Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 1.17, 5-year impact factor: 4.197
Url: Not available.
Keywords: Animals, Biomarkers Analysis, Contrast Media Chemistry, Humans, Hydrogen-Ion Concentration, Image Processing, Computer-Assisted Methods, Kidney Physiology, Magnetic Resonance Imaging Methods, Monitoring, Physiologic Methods, Phantoms, Software, Acute Kidney Injury, Chemical Exchange Saturation Transfer (cest), Iopamidol, Ischemia–reperfusion Injury, Magnetic Resonance Imaging (mri), Renal Damage,
Affiliations: *** IBB - CNR ***
Institute of Biostructures and Bioimaging (IBB), Italian National Research Council (CNR), Torino, Italy. dariolivio.longo@cnr.it.
University of Campania "Luigi Vanvitelli", Napoli, Italy.
Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Division of MR Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
References: Not available.
Renal pH Imaging Using Chemical Exchange Saturation Transfer (CEST) MRI: Basic Concept
Magnetic Resonance Imaging (MRI) has been actively explored in the last several decades for assessing renal function by providing several physiological information, including glomerular filtration rate, renal plasma flow, tissue oxygenation and water diffusion. Within MRI, the developing field of chemical exchange saturation transfer (CEST) has potential to provide further functional information for diagnosing kidney diseases. Both endogenous produced molecules as well as exogenously administered CEST agents have been exploited for providing functional information related to kidney diseases in preclinical studies. In particular, CEST MRI has been exploited for assessing the acid-base homeostasis in the kidney and for monitoring pH changes in several disease models. This review summarizes several CEST MRI procedures for assessing kidney functionality and pH, for monitoring renal pH changes in different kidney injury models and for evaluating renal allograft rejection.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by two separate chapters describing the experimental procedure and data analysis.
Renal pH Imaging Using Chemical Exchange Saturation Transfer (CEST) MRI: Basic Concept
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(990 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote