Proteomic Analysis of Human U937 Cell Line Activation Mediated by Haemophilus influenzae Type b P2 Porin and Its Surface-Exposed Loop(535 views) Severino V, Chambery A, Vitiello M, Cantisani M, Galdiero S, Galdiero M, Malorni L, Di Maro A, Parente A
J Proteome Res (ISSN: 1535-3893), 2010 Feb; 9(2): 1050-1062.
Keywords: Haemophilus Influenzae Type B, Immune Response, Pathogen-Host Interaction, Porin, Proteomic Profiling, Loop 7 Peptide, P2 Porin, Unclassified Drug, Article, Cell Activation, Cell Strain U937, Controlled Study, Cytoskeleton, Disease Course, Host Pathogen Interaction, Human, Human Cell, Inflammation, Mass Spectrometry, Metabolism, Nucleotide Sequence, Priority Journal, Protein Analysis, Protein Expression, Signal Transduction, Stress, Two Dimensional Electrophoresis, Bacterial Proteins, Blotting, Western, Two-Dimensional, Matrix-Assisted Laser Desorption-Ionization, U937 Cells, Bacteria (microorganisms), Haemophilus Influenzae Serotype B,
Affiliations: *** IBB - CNR ***
Department of Life Science, Second University of Naples, Via Vivaldi 43, I-81100 Caserta, Italy
Department of Experimental Medicine, Second University of Naples, Via De Crecchio 7, I-80138 Napoli, Italy
Department of Biological Sciences, University of Naples Federico II, Via Mezzocannone 16, I-80134, Napoli, Italy
Institute of Biostructure and Bioimaging, C.N.R., Via Mezzocannone 16, I-80134, Napoli, Italy
Proteomic and Biomolecular Mass Spectrometry Center, Institute of Food Science and Technology, C.N.R., Via Roma 52 A-C, I-83100 Avellino, Italy
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Dufrene, Y. F., Using nanotechniques to explore microbial surfaces (2004) Nat. Rev. Microbiol, 2 (6), pp. 451-460
McDonald, P. P., Bald, A., Cassatella, M. A., Activation of the NF- B pathway by inflammatory stimuli in human neutrophils (1997) Blood, 89 (9), pp. 3421-3433
Cassatella, M. A., The production of cytokines by polymorphonuclear neutrophils (1995) Immunol. Today, 16 (1), pp. 21-26
Fessler, M. B., Malcolm, K. C., Duncan, M. W., Worthen, G. S., A genomic and proteomic analysis of activation of the human neutrophil by lipopolysaccharide and its mediation by p38 mitogen-activated protein kinase (2002) J. Biol. Chem, 277 (35), pp. 31291-31302
Gadgil, H. S., Pabst, K. M., Giorgianni, F., Umstot, E. S., Desiderio, D. M., Beranova-Giorgianni, S., Gerling, I. C., Pabst, M. J., Proteome of monocytes primed with lipopolysaccharide: Analysis of the abundant proteins (2003) Proteomics, 3 (9), pp. 1767-1780
Coulton, J. W., Wan, D. T., The outer membrane of Haemophilus influenzae type b: Cell envelope associations of major proteins (1983) Can. J. Microbiol, 29 (2), pp. 280-287
Lowry, O. H., Rosebrough, N. J., Farr, A. L., Randall, R. J., Protein measurement with the Folin phenol reagent (1951) J. Biol. Chem, 193 (1), pp. 265-275
Yin, E. T., Galanos, C., Kinsky, S., Bradshaw, R. A., Wessler, S., Luderitz, O., Sarmiento, M. E., Picogram-sensitive assay for endotoxin: Gelation of Limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid A from Gram-negative bacteria (1972) Biochim. Biophys. Acta, 261 (1), pp. 284-289
Mendelsohn, B. A., Malone, J. P., Townsend, R., Gitlin, J., Proteomic analysis of anoxia tolerance in the developing zebrafish embryo (2009) Comp. Biochem. Physiol., Part D, 4 (1), pp. 21-31
Tsan, M. F., Gao, B., Cytokine function of heat shock proteins (2004) Am. J. Physiol.: Cell Physiol, 286 (4), pp. C739-C744
Haddad, J. J., Land, S. C., Redox/ROS regulation of lipopolysaccharide- induced mitogen-activated protein kinase (MAPK) activation and MAPK-mediated TNF-alpha biosynthesis (2002) Br. J. Pharmacol, 135 (2), pp. 520-536
Lavoie, J. N., Hickey, E., Weber, L. A., Landry, J., Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27 (1993) J. Biol. Chem, 268 (32), pp. 24210-24214
Yin, H. L., Hartwig, J. H., The structure of the macrophage actin skeleton (1988) J. Cell Sci. Suppl, 9, pp. 169-184
Eswarappa, S. M., Pareek, V., Chakravortty, D., Role of actin cytoskeleton in LPS-induced NF-kappaB activation and nitric oxide production in murine macrophages (2008) Innate Immun, 14 (5), pp. 309-318
Vabulas, R. M., Ahmad-Nejad, P., da Costa, C., Miethke, T., Kirschning, C. J., Hacker, H., Wagner, H., Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells (2001) J. Biol. Chem, 276 (33), pp. 31332-31339
Kim, Y. S., Koh, J. M., Lee, Y. S., Kim, B. J., Lee, S. H., Lee, K. U., Kim, G. S., Increased circulating heat shock protein 60 induced by menopause, stimulates apoptosis of osteoblast-lineage cells via upregulation of toll-like receptors (2009) Bone, 45 (1), pp. 68-76
Vertessy, B. G., Toth, J., Keeping uracil out of DNA: Physiological role, structure and catalytic mechanism of dUTPases (2009) Acc. Chem. Res, 42 (1), pp. 97-106
Ariza, M. E., Glaser, R., Kaumaya, P. T., Jones, C., Williams, M. V., The EBV-encoded dUTPase activates NF-kappa B through the TLR2 and MyD88-dependent signaling pathway (2009) J. Immunol, 182 (2), pp. 851-859
Waldman, W. J., Williams Jr., M. V., Lemeshow, S., Binkley, P., Guttridge, D., Kiecolt-Glaser, J. K., Knight, D. A., Glaser, R., Epstein-Barr virus-encoded dUTPase enhances proin-flammatory cytokine production by macrophages in contact with endothelial cells: Evidence for depression-induced atherosclerotic risk (2008) Brain Behav. Immun, 22 (2), pp. 215-223
Kim, H., Kim, W. J., Jeon, S. T., Koh, E. M., Cha, H. S., Ahn, K. S., Lee, W. H., Cyclophilin A may contribute to the inflammatory processes in rheumatoid arthritis through induction of matrix degrading enzymes and inflammatory cytokines from macrophages (2005) Clin. Immunol, 116 (3), pp. 217-224
Jin, Z. G., Lungu, A. O., Xie, L., Wang, M., Wong, C., Berk, B. C., Cyclophilin A is a proinflammatory cytokine that activates endothelial cells (2004) Arterioscler., Thromb., Vasc. Biol, 24 (7), pp. 1186-1191
Proteomic Analysis of Human U937 Cell Line Activation Mediated by Haemophilus influenzae Type b P2 Porin and Its Surface-Exposed Loop