Proteomic Analysis of Human U937 Cell Line Activation Mediated by Haemophilus influenzae Type b P2 Porin and Its Surface-Exposed Loop (974 views)
J Proteome Res (ISSN: 1535-3893), 2010 Feb; 9(2): 1050-1062.
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Paper type: Journal Article,
Impact factor: 5.46, 5-year impact factor: 5.617
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-76149115883&partnerID=40&md5=9187146c8c50952df789f53113e232ac
Keywords: Haemophilus Influenzae Type B, Immune Response, Pathogen-Host Interaction, Porin, Proteomic Profiling, Loop 7 Peptide, P2 Porin, Unclassified Drug, Article, Cell Activation, Cell Strain U937, Controlled Study, Cytoskeleton, Disease Course, Host Pathogen Interaction, Human, Human Cell, Inflammation, Mass Spectrometry, Metabolism, Nucleotide Sequence, Priority Journal, Protein Analysis, Protein Expression, Signal Transduction, Stress, Two Dimensional Electrophoresis, Bacterial Proteins, Blotting, Western, Two-Dimensional, Matrix-Assisted Laser Desorption-Ionization, U937 Cells, Bacteria (microorganisms), Haemophilus Influenzae Serotype B,
Affiliations:
*** IBB - CNR ***
Department of Life Science, Second University of Naples, Via Vivaldi 43, I-81100 Caserta, Italy
Department of Experimental Medicine, Second University of Naples, Via De Crecchio 7, I-80138 Napoli, Italy
Department of Biological Sciences, University of Naples Federico II, Via Mezzocannone 16, I-80134, Napoli, Italy
Institute of Biostructure and Bioimaging, C.N.R., Via Mezzocannone 16, I-80134, Napoli, Italy
Proteomic and Biomolecular Mass Spectrometry Center, Institute of Food Science and Technology, C.N.R., Via Roma 52 A-C, I-83100 Avellino, Italy
References:
Not available.
J Proteome Res (ISSN: 1535-3893), 2010 Feb; 9(2): 1050-1062.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.46, 5-year impact factor: 5.617
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-76149115883&partnerID=40&md5=9187146c8c50952df789f53113e232ac
Keywords: Haemophilus Influenzae Type B, Immune Response, Pathogen-Host Interaction, Porin, Proteomic Profiling, Loop 7 Peptide, P2 Porin, Unclassified Drug, Article, Cell Activation, Cell Strain U937, Controlled Study, Cytoskeleton, Disease Course, Host Pathogen Interaction, Human, Human Cell, Inflammation, Mass Spectrometry, Metabolism, Nucleotide Sequence, Priority Journal, Protein Analysis, Protein Expression, Signal Transduction, Stress, Two Dimensional Electrophoresis, Bacterial Proteins, Blotting, Western, Two-Dimensional, Matrix-Assisted Laser Desorption-Ionization, U937 Cells, Bacteria (microorganisms), Haemophilus Influenzae Serotype B,
Affiliations:
*** IBB - CNR ***
Department of Life Science, Second University of Naples, Via Vivaldi 43, I-81100 Caserta, Italy
Department of Experimental Medicine, Second University of Naples, Via De Crecchio 7, I-80138 Napoli, Italy
Department of Biological Sciences, University of Naples Federico II, Via Mezzocannone 16, I-80134, Napoli, Italy
Institute of Biostructure and Bioimaging, C.N.R., Via Mezzocannone 16, I-80134, Napoli, Italy
Proteomic and Biomolecular Mass Spectrometry Center, Institute of Food Science and Technology, C.N.R., Via Roma 52 A-C, I-83100 Avellino, Italy
References:
Not available.
Proteomic Analysis of Human U937 Cell Line Activation Mediated by Haemophilus influenzae Type b P2 Porin and Its Surface-Exposed Loop
The virulence of Haemophilus influenzae type b (Hib) has been attributed to a variety of potential factors associated with its cell surface, including lipopolysaccharides (LPS) and major outer membrane proteins (OMPs). P2 porin, one of the best-characterized porins in terms of its functional characteristics, is the most abundant OMP in Hib and has also been shown to possess proinflammatory activity. To characterize the role played by bacterial surface components in disease onset and development, the proteomic profiling of human U937 cell line activated by H. influenzae type b P2 porin and its most active surface-exposed loop (L7) was performed by means of two-dimensional electrophoresis and mass spectrometry. The study provided a list of candidate proteins with potential relevance in the host immune and inflammatory response. Most of the differentially expressed proteins are involved in metabolic processes, remodelling of cytoskeleton, stress response and signal transduction pathways. The results constitute the basis for dissecting signal transduction cascades activated by P2 stimulation and gain insights into the molecular events involved in the modulation of pathogen-host cell interactions. © 2010 American Chemical Society.
The virulence of Haemophilus influenzae type b (Hib) has been attributed to a variety of potential factors associated with its cell surface, including lipopolysaccharides (LPS) and major outer membrane proteins (OMPs). P2 porin, one of the best-characterized porins in terms of its functional characteristics, is the most abundant OMP in Hib and has also been shown to possess proinflammatory activity. To characterize the role played by bacterial surface components in disease onset and development, the proteomic profiling of human U937 cell line activated by H. influenzae type b P2 porin and its most active surface-exposed loop (L7) was performed by means of two-dimensional electrophoresis and mass spectrometry. The study provided a list of candidate proteins with potential relevance in the host immune and inflammatory response. Most of the differentially expressed proteins are involved in metabolic processes, remodelling of cytoskeleton, stress response and signal transduction pathways. The results constitute the basis for dissecting signal transduction cascades activated by P2 stimulation and gain insights into the molecular events involved in the modulation of pathogen-host cell interactions. © 2010 American Chemical Society.
Proteomic Analysis of Human U937 Cell Line Activation Mediated by Haemophilus influenzae Type b P2 Porin and Its Surface-Exposed Loop
Proteomic Analysis of Human U937 Cell Line Activation Mediated by Haemophilus influenzae Type b P2 Porin and Its Surface-Exposed Loop
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15 Records (15 excluding Abstracts).
Total impact factor: 56.197 (56.197 excluding Abstracts).
Total 5 year impact factor: 50.332 (50.332 excluding Abstracts).
Total impact factor: 56.197 (56.197 excluding Abstracts).
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