Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography
Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography(830 views) Woo LWL, Fischer DS, Sharland CM, Trusselle M, Foster PA, Chander SK, Di Fiore A, Supuran CT, De Simone G, Purohit A, Reed MJ, Potter BVL
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic), 2008 Sep; 7(8): 2435-2444.
Keywords: 3 Hydroxy N 3, 3 Trifluoropropyl 16, 17 Seco Estra 1, 5(10) Triene 16, 17 Imide, 3 Sulfamoyloxy N 3, 667 Coumarin, Antineoplastic Agent, Estrone, Estrone 3 O Sulfamic Acid, Stx 64, Unclassified Drug, Animal Experiment, Animal Model, Antineoplastic Activity, Article, Binding Site, Breast Cancer, Controlled Study, Crystallization, Crystallography, Drug Synthesis, Female, Hydrogen Bond, Hydrophobicity, Molecular Model, Nonhuman, Priority Journal, Protein Interaction, Single Drug Dose, Chromatography, Liquid, X-Ray, Enzyme Inhibitors, Fluorine, Magnetic Resonance Spectroscopy, Protein Conformation, Wistar, Spectrometry, Electrospray Ionization, Steryl-Sulfatase, 5 (10) Triene 16,
Affiliations: *** IBB - CNR ***
Department of Pharmacy and Pharmacology, Sterix Ltd., University of Bath, Bath, United Kingdom
Department of Endocrinology and Metabolic Medicine, Imperial College London, St. Mary's Hospital, London, United Kingdom
Istituto di Biostrutture e Bioimmagini-CNR, Naples, Italy
Università degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Florence, Italy
Universit degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Florence, Italy
References: Not available.
Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography
Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography
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Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography