hydroxyl Radical Analysis , Magnetic Resonance Imaging , Inbred Balb C,
Affiliations:
*** IBB - CNR ***
High-field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tubingen, Germany., Molecular Imaging Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy., Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Institute of Biostructures and Bioimaging (IBB), Italian National Research Council (CNR), Torino, Italy., School of Chemisty, Tel-Aviv University, Tel-Aviv, Israel., Institute of Neurology, University College London, London, UK., Department of Biomedical Magnetic Resonance, Eberhard-Karls University Tubingen, Tubingen, Germany.,
Molecular Imaging Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Institute of Biostructures and Bioimaging (IBB), Italian National Research Council (CNR), Torino, Italy.
School of Chemisty, Tel-Aviv University, Tel-Aviv, Israel.
Institute of Neurology, University College London, London, UK.
Department of Biomedical Magnetic Resonance, Eberhard-Karls University Tübingen, Tübingen, Germany.
References:
Not available.
Quantification of hydroxyl exchange of D-Glucose at physiological conditions for optimization of glucoCEST MRI at 3, 7 and 9. 4 Tesla
AIMS: To determine individual glucose hydroxyl exchange rates at physiological conditions and use this information for numerical optimization of glucoCEST/CESL preparation. To give guidelines for in vivo glucoCEST/CESL measurement parameters at clinical and ultra-high field strengths. METHODS: Five glucose solution samples at different pH values were measured at 14.1 T at various B1 power levels. Multi-B1 -Z-spectra Bloch-McConnell fits at physiological pH were further improved by the fitting of Z-spectra of five pH values simultaneously. The obtained exchange rates were used in a six-pool Bloch-McConnell simulation including a tissue-like water pool and semi-solid MT pool with different CEST and CESL presaturation pulse trains. In vivo glucose injection experiments were performed in a tumor mouse model at 7 T. RESULTS AND DISCUSSION: Glucose Z-spectra could be fitted with four exchanging pools at 0.66, 1.28, 2.08 and 2.88 ppm. Corresponding hydroxyl exchange rates could be determined at pH = 7.2, T = 37 degrees C and 1X PBS. Simulation of saturation transfer for this glucose system in a gray matter-like and a tumor-like system revealed optimal pulses at different field strengths of 9.4, 7 and 3 T. Different existing sequences and approaches are simulated and discussed. The optima found could be experimentally verified in an animal model at 7 T. CONCLUSION: For the determined fast exchange regime, presaturation pulses in the spin-lock regime (long recover time, short yet strong saturation) were found to be optimal. This study gives an estimation for optimization of the glucoCEST signal in vivo on the basis of glucose exchange rate at physiological conditions.
AIMS: To determine individual glucose hydroxyl exchange rates at physiological conditions and use this information for numerical optimization of glucoCEST/CESL preparation. To give guidelines for in vivo glucoCEST/CESL measurement parameters at clinical and ultra-high field strengths. METHODS: Five glucose solution samples at different pH values were measured at 14.1 T at various B1 power levels. Multi-B1 -Z-spectra Bloch-McConnell fits at physiological pH were further improved by the fitting of Z-spectra of five pH values simultaneously. The obtained exchange rates were used in a six-pool Bloch-McConnell simulation including a tissue-like water pool and semi-solid MT pool with different CEST and CESL presaturation pulse trains. In vivo glucose injection experiments were performed in a tumor mouse model at 7 T. RESULTS AND DISCUSSION: Glucose Z-spectra could be fitted with four exchanging pools at 0.66, 1.28, 2.08 and 2.88 ppm. Corresponding hydroxyl exchange rates could be determined at pH = 7.2, T = 37 degrees C and 1X PBS. Simulation of saturation transfer for this glucose system in a gray matter-like and a tumor-like system revealed optimal pulses at different field strengths of 9.4, 7 and 3 T. Different existing sequences and approaches are simulated and discussed. The optima found could be experimentally verified in an animal model at 7 T. CONCLUSION: For the determined fast exchange regime, presaturation pulses in the spin-lock regime (long recover time, short yet strong saturation) were found to be optimal. This study gives an estimation for optimization of the glucoCEST signal in vivo on the basis of glucose exchange rate at physiological conditions.
Quantification of hydroxyl exchange of D-Glucose at physiological conditions for optimization of glucoCEST MRI at 3, 7 and 9. 4 Tesla
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Quantification of hydroxyl exchange of D-Glucose at physiological conditions for optimization of glucoCEST MRI at 3, 7 and 9. 4 Tesla
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Nmr Biomed (ISSN: 0952-3480linking, 1099-1492electronic), 2021 Aug 22; N/D: e4602-N/D.
Impact Factor: 3.221
View Export to BibTeX Export to EndNote
Consolino L, Irrera P, Romdhane F, Anemone A, Longo DL
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Magn Reson Med (ISSN: 0740-3194linking, 1522-2594electronic), 2021 Aug; 86(2): 995-1007.
Impact Factor: 3.635
View Export to BibTeX Export to EndNote
Kim H, Wu Y, Villano D, Longo DL, Mcmahon MT, Sun PZ
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Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 667-688.
Impact Factor: 1.17
View Export to BibTeX Export to EndNote
Longo DL, Irrera P, Consolino L, Sun PZ, Mcmahon MT
* Renal pH Imaging Using Chemical Exchange Saturation Transfer (CEST) MRI: Basic Concept (178 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 241-256.
Impact Factor: 1.17
View Export to BibTeX Export to EndNote
Pavuluri KD, Consolino L, Longo DL, Irrera P, Sun PZ, Mcmahon MT
* Renal pH Mapping Using Chemical Exchange Saturation Transfer (CEST) MRI: Experimental Protocol (150 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 455-471.
Impact Factor: 1.17
View Export to BibTeX Export to EndNote
Anemone A, Consolino L, Arena F, Capozza M, Longo DL
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Cancer Metastasis Rev (ISSN: 0167-7659linking), 2019 Jun; 38(1-2): 25-49.
Impact Factor: 6.667
View Export to BibTeX Export to EndNote
Kujawa A, Kim M, Demetriou E, Anemone A, Livio Longo D, Zaiss M, Golay X
* Assessment of a clinically feasible Bayesian fitting algorithm using a simplified description of Chemical Exchange Saturation Transfer (CEST) imaging (85 views)
J Magn Reson (ISSN: 1090-7807linking), 2019 Mar; 300: 120-134.
Impact Factor: 2.586
View Export to BibTeX Export to EndNote
Goerke S, Breitling J, Zaiss M, Windschuh J, Kunz P, Schuenke P, Paech D, Longo DL, Klika KD, Ladd ME, Bachert P
* Dual-frequency irradiation CEST-MRI of endogenous bulk mobile proteins (467 views)
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Impact Factor: 2.872
View Export to BibTeX Export to EndNote
Arena F, Irrera P, Consolino L, Colombo Serra S, Zaiss M, Longo DL
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J Magn Reson (ISSN: 1090-7807, 1090-7807linking), 2017 Dec 11; 287: 1-9.
Impact Factor: 2.586
View Export to BibTeX Export to EndNote
Longo DL, Aime S
* A generalized ratiometric chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH using iopamidol (369 views)
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Impact Factor: 4.082
View Export to BibTeX Export to EndNote
Longo DL, Moustaghfir FZ, Zerbo A, Consolino L, Anemone A, Bracesco M, Aime S
* EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging (827 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2017; 525(1): 275-281.
Impact Factor: 3.862
View Export to BibTeX Export to EndNote
Anemone A, Consolino L, Longo DL
* MRI-CEST assessment of tumour perfusion using X-ray iodinated agents: comparison with a conventional Gd-based agent (281 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2017; 27(5): 2170-2179.
Impact Factor: 4.027
View Export to BibTeX Export to EndNote
Longo DL, Cutrin JC, Michelotti F, Irrera P, Aime S
* Noninvasive evaluation of renal pH homeostasis after ischemia reperfusion injury by CEST-MRI (439 views)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2017; 30(7): N/D-N/D.
Impact Factor: 3.031
View Export to BibTeX Export to EndNote
Longo DL, Michelotti F, Consolino L, Bardini P, Digilio G, Xiao G, Sun PZ, Aime S
* In Vitro and In Vivo Assessment of Nonionic Iodinated Radiographic Molecules as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Tumor Perfusion Agents (414 views)
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2015 Oct 12; 51(3): 155-162.
Impact Factor: 4.887
View Export to BibTeX Export to EndNote
Terreno E, Boffa C, Menchise V, Fedeli F, Carrera C, Castelli DD, Digilio G, Aime S
* Gadolinium-doped LipoCEST agents: A potential novel class of dual 1H-MRI probes (516 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011 Apr 28; 47(16): 4667-4669.
Impact Factor: 6.169
View Export to BibTeX Export to EndNote
15 Records (15 excluding Abstracts).
Total impact factor: 51.135 (51.135 excluding Abstracts).
Total 5 year impact factor: 55.706 (55.706 excluding Abstracts).
Total impact factor: 51.135 (51.135 excluding Abstracts).
Total 5 year impact factor: 55.706 (55.706 excluding Abstracts).
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