Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 4.379, 5-year impact factor: 5.078
Url: Not available.
Keywords: Not available.
Affiliations: *** IBB - CNR ***
IRCCS SDN, Via E. Gianturco 113, 80143, Naples, Italy.
Department of Pharmacy, Research Centre on Bioactive Peptides (CIRPeB), University of Naples "Federico II", Via Mezzocannone 16, 80134, Naples, Italy.
Institute of Biostructures and Bioimaging (IBB), CNR, Via Mezzocannone 16, 80134, Naples, Italy.
Institute of Crystallography (IC), CNR, Via Amendola 122, 70126, Bari, Italy.
Department of Chemical, Materials and Industrial Production Engineering, DICMaPI, University of Naples "Federico II", Piazzale V. Tecchio 80, 80125, Naples, Italy.
References: Not available.
Fabrication of fluorescent nanospheres by heating PEGylated tetratyrosine nanofibers
Aromatic polypeptides have recently drawn the interest of the research community for their capability to self-assemble into a variety of functional nanostructures. Due to their interesting mechanical, electrical and optical properties, these nanostructures have been proposed as innovative materials in different biomedical, biotechnological and industrial fields. Recently, several efforts have been employed in the development of these innovative materials as nanoscale fluorescence (FL) imaging probes. In this context, we describe the synthesis and the functional properties of a novel fluorescent tyrosine (Tyr, Y)-based nanospheres, obtained by heating at 200 °C a solution of the PEGylated tetra-peptide PEG6-Y4. At room temperature, this peptide self-assembles into not fluorescent low ordered water-soluble fibrillary aggregates. After heating, the aggregation of different polyphenolic species generates Y4-based nanospheres able to emit FL into blue, green and red spectral regions, both in solution and at the solid state. The aggregation features of PEG6-Y4 before and after heating were studied using a set of complementary techniques (Fluorescence, CD, FT-IR, Small and Wide-Angle X-ray Scattering and SEM). After a deep investigation of their optoelectronic properties, these nanospheres could be exploited as promising tools for precise biomedicine in advanced nanomedical technologies (local bioimaging, light diagnostics, therapy, optogenetics and health monitoring).
Fabrication of fluorescent nanospheres by heating PEGylated tetratyrosine nanofibers
No results.
Fabrication of fluorescent nanospheres by heating PEGylated tetratyrosine nanofibers
Malvindi MA, Greco A, Conversano F, Figuerola A, Corti M, Bonora M, Lascialfari A, Doumari HA, Moscardini M, Cingolani R, Gigli G, Casciaro S, Pellegrino T, Ragusa A * MR Contrast Agents(431 views) Small Animal Imaging, 2011 Jul 8; 21(13): 2548-2555. Impact Factor:1.784 ViewExport to BibTeXExport to EndNote