The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: The carbonic anhydrase I-topiramate complex
The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: The carbonic anhydrase I-topiramate complex(640 views) Alterio V, Monti SM, Truppo E, Pedone C, Supuran CT, De Simone G
Keywords: Active Site, Amino Acid Residues, Antiepileptic Drugs, Carbonic Anhydrases, Crystallographic Structure, Drug Design, H-Bond Network, In-Vitro, Inhibition Constants, Isoforms, Lipogenesis, Obesity Drugs, Structural Comparison, Weight Loss, Drug Interactions, Nutrition, Organic Acids, Thermoelectric Power, Carbonate Dehydratase I, Carbonate Dehydratase Inhibitor, Drug Derivative, Fructose, Isoenzyme, Topiramate, Amino Acid Sequence, Article, Chemical Structure, Chemistry, Drug Antagonism, Enzyme Active Site, Human, Metabolism, Molecular Genetics, Protein Binding, X Ray Crystallography, Carbonic Anhydrase Inhibitors, Catalytic Domain, X-Ray, Models, Molecular Sequence Data, Analogs And Derivatives, Antagonists And Inhibitors,
Affiliations: *** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy
Università Degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Via della Lastruccia 3, I-50019 Sesto Fiorentino (Firenze), Italy
Universit Degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Via della Lastruccia 3, I-50019 Sesto Fiorentino (Firenze), Italy
References: Not available.
The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: The carbonic anhydrase I-topiramate complex
The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: The carbonic anhydrase I-topiramate complex
The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: The carbonic anhydrase I-topiramate complex