Benzyl alcohol inhibits carbonic anhydrases by anchoring to the zinc coordinated water molecule (125 views)
Biochem Biophys Res Commun (ISSN: 0006-291xlinking), 2021 Apr 9; 548: 217-221.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.575, 5-year impact factor: 2.823
Url: Not available.
Keywords: Benzyl Alcohol, Carbonic Anhydrase Inhibition, Primary Alcohol, Stopped Flow Co(2) Hydration Assay, X-Ray Crystal Structure, Acetazolamide Pharmacology , Benzyl Alcohol Chemistry Pharmacology , Carbonic Anhydrase Inhibitors Chemistry Pharmacology , Catalytic Domain , Isoenzymes Metabolism , Models, Molecular , Water Metabolism , Zinc Metabolism,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini-CNR, Naples, Italy. Electronic address: giuseppina.desimone@cnr.it., Neurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, Università degli Studi di Firenze, Sesto Fiorentino, Florence, Italy., Istituto di Biostrutture e Bioimmagini-CNR, Naples, Italy. Electronic address: vincenzo.alterio@cnr.it.,
References:
Not available.
Biochem Biophys Res Commun (ISSN: 0006-291xlinking), 2021 Apr 9; 548: 217-221.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.575, 5-year impact factor: 2.823
Url: Not available.
Keywords: Benzyl Alcohol, Carbonic Anhydrase Inhibition, Primary Alcohol, Stopped Flow Co(2) Hydration Assay, X-Ray Crystal Structure, Acetazolamide Pharmacology , Benzyl Alcohol Chemistry Pharmacology , Carbonic Anhydrase Inhibitors Chemistry Pharmacology , Catalytic Domain , Isoenzymes Metabolism , Models, Molecular , Water Metabolism , Zinc Metabolism,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini-CNR, Naples, Italy. Electronic address: giuseppina.desimone@cnr.it., Neurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, Università degli Studi di Firenze, Sesto Fiorentino, Florence, Italy., Istituto di Biostrutture e Bioimmagini-CNR, Naples, Italy. Electronic address: vincenzo.alterio@cnr.it.,
References:
Not available.
Benzyl alcohol inhibits carbonic anhydrases by anchoring to the zinc coordinated water molecule
Up to date alcohols have been scarcely investigated as carbonic anhydrase (CA) inhibitors. To get more insights into the CA inhibition properties of this class of molecules, in this paper, by means of inhibition assays and X-ray crystallographic studies we report a detailed characterization of the CA inhibition properties and the binding mode to human CA II of benzyl alcohol. Results show that, although possessing a very simple scaffold, this molecule acts as a micromolar CA II inhibitor, which anchors to the enzyme active site by means of an H-bond interaction with the zinc bound solvent molecule. Taken together our results clearly indicate primary alcohols as a class of CA inhibitors that deserve to be more investigated.
Up to date alcohols have been scarcely investigated as carbonic anhydrase (CA) inhibitors. To get more insights into the CA inhibition properties of this class of molecules, in this paper, by means of inhibition assays and X-ray crystallographic studies we report a detailed characterization of the CA inhibition properties and the binding mode to human CA II of benzyl alcohol. Results show that, although possessing a very simple scaffold, this molecule acts as a micromolar CA II inhibitor, which anchors to the enzyme active site by means of an H-bond interaction with the zinc bound solvent molecule. Taken together our results clearly indicate primary alcohols as a class of CA inhibitors that deserve to be more investigated.
Benzyl alcohol inhibits carbonic anhydrases by anchoring to the zinc coordinated water molecule
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Benzyl alcohol inhibits carbonic anhydrases by anchoring to the zinc coordinated water molecule
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Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2016 Sep 29; 52(80): 11983-11986.
Impact Factor: 6.319
View Export to BibTeX Export to EndNote
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Impact Factor: 2.406
View Export to BibTeX Export to EndNote
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Bioorg Med Chem Lett (ISSN: 1464-3405, 0960-894x, 1464-3405electronic), 2008 Apr 15; 18(8): 2669-2674.
Impact Factor: 2.531
View Export to BibTeX Export to EndNote
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J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2005 Sep 8; 48(18): 5721-5727.
Impact Factor: 4.926
View Export to BibTeX Export to EndNote
Di Fiore A, De Simone G, Menchise V, Pedone C, Casini A, Scozzafava A, Supuran CT
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Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Apr 1; 15(7): 1937-1942.
Impact Factor: 2.478
View Export to BibTeX Export to EndNote
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Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1999; 51(1): 19-39.
Impact Factor: 2.331
View Export to BibTeX Export to EndNote
Pavone V, De Simone G, Nastri F, Galdiero S, Staiano N, Lombardi A, Pedone C
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Biol Chem Biological Chemistry (ISSN: 1431-6730, 1437-4315), 1998 Sep; 379(8-9): 987-1006.
Impact Factor: 2.636
View Export to BibTeX Export to EndNote
De Simone G, Lombardi A, Galdiero S, Nastri F, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V
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Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 1998 Feb; 7(2): 243-253.
Impact Factor: 4.44
View Export to BibTeX Export to EndNote
Pavone V, Lombardi A, Saviano M, Di Blasio B, Nastri F, Fattorusso R, Zaccaro L, Maglio O, Yamada T, Omote Y
Mixed conformation in C(α, α)-disubstituted tripeptides: X-ray crystal structures of Z-Aib-Dph-Gly-OMe and Bz-Dph-Dph-Gly-OMe (508 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Dec; 34(12): 1595-1604.
Impact Factor: 2.425
View Export to BibTeX Export to EndNote
9 Records (9 excluding Abstracts).
Total impact factor: 30.492 (30.492 excluding Abstracts).
Total 5 year impact factor: 30.898 (30.898 excluding Abstracts).
Total impact factor: 30.492 (30.492 excluding Abstracts).
Total 5 year impact factor: 30.898 (30.898 excluding Abstracts).
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