Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study (735 views)
Annals Of Oncology (ISSN: 0923-7534), 2009 May; 20(5): 906-912.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.647, 5-year impact factor: 5.376
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-65549151863&partnerID=40&md5=857b404f6ce316dd333047ac9aef8795
Keywords: Chemoradiotherapy, Neo-Adjuvant, Rectal Cancer, Capecitabine, Oxaliplatin, Adult, Aged, Anemia, Article, Asthenia, Cancer Adjuvant Therapy, Cancer Recurrence, Cancer Regression, Cancer Staging, Clinical Article, Clinical Trial, Computer Assisted Radiotherapy, Diarrhea, Female, Human, Leukopenia, Lymph Node Metastasis, Nausea, Peripheral Neuropathy, Phase 2 Clinical Trial, Preoperative Radiotherapy, Preoperative Treatment, Priority Journal, Proctitis, Rectum Cancer, Stomatitis, Tenesmus, Thrombocytopenia, Treatment Response, Vomiting, Antineoplastic Combined Chemotherapy Protocols, Deoxycytidine, Digestive System Surgical Procedures, Disease-Free Survival, Fluorouracil, Middle Aged, Neoadjuvant Therapy, Neoplasm Metastasis, Neoplasm Recurrence, Local, Organoplatinum Compounds, Conformal, Rectal Neoplasms, Time Factors, Treatment Outcome,
Affiliations:
*** IBB - CNR ***
Department of Endocrinology and Molecular and Clinical Oncology, Università Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy
Department of Biomorphological and Functional Sciences, Faculty of Medicine, Università Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy
Department of General Surgery, Geriatrics, Oncology and Advanced Technologies, Faculty of Medicine, Università Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy
Department of Surgery, Orthopaedic, Trauma and Emergency Sciences, Faculty of Medicine and Surgery, Università Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy
References:
Kamangar, F., Dores, G.M., Anderson, W.F., Pattern of incidence, mortality and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world (2006) J Clin Oncol, 24, pp. 2137-215
Prolongation of the disease-free interval in surgically treated rectal carcinoma (1985) N Engl J Med, 312, pp. 1465-1472. , GITSG
Krook, J.E., Moertel, C.G., Gunderson, L.L., Effective surgical adjuvant therapy for high-risk rectal carcinoma (1991) New Engl J Med, 324, pp. 709-715
Tveit, K.M., Guldvog, I., Hagen, S., Randomized controlled trial of postoperative radiotherapy and short-term time-scheduled 5-fluorouracil against surgery alone in the treatment of Dukes B and C rectal cancer (1997) Br J Surg, 84, pp. 1130-1135
Cammà, C., Giunta, M., Fiorica, F., Preoperative radiotherapy for respectable rectal cancer: A meta-analysis (2000) JAMA, 284, pp. 1008-1015
Peeters, K.C.M.Y., Marijnen, C.A.M., Nagtegaal, I.D., The TME trial after a median follow-up of 6 years. Increased local control but no survival benefit in irradiated patients with respectable rectal carcinoma (2007) Ann Surg, 246, pp. 693-701
Gerard, J.P., Conroy, T., Bonnetain, F., Preoperative radiotherapy, with or without concurrent 5fluorouracil and leucovorin in T3-T4 rectal cancers: Results of the FFCD 9203 trial (2006) J Clin Oncol, 24, pp. 4620-4625
Bosset, J.F., Colette, L., Calais, G., Chemotherapy with preoperative radiotherapy in rectal cancer (2006) N Engl J Med, 355, pp. 1114-1123
Sauer, R., Becker, H., Hohenberger, W., Preoperative versus postoperative chemoradiotherapy for rectal cancer (2004) New Engl J Med, 351, pp. 1731-1740
Bouzourene, H., Bosman, F.T., Seelentag, W., Importance of tumour regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy (2002) Cancer, 94, pp. 11212-21130
Rödel, C., Martus, P., Papadopulos, T., Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer (2005) J Clin Oncol, 23, pp. 8688-8696
Chan, A.K.P., Wong, A., Jenken, D., Post-treatment TNM staging is a prognostic indicator of survival and recurrence in tethered or fixed rectal carcinoma after preoperative chemotherapy and radiotherapy (2005) Int J Rad Oncol Biol Phys, 61, pp. 665-676
Hartley, A., Ho, K.F., McConkey, C., Geh, J.I., Pathological complete response following pre-operative chemoradiotherapy in rectal cancer: Analysis of phase II/III trials (2005) Br J Radiol, 78, pp. 934-938
Ben-Josef, E., Capecitabine and radiotherapy as neoadjuvant treatment for rectal cancer (2007) Am J Clin Oncol, 30, pp. 649-655
De Gramont, A., Figer, A., Seymour, M., Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer (2000) J Clin Oncol, 18, pp. 2938-2967
De Gramont, A., Boni, C., Navarro, M., Oxaliplatin/5FU/LV in adjuvant colon cancer: Updated efficacy results of the MOSAIC trial, including survival, with a median follow up of six years (2007) J Clin Oncol, p. 25. , 18S Suppl, Abstr 4007
Kuebler, J.P., Wieand, H.S., O'Connel, M.J., Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: Results from NSABP C-07 (2007) J Clin Oncol, 25, pp. 2198-2204
Diaz-Rubio, E., Tabernero, J., Gomez-Espana, A., Phase III study of capecitabine plus oxaliplatin compared with continuous-infusion fluorouracil plus oxaliplatin as first-line therapy in metastatic colorectal cancer: Final report of the Spanish cooperative group for treatment of digestive tumors trial (2007) J Clin Oncol, 25, pp. 4224-4230
Porschen, R., Arkenau, H.T., Kubicka, S., Phase III study of capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin in metastatic colorectal cancer: A final report of the AIO colorectal study group (2007) J Clin Oncol, 25, pp. 4217-4223
Cassidy, J., Clarke, S., Diaz-Rubio, E., Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line treatment for metastatic colorectal cancer (2008) J Clin Oncol, 26, pp. 2006-2012
Hochster, H.S., Hart, L.L., Ramanathan, R.K., Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: Results of the TREE study (2008) J Clin Oncol, 26, pp. 3523-3529
Saltz, L., Clarke, S., Diaz-Rubio, E., Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III trial (2008) J Clin Oncol, 26, pp. 2013-2019
Sawada, N., Ishikawa, T., Sekiguchi, F., X-ray irradiation induces thymidine-phosphorylase and enhances the efficacy of capecitabne (xeloda) in human cancer xenografts (1999) Clin Cancer Res, 5, pp. 2948-2953
Cividalli, A., Ceciarelli, F., Livdi, E., Radiosensitization by oxaliplatin in a mouse adenocarcinoma: Influence of treatment schedule (2002) Int J Radiat Oncol Biol Phys, 52, pp. 1092-1098
Rödel, C., Grabenbauer, G.G., Papadopoulos, T., Phase I/II trial of capecitabine, oxaliplatin, and radiation for rectal cancer (2003) J Clin Oncol, 21, pp. 3098-3104
Mandard, A.M., Dalibard, F., Mandard, J.C., Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma (1994) Cancer, 73, pp. 2680-2686
Simon, R., Optimal two-stage designs for phase II clinical trials (1989) Control Clin Trials, 10, pp. 1-13
Vecchio, F.M., Valentini, V., Minsky, B., The relationship of pathological tumor regression grade (TRG) and outcomes after preoperative therapy in rectal cancer (2005) Int J Radiat Oncol Biol Phys, 62, pp. 752-760
Theodoropoulos, G., Wise, W.E., Padmanabhan, A., T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival (2002) Dis Colon Rectum, 45, pp. 895-903
Kuo, L.J., Liu, M.C., Jian, J.J., Is final TNM staging a predictor for survival in locally advanced rectal cancer after preoperative chemoradiation therapy? (2007) Ann Surg Oncol, 14, pp. 2766-2772
Capirci, C., Velantini, V., Cionini, L., Prognostic value of complete response after neoadjuvant therapy in locally advanced rectal cancer: Long-term analysis of 566 ypCR patients (2008) Int J Radiat Oncol Biol Phys, 72, pp. 99-107
Machiels, J.P., Duck, L., Honhon, B., Phase II study of preoperative oxaliplatin, capecitabine and external beam radiotherapy in patients with rectal cancer: The RadiOxCape Study (2005) Ann Oncol, 16, pp. 1898-1905
Rödel, C., Liersch, T., Hermann, R.M., Multicenter phase II trial of chemotherapy with oxaliplatin for rectal cancer (2007) J Clin Oncol, 25, pp. 110-117
Hospers, G.A., Punt, C.J., Tesselaar, M.E., Preoperative chemoradiotherapy with capecitabine and oxaliplatin in locally advanced rectal cancer. A phase I-II multicenter study of the Dutch Colorectal Cancer Group (2007) Ann Surg Oncol, 14, pp. 2773-2779
Fakih, M.G., Bullard Dun, K., Yang, G.Y., A phase II study of weekly intravenous oxaliplatin with oral daily capecitabine and radiotherapy with biological correlates in neoadjuvant treatment of rectal adenocarcinoma (2008) Int J Rad Oncol Biol Phys, 72, pp. 650-657
Rutten, H., Sebag-Montefiore, D., Glynne-Jones, R., Capecitabine, oxaliplatin, radiotherapy and excision (CORE) in patients with MRI-defined locally advanced rectal adenocarcinoma: Results of an international multicenter phase II study (2006) J Clin Oncol, 24 (SUPPL.). , Abstr 3528
Alonso, V., Lambea, J., Salud, A., Preoperative chemoradiotherapy with capecitabine and oxaliplatin in locally advanced rectal carcinoma: A phase II trial (2007) J Clin Oncol, 25 (SUPPL.). , Abstr 4044
Majem, M., Navarro, M., Losa, F., Phase II clinical trial of weekly oxaliplatin with concurrent capecitabine plus preoperative radiotherapy in locally advanced respectable rectal cancer (2008) J Clin Oncol, 26 (SUPPL.). , Abstr 15013
Marijnen, C.A.M., Kapiteijn, E., van de Velde, C.J.H., Acute effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: Report of a multicenter randomized trial (2002) J Clin Oncol, 20, pp. 817-825
Krook, J. E., Moertel, C. G., Gunderson, L. L., Effective surgical adjuvant therapy for high-risk rectal carcinoma (1991) New Engl J Med, 324, pp. 709-715
Tveit, K. M., Guldvog, I., Hagen, S., Randomized controlled trial of postoperative radiotherapy and short-term time-scheduled 5-fluorouracil against surgery alone in the treatment of Dukes B and C rectal cancer (1997) Br J Surg, 84, pp. 1130-1135
Camm, C., Giunta, M., Fiorica, F., Preoperative radiotherapy for respectable rectal cancer: A meta-analysis (2000) JAMA, 284, pp. 1008-1015
Peeters, K. C. M. Y., Marijnen, C. A. M., Nagtegaal, I. D., The TME trial after a median follow-up of 6 years. Increased local control but no survival benefit in irradiated patients with respectable rectal carcinoma (2007) Ann Surg, 246, pp. 693-701
Gerard, J. P., Conroy, T., Bonnetain, F., Preoperative radiotherapy, with or without concurrent 5fluorouracil and leucovorin in T3-T4 rectal cancers: Results of the FFCD 9203 trial (2006) J Clin Oncol, 24, pp. 4620-4625
Bosset, J. F., Colette, L., Calais, G., Chemotherapy with preoperative radiotherapy in rectal cancer (2006) N Engl J Med, 355, pp. 1114-1123
R del, C., Martus, P., Papadopulos, T., Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer (2005) J Clin Oncol, 23, pp. 8688-8696
Chan, A. K. P., Wong, A., Jenken, D., Post-treatment TNM staging is a prognostic indicator of survival and recurrence in tethered or fixed rectal carcinoma after preoperative chemotherapy and radiotherapy (2005) Int J Rad Oncol Biol Phys, 61, pp. 665-676
Kuebler, J. P., Wieand, H. S., O'Connel, M. J., Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: Results from NSABP C-07 (2007) J Clin Oncol, 25, pp. 2198-2204
Hochster, H. S., Hart, L. L., Ramanathan, R. K., Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: Results of the TREE study (2008) J Clin Oncol, 26, pp. 3523-3529
R del, C., Grabenbauer, G. G., Papadopoulos, T., Phase I/II trial of capecitabine, oxaliplatin, and radiation for rectal cancer (2003) J Clin Oncol, 21, pp. 3098-3104
Mandard, A. M., Dalibard, F., Mandard, J. C., Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma (1994) Cancer, 73, pp. 2680-2686
Vecchio, F. M., Valentini, V., Minsky, B., The relationship of pathological tumor regression grade (TRG) and outcomes after preoperative therapy in rectal cancer (2005) Int J Radiat Oncol Biol Phys, 62, pp. 752-760
Kuo, L. J., Liu, M. C., Jian, J. J., Is final TNM staging a predictor for survival in locally advanced rectal cancer after preoperative chemoradiation therapy? (2007) Ann Surg Oncol, 14, pp. 2766-2772
Machiels, J. P., Duck, L., Honhon, B., Phase II study of preoperative oxaliplatin, capecitabine and external beam radiotherapy in patients with rectal cancer: The RadiOxCape Study (2005) Ann Oncol, 16, pp. 1898-1905
R del, C., Liersch, T., Hermann, R. M., Multicenter phase II trial of chemotherapy with oxaliplatin for rectal cancer (2007) J Clin Oncol, 25, pp. 110-117
Hospers, G. A., Punt, C. J., Tesselaar, M. E., Preoperative chemoradiotherapy with capecitabine and oxaliplatin in locally advanced rectal cancer. A phase I-II multicenter study of the Dutch Colorectal Cancer Group (2007) Ann Surg Oncol, 14, pp. 2773-2779
Fakih, M. G., Bullard Dun, K., Yang, G. Y., A phase II study of weekly intravenous oxaliplatin with oral daily capecitabine and radiotherapy with biological correlates in neoadjuvant treatment of rectal adenocarcinoma (2008) Int J Rad Oncol Biol Phys, 72, pp. 650-657
Annals Of Oncology (ISSN: 0923-7534), 2009 May; 20(5): 906-912.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.647, 5-year impact factor: 5.376
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-65549151863&partnerID=40&md5=857b404f6ce316dd333047ac9aef8795
Keywords: Chemoradiotherapy, Neo-Adjuvant, Rectal Cancer, Capecitabine, Oxaliplatin, Adult, Aged, Anemia, Article, Asthenia, Cancer Adjuvant Therapy, Cancer Recurrence, Cancer Regression, Cancer Staging, Clinical Article, Clinical Trial, Computer Assisted Radiotherapy, Diarrhea, Female, Human, Leukopenia, Lymph Node Metastasis, Nausea, Peripheral Neuropathy, Phase 2 Clinical Trial, Preoperative Radiotherapy, Preoperative Treatment, Priority Journal, Proctitis, Rectum Cancer, Stomatitis, Tenesmus, Thrombocytopenia, Treatment Response, Vomiting, Antineoplastic Combined Chemotherapy Protocols, Deoxycytidine, Digestive System Surgical Procedures, Disease-Free Survival, Fluorouracil, Middle Aged, Neoadjuvant Therapy, Neoplasm Metastasis, Neoplasm Recurrence, Local, Organoplatinum Compounds, Conformal, Rectal Neoplasms, Time Factors, Treatment Outcome,
Affiliations:
*** IBB - CNR ***
Department of Endocrinology and Molecular and Clinical Oncology, Università Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy
Department of Biomorphological and Functional Sciences, Faculty of Medicine, Università Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy
Department of General Surgery, Geriatrics, Oncology and Advanced Technologies, Faculty of Medicine, Università Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy
Department of Surgery, Orthopaedic, Trauma and Emergency Sciences, Faculty of Medicine and Surgery, Università Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy
References:
Kamangar, F., Dores, G.M., Anderson, W.F., Pattern of incidence, mortality and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world (2006) J Clin Oncol, 24, pp. 2137-215
Prolongation of the disease-free interval in surgically treated rectal carcinoma (1985) N Engl J Med, 312, pp. 1465-1472. , GITSG
Krook, J.E., Moertel, C.G., Gunderson, L.L., Effective surgical adjuvant therapy for high-risk rectal carcinoma (1991) New Engl J Med, 324, pp. 709-715
Tveit, K.M., Guldvog, I., Hagen, S., Randomized controlled trial of postoperative radiotherapy and short-term time-scheduled 5-fluorouracil against surgery alone in the treatment of Dukes B and C rectal cancer (1997) Br J Surg, 84, pp. 1130-1135
Cammà, C., Giunta, M., Fiorica, F., Preoperative radiotherapy for respectable rectal cancer: A meta-analysis (2000) JAMA, 284, pp. 1008-1015
Peeters, K.C.M.Y., Marijnen, C.A.M., Nagtegaal, I.D., The TME trial after a median follow-up of 6 years. Increased local control but no survival benefit in irradiated patients with respectable rectal carcinoma (2007) Ann Surg, 246, pp. 693-701
Gerard, J.P., Conroy, T., Bonnetain, F., Preoperative radiotherapy, with or without concurrent 5fluorouracil and leucovorin in T3-T4 rectal cancers: Results of the FFCD 9203 trial (2006) J Clin Oncol, 24, pp. 4620-4625
Bosset, J.F., Colette, L., Calais, G., Chemotherapy with preoperative radiotherapy in rectal cancer (2006) N Engl J Med, 355, pp. 1114-1123
Sauer, R., Becker, H., Hohenberger, W., Preoperative versus postoperative chemoradiotherapy for rectal cancer (2004) New Engl J Med, 351, pp. 1731-1740
Bouzourene, H., Bosman, F.T., Seelentag, W., Importance of tumour regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy (2002) Cancer, 94, pp. 11212-21130
Rödel, C., Martus, P., Papadopulos, T., Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer (2005) J Clin Oncol, 23, pp. 8688-8696
Chan, A.K.P., Wong, A., Jenken, D., Post-treatment TNM staging is a prognostic indicator of survival and recurrence in tethered or fixed rectal carcinoma after preoperative chemotherapy and radiotherapy (2005) Int J Rad Oncol Biol Phys, 61, pp. 665-676
Hartley, A., Ho, K.F., McConkey, C., Geh, J.I., Pathological complete response following pre-operative chemoradiotherapy in rectal cancer: Analysis of phase II/III trials (2005) Br J Radiol, 78, pp. 934-938
Ben-Josef, E., Capecitabine and radiotherapy as neoadjuvant treatment for rectal cancer (2007) Am J Clin Oncol, 30, pp. 649-655
De Gramont, A., Figer, A., Seymour, M., Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer (2000) J Clin Oncol, 18, pp. 2938-2967
De Gramont, A., Boni, C., Navarro, M., Oxaliplatin/5FU/LV in adjuvant colon cancer: Updated efficacy results of the MOSAIC trial, including survival, with a median follow up of six years (2007) J Clin Oncol, p. 25. , 18S Suppl, Abstr 4007
Kuebler, J.P., Wieand, H.S., O'Connel, M.J., Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: Results from NSABP C-07 (2007) J Clin Oncol, 25, pp. 2198-2204
Diaz-Rubio, E., Tabernero, J., Gomez-Espana, A., Phase III study of capecitabine plus oxaliplatin compared with continuous-infusion fluorouracil plus oxaliplatin as first-line therapy in metastatic colorectal cancer: Final report of the Spanish cooperative group for treatment of digestive tumors trial (2007) J Clin Oncol, 25, pp. 4224-4230
Porschen, R., Arkenau, H.T., Kubicka, S., Phase III study of capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin in metastatic colorectal cancer: A final report of the AIO colorectal study group (2007) J Clin Oncol, 25, pp. 4217-4223
Cassidy, J., Clarke, S., Diaz-Rubio, E., Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line treatment for metastatic colorectal cancer (2008) J Clin Oncol, 26, pp. 2006-2012
Hochster, H.S., Hart, L.L., Ramanathan, R.K., Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: Results of the TREE study (2008) J Clin Oncol, 26, pp. 3523-3529
Saltz, L., Clarke, S., Diaz-Rubio, E., Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III trial (2008) J Clin Oncol, 26, pp. 2013-2019
Sawada, N., Ishikawa, T., Sekiguchi, F., X-ray irradiation induces thymidine-phosphorylase and enhances the efficacy of capecitabne (xeloda) in human cancer xenografts (1999) Clin Cancer Res, 5, pp. 2948-2953
Cividalli, A., Ceciarelli, F., Livdi, E., Radiosensitization by oxaliplatin in a mouse adenocarcinoma: Influence of treatment schedule (2002) Int J Radiat Oncol Biol Phys, 52, pp. 1092-1098
Rödel, C., Grabenbauer, G.G., Papadopoulos, T., Phase I/II trial of capecitabine, oxaliplatin, and radiation for rectal cancer (2003) J Clin Oncol, 21, pp. 3098-3104
Mandard, A.M., Dalibard, F., Mandard, J.C., Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma (1994) Cancer, 73, pp. 2680-2686
Simon, R., Optimal two-stage designs for phase II clinical trials (1989) Control Clin Trials, 10, pp. 1-13
Vecchio, F.M., Valentini, V., Minsky, B., The relationship of pathological tumor regression grade (TRG) and outcomes after preoperative therapy in rectal cancer (2005) Int J Radiat Oncol Biol Phys, 62, pp. 752-760
Theodoropoulos, G., Wise, W.E., Padmanabhan, A., T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival (2002) Dis Colon Rectum, 45, pp. 895-903
Kuo, L.J., Liu, M.C., Jian, J.J., Is final TNM staging a predictor for survival in locally advanced rectal cancer after preoperative chemoradiation therapy? (2007) Ann Surg Oncol, 14, pp. 2766-2772
Capirci, C., Velantini, V., Cionini, L., Prognostic value of complete response after neoadjuvant therapy in locally advanced rectal cancer: Long-term analysis of 566 ypCR patients (2008) Int J Radiat Oncol Biol Phys, 72, pp. 99-107
Machiels, J.P., Duck, L., Honhon, B., Phase II study of preoperative oxaliplatin, capecitabine and external beam radiotherapy in patients with rectal cancer: The RadiOxCape Study (2005) Ann Oncol, 16, pp. 1898-1905
Rödel, C., Liersch, T., Hermann, R.M., Multicenter phase II trial of chemotherapy with oxaliplatin for rectal cancer (2007) J Clin Oncol, 25, pp. 110-117
Hospers, G.A., Punt, C.J., Tesselaar, M.E., Preoperative chemoradiotherapy with capecitabine and oxaliplatin in locally advanced rectal cancer. A phase I-II multicenter study of the Dutch Colorectal Cancer Group (2007) Ann Surg Oncol, 14, pp. 2773-2779
Fakih, M.G., Bullard Dun, K., Yang, G.Y., A phase II study of weekly intravenous oxaliplatin with oral daily capecitabine and radiotherapy with biological correlates in neoadjuvant treatment of rectal adenocarcinoma (2008) Int J Rad Oncol Biol Phys, 72, pp. 650-657
Rutten, H., Sebag-Montefiore, D., Glynne-Jones, R., Capecitabine, oxaliplatin, radiotherapy and excision (CORE) in patients with MRI-defined locally advanced rectal adenocarcinoma: Results of an international multicenter phase II study (2006) J Clin Oncol, 24 (SUPPL.). , Abstr 3528
Alonso, V., Lambea, J., Salud, A., Preoperative chemoradiotherapy with capecitabine and oxaliplatin in locally advanced rectal carcinoma: A phase II trial (2007) J Clin Oncol, 25 (SUPPL.). , Abstr 4044
Majem, M., Navarro, M., Losa, F., Phase II clinical trial of weekly oxaliplatin with concurrent capecitabine plus preoperative radiotherapy in locally advanced respectable rectal cancer (2008) J Clin Oncol, 26 (SUPPL.). , Abstr 15013
Marijnen, C.A.M., Kapiteijn, E., van de Velde, C.J.H., Acute effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: Report of a multicenter randomized trial (2002) J Clin Oncol, 20, pp. 817-825
Krook, J. E., Moertel, C. G., Gunderson, L. L., Effective surgical adjuvant therapy for high-risk rectal carcinoma (1991) New Engl J Med, 324, pp. 709-715
Tveit, K. M., Guldvog, I., Hagen, S., Randomized controlled trial of postoperative radiotherapy and short-term time-scheduled 5-fluorouracil against surgery alone in the treatment of Dukes B and C rectal cancer (1997) Br J Surg, 84, pp. 1130-1135
Camm, C., Giunta, M., Fiorica, F., Preoperative radiotherapy for respectable rectal cancer: A meta-analysis (2000) JAMA, 284, pp. 1008-1015
Peeters, K. C. M. Y., Marijnen, C. A. M., Nagtegaal, I. D., The TME trial after a median follow-up of 6 years. Increased local control but no survival benefit in irradiated patients with respectable rectal carcinoma (2007) Ann Surg, 246, pp. 693-701
Gerard, J. P., Conroy, T., Bonnetain, F., Preoperative radiotherapy, with or without concurrent 5fluorouracil and leucovorin in T3-T4 rectal cancers: Results of the FFCD 9203 trial (2006) J Clin Oncol, 24, pp. 4620-4625
Bosset, J. F., Colette, L., Calais, G., Chemotherapy with preoperative radiotherapy in rectal cancer (2006) N Engl J Med, 355, pp. 1114-1123
R del, C., Martus, P., Papadopulos, T., Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer (2005) J Clin Oncol, 23, pp. 8688-8696
Chan, A. K. P., Wong, A., Jenken, D., Post-treatment TNM staging is a prognostic indicator of survival and recurrence in tethered or fixed rectal carcinoma after preoperative chemotherapy and radiotherapy (2005) Int J Rad Oncol Biol Phys, 61, pp. 665-676
Kuebler, J. P., Wieand, H. S., O'Connel, M. J., Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: Results from NSABP C-07 (2007) J Clin Oncol, 25, pp. 2198-2204
Hochster, H. S., Hart, L. L., Ramanathan, R. K., Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: Results of the TREE study (2008) J Clin Oncol, 26, pp. 3523-3529
R del, C., Grabenbauer, G. G., Papadopoulos, T., Phase I/II trial of capecitabine, oxaliplatin, and radiation for rectal cancer (2003) J Clin Oncol, 21, pp. 3098-3104
Mandard, A. M., Dalibard, F., Mandard, J. C., Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma (1994) Cancer, 73, pp. 2680-2686
Vecchio, F. M., Valentini, V., Minsky, B., The relationship of pathological tumor regression grade (TRG) and outcomes after preoperative therapy in rectal cancer (2005) Int J Radiat Oncol Biol Phys, 62, pp. 752-760
Kuo, L. J., Liu, M. C., Jian, J. J., Is final TNM staging a predictor for survival in locally advanced rectal cancer after preoperative chemoradiation therapy? (2007) Ann Surg Oncol, 14, pp. 2766-2772
Machiels, J. P., Duck, L., Honhon, B., Phase II study of preoperative oxaliplatin, capecitabine and external beam radiotherapy in patients with rectal cancer: The RadiOxCape Study (2005) Ann Oncol, 16, pp. 1898-1905
R del, C., Liersch, T., Hermann, R. M., Multicenter phase II trial of chemotherapy with oxaliplatin for rectal cancer (2007) J Clin Oncol, 25, pp. 110-117
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Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study
Background: Preoperative chemoradiation is now standard treatment for stages II-III rectal cancer. Capecitabine (CAP) and oxaliplatin (OX) are synergistic with radiotherapy (RT) and active in colorectal neoplasms. Patients and methods: Two cycles of CAP 825 mg/m 2 b.i.d. (days 1-14) and OX 50 mg/m 2 (days 1 and 8) every 3 weeks were given concomitantly with pelvic conformal RT (45 Gy). Patients with a ≥T3 and/or node-positive rectal tumour were eligible. The pathologic tumour response was defined according to the tumour regression grade (TRG) scale. Results: Forty-six patients were enrolled. Gastrointestinal adverse events were mostly G1-G2; only two patients experienced G3 vomiting and diarrhoea and six patients had G1 peripheral neuropathy. Haematological toxicity was rare. G2 proctitis and anal pain occurred in two patients. Pathological complete response (TRG1) was observed in nine patients (20.9%; 95% CI 8.7%-33.1%); TRG2 in 19 patients (44.2%); TRG3 in 12 patients (27.9%); and TRG4 in three patients (7%). Overall, nine patients recurred: five with distant metastases, one with local recurrence, and three with both local recurrence and distant metastases. Conclusions: CAP-OX-RT as preoperative treatment for rectal cancer induces a remarkable rate of complete or near-complete pathologically documented response and is well tolerated. © The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.
Background: Preoperative chemoradiation is now standard treatment for stages II-III rectal cancer. Capecitabine (CAP) and oxaliplatin (OX) are synergistic with radiotherapy (RT) and active in colorectal neoplasms. Patients and methods: Two cycles of CAP 825 mg/m 2 b.i.d. (days 1-14) and OX 50 mg/m 2 (days 1 and 8) every 3 weeks were given concomitantly with pelvic conformal RT (45 Gy). Patients with a ≥T3 and/or node-positive rectal tumour were eligible. The pathologic tumour response was defined according to the tumour regression grade (TRG) scale. Results: Forty-six patients were enrolled. Gastrointestinal adverse events were mostly G1-G2; only two patients experienced G3 vomiting and diarrhoea and six patients had G1 peripheral neuropathy. Haematological toxicity was rare. G2 proctitis and anal pain occurred in two patients. Pathological complete response (TRG1) was observed in nine patients (20.9%; 95% CI 8.7%-33.1%); TRG2 in 19 patients (44.2%); TRG3 in 12 patients (27.9%); and TRG4 in three patients (7%). Overall, nine patients recurred: five with distant metastases, one with local recurrence, and three with both local recurrence and distant metastases. Conclusions: CAP-OX-RT as preoperative treatment for rectal cancer induces a remarkable rate of complete or near-complete pathologically documented response and is well tolerated. © The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.
Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study
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Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study
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Affimer Tagged Cubosomes: Targeting of Carcinoembryonic Antigen Expressing Colorectal Cancer Cells Using In Vitro and In Vivo Models (3 views)
Acs Appl Mater Interfaces (ISSN: 1944-8252electronic), 2022 Mar 09; 14 (9 ): 11078-11091.
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Akgül Ö, Lucarini E, Mannelli LDC, Ghelardini C, D'Xambrosio K, Buonanno M, Monti SM, De Simone G, Angeli A, Supuran CT, Carta F
* Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain (17 views)
Eur J Med Chem (ISSN: 0223-5234linking), 2022 Jan 5; 227: 113956-113956.
Impact Factor: 7.088
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Stanzione A, Verde F, Romeo V, Boccadifuoco F, Mainenti PP, Maurea S
* Radiomics and machine learning applications in rectal cancer: Current update and future perspectives (47 views)
World J Gastroentero (ISSN: 1007-9327linking, 2219-2840), 2021 Aug 28; 27(32): 5306-5321.
Impact Factor: 3.665
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Manco M, Ala U, Cantarella D, Tolosano E, Medico E, Altruda F, Fagoonee S
* The RNA-Binding Protein ESRP1 Modulates the Expression of RAC1b in Colorectal Cancer Cells (4 views)
Cancers (ISSN: 2072-6694linking), 2021 Aug 13; 13(16): N/D-N/D.
Impact Factor: 6.126
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Susana F, Fagoonee S, Alessandro S, Valentina G, Chiara R, Marco P, Fiorella A, Danilo D
* Impedance-based drug-resistance characterization of colon cancer cells through real-time cell culture monitoring (82 views)
Talanta (ISSN: 0039-9140linking), 2021 Jan 15; 222: 121441-121441.
Impact Factor: 5.339
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D'Alterio C, Zannetti A, Trotta AM, Ieranò C, Napolitano M, Rea G, Greco A, Maiolino P, Albanese S, Scognamiglio G, Tatangelo F, Tafuto S, Portella L, Santagata S, Nasti G, Ottaiano A, Pacelli R, Delrio P, Botti G, Scala S
* New CXCR4 Antagonist Peptide R (Pep R) Improves Standard Therapy in Colorectal Cancer (149 views) (PDF 47 views)
Cancers (ISSN: 2072-6694linking), 2020 Jul 18; 12(7): 1952-1952.
Impact Factor: 6.126
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Nocentini A, Alterio V, Bua S, Micheli L, Esposito D, Buonanno M, Bartolucci G, Osman SM, Alothman ZA, Cirilli R, Pierini M, Monti SM, Di Cesare Mannelli L, Gratteri P, Ghelardini C, De Simone G, Supuran CT
* Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy (112 views)
J Med Chem (ISSN: 0022-2623linking, 0022-2623print), 2020 May 28; 63(10): 5185-5200.
Impact Factor: 6.205
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Ala U, Manco M, Mandili G, Tolosano E, Novelli F, Provero P, Altruda F, Fagoonee S
* Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells (128 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2020 Jan 16; 21 (2 ): N/D-N/D.
Impact Factor: 2.598
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Mainenti PP, Stanzione A, Guarino S, Romeo V, Ugga L, Romano F, Storto G, Maurea S, Brunetti A
* Colorectal cancer: Parametric evaluation of morphological, functional and molecular tomographic imaging (137 views)
World J Gastroentero (ISSN: 1007-9327linking, 2219-2840), 2019 Sep 21; 25 (35 ): 5233-5256.
Impact Factor: 2.24
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Barresi V, Valenti G, Spampinato G, Musso N, Castorina S, Rizzarelli E, Condorelli DF
* Transcriptome analysis reveals an altered expression profile of zinc transporters in colorectal cancer (185 views)
J Cell Biochem (ISSN: 0730-2312linking), 2018 Dec; 119(12): 9707-9719.
Impact Factor: 2.959
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Perri F, Longo F, Della Vittoria Scarpati G, Pisconti S, Longo V, Addeo R, Carducci F, Buonerba C, Fulciniti F, Solla R
* Metastatic HPV-related oropharyngeal carcinoma cured with chemoradiotherapy: importance of pretherapy biomolecular assessment (307 views)
Clin Case Rep (ISSN: 2050-0904print, 2050-0904linking), 2017 Nov 24; 6(1): 56-62.
Impact Factor: 0.54
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Picone D, Donnarumma F, Ferraro G, Gotte G, Fagagnini A, Butera G, Donadelli M, Merlino A
* A comparison study on RNase A oligomerization induced by cisplatin, carboplatin and oxaliplatin (343 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2017 Aug; 173: 105-112.
Impact Factor: 3.063
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Caprio MG, Simonetti I, Tarotto L, Trovato P, Mainolfi CG, Salvatore B, Pace L
* 18-F-FDG PET, PET/CT AND MDCT IN LOCALLY ADVANCED COLORECTAL CANCER (163 views) (PDF 157 views)
Int J Of Current Res, 2017 Jul; 9: 53960-53964.
Impact Factor: 7.086
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Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfo I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F
* The RNA-binding protein ESRP1 promotes human colorectal cancer progression (365 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2016 Dec 28; 8(6): 10007-10024.
Impact Factor: 5.168
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Caviglia GP, Cabianca L, Fagoonee S, Gili FM
* Colorectal cancer detection in an asymptomatic population: Fecal immunochemical test for hemoglobin vs. Fecal M2-type pyruvate kinase (329 views)
Biochem Medica (ISSN: 1330-0962), 2016; 26(1): 114-120.
Impact Factor: 2.934
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Cella L, D'Avino V, Palma G, Conson M, Liuzzi R, Picardi M, Pressello MC, Boboc GI, Battistini R, Donato V, Pacelli R
* Modeling the risk of radiation-induced lung fibrosis: Irradiated heart tissue is as important as irradiated lung (415 views) (PDF 197 views)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 0167-8140linking), 2015 Aug 12; 117(1): 36-43.
Impact Factor: 4.817
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Mainenti PP, Romano F, Pizzuti L, Segreto S, Storto G, Mannelli L, Imbriaco M, Camera L, Maurea S
* Non-invasive diagnostic imaging of colorectal liver metastases (254 views)
World J Radiol (ISSN: 1949-8470electronic, 1949-8470linking), 2015 Jul 28; 7(7): 157-169.
Impact Factor: 0.567
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Cella L, Oh JH, Deasy JO, Palma G, Liuzzi R, D'Avino V, Conson M, Picardi M, Salvatore M, Pacelli R
* Predicting radiation-induced valvular heart damage (334 views)
Acta Oncol (ISSN: 0284-186x, 0284-186xlinking), 2015 Mar 24; 54(10): 1796-1804.
Impact Factor: 3.73
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Messori L, Marzo T, Merlino A
* Interactions of carboplatin and oxaliplatin with proteins: Insights from X-ray structures and mass spectrometry studies of their ribonuclease A adducts (312 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; N/D: N/D-N/D.
Impact Factor: 3.205
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Greco A, D'Alterio C, Auletta L, Albanese S, Napolitano M, Portella L, Santagata S, Ierano C, Brunetti A, Scala S, Zannetti A
* Longitudinal evaluation with High Frequency Ultrasound imaging of response to CXCR4 new cyclic peptide antagonist with conventional chemotherapy in colorectal cancer mice model (397 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2015; 42: S425-S425.
Impact Factor: 5.537
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Marasco D, Messori L, Marzo T, Merlino A
* Oxaliplatin vs. cisplatin: Competition experiments on their binding to lysozyme (724 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2015; 44(22): 10392-10398.
Impact Factor: 4.177
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Napolitano M, D'Alterio C, Cardone E, Trotta AM, Pecori B, Rega D, Pace U, Scala D, Scognamiglio G, Tatangelo F, Cacciapuoti C, Pacelli R, Delrio P, Scala S
* Peripheral myeloid-derived suppressor and T regulatory PD-1 positive cells predict response to neoadjuvant short-course radiotherapy in rectal cancer patients (523 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic), 2015; 6(10): 8261-8270.
Impact Factor: 5.008
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Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, de Falco S
* Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models (470 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2015; 6(12): 10563-10576.
Impact Factor: 5.008
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Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (524 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
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D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
* A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (441 views)
Int J Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
Impact Factor: 5.085
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Orditura M, Galizia G, Di Martino N, Ancona E, Castoro C, Pacelli R, Morgillo F, Rossetti S, Gambardella V, Farella A, Laterza MM, Ruol A, Fabozzi A, Napolitano V, Iovino F, Lieto E, Fei L, Conzo G, Ciardiello F, De Vita F
* Effect of preoperative chemoradiotherapy on outcome of patients with locally advanced esophagogastric junction adenocarcinoma-a pilot study (1873 views)
Curr Oncol (ISSN: 1198-0052, 1718-7729electronic, 1198-0052linking), 2014 Jun; 21(3): 125-133.
Impact Factor: 1.785
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Cella L, Liuzzi R, D'Avino V, Conson M, Di Biase A, Picardi M, Pugliese N, Solla R, Salvatore M, Pacelli R
* Pulmonary damage in Hodgkin's lymphoma patients treated with sequential chemo-radiotherapy: Predictors of radiation-induced lung injury (379 views)
Acta Oncol (ISSN: 0284-186x), 2014 May; 53(5): 613-619.
Impact Factor: 2.997
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Napolitano S, Troiani T, Morgillo F, Ciardiello F, Belli G, Cioffi L, Sirignano C, Martinelli E
* Predictive Biomarkers To Anti-Egfr Inhibitors Treatment In The Management Of Metastatic Colorectal Cancer (245 views) (PDF 12 views)
Journal Of Carcinogenesis & Mutagenesis, 2014; N/D: 2157-2518.
Impact Factor: 3.445
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Cella L, Liuzzi R, Conson M, D'Avino V, Salvatore M, Pacelli R
* Multivariate normal tissue complication probability modeling of heart valve dysfunction in Hodgkin lymphoma survivors (435 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2013 Oct 1; 87(2): 304-310.
Impact Factor: 4.176
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Giacomobono S, Gallicchio R, Capacchione D, Nardelli A, Gattozzi D, Lettini G, Molinari L, Mainenti P, Cammarota A, Storto G
* F-18 FDG PET/CT in the assessment of patients with unexplained CEA rise after surgical curative resection for colorectal cancer (301 views)
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 2013 Jul 12; 28(12): 1699-1705.
Impact Factor: 2.415
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Cella L, Conson M, Liuzzi R, Pacelli R
* In regard to boomsma et al (354 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2013 Jan 1; 85(1): 11-11.
Impact Factor: 4.176
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Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D'Amato C, D'Amato V, Damiano V, Marf G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, De Placido S, Bianco R
* Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models (673 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2013 Jan 1; 19(1): 138-147.
Impact Factor: 8.193
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Cella L, Liuzzi R, Conson M, D'Avino V, Salvatore M, Pacelli R
* Development of multivariate NTCP models for radiation-induced hypothyroidism: A comparative analysis (446 views) (PDF 236 views)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2012 Dec 27; 7(1): 224-224.
Impact Factor: 2.107
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Cella L, Conson M, Caterino M, De Rosa N, Liuzzi R, Picardi M, Grimaldi F, Solla R, Farella A, Salvatore M, Pacelli R
* Thyroid V30 predicts radiation-induced hypothyroidism in patients treated with sequential chemo-radiotherapy for Hodgkin's lymphoma (493 views) (PDF 236 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2012 Apr 1; 82(5): 1802-1808.
Impact Factor: 4.524
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Orditura M, Galizia G, Morgillo F, Martinelli E, Lieto E, Vitiello F, Di Martino N, Pacelli R, Renda A, Ciardiello F, De Vita F
* Complete Response To Preoperative Chemoradiation And Survival In Esophageal Cancer: A Pooled Analysis Of Three Single-Institution Phase Ii Trials (394 views)
Diseases Of The Esophagus, 2012 Feb; 142(5): 130-136.
Impact Factor: 2.057
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Cella L, Liuzzi R, Conson M, Torre G, Caterino M, De Rosa N, Picardi M, Camera L, Solla R, Farella A, Salvatore M, Pacelli R
* Dosimetric predictors of asymptomatic heart valvular dysfunction following mediastinal irradiation for Hodgkin's lymphoma (470 views)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 1879-0887electronic), 2011 Nov; 101(2): 316-321.
Impact Factor: 5.58
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Mainenti PP, Iodice D, Segreto S, Storto G, Magliulo M, De Palma GD, Salvatore M, Pace L
* Colorectal cancer and 18FDG-PET/CT: what about adding the T to the N parameter in loco-regional staging? (335 views)
World J Gastroentero (ISSN: 2219-2840, 1007-9327, 1007-9327linking), 2011 Mar 21; 17(11): 1427-1433.
Impact Factor: 2.471
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Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (445 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
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Orditura M, Galizia G, Napolitano V, Martinelli E, Pacelli R, Lieto E, Aurilio G, Vecchione L, Morgillo F, Catalano G, Ciardiello F, Del Genio A, Di Martino N, De Vita F
* Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study (351 views)
Cancer Investigation (ISSN: 0735-7907), 2010 Oct; 28(8): 820-827.
Impact Factor: 2.39
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Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (431 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Impact Factor: 2.773
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Giacomobono S, Capacchione D, Lancellotti M, Nardelli A, Gallicchio R, Improta G, Nappi A, Cammarota A, Di Leo A, Pace L, Storto G
* F-18 FDG PET/CT in the assessment of patients with unexplained CEA rise after surgical curative resection for colorectal cancer (250 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Sep; 36: N/D-N/D.
Impact Factor: 4.531
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Storto G, Nicolai E, Salvatore M
* [18F]FDG-PET-CT for early monitoring of tumor response: When and why (372 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2009 Apr; 53(2): 167-180.
Impact Factor: 1.724
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Cella L, Ciscognetti N, Martin G, Liuzzi R, Punzo G, Solla R, Farella A, Salvatore M, Pacelli R
* Preoperative Radiation Treatment for Rectal Cancer: Comparison of Target Coverage and Small Bowel NTCP in Conventional vs. 3D-Conformal Planning (533 views)
Med Dosim (ISSN: 0958-3947, 1873-4022), 2009 Mar; 34(1): 75-81.
Impact Factor: 1.256
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Salvatore B, Simeone R, Fonti R, Marciano R, Bianco R, Damiano V, Tortora G, Pace L, Del Vecchio S, Salvatore M
* 18F-FDG PET/CT in the assessment of early response to chemotherapy and molecularly targeted agents in metastatic colorectal cancer (250 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Oct; 35: N/D-N/D.
Impact Factor: 4.532
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Mainenti PP, Cirillo LC, Camera L, Persico F, Cantalupo T, Pace L, De Palma GD, Persico G, Salvatore M
* Accuracy of single phase contrast enhanced multidetector CT colonography in the preoperative staging of colo-rectal cancer (321 views)
Eur J Radiol (ISSN: 0720-048x), 2006 Dec; 60(3): 453-459.
Impact Factor: 1.332
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De Cicco L, Argenone A, Ciscognetti N, Solla R, Farella A, Gaetano M, Punzo G, Cella L, Totaro G, Di Stazio F, Liuzzi R, Pacelli R, Salvatore M
* Effectivenes And Toxicity Of Perioperative Radiation Therapy In Rectal Cancer: Report On 123 Consecutive Cases Of A Single Institution Experience (282 views)
Igrt - Orbi Posters, 2006 Oct; 0: 0-0.
Impact Factor: 0
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Cella L, Punzo G, Martin G, Ciscognetti N, Liuzzi R, Solla R, Farella A, Salvatore M, Pacelli R
* Preoperative radiation treatment for rectal cancer: Comparison of target coverage and small bowel NTCP in conventional versus 3D-conformal planning (352 views)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 1879-0887electronic), 2006 Oct; 81: N/D-N/D.
Impact Factor: 3.97
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Caprio MG, Cantalupo T, Mainenti PP, Mainolfi CG, Varrone A, Salvatore B, Persico F, D'Antonio D, Pace L, Salvatore M
* 18F-fdg pet, pet/ct and ce-mdct in locally advanced colorectal cancer (282 views) (PDF 157 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Sep; 33: N/D-N/D.
Impact Factor: 4.041
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Storto G, Mainenti PP, Varrone A, Mainolfi C, Salvatore B, Caprio MG, Cella L, Soricelli A, Pace L, Salvatore M
* Role of FDG-PET/CT in the staging of colorectal cancer (427 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Sep; 33: N/D-N/D.
Impact Factor: 4.041
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (585 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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Mainenti PP, Romano M, Imbriaco M, Camera L, Pace L, D'Antonio D, Bucci L, Galloro G, Salvatore M
* Added value of CT colonography after a positive conventional colonoscopy: Impact on treatment strategy (431 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2005 Jan; 30(1): 42-47.
Impact Factor: 1.034
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (317 views)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
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Alfano B, Coucourde F, Malgieri F, Ragozzino A
PET/CT and radiotherapy (2849 views)
Q J Nucl Med Mol Imaging, 1980 Oct; 50(1): 4-14.
Impact Factor: 0
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53 Records (47 excluding Abstracts).
Total impact factor: 183.617 (162.502 excluding Abstracts).
Total 5 year impact factor: 157.835 (134.82 excluding Abstracts).
Total impact factor: 183.617 (162.502 excluding Abstracts).
Total 5 year impact factor: 157.835 (134.82 excluding Abstracts).
735 views. Last view on Wednesday 24 May 2023, 18:13:10
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