Translational Insights and New Therapeutic Perspectives in Head and Neck Tumors(61 views) Fasano M, Perri F, Della Corte CM, Di Liello R, Della Vittoria Scarpati G, Cascella M, Ottaiano A, Ciardiello F, Solla R
Biomedicines (ISSN: 2227-9059linking), 2021 Aug 19; 9(8): N/D-N/D.
Keywords: Dna Damage Response, Epithelial Growth Factor Receptor, Head And Neck Squamous Cell Carcinoma, Immunotherapy,
Affiliations: *** IBB - CNR ***
Medical Oncology, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Medical and Experimental Head and Neck Oncology Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, Via M. Semmola, 80131 Naples, Italy.
Medical Oncology Unit, Hospital Sir Apicella, Pollena Trocchia, 80040 Naples, Italy.
Division of Anesthesia, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, 80100 Naples, Italy.
SSD Innovative Therapies for Abdominal Metastases, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, 80100 Naples, Italy.
Italian National Research Council, Institute of Biostructure & Bioimaging, 80131 Naples, Italy.
References: Not available.
Translational Insights and New Therapeutic Perspectives in Head and Neck Tumors
Head and neck squamous cell carcinoma (HNSCC) is characterized by a high mortality rate owing to very few available oncological treatments. For many years, a combination of platinum-based chemotherapy and anti-EGFR antibody cetuximab has represented the only available option for first-line therapy. Recently, immunotherapy has been presented an alternative for positive PD-L1 HNSCC. However, the oncologists' community foresees that a new therapeutic era is approaching. In fact, no-chemo options and some molecular targets are on the horizon. This narrative review addresses past, present, and future therapeutic options for HNSCC from a translational point of view.
Translational Insights and New Therapeutic Perspectives in Head and Neck Tumors
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Translational Insights and New Therapeutic Perspectives in Head and Neck Tumors