Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice (383 views)
Nat Med (ISSN: 1078-8956, 0034-7264), 2005 Jul; 11(7): 765-773.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 28.878, 5-year impact factor: 26.501
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-22544482628&partnerID=40&md5=c77a14a0a696c09542794cc38392072e
Keywords: Glucose Transporter 4, High Mobility Group A1 Protein, Insulin Receptor, Nucleic Acid Binding Protein, Somatomedin Binding Protein 1, Unclassified Drug, Adult, Animal Experiment, Animal Model, Animal Tissue, Article, Case Report, Cellular Distribution, Controlled Study, Female, Gene Disruption, Gene Mutation, Genetic Analysis, Genetic Susceptibility, Genetic Transcription, Glucose Homeostasis, Human, In Vitro Study, Insulin Binding, Insulin Release, Insulin Resistance, Insulin Sensitivity, Mouse, Non Insulin Dependent Diabetes Mellitus, Nonhuman, Nucleotide Sequence, Pancreas Islet, Pedigree, Phenotype, Positron Emission Tomography, Priority Journal, Protein Expression, School Child, Signal Transduction, Wild Type, Untranslated Regions, Adolescent, Antigens, Cultured, Gene Expression Regulation, Glucose Transporter Type 4, Hmga1a Protein, Insulin-Like Growth Factor Binding Protein 1, Mutant Strains, Monosaccharide Transport Proteins, Muscle Proteins, Positron-Emission Tomography, Pregnancy Proteins, Rna Stability, Diagnosis, Treatment, 4 Thiazolidinedione Derivative, Biguanide, Glibenclamide, Glycosidase Inhibitor, Insulin Derivative, Insulin Lispro, Meglitinide, Metformin, Nateglinide, Peroxisome Proliferator Activated Receptor Gamma, Pioglitazone, Rosiglitazone, Sulfonylurea, Troglitazone, Tumor Necrosis Factor Alpha, Exercise, Glucose Intolerance, Glucose Tolerance, Insulin Pump, Insulin Treatment, Pathophysiology, Metabolism, Secretion, Pathology,
Affiliations:
*** IBB - CNR ***
Dipartimento di Medicina Sperimentale e Clinica G. Salvatore, Università di Catanzaro Magna Graecia, via T. Campanella 115, 88100 Catanzaro, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, c/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università di Napoli Federico II, via Pansini 5, 80131 Napoli, Italy
IRCCS, Ospedale Pediatrico Bambino Gesù, 00100 Roma, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Università di Napoli Federico II, via Pansini 5, 80131 Napoli, Italy
Division of Human Cancer Genetics, Comprehensive Cancer Center, Ohio State University, 410 West 12th Avenue, Columbus, OH 43210, United States
Grupo de Obesidade e Doen as Metab licas, Servi o de Endocrinologia e Metabologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HC-FMUSP), Brazil
Departamento de Obesidade da Sociedade Brasileira de Endocrinologia e Metabologia, Brazil
Hospital Brigadeiro, Brazil
R. Alves Guimaraes. 462, CEP 05410-000 - S o Paulo - SP, Brazil
References:
Kahn, C.R., Insulin action, diabetogenes, and the cause of type II diabetes (Banting Lecture) (1994) Diabetes, 43, pp. 1066-108
Polonsky, K.S., Sturis, J., Bell, G.I., Non-insulin-dependent diabetes mellitus - A genetically programmed failure of the beta cell to compensate for insulin resistance (1996) N. Engl. J. Med., 334, pp. 777-783
Taylor, S.I., Insulin resistance or insulin deficiency: Which is the primary cause of NIDDM? (1994) Diabetes, 43, pp. 735-740
Goldfine, I.D., The insulin receptor: Molecular biology and transmembrane signalling (1987) Endocr. Rev., 8, pp. 235-255
Taylor, S.I., Mutations in the insulin receptor gene (1992) Endocr. Rev., 13, pp. 566-595
Bustin, M., Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins (1999) Mol. Cell. Biol., 19, pp. 5237-5246
Reeves, R., Beckerbauer, L., HMGI/Y proteins: Flexible regulators of transcription and chromatin structure (2001) Biochim. Biophys. Acta, 1519, pp. 13-29
Thanos, D., Maniatis, T., The high mobility group protein HMG I(Y) is required for NF-kB-dependent virus induction of the human IFN-β gene (1992) Cell, 71, pp. 777-789
Brunetti, A., Manfioletti, G., Chiefari, E., Goldfine, I.D., Foti, D., Transcriptional regulation of human insulin receptor gene by the high-mobility-group protein HMGI-Y (2001) FASEB J., 15, pp. 492-500
Foti, D., Iuliano, R., Chiefari, E., Brunetti, A., A nucleoprotein complex containing Sp1, C/EBPβ, and HMGI-Y controls human insulin receptor gene transcription (2003) Mol. Cell. Biol., 23, pp. 2720-2732
Brunetti, A., Brunetti, L., Foti, D., Accili, D., Goldfine, I.D., Human diabetes associated with defects in regulatory proteins for the insulin receptor gene (1996) J. Clin. Invest., 97, pp. 258-262
Holth, L.T., Thorlacius, A.E., Reeves, R., Effect of epidermal growth factor and estrogen on the regulation of the HMGI/Y gene in human mammary epithelial cell lines (1997) DNA Cell Biol., 16, pp. 1299-1309
Borrmann, L., Wilkening, S., Bullerdiek, J., The expression of HMGA genes is regulated by their 3'UTR (2001) Oncogene, 20, pp. 4537-4541
Kahn, C.R., The syndromes of insulin resistance and acanthosis nigricans (1976) N. Engl. J. Med., 294, pp. 739-745
Fidanza, V., Double knockout of the ALL-1 gene blocks hematopoietic differentiation in vitro (1996) Cancer. Res., 56, pp. 1179-1183
White, M.F., The IRS-signalling system: A network of docking proteins that mediate insulin action (1998) Mol. Cell. Biochem., 182, pp. 3-11
Saltiel, A.R., Pessin, J.E., Insulin signaling pathways in time and space (2002) Trends Cell Biol., 12, pp. 65-71
Cho, H., Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ) (2001) Science, 292, pp. 1728-1731
Bruning, J.C., Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 nullalleles (1997) Cell, 88, pp. 561-572
Kulkarni, R.N., Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes (1999) Cell, 96, pp. 329-339
Kitamura, T., Kahn, C.R., Accili, D., Insulin receptor knockout mice (2003) Annu. Rev. Physiol., 65, pp. 313-332
Shimomura, I., Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice (2000) Mol. Cell, 6, pp. 77-86
Rane, S.G., Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia (1999) Nat. Genet., 22, pp. 44-52
Belke, D.D., Larsen, T.S., Gibbs, E.M., Severson, D.L., Glucose metabolism in perfused mouse hearts overexpressing human GLUT-4 glucose transporter (2001) Am. J. Physiol. Endocrinol. Metab., 280, pp. E420-E427
Bilan, P.J., Ramlal, T., Klip, A., IGF-1 mediated recruitment of glucose transporters from intracellular membranes to plasma membranes in L6 muscle cells (1991) Adv. Exp. Med. Biol., 293, pp. 273-288
Weiland, M., The signaling potential of the receptors for insulin and insulin-like growth factor I (IGF-1) in 3T3-L1 adipocytes: Comparison of glucose transport activity, induction of oncogene c-fos, glucose transporter mRNA, and DNA-synthesis (1991) J. Cell. Physiol., 149, pp. 428-435
Sandhu, M.S., Circulating concentrations of insulin-like growth factor-1 and development of glucose intolerance: A prospective observational study (2002) Lancet, 359, pp. 1740-1745
Allander, S.V., Hepatic nuclear factor 3 and high mobility group I/Y proteins bind the insulin response element of the insulin-like growth factor-binding protein-1 promoter (1997) Endocrinology, 138, pp. 4291-4300
Di Cola, G., Cool, M.H., Accili, D., Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors (1997) J. Clin. Invest., 99, pp. 2538-2544
Ohneda, K., Mirmira, R.G., Wang, J., Johnson, J.D., German, M.S., The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter (2000) Mol. Cell. Biol., 20, pp. 900-911
Taylor, S.I., Deconstructing type 2 diabetes (1999) Cell, 97, pp. 9-12
Kim, S.K., Hebrok, M., Intercellular signals regulating pancreas development and function (2001) Genes & Dev., 15, pp. 111-127
Eizirik, D.L., Major species differences between humans and rodents in the susceptibility to pancreatic β-cell injury (1994) Proc. Natl. Acad. Sci. USA, 91, pp. 9253-9256
Nat Med (ISSN: 1078-8956, 0034-7264), 2005 Jul; 11(7): 765-773.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 28.878, 5-year impact factor: 26.501
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-22544482628&partnerID=40&md5=c77a14a0a696c09542794cc38392072e
Keywords: Glucose Transporter 4, High Mobility Group A1 Protein, Insulin Receptor, Nucleic Acid Binding Protein, Somatomedin Binding Protein 1, Unclassified Drug, Adult, Animal Experiment, Animal Model, Animal Tissue, Article, Case Report, Cellular Distribution, Controlled Study, Female, Gene Disruption, Gene Mutation, Genetic Analysis, Genetic Susceptibility, Genetic Transcription, Glucose Homeostasis, Human, In Vitro Study, Insulin Binding, Insulin Release, Insulin Resistance, Insulin Sensitivity, Mouse, Non Insulin Dependent Diabetes Mellitus, Nonhuman, Nucleotide Sequence, Pancreas Islet, Pedigree, Phenotype, Positron Emission Tomography, Priority Journal, Protein Expression, School Child, Signal Transduction, Wild Type, Untranslated Regions, Adolescent, Antigens, Cultured, Gene Expression Regulation, Glucose Transporter Type 4, Hmga1a Protein, Insulin-Like Growth Factor Binding Protein 1, Mutant Strains, Monosaccharide Transport Proteins, Muscle Proteins, Positron-Emission Tomography, Pregnancy Proteins, Rna Stability, Diagnosis, Treatment, 4 Thiazolidinedione Derivative, Biguanide, Glibenclamide, Glycosidase Inhibitor, Insulin Derivative, Insulin Lispro, Meglitinide, Metformin, Nateglinide, Peroxisome Proliferator Activated Receptor Gamma, Pioglitazone, Rosiglitazone, Sulfonylurea, Troglitazone, Tumor Necrosis Factor Alpha, Exercise, Glucose Intolerance, Glucose Tolerance, Insulin Pump, Insulin Treatment, Pathophysiology, Metabolism, Secretion, Pathology,
Affiliations:
*** IBB - CNR ***
Dipartimento di Medicina Sperimentale e Clinica G. Salvatore, Università di Catanzaro Magna Graecia, via T. Campanella 115, 88100 Catanzaro, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, c/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università di Napoli Federico II, via Pansini 5, 80131 Napoli, Italy
IRCCS, Ospedale Pediatrico Bambino Gesù, 00100 Roma, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Università di Napoli Federico II, via Pansini 5, 80131 Napoli, Italy
Division of Human Cancer Genetics, Comprehensive Cancer Center, Ohio State University, 410 West 12th Avenue, Columbus, OH 43210, United States
Grupo de Obesidade e Doen as Metab licas, Servi o de Endocrinologia e Metabologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HC-FMUSP), Brazil
Departamento de Obesidade da Sociedade Brasileira de Endocrinologia e Metabologia, Brazil
Hospital Brigadeiro, Brazil
R. Alves Guimaraes. 462, CEP 05410-000 - S o Paulo - SP, Brazil
References:
Kahn, C.R., Insulin action, diabetogenes, and the cause of type II diabetes (Banting Lecture) (1994) Diabetes, 43, pp. 1066-108
Polonsky, K.S., Sturis, J., Bell, G.I., Non-insulin-dependent diabetes mellitus - A genetically programmed failure of the beta cell to compensate for insulin resistance (1996) N. Engl. J. Med., 334, pp. 777-783
Taylor, S.I., Insulin resistance or insulin deficiency: Which is the primary cause of NIDDM? (1994) Diabetes, 43, pp. 735-740
Goldfine, I.D., The insulin receptor: Molecular biology and transmembrane signalling (1987) Endocr. Rev., 8, pp. 235-255
Taylor, S.I., Mutations in the insulin receptor gene (1992) Endocr. Rev., 13, pp. 566-595
Bustin, M., Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins (1999) Mol. Cell. Biol., 19, pp. 5237-5246
Reeves, R., Beckerbauer, L., HMGI/Y proteins: Flexible regulators of transcription and chromatin structure (2001) Biochim. Biophys. Acta, 1519, pp. 13-29
Thanos, D., Maniatis, T., The high mobility group protein HMG I(Y) is required for NF-kB-dependent virus induction of the human IFN-β gene (1992) Cell, 71, pp. 777-789
Brunetti, A., Manfioletti, G., Chiefari, E., Goldfine, I.D., Foti, D., Transcriptional regulation of human insulin receptor gene by the high-mobility-group protein HMGI-Y (2001) FASEB J., 15, pp. 492-500
Foti, D., Iuliano, R., Chiefari, E., Brunetti, A., A nucleoprotein complex containing Sp1, C/EBPβ, and HMGI-Y controls human insulin receptor gene transcription (2003) Mol. Cell. Biol., 23, pp. 2720-2732
Brunetti, A., Brunetti, L., Foti, D., Accili, D., Goldfine, I.D., Human diabetes associated with defects in regulatory proteins for the insulin receptor gene (1996) J. Clin. Invest., 97, pp. 258-262
Holth, L.T., Thorlacius, A.E., Reeves, R., Effect of epidermal growth factor and estrogen on the regulation of the HMGI/Y gene in human mammary epithelial cell lines (1997) DNA Cell Biol., 16, pp. 1299-1309
Borrmann, L., Wilkening, S., Bullerdiek, J., The expression of HMGA genes is regulated by their 3'UTR (2001) Oncogene, 20, pp. 4537-4541
Kahn, C.R., The syndromes of insulin resistance and acanthosis nigricans (1976) N. Engl. J. Med., 294, pp. 739-745
Fidanza, V., Double knockout of the ALL-1 gene blocks hematopoietic differentiation in vitro (1996) Cancer. Res., 56, pp. 1179-1183
White, M.F., The IRS-signalling system: A network of docking proteins that mediate insulin action (1998) Mol. Cell. Biochem., 182, pp. 3-11
Saltiel, A.R., Pessin, J.E., Insulin signaling pathways in time and space (2002) Trends Cell Biol., 12, pp. 65-71
Cho, H., Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ) (2001) Science, 292, pp. 1728-1731
Bruning, J.C., Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 nullalleles (1997) Cell, 88, pp. 561-572
Kulkarni, R.N., Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes (1999) Cell, 96, pp. 329-339
Kitamura, T., Kahn, C.R., Accili, D., Insulin receptor knockout mice (2003) Annu. Rev. Physiol., 65, pp. 313-332
Shimomura, I., Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice (2000) Mol. Cell, 6, pp. 77-86
Rane, S.G., Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia (1999) Nat. Genet., 22, pp. 44-52
Belke, D.D., Larsen, T.S., Gibbs, E.M., Severson, D.L., Glucose metabolism in perfused mouse hearts overexpressing human GLUT-4 glucose transporter (2001) Am. J. Physiol. Endocrinol. Metab., 280, pp. E420-E427
Bilan, P.J., Ramlal, T., Klip, A., IGF-1 mediated recruitment of glucose transporters from intracellular membranes to plasma membranes in L6 muscle cells (1991) Adv. Exp. Med. Biol., 293, pp. 273-288
Weiland, M., The signaling potential of the receptors for insulin and insulin-like growth factor I (IGF-1) in 3T3-L1 adipocytes: Comparison of glucose transport activity, induction of oncogene c-fos, glucose transporter mRNA, and DNA-synthesis (1991) J. Cell. Physiol., 149, pp. 428-435
Sandhu, M.S., Circulating concentrations of insulin-like growth factor-1 and development of glucose intolerance: A prospective observational study (2002) Lancet, 359, pp. 1740-1745
Allander, S.V., Hepatic nuclear factor 3 and high mobility group I/Y proteins bind the insulin response element of the insulin-like growth factor-binding protein-1 promoter (1997) Endocrinology, 138, pp. 4291-4300
Di Cola, G., Cool, M.H., Accili, D., Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors (1997) J. Clin. Invest., 99, pp. 2538-2544
Ohneda, K., Mirmira, R.G., Wang, J., Johnson, J.D., German, M.S., The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter (2000) Mol. Cell. Biol., 20, pp. 900-911
Taylor, S.I., Deconstructing type 2 diabetes (1999) Cell, 97, pp. 9-12
Kim, S.K., Hebrok, M., Intercellular signals regulating pancreas development and function (2001) Genes & Dev., 15, pp. 111-127
Eizirik, D.L., Major species differences between humans and rodents in the susceptibility to pancreatic β-cell injury (1994) Proc. Natl. Acad. Sci. USA, 91, pp. 9253-9256
Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice
Type 2 diabetes mellitus is a widespread disease, affecting millions of people globally. Although genetics and environmental factors seem to have a role, the cause of this metabolic disorder is largely unknown. Here we report a genetic flaw that markedly reduced the intracellular expression of the high mobility group A1 (HMGA1) protein, and adversely affected insulin receptor expression in cells and tissues from four subjects with insulin resistance and type 2 diabetes. Restoration of HMGA1 protein expression in subjects' cells enhanced INSR gene transcription, and restored cell-surface insulin receptor protein expression and insulin-binding capacity. Loss of Hmga1 expression, induced in mice by disrupting the Hmga1 gene, considerably decreased insulin receptor expression in the major targets of insulin action, largely impaired insulin signaling and severely reduced insulin secretion, causing a phenotype characteristic of human type 2 diabetes.
Type 2 diabetes mellitus is a widespread disease, affecting millions of people globally. Although genetics and environmental factors seem to have a role, the cause of this metabolic disorder is largely unknown. Here we report a genetic flaw that markedly reduced the intracellular expression of the high mobility group A1 (HMGA1) protein, and adversely affected insulin receptor expression in cells and tissues from four subjects with insulin resistance and type 2 diabetes. Restoration of HMGA1 protein expression in subjects' cells enhanced INSR gene transcription, and restored cell-surface insulin receptor protein expression and insulin-binding capacity. Loss of Hmga1 expression, induced in mice by disrupting the Hmga1 gene, considerably decreased insulin receptor expression in the major targets of insulin action, largely impaired insulin signaling and severely reduced insulin secretion, causing a phenotype characteristic of human type 2 diabetes.
Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice
No results. |
Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice
Other filter: ([btitle,keywords] "Glucose Transporter ...
Vigneri R, Goldfine ID, Frittitta L
* Insulin, insulin receptors, and cancer (250 views)
J Endocrinol Invest (ISSN: 1720-8386, 0391-4097, 1720-8386electronic), 2016 Dec; 39(12): 1365-1376.
Impact Factor: 2.633
View Export to BibTeX Export to EndNote
Milardi D, Sciacca MF, Randazzo L, Raudino A, La Rosa C
* The role of calcium, lipid membranes and islet amyloid polypeptide in the onset of type 2 diabetes: Innocent bystanders or partners in a crime? (457 views)
Front Endocrinol (ISSN: 1664-2392, 1664-2392linking, 1664-2392print), 2014; 5(DEC): 216-216.
Impact Factor: 3.675
View Export to BibTeX Export to EndNote
Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
* Tumors, IGF-2, and Hypoglycemia: Insights From the Clinic, the Laboratory, and the Historical Archive (1518 views)
Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826.
Impact Factor: 19.358
View Export to BibTeX Export to EndNote
Iiritano S, Chiefari E, Ventura V, Arcidiacono B, Possidente K, Nocera A, Nevolo MT, Fedele M, Greco A, Greco M, Brunetti G, Fusco A, Foti D, Brunetti A
* The HMGA1-IGF-I/IGFBP system: a novel pathway for modulating glucose uptake (660 views)
Molecular Endocrinology (ISSN: 0888-8809, 1944-9917electronic), 2012 Sep; 26(9): 1578-1589.
Impact Factor: 4.746
View Export to BibTeX Export to EndNote
Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (500 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
View Export to BibTeX Export to EndNote
Palmieri D, Valentino T, D'Angelo D, De Martino I, Postiglione I, Pacelli R, Croce CM, Fedele M, Fusco A
* HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents (786 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
Impact Factor: 6.373
View Export to BibTeX Export to EndNote
D'Auria G, Esposito C, Falcigno L, Calvanese L, Iaccarino E, Ruggiero A, Pedone C, Pedone E, Berisio R
* Dynamical properties of cold shock protein A from Mycobacterium tuberculosis (319 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 1090-2104, 1090-2104electronic), 2010 Nov 26; 402(4): 693-698.
Impact Factor: 2.595
View Export to BibTeX Export to EndNote
Illario M, Monaco S, Cavallo AL, Esposito I, Formisano P, D'Andrea LD, Cipolletta E, Trimarco B, Fenzi G, Rossi G, Vitale M
* Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake (385 views)
Cell Signal (ISSN: 0898-6568), 2009 May; 21(5): 786-792.
Impact Factor: 4.094
View Export to BibTeX Export to EndNote
Frasca F, Pandini G, Sciacca L, Pezzino V, Squatrito S, Belfiore A, Vigneri R
* The role of insulin receptors and IGF-I receptors in cancer and other diseases (1578 views)
Archives Of Physiology And Biochemistry (ISSN: 1381-3455), 2008 Feb; 114(1): 23-37.
Impact Factor: 2.028
View Export to BibTeX Export to EndNote
Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L
* The role of membrane glycoprotein plasma cell antigen 1 ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities (696 views)
Endocrine Reviews (ISSN: 0163-769x), 2008 Feb; 29(1): 62-75.
Impact Factor: 18.562
View Export to BibTeX Export to EndNote
Bucci EM, Valente M, Musumeci D, Sapio R, Anrò V, Roviello GN, Moccia M
* ODN-based drugs for targeting of extracellular proteins (282 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1047-1050.
Impact Factor: 0.723
View Export to BibTeX Export to EndNote
Fiory F, Alberobello AT, Miele C, Oriente F, Esposito I, Corbo V, Ruvo M, Tizzano B, Rasmussen TE, Gammeltoft S, Formisano P, Beguinot F
* Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling (460 views)
Mol Cell Biol (ISSN: 0270-7306, 1098-5549), 2005 Dec; 25(24): 10803-10814.
Impact Factor: 7.093
View Export to BibTeX Export to EndNote
FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (445 views)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
View Export to BibTeX Export to EndNote
Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID
Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells (442 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1990 Dec 15; 50(24): 7858-7862.
Impact Factor: 8.426
View Export to BibTeX Export to EndNote
Trischitta V, Brunetti A, Chiavetta A, Benzi L, Papa V, Vigneri R
Defects in insulin-receptor internalization and processing in monocytes of obese subjects and obese NIDDM patients (314 views)
Diabetesdiabetes (ISSN: 0012-1797), 1989 Dec; 38(12): 1579-1584.
Impact Factor: 8.675
View Export to BibTeX Export to EndNote
Pezzino V, Papa V, Trischitta V, Brunetti A, Goodman PA, Treutelaar MK, Williams JA, Maddux BA, Vigneri R, Goldfine ID
Human insulin receptor radioimmunoassay: Applicability to insulin-resistant states (263 views)
Am J Physiol Endocrinol Metab (ISSN: 0002-9513), 1989 Sep; 257(3): N/D-N/D.
Impact Factor: 3.116
View Export to BibTeX Export to EndNote
Trischitta V, Wong KY, Brunetti A, Scalisi R, Vigneri R, Goldfine ID
Endocytosis, recycling, and degradation of the insulin receptor. Studies with monoclonal antireceptor antibodies that do not activate receptor kinase (316 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1989 Mar 25; 264(9): 5041-5046.
Impact Factor: 6.963
View Export to BibTeX Export to EndNote
* Insulin, insulin receptors, and cancer (250 views)
J Endocrinol Invest (ISSN: 1720-8386, 0391-4097, 1720-8386electronic), 2016 Dec; 39(12): 1365-1376.
Impact Factor: 2.633
View Export to BibTeX Export to EndNote
Milardi D, Sciacca MF, Randazzo L, Raudino A, La Rosa C
* The role of calcium, lipid membranes and islet amyloid polypeptide in the onset of type 2 diabetes: Innocent bystanders or partners in a crime? (457 views)
Front Endocrinol (ISSN: 1664-2392, 1664-2392linking, 1664-2392print), 2014; 5(DEC): 216-216.
Impact Factor: 3.675
View Export to BibTeX Export to EndNote
Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
* Tumors, IGF-2, and Hypoglycemia: Insights From the Clinic, the Laboratory, and the Historical Archive (1518 views)
Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826.
Impact Factor: 19.358
View Export to BibTeX Export to EndNote
Iiritano S, Chiefari E, Ventura V, Arcidiacono B, Possidente K, Nocera A, Nevolo MT, Fedele M, Greco A, Greco M, Brunetti G, Fusco A, Foti D, Brunetti A
* The HMGA1-IGF-I/IGFBP system: a novel pathway for modulating glucose uptake (660 views)
Molecular Endocrinology (ISSN: 0888-8809, 1944-9917electronic), 2012 Sep; 26(9): 1578-1589.
Impact Factor: 4.746
View Export to BibTeX Export to EndNote
Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (500 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
View Export to BibTeX Export to EndNote
Palmieri D, Valentino T, D'Angelo D, De Martino I, Postiglione I, Pacelli R, Croce CM, Fedele M, Fusco A
* HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents (786 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
Impact Factor: 6.373
View Export to BibTeX Export to EndNote
D'Auria G, Esposito C, Falcigno L, Calvanese L, Iaccarino E, Ruggiero A, Pedone C, Pedone E, Berisio R
* Dynamical properties of cold shock protein A from Mycobacterium tuberculosis (319 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 1090-2104, 1090-2104electronic), 2010 Nov 26; 402(4): 693-698.
Impact Factor: 2.595
View Export to BibTeX Export to EndNote
Illario M, Monaco S, Cavallo AL, Esposito I, Formisano P, D'Andrea LD, Cipolletta E, Trimarco B, Fenzi G, Rossi G, Vitale M
* Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake (385 views)
Cell Signal (ISSN: 0898-6568), 2009 May; 21(5): 786-792.
Impact Factor: 4.094
View Export to BibTeX Export to EndNote
Frasca F, Pandini G, Sciacca L, Pezzino V, Squatrito S, Belfiore A, Vigneri R
* The role of insulin receptors and IGF-I receptors in cancer and other diseases (1578 views)
Archives Of Physiology And Biochemistry (ISSN: 1381-3455), 2008 Feb; 114(1): 23-37.
Impact Factor: 2.028
View Export to BibTeX Export to EndNote
Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L
* The role of membrane glycoprotein plasma cell antigen 1 ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities (696 views)
Endocrine Reviews (ISSN: 0163-769x), 2008 Feb; 29(1): 62-75.
Impact Factor: 18.562
View Export to BibTeX Export to EndNote
Bucci EM, Valente M, Musumeci D, Sapio R, Anrò V, Roviello GN, Moccia M
* ODN-based drugs for targeting of extracellular proteins (282 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1047-1050.
Impact Factor: 0.723
View Export to BibTeX Export to EndNote
Fiory F, Alberobello AT, Miele C, Oriente F, Esposito I, Corbo V, Ruvo M, Tizzano B, Rasmussen TE, Gammeltoft S, Formisano P, Beguinot F
* Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling (460 views)
Mol Cell Biol (ISSN: 0270-7306, 1098-5549), 2005 Dec; 25(24): 10803-10814.
Impact Factor: 7.093
View Export to BibTeX Export to EndNote
FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (445 views)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
View Export to BibTeX Export to EndNote
Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID
Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells (442 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1990 Dec 15; 50(24): 7858-7862.
Impact Factor: 8.426
View Export to BibTeX Export to EndNote
Trischitta V, Brunetti A, Chiavetta A, Benzi L, Papa V, Vigneri R
Defects in insulin-receptor internalization and processing in monocytes of obese subjects and obese NIDDM patients (314 views)
Diabetesdiabetes (ISSN: 0012-1797), 1989 Dec; 38(12): 1579-1584.
Impact Factor: 8.675
View Export to BibTeX Export to EndNote
Pezzino V, Papa V, Trischitta V, Brunetti A, Goodman PA, Treutelaar MK, Williams JA, Maddux BA, Vigneri R, Goldfine ID
Human insulin receptor radioimmunoassay: Applicability to insulin-resistant states (263 views)
Am J Physiol Endocrinol Metab (ISSN: 0002-9513), 1989 Sep; 257(3): N/D-N/D.
Impact Factor: 3.116
View Export to BibTeX Export to EndNote
Trischitta V, Wong KY, Brunetti A, Scalisi R, Vigneri R, Goldfine ID
Endocytosis, recycling, and degradation of the insulin receptor. Studies with monoclonal antireceptor antibodies that do not activate receptor kinase (316 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1989 Mar 25; 264(9): 5041-5046.
Impact Factor: 6.963
View Export to BibTeX Export to EndNote
17 Records (14 excluding Abstracts).
Total impact factor: 107.534 (94.699 excluding Abstracts).
Total 5 year impact factor: 109.38 (103.336 excluding Abstracts).
Total impact factor: 107.534 (94.699 excluding Abstracts).
Total 5 year impact factor: 109.38 (103.336 excluding Abstracts).
383 views. Last view on Saturday 14 January 2023, 19:39:23
ibb.cnr.it