A simplified model of the interaction between SDF-1 chemokine and the CXCR4 receptor(571 views) Palladino P, De Capua A, Pedone C, Ragone R, Rossi F, Limatola C, Ragozzino D, Benedetti E
Ist. di Biostrutture e Bioimmagini, Dipartimento di Chimica Biologica, Univ. Federico II di Napoli, Via Mezzocannone 6, 80134 Naples, Italy
Dipto. di Biochimica e Biofisica, C.R.I.S.C.E.B., Seconda Università di Napoli, Via Costantinopoli 16, 80138 Naples, Italy
References: Not available.
A simplified model of the interaction between SDF-1 chemokine and the CXCR4 receptor
We have synthesised the CXC chemokine receptor 4 (29-39) peptide, CXCR4 {29-39}. This peptide is located in the N-terminal region of the receptor and is likely to be involved in the docking step of the receptor interaction with its natural ligand stromal cell-derived factor-1 chemokine, SDF-1. Preliminary experiments, performed in the presence of micellar detergents to model a membrane-like environment, show that the (1-17) segment of SDF-1 binds to CXCR4 {29-39}
A simplified model of the interaction between SDF-1 chemokine and the CXCR4 receptor