Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice (491 views)
Nat Med (ISSN: 1078-8956, 0034-7264), 2005 Jul; 11(7): 765-773.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 28.878, 5-year impact factor: 26.501
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-22544482628&partnerID=40&md5=c77a14a0a696c09542794cc38392072e
Keywords: Glucose Transporter 4, High Mobility Group A1 Protein, Insulin Receptor, Nucleic Acid Binding Protein, Somatomedin Binding Protein 1, Unclassified Drug, Adult, Animal Experiment, Animal Model, Animal Tissue, Article, Case Report, Cellular Distribution, Controlled Study, Female, Gene Disruption, Gene Mutation, Genetic Analysis, Genetic Susceptibility, Genetic Transcription, Glucose Homeostasis, Human, In Vitro Study, Insulin Binding, Insulin Release, Insulin Resistance, Insulin Sensitivity, Mouse, Non Insulin Dependent Diabetes Mellitus, Nonhuman, Nucleotide Sequence, Pancreas Islet, Pedigree, Phenotype, Positron Emission Tomography, Priority Journal, Protein Expression, School Child, Signal Transduction, Wild Type, Untranslated Regions, Adolescent, Antigens, Cultured, Gene Expression Regulation, Glucose Transporter Type 4, Hmga1a Protein, Insulin-Like Growth Factor Binding Protein 1, Mutant Strains, Monosaccharide Transport Proteins, Muscle Proteins, Positron-Emission Tomography, Pregnancy Proteins, Rna Stability, Diagnosis, Treatment, 4 Thiazolidinedione Derivative, Biguanide, Glibenclamide, Glycosidase Inhibitor, Insulin Derivative, Insulin Lispro, Meglitinide, Metformin, Nateglinide, Peroxisome Proliferator Activated Receptor Gamma, Pioglitazone, Rosiglitazone, Sulfonylurea, Troglitazone, Tumor Necrosis Factor Alpha, Exercise, Glucose Intolerance, Glucose Tolerance, Insulin Pump, Insulin Treatment, Pathophysiology, Metabolism, Secretion, Pathology,
Affiliations:
*** IBB - CNR ***
Dipartimento di Medicina Sperimentale e Clinica G. Salvatore, Università di Catanzaro Magna Graecia, via T. Campanella 115, 88100 Catanzaro, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, c/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università di Napoli Federico II, via Pansini 5, 80131 Napoli, Italy
IRCCS, Ospedale Pediatrico Bambino Gesù, 00100 Roma, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Università di Napoli Federico II, via Pansini 5, 80131 Napoli, Italy
Division of Human Cancer Genetics, Comprehensive Cancer Center, Ohio State University, 410 West 12th Avenue, Columbus, OH 43210, United States
Grupo de Obesidade e Doen as Metab licas, Servi o de Endocrinologia e Metabologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HC-FMUSP), Brazil
Departamento de Obesidade da Sociedade Brasileira de Endocrinologia e Metabologia, Brazil
Hospital Brigadeiro, Brazil
R. Alves Guimaraes. 462, CEP 05410-000 - S o Paulo - SP, Brazil
References:
Not available.
Nat Med (ISSN: 1078-8956, 0034-7264), 2005 Jul; 11(7): 765-773.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 28.878, 5-year impact factor: 26.501
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-22544482628&partnerID=40&md5=c77a14a0a696c09542794cc38392072e
Keywords: Glucose Transporter 4, High Mobility Group A1 Protein, Insulin Receptor, Nucleic Acid Binding Protein, Somatomedin Binding Protein 1, Unclassified Drug, Adult, Animal Experiment, Animal Model, Animal Tissue, Article, Case Report, Cellular Distribution, Controlled Study, Female, Gene Disruption, Gene Mutation, Genetic Analysis, Genetic Susceptibility, Genetic Transcription, Glucose Homeostasis, Human, In Vitro Study, Insulin Binding, Insulin Release, Insulin Resistance, Insulin Sensitivity, Mouse, Non Insulin Dependent Diabetes Mellitus, Nonhuman, Nucleotide Sequence, Pancreas Islet, Pedigree, Phenotype, Positron Emission Tomography, Priority Journal, Protein Expression, School Child, Signal Transduction, Wild Type, Untranslated Regions, Adolescent, Antigens, Cultured, Gene Expression Regulation, Glucose Transporter Type 4, Hmga1a Protein, Insulin-Like Growth Factor Binding Protein 1, Mutant Strains, Monosaccharide Transport Proteins, Muscle Proteins, Positron-Emission Tomography, Pregnancy Proteins, Rna Stability, Diagnosis, Treatment, 4 Thiazolidinedione Derivative, Biguanide, Glibenclamide, Glycosidase Inhibitor, Insulin Derivative, Insulin Lispro, Meglitinide, Metformin, Nateglinide, Peroxisome Proliferator Activated Receptor Gamma, Pioglitazone, Rosiglitazone, Sulfonylurea, Troglitazone, Tumor Necrosis Factor Alpha, Exercise, Glucose Intolerance, Glucose Tolerance, Insulin Pump, Insulin Treatment, Pathophysiology, Metabolism, Secretion, Pathology,
Affiliations:
*** IBB - CNR ***
Dipartimento di Medicina Sperimentale e Clinica G. Salvatore, Università di Catanzaro Magna Graecia, via T. Campanella 115, 88100 Catanzaro, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, c/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università di Napoli Federico II, via Pansini 5, 80131 Napoli, Italy
IRCCS, Ospedale Pediatrico Bambino Gesù, 00100 Roma, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Università di Napoli Federico II, via Pansini 5, 80131 Napoli, Italy
Division of Human Cancer Genetics, Comprehensive Cancer Center, Ohio State University, 410 West 12th Avenue, Columbus, OH 43210, United States
Grupo de Obesidade e Doen as Metab licas, Servi o de Endocrinologia e Metabologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HC-FMUSP), Brazil
Departamento de Obesidade da Sociedade Brasileira de Endocrinologia e Metabologia, Brazil
Hospital Brigadeiro, Brazil
R. Alves Guimaraes. 462, CEP 05410-000 - S o Paulo - SP, Brazil
References:
Not available.
Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice
Type 2 diabetes mellitus is a widespread disease, affecting millions of people globally. Although genetics and environmental factors seem to have a role, the cause of this metabolic disorder is largely unknown. Here we report a genetic flaw that markedly reduced the intracellular expression of the high mobility group A1 (HMGA1) protein, and adversely affected insulin receptor expression in cells and tissues from four subjects with insulin resistance and type 2 diabetes. Restoration of HMGA1 protein expression in subjects' cells enhanced INSR gene transcription, and restored cell-surface insulin receptor protein expression and insulin-binding capacity. Loss of Hmga1 expression, induced in mice by disrupting the Hmga1 gene, considerably decreased insulin receptor expression in the major targets of insulin action, largely impaired insulin signaling and severely reduced insulin secretion, causing a phenotype characteristic of human type 2 diabetes.
Type 2 diabetes mellitus is a widespread disease, affecting millions of people globally. Although genetics and environmental factors seem to have a role, the cause of this metabolic disorder is largely unknown. Here we report a genetic flaw that markedly reduced the intracellular expression of the high mobility group A1 (HMGA1) protein, and adversely affected insulin receptor expression in cells and tissues from four subjects with insulin resistance and type 2 diabetes. Restoration of HMGA1 protein expression in subjects' cells enhanced INSR gene transcription, and restored cell-surface insulin receptor protein expression and insulin-binding capacity. Loss of Hmga1 expression, induced in mice by disrupting the Hmga1 gene, considerably decreased insulin receptor expression in the major targets of insulin action, largely impaired insulin signaling and severely reduced insulin secretion, causing a phenotype characteristic of human type 2 diabetes.
Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice
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Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice
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View Export to BibTeX Export to EndNote
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Impact Factor: 2.633
View Export to BibTeX Export to EndNote
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Impact Factor: 3.675
View Export to BibTeX Export to EndNote
Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
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Impact Factor: 19.358
View Export to BibTeX Export to EndNote
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Impact Factor: 4.746
View Export to BibTeX Export to EndNote
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Impact Factor: 6.044
View Export to BibTeX Export to EndNote
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Impact Factor: 6.373
View Export to BibTeX Export to EndNote
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Impact Factor: 2.595
View Export to BibTeX Export to EndNote
Illario M, Monaco S, Cavallo AL, Esposito I, Formisano P, D'Andrea LD, Cipolletta E, Trimarco B, Fenzi G, Rossi G, Vitale M
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Impact Factor: 4.094
View Export to BibTeX Export to EndNote
Frasca F, Pandini G, Sciacca L, Pezzino V, Squatrito S, Belfiore A, Vigneri R
* The role of insulin receptors and IGF-I receptors in cancer and other diseases (1721 views)
Archives Of Physiology And Biochemistry (ISSN: 1381-3455), 2008 Feb; 114(1): 23-37.
Impact Factor: 2.028
View Export to BibTeX Export to EndNote
Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L
* The role of membrane glycoprotein plasma cell antigen 1 ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities (1441 views)
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Impact Factor: 18.562
View Export to BibTeX Export to EndNote
Bucci EM, Valente M, Musumeci D, Sapio R, Anrò V, Roviello GN, Moccia M
* ODN-based drugs for targeting of extracellular proteins (371 views)
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Impact Factor: 0.723
View Export to BibTeX Export to EndNote
Fiory F, Alberobello AT, Miele C, Oriente F, Esposito I, Corbo V, Ruvo M, Tizzano B, Rasmussen TE, Gammeltoft S, Formisano P, Beguinot F
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Impact Factor: 7.093
View Export to BibTeX Export to EndNote
FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
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Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
View Export to BibTeX Export to EndNote
Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID
Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells (593 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1990 Dec 15; 50(24): 7858-7862.
Impact Factor: 8.426
View Export to BibTeX Export to EndNote
Trischitta V, Brunetti A, Chiavetta A, Benzi L, Papa V, Vigneri R
Defects in insulin-receptor internalization and processing in monocytes of obese subjects and obese NIDDM patients (367 views)
Diabetesdiabetes (ISSN: 0012-1797), 1989 Dec; 38(12): 1579-1584.
Impact Factor: 8.675
View Export to BibTeX Export to EndNote
Pezzino V, Papa V, Trischitta V, Brunetti A, Goodman PA, Treutelaar MK, Williams JA, Maddux BA, Vigneri R, Goldfine ID
Human insulin receptor radioimmunoassay: Applicability to insulin-resistant states (354 views)
Am J Physiol Endocrinol Metab (ISSN: 0002-9513), 1989 Sep; 257(3): N/D-N/D.
Impact Factor: 3.116
View Export to BibTeX Export to EndNote
Trischitta V, Wong KY, Brunetti A, Scalisi R, Vigneri R, Goldfine ID
Endocytosis, recycling, and degradation of the insulin receptor. Studies with monoclonal antireceptor antibodies that do not activate receptor kinase (366 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1989 Mar 25; 264(9): 5041-5046.
Impact Factor: 6.963
View Export to BibTeX Export to EndNote
17 Records (14 excluding Abstracts).
Total impact factor: 107.534 (94.699 excluding Abstracts).
Total 5 year impact factor: 109.38 (103.336 excluding Abstracts).
Total impact factor: 107.534 (94.699 excluding Abstracts).
Total 5 year impact factor: 109.38 (103.336 excluding Abstracts).
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