Evolving Cell-Based and Cell-Free Clinical Strategies for Treating Severe Human Liver Diseases (148 views)
Cells (ISSN: 2073-4409linking, 2073-4409electronic), 2020 Feb 7; 9(2): N/D-N/D.
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Paper type: Journal Article, Review, Research Support, Non-U. S. Gov'T,
Impact factor: 4.366, 5-year impact factor: 5.276
Url: Not available.
Keywords: Cell Therapy, Extracellular Vesicles, Liver Diseases, Organ Printing, Organoids, Scaffolds, Transplantation,
Affiliations:
*** IBB - CNR ***
Department of Molecular Biotechnology and Health Sciences, University of Turin, Via Nizza 52, 10126 Turin, Italy.
Maria Pia Hospital, 10126 Turin, Italy.
Unit of Gastroenterology, Molinette Hospital, 10126 Turin, Italy.
Institute of Biostructure and Bioimaging, National Research Council, Molecular Biotechnology Center, Via Nizza 52, 10126 Turin, Italy.
vivianacerni@hotmail.com (V.C.)
rossellapeluso14@gmail.com (R.P.)
beatrice.zedd@gmail.com (B.Z.)
lorenzo.silengo@unito.it (L.S.)
emanuela.tolosano@unito.it (E.T.)
rinaldo_pellican@hotmail.com
References:
Not available.
Cells (ISSN: 2073-4409linking, 2073-4409electronic), 2020 Feb 7; 9(2): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Review, Research Support, Non-U. S. Gov'T,
Impact factor: 4.366, 5-year impact factor: 5.276
Url: Not available.
Keywords: Cell Therapy, Extracellular Vesicles, Liver Diseases, Organ Printing, Organoids, Scaffolds, Transplantation,
Affiliations:
*** IBB - CNR ***
Department of Molecular Biotechnology and Health Sciences, University of Turin, Via Nizza 52, 10126 Turin, Italy.
Maria Pia Hospital, 10126 Turin, Italy.
Unit of Gastroenterology, Molinette Hospital, 10126 Turin, Italy.
Institute of Biostructure and Bioimaging, National Research Council, Molecular Biotechnology Center, Via Nizza 52, 10126 Turin, Italy.
vivianacerni@hotmail.com (V.C.)
rossellapeluso14@gmail.com (R.P.)
beatrice.zedd@gmail.com (B.Z.)
lorenzo.silengo@unito.it (L.S.)
emanuela.tolosano@unito.it (E.T.)
rinaldo_pellican@hotmail.com
References:
Not available.
Evolving Cell-Based and Cell-Free Clinical Strategies for Treating Severe Human Liver Diseases
Liver diseases represent a major global health issue, and currently, liver transplantation is the only viable alternative to reduce mortality rates in patients with end-stage liver diseases. However, scarcity of donor organs and risk of recidivism requiring a re-transplantation remain major obstacles. Hence, much hope has turned towards cell-based therapy. Hepatocyte-like cells obtained from embryonic stem cells or adult stem cells bearing multipotent or pluripotent characteristics, as well as cell-based systems, such as organoids, bio-artificial liver devices, bioscaffolds and organ printing are indeed promising. New approaches based on extracellular vesicles are also being investigated as cell substitutes. Extracellular vesicles, through the transfer of bioactive molecules, can modulate liver regeneration and restore hepatic function. This review provides an update on the current state-of-art cell-based and cell-free strategies as alternatives to liver transplantation for patients with end-stage liver diseases.
Liver diseases represent a major global health issue, and currently, liver transplantation is the only viable alternative to reduce mortality rates in patients with end-stage liver diseases. However, scarcity of donor organs and risk of recidivism requiring a re-transplantation remain major obstacles. Hence, much hope has turned towards cell-based therapy. Hepatocyte-like cells obtained from embryonic stem cells or adult stem cells bearing multipotent or pluripotent characteristics, as well as cell-based systems, such as organoids, bio-artificial liver devices, bioscaffolds and organ printing are indeed promising. New approaches based on extracellular vesicles are also being investigated as cell substitutes. Extracellular vesicles, through the transfer of bioactive molecules, can modulate liver regeneration and restore hepatic function. This review provides an update on the current state-of-art cell-based and cell-free strategies as alternatives to liver transplantation for patients with end-stage liver diseases.
Evolving Cell-Based and Cell-Free Clinical Strategies for Treating Severe Human Liver Diseases
| ▼ High-resolution positron emission tomography of the ischaemic mouse heart |
Evolving Cell-Based and Cell-Free Clinical Strategies for Treating Severe Human Liver Diseases
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View Export to BibTeX Export to EndNote
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Impact Factor: 4.241
View Export to BibTeX Export to EndNote
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Impact Factor: 2.719
View Export to BibTeX Export to EndNote
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J Ultrasound (ISSN: 1876-7931linking, 1876-7931electronic), 2020 Mar; 23(1): 87-103.
Impact Factor: 1.547
View Export to BibTeX Export to EndNote
Famulari ES, Navarro-tableros V, Herrera Sanchez MB, Bortolussi G, Gai M, Conti L, Silengo L, Tolosano E, Tetta C, Muro AF, Camussi G, Fagoonee S, Altruda F
* Human liver stem cells express UGT1A1 and improve phenotype of immunocompromised Crigler Najjar syndrome type I mice (239 views)
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2020 Jan 21; 10 (1 ): 887-887.
Impact Factor: 5.078
View Export to BibTeX Export to EndNote
Durazzo M, Ponzo E, Bonetto S, Fagoonee S, Pellicano R
* Liver diseases in the elderly (401 views)
Hepatology (ISSN: 0026-4806linking, 1827-1669electronic), 2018 Oct 11; 110(1): 35-51.
Impact Factor: 2.863
View Export to BibTeX Export to EndNote
Della Pepa R, Cerchione C, Pugliese N, Colicchio R, Salvatore P, Sirignano C, Soscia E, Pagano L, Sanguinetti M, Pane F, Picardi M
* Diagnostic-driven antifungal approach in neutropenic patients at high risk for chronic disseminated candidiasis: preliminary observations on the role of 1, 3-ß-D-glucan antigenemia and multiphasic contrast-enhanced computed tomography (288 views) (PDF 32 views)
Supportive Care Cancer (ISSN: 0941-4355), 2018 Jun; 26(6): 1691-1694.
Impact Factor: 2.676
View Export to BibTeX Export to EndNote
Ricco G, Cavallone D, Cosma C, Caviglia GP, Oliveri F, Biasiolo A, Abate ML, Plebani M, Smedile A, Bonino F, Pontisso P, Brunetto MR
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Cancer Biomark (ISSN: 1574-0153, 1574-0153linking), 2017 Dec 15; 21(3): 603-612.
Impact Factor: 2.392
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Mancini M, Salomone Megna A, Ragucci M, De Luca M, Marino Marsilia G, Nardone G, Coccoli P, Prinster A, Mannelli L, Vergara E, Monti S, Liuzzi R, Incoronato M
* Reproducibility of shear wave elastography (SWE) in patients with chronic liver disease (309 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2017 Oct 12; 12(10): e0185391-e0185391.
Impact Factor: 2.766
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Filippi M, Boido M, Terreno E
* Imaging of MSC transplantation in neuroscience (255 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2017 Feb 14; 8(7): 10781-10782.
Impact Factor: 5.008
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Fagoonee S, Famulari ES, Silengo L, Camussi G, Altruda F
* Prospects for Adult Stem Cells in the Treatment of Liver Diseases (263 views)
Stem Cells Dev (ISSN: 1547-3287, 1547-3287linking), 2016 Sep 7; 25(20): 1471-1482.
Impact Factor: 3.562
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Filippi M, Boido M, Pasquino C, Garello F, Boffa C, Terreno E
* Successful in vivo MRI tracking of MSCs labeled with Gadoteridol in a Spinal Cord Injury experimental model (412 views)
Exp Neurol (ISSN: 0014-4886), 2016 Aug; 282: 66-77.
Impact Factor: 4.706
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Rosa D, Balato G, Ciaramella G, Soscia E, Improta G, Triassi M
* Long-term clinical results and MRI changes after autologous chondrocyte implantation in the knee of young and active middle aged patients (503 views)
J Orthop Traumatol (ISSN: 1590-9999electronic, 1590-9921linking), 2015 Oct 24; 17(1): 55-62.
Impact Factor: 1.28
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De Chiara L, Fagoonee S, Ranghino A, Bruno S, Camussi G, Tolosano E, Silengo L, Altruda F
* Renal cells from spermatogonial germline stem cells protect against kidney injury (412 views)
J Am Soc Nephrol (ISSN: 1046-6673), 2014 Feb; 25(2): 316-328.
Impact Factor: 9.343
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Carotenuto M, Pedone E, Diana D, de Antonellis P, Džeroski S, Marino N, Navas L, Di Dato V, Scoppettuolo MN, Cimmino F, Correale S, Pirone L, Monti SM, Bruder E, Zenko B, Slavkov I, Pastorino F, Ponzoni M, Schulte JH, Schramm A, Eggert A, Westermann F, Arrigoni G, Accordi B, Basso G, Saviano M, Fattorusso R, Zollo M
* Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction (639 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2013 Mar 1; 3: 1351-1351.
Impact Factor: 5.078
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Fonti R, Larobina M, Del Vecchio S, Fabbricini R, Catalano L, Pane F, Salvatore M, Pace L
* Metabolic tumor volume assessed by 18F-FDG PET/CT for the prediction of outcome in patients with multiple myeloma (832 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Dec; 53(12): 1829-1835.
Impact Factor: 5.774
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Balbi L, Greco D, Innocenti S, Sirignano C, Palma G, Soscia E, Alfano B, Salvatore M
* T2 & T2ρ Maps: Sequence Development And Clinical Impact On Joint Study (452 views) (PDF 252 views)
Ecr 2012, 2012 Oct; N/D: C-2444.
Impact Factor: 0
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Riccio A, Cubellis MV
* Gain of function in CDKN1C (576 views)
Nature Genetics (ISSN: 1061-4036), 2012 Jul; 44(7): 737-738.
Impact Factor: 35.209
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Pier PM
* RE: Imaging Features of Hepato-Splenic Amyloidosis at PET/CT (397 views)
Korean Journal Of Radiology (ISSN: 1229-6929), 2012 May; 13(3): 368-369.
Impact Factor: 1.555
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Perrone-Filardi P, Paolillo S, Dellegrottaglie S, Gargiulo P, Savarese G, Marciano C, Casaretti L, Cecere M, Musella F, Pirozzi E, Parente A, Cuocolo A
* Assessment of cardiac sympathetic activity by MIBG imaging in patients with heart failure: a clinical appraisal (368 views)
Heart (ISSN: 1468-201x, 1355-6037), 2011 Nov; 97(22): 1828-1833.
Impact Factor: 4.223
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Basile A, Del Gatto A, Diana D, Di Stasi R, Falco A, Festa M, Rosati A, Barbieri A, Franco R, Arra C, Pedone C, Fattorusso R, Turco MC, D'Andrea LD
* Characterization of a designed vascular endothelial growth factor receptor antagonist helical peptide with antiangiogenic activity in vivo (703 views)
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2011 Mar 10; 54(5): 1391-1400.
Impact Factor: 5.248
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Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G
* A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease (865 views)
Stem Cells (ISSN: 1066-5099), 2010 Sep; 28(8): 1326-1337.
Impact Factor: 7.871
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Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L
* Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (505 views)
Radiology (ISSN: 0033-8419, 1527-1315, 0033-8419linking), 2010 Jan; 254(1): 245-252.
Impact Factor: 6.069
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Romano S, D'Angelillo A, Pacelli R, Staibano S, De Luna E, Bisogni R, Eskelinen EL, Mascolo M, Calì G, Arra C, Romano M
* Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells (562 views)
Cell Death Differ (ISSN: 1350-9047, 1476-5403electronic, 1350-9047linking), 2010 Jan; 17(1): 145-157.
Impact Factor: 9.05
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Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of alpha(v)beta(3) expression by a bifunctional chimeric RGD peptide not cross-reacting with alpha(v)beta(5) (549 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
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Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (1052 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
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Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (585 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
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D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (472 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
Impact Factor: 2.823
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Picardi M, De Renzo A, Pane F, Nicolai E, Pacelli R, Salvatore M, Rotoli B
* Randomized comparison of consolidation radiation versus observation in bulky Hodgkin's lymphoma with post-chemotherapy negative positron emission tomography scans (576 views)
Leuk Lymphoma (ISSN: 1042-8194, 1026-8022linking), 2007 Sep; 48(9): 1721-1727.
Impact Factor: 1.512
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Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (509 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2007 Apr; 13(4): 211-219.
Impact Factor: 1.768
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Maestri R, Pinna G, Accardo A, Allegrini P, Balocchi R, D'ADDIO G, Ferrario M, Menicucci D, Porta A, Sassi R
* Nonlinear indices of heart rate variability in chronic heart failure patients: Redundancy and comparative clinical value (481 views)
J Cardiovasc Electrophysiol (ISSN: 1045-3873), 2007; 18(4): 425-433.
Impact Factor: 3.475
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Mancini M, Mainenti PP, Speranza A, Liuzzi R, Soscia E, Sabbatini M, Ferrara LA, Federico S, Salvatore M
* Accuracy of sonographic volume measurements of kidney transplant (650 views)
Journal Of Clinical Ultrasound (ISSN: 0091-2751), 2006 May; 34(4): 184-189.
Impact Factor: 0.573
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De Rosa P, Santangelo M, Scala A, Vallefuoco D, Caggiano L, Imbriaco M, Spinosag
* Difficult Vascular Conditions in Kidney Transplantation (290 views)
Transplant Proc (ISSN: 0041-1345), 2006; 38(4): 1040-1043.
Impact Factor: 0.962
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Mancini M, Daniele S, Raffio T, Liuzzi R, Sabbatini M, Cianciaruso B, Ferrara LA, Salvatore M
* Intra and interobserver variability of renal allograft ultrasound volume and resistive index measurements (576 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2005 Apr; 109(4): 385-394.
Impact Factor: 1.368
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Andretta C, Catalano L, Pace L, Fonti R, Annunziata G, Rotoli B
* 99mTc-sestaMIBI scintigraphy in thalidomide-treated refractory or relapsed multiple myeloma patients [2] (365 views)
Leuk Lymphoma (ISSN: 1042-8194, 1026-8022linking), 2003 Jun; 44(6): 1081-1082.
Impact Factor: 1.163
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Tauchmanova L, De Rosa G, Serio B, Fazioli F, Mainolfi C, Lombardi G, Colao A, Salvatore M, Rotoli B, Selleri C
* Avascular necrosis in long-term survivors after allogeneic or autologous stem cell transplantation: A single center experience and a review (502 views)
Cancer (ISSN: 0008-543x), 2003 May 15; 97(10): 2453-2461.
Impact Factor: 2.045
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Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
* Radiolabeling approaches for cholecystokinin B receptor imaging (616 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002; 66(6): 370-380.
Impact Factor: 2.372
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Fonti R, Levchenko A, Mehta BM, Zhang J, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in human neuroblastoma xenografts using in vitro quantitative autoradiography (376 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999 Jan; 26(1): 35-41.
Impact Factor: 1.623
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Fonti R, Cheung N-KV, Bridger GJ, Guo H-F, Abrams MJ, Larson SM
99mTc-monoclonal antibody radiolabeled via hydrazino nicotinamide derivative for imaging disialoganglioside G(D2)-positive tumors (546 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999; 26(6): 681-686.
Impact Factor: 1.623
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42 Records (37 excluding Abstracts).
Total impact factor: 183.914 (161.347 excluding Abstracts).
Total 5 year impact factor: 176.868 (153.092 excluding Abstracts).
Total impact factor: 183.914 (161.347 excluding Abstracts).
Total 5 year impact factor: 176.868 (153.092 excluding Abstracts).
148 views. Last view on Tuesday 08 October 2024, 1:14:05
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