Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (700 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
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Paper type: Journal Article, Comparative Study, Research Support, Non-U. S. Gov'T,
Impact factor: 1.995, 5-year impact factor: 1.817
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-23044437134&partnerID=40&md5=c106ba137fd297901c611eaa015605eb
Keywords: β-Amyloid, σ1 Receptor Agonists, Neuronal Apoptosis, 1 Phenylcyclohexanecarboxylic Acid 2 Morpholinoethyl Ester, 2 (4 Morpholinethyl)1 Phenylcyclohexanecarboxylate, 2 [4 Methoxy 3 (2 Phenylethoxy)phenyl] N, N Dipropylethylamine, 7 Dinitro 2, 3 Quinoxalinedione, Amyloid Beta Protein[25-35], Carboxylic Acid Derivative, Dizocilpine, Methyl 2 [1 Adamantyl(methyl)amino] Methyl 1 Phenylcyclopropanecarboxylate, Mr 22, Opiate Agonist, Opiate Antagonist, Protein Bax, Sigma Receptor Ligand, Unclassified Drug, Alzheimer Disease, Animal Cell, Article, Cell Death, Controlled Study, Cytotoxicity, Drug Antagonism, Drug Synthesis, Neuroprotection, Nonhuman, Priority Journal, Amyloid Beta-Protein, Anisoles, Bcl-2-Associated X Protein, Blotting, Western, Cell Count, Cell Survival, Cultured, Cerebral Cortex, Dose-Response Relationship, Drug Interactions, Embryo, Excitatory Amino Acid Antagonists, Neuroprotective Agents, Peptide Fragments, Propylamines, Proto-Oncogene Proteins C-Bcl-2, Amyloid Beta-Peptides, Inhibitors, Pharmacology, Drug Effects, Cytology, Mammalian, Metabolism,
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Catania, Catania, Italy
I.B.B., CNR-Catania, Catania, Italy
Cellular Neurobiology Research Branch, NIDA, NIH, Baltimore, MD, United States
References:
Not available.
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Comparative Study, Research Support, Non-U. S. Gov'T,
Impact factor: 1.995, 5-year impact factor: 1.817
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-23044437134&partnerID=40&md5=c106ba137fd297901c611eaa015605eb
Keywords: β-Amyloid, σ1 Receptor Agonists, Neuronal Apoptosis, 1 Phenylcyclohexanecarboxylic Acid 2 Morpholinoethyl Ester, 2 (4 Morpholinethyl)1 Phenylcyclohexanecarboxylate, 2 [4 Methoxy 3 (2 Phenylethoxy)phenyl] N, N Dipropylethylamine, 7 Dinitro 2, 3 Quinoxalinedione, Amyloid Beta Protein[25-35], Carboxylic Acid Derivative, Dizocilpine, Methyl 2 [1 Adamantyl(methyl)amino] Methyl 1 Phenylcyclopropanecarboxylate, Mr 22, Opiate Agonist, Opiate Antagonist, Protein Bax, Sigma Receptor Ligand, Unclassified Drug, Alzheimer Disease, Animal Cell, Article, Cell Death, Controlled Study, Cytotoxicity, Drug Antagonism, Drug Synthesis, Neuroprotection, Nonhuman, Priority Journal, Amyloid Beta-Protein, Anisoles, Bcl-2-Associated X Protein, Blotting, Western, Cell Count, Cell Survival, Cultured, Cerebral Cortex, Dose-Response Relationship, Drug Interactions, Embryo, Excitatory Amino Acid Antagonists, Neuroprotective Agents, Peptide Fragments, Propylamines, Proto-Oncogene Proteins C-Bcl-2, Amyloid Beta-Peptides, Inhibitors, Pharmacology, Drug Effects, Cytology, Mammalian, Metabolism,
Affiliations:
*** IBB - CNR ***
Department of Pharmaceutical Sciences, University of Catania, Catania, Italy
I.B.B., CNR-Catania, Catania, Italy
Cellular Neurobiology Research Branch, NIDA, NIH, Baltimore, MD, United States
References:
Not available.
Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity
Prolonged exposure of cultured cortical neurons to the residue 25-35 fragment of β-amyloid protein, in the presence of dizocilpine, an antagonist of the N-methyl-D-aspartate receptor, and of 6,7-dinitroquinoxaline- 2,3-dione, an antagonist of α-amino-3-hydroxy-5-methylisoxazole-4- propionate receptors, resulted in the expression of the proapoptotic protein Bax and neuronal death. Beta-amyloid protein(25-35)-induced neuronal death was substantially attenuated by the σ1 receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate. The neuroprotective action of 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate was mimicked by the σ1 ligand methyl (1S,2R)-2-[1-adamantyl(methyl)amino]methyl-1- phenylcyclopropanecarboxylate and was antagonized by the σ1 receptor antagonist N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)-phenyl]- ethylamine monohydrochloride. These results suggest that σ1 receptor agonists might function as neuroprotectant agents in Alzheimer's disease. © 2005 Lippincott Williams & Wilkins.
Prolonged exposure of cultured cortical neurons to the residue 25-35 fragment of β-amyloid protein, in the presence of dizocilpine, an antagonist of the N-methyl-D-aspartate receptor, and of 6,7-dinitroquinoxaline- 2,3-dione, an antagonist of α-amino-3-hydroxy-5-methylisoxazole-4- propionate receptors, resulted in the expression of the proapoptotic protein Bax and neuronal death. Beta-amyloid protein(25-35)-induced neuronal death was substantially attenuated by the σ1 receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate. The neuroprotective action of 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate was mimicked by the σ1 ligand methyl (1S,2R)-2-[1-adamantyl(methyl)amino]methyl-1- phenylcyclopropanecarboxylate and was antagonized by the σ1 receptor antagonist N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)-phenyl]- ethylamine monohydrochloride. These results suggest that σ1 receptor agonists might function as neuroprotectant agents in Alzheimer's disease. © 2005 Lippincott Williams & Wilkins.
Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity
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Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 2.384
View Export to BibTeX Export to EndNote
15 Records (15 excluding Abstracts).
Total impact factor: 57.544 (57.544 excluding Abstracts).
Total 5 year impact factor: 58.227 (58.227 excluding Abstracts).
Total impact factor: 57.544 (57.544 excluding Abstracts).
Total 5 year impact factor: 58.227 (58.227 excluding Abstracts).
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