Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis (481 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2003 Jun; 88(6): 2900-2907.
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Paper type: Journal Article,
Impact factor: 5.873, 5-year impact factor: 1.273
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0037901947&partnerID=40&md5=276cdd233a2f010e899401707f9fe1a4
Keywords: Benzyloxycarbonylvalylalanylaspartyl Fluoromethylketone, Bovine Seminal Ribonuclease, Caspase, Caspase Inhibitor, Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase, Pancreatic Ribonuclease, Protein Kinase B, Protein Serine Threonine Kinase, Unclassified Drug, Animal Experiment, Animal Model, Antineoplastic Activity, Apoptosis, Article, Cancer Cell, Cancer Cell Culture, Carcinoma Cell, Cell Killing, Cell Survival, Controlled Study, Drug Effect, Drug Selectivity, Human, Human Cell, Mouse, Nonhuman, Nude Mouse, Priority Journal, Protein Degradation, Protein Phosphorylation, Thyroid Carcinoma, Amino Acid Chloromethyl Ketones, Antineoplastic Agents, Cysteine Proteinase Inhibitors, Endoribonucleases, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins, Proto-Oncogene Proteins C-Akt, Thyroid Neoplasms, Tumor Cells, Mus Musculus,
Affiliations:
*** IBB - CNR ***
Ist. Endocrinol. Oncol. Sperim. C., Dipto. Biol. e Patol. Cell. e Molec., Univ. di Napoli Federico II, 80131 Naples, Italy
Dipartimento di Chimica Biologica, Univ. di Napoli Federico II, 80134 Naples, Italy
Ist. Biostrutture e Bioimmagini-CNR, 80134 Naples, Italy
References:
Not available.
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2003 Jun; 88(6): 2900-2907.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.873, 5-year impact factor: 1.273
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0037901947&partnerID=40&md5=276cdd233a2f010e899401707f9fe1a4
Keywords: Benzyloxycarbonylvalylalanylaspartyl Fluoromethylketone, Bovine Seminal Ribonuclease, Caspase, Caspase Inhibitor, Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase, Pancreatic Ribonuclease, Protein Kinase B, Protein Serine Threonine Kinase, Unclassified Drug, Animal Experiment, Animal Model, Antineoplastic Activity, Apoptosis, Article, Cancer Cell, Cancer Cell Culture, Carcinoma Cell, Cell Killing, Cell Survival, Controlled Study, Drug Effect, Drug Selectivity, Human, Human Cell, Mouse, Nonhuman, Nude Mouse, Priority Journal, Protein Degradation, Protein Phosphorylation, Thyroid Carcinoma, Amino Acid Chloromethyl Ketones, Antineoplastic Agents, Cysteine Proteinase Inhibitors, Endoribonucleases, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins, Proto-Oncogene Proteins C-Akt, Thyroid Neoplasms, Tumor Cells, Mus Musculus,
Affiliations:
*** IBB - CNR ***
Ist. Endocrinol. Oncol. Sperim. C., Dipto. Biol. e Patol. Cell. e Molec., Univ. di Napoli Federico II, 80131 Naples, Italy
Dipartimento di Chimica Biologica, Univ. di Napoli Federico II, 80134 Naples, Italy
Ist. Biostrutture e Bioimmagini-CNR, 80134 Naples, Italy
References:
Not available.
Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis
Bovine seminal ribonuclease ( BS- RNase), a natural dimeric homolog of bovine pancreatic RNase ( RNase A), and HHP2-RNase, an engineered dimeric form of human pancreatic RNase ( HP- RNase), are endowed with powerful antitumor effects. Here we show that BS- and HHP2- RNases, but not monomeric RNase A, induce apoptosis of human thyroid carcinoma cell lines. RNase- induced apoptosis was associated with activation of initiation caspase- 8 and - 9. This was followed by activation of executioner caspase- 3, leading to the proteolytic cleavage of poly( ADP- ribose) polymerase. The caspase inhibitor Z- Val- Ala- Asp-( OMe)- fluoromethylketone protected thyroid cancer cells from BS- RNase- induced apoptosis. RNase- triggered apoptosis and caspase activation were accompanied by reduced phosphorylation of Akt/ protein kinase B ( PKB), a serine- threonine kinase that when phosphorylated is able to deliver survival signals to cancer cells. BS- RNase antitumor effects in nude mice were accompanied by caspase activation and apoptosis. Because of the high selectivity of apoptotic effects for malignant cells, BS- and HHP2- RNase are promising tools for the treatment of aggressive thyroid cancer.
Bovine seminal ribonuclease ( BS- RNase), a natural dimeric homolog of bovine pancreatic RNase ( RNase A), and HHP2-RNase, an engineered dimeric form of human pancreatic RNase ( HP- RNase), are endowed with powerful antitumor effects. Here we show that BS- and HHP2- RNases, but not monomeric RNase A, induce apoptosis of human thyroid carcinoma cell lines. RNase- induced apoptosis was associated with activation of initiation caspase- 8 and - 9. This was followed by activation of executioner caspase- 3, leading to the proteolytic cleavage of poly( ADP- ribose) polymerase. The caspase inhibitor Z- Val- Ala- Asp-( OMe)- fluoromethylketone protected thyroid cancer cells from BS- RNase- induced apoptosis. RNase- triggered apoptosis and caspase activation were accompanied by reduced phosphorylation of Akt/ protein kinase B ( PKB), a serine- threonine kinase that when phosphorylated is able to deliver survival signals to cancer cells. BS- RNase antitumor effects in nude mice were accompanied by caspase activation and apoptosis. Because of the high selectivity of apoptotic effects for malignant cells, BS- and HHP2- RNase are promising tools for the treatment of aggressive thyroid cancer.
Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis
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Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis
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View Export to BibTeX Export to EndNote
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Impact Factor: 3.527
View Export to BibTeX Export to EndNote
Sica F, Pica A, Merlino A, Russo Krauss I, Ercole C, Picone D
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Impact Factor: 3.341
View Export to BibTeX Export to EndNote
Vergara A, Russo Krauss I, Montesarchio D, Paduano L, Merlino A
* Investigating the Ruthenium Metalation of Proteins: X-ray Structure and Raman Microspectroscopy of the Complex between RNase A and AziRu (396 views)
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Impact Factor: 4.794
View Export to BibTeX Export to EndNote
Pica A, Merlino A, Buell AK, Knowles TJ, Pizzo E, D'Alessio G, Sica F, Mazzarella L
* Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase (1285 views)
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Impact Factor: 7.232
View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 4.593
View Export to BibTeX Export to EndNote
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Impact Factor: 2.608
View Export to BibTeX Export to EndNote
La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (554 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
View Export to BibTeX Export to EndNote
Merlino A, Russo Krauss I, Perillo M, Mattia CA, Ercole C, Picone D, Vergara A, Sica F
* Toward an Antitumor Form of Bovine Pancreatic Ribonuclease: The Crystal Structure of Three Noncovalent Dimeric Mutants (499 views)
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Impact Factor: 2.605
View Export to BibTeX Export to EndNote
Merlino A, Avella G, Di Gaetano S, Arciello A, Piccoli R, Mazzarella L, Sica F
* Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant (434 views)
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Impact Factor: 2.937
View Export to BibTeX Export to EndNote
Merlino A, Ercole C, Picone D, Pizzo E, Mazzarella L, Sica F
* The buried diversity of bovine seminal ribonuclease: Shape and cytotoxicity of the swapped non-covalent form of the enzyme (743 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2008 Feb 15; 376(2): 427-437.
Impact Factor: 4.146
View Export to BibTeX Export to EndNote
Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
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Impact Factor: 4.214
View Export to BibTeX Export to EndNote
Picone D, Di Fiore A, Ercole C, Franzese M, Sica F, Tomaselli S, Mazzarella L
* The role of the hinge loop in domain swapping - The special case of bovine seminal ribonuclease (580 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Apr 8; 280(14): 13771-13778.
Impact Factor: 5.854
View Export to BibTeX Export to EndNote
Cozzolino R, Palladino P, Rossi F, Cali G, Benedetti E, Laccetti P
* Antineoplastic cyclic astin analogues kill tumour cells via caspase-mediated induction of apoptosis (629 views)
Carcinogenesis (ISSN: 0143-3334), 2005 Apr; 26(4): 733-739.
Impact Factor: 5.108
View Export to BibTeX Export to EndNote
Esposito L, Daggett V
* Insight into ribonuclease A domain swapping by molecular dynamics unfolding simulations (695 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2005 Mar 8; 44(9): 3358-3368.
Impact Factor: 3.848
View Export to BibTeX Export to EndNote
Merlino A, Ceruso MA, Vitagliano L, Mazzarella L
* Open interface and large quaternary structure movements in 3D domain swapped proteins: Insights from molecular dynamics simulations of the C-terminal swapped dimer of ribonuclease (736 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2005 Mar; 88(3): 2003-2012.
Impact Factor: 4.507
View Export to BibTeX Export to EndNote
Sica F, Di Fiore A, Merlino A, Mazzarella L
* Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease - An enzyme tailored to evade ribonuclease protein inhibitor (591 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2004 Sep 27; 279(35): 36753-36760.
Impact Factor: 6.355
View Export to BibTeX Export to EndNote
Merlino A, Vitagliano L, Sica F, Zagari A, Mazzarella L
* Population shift vs induced fit: The case of bovine seminal ribonuclease swapping dimer (438 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004 Apr 15; 73(6): 689-695.
Impact Factor: 2.863
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Berisio R, Sica F, De Lorenzo C, Di Fiore A, Piccoli R, Zagari A, Mazzarella L
* Crystal Structure Of The Dimeric Un-Swapped Form Of Bovine Seminal Ribonuclease (454 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2003 Nov 6; 554(1-2): 105-110.
Impact Factor: 3.609
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Sica F, Di Fiore A, Zagari A, Mazzarella L
* The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative (420 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2003 Sep 1; 52(2): 263-271.
Impact Factor: 4.313
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Berisio R, Sica F, Lamzin VS, Wilson KS, Zagari A, Mazzarella L
* Atomic resolution structures of ribonuclease A at six pH values (1127 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2002; 58(3): 441-450.
Impact Factor: 1.76
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Esposito L, Vitagliano L, Sica F, Sorrentino G, Zagari A, Mazzarella L
The ultrahigh resolution crystal structure of ribonuclease A containing an isoaspartyl residue: Hydration and sterochemical analysis (841 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2000 Mar 31; 297(3): 713-732.
Impact Factor: 5.388
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Vitagliano L, Adinolfi S, Sica F, Merlino A, Zagari A, Mazzarella L
A potential allosteric subsite generated by domain swapping in bovine seminal ribonuclease (537 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1999 Oct 29; 293(3): 569-577.
Impact Factor: 5.501
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Sica F, Adinolfi S, Berisio R, De Lorenzo C, Mazzarella L, Piccoli R, Vitagliano L, Zagari A
Crystallization of multiple forms of bovine seminal ribonuclease in the liganded and unliganded state (380 views)
J Cryst Growth (ISSN: 0022-0248), 1999; 196(2-4): 305-312.
Impact Factor: 1.492
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Vitagliano L, Adinolfi S, Riccio A, Sica F, Zagari A, Mazzarella L
Binding of a substrate analog to a domain swapping protein: X-ray structure of the complex of bovine seminal ribonuclease with uridylyl(2 ', 5 ')adenosine (565 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 1998 Sep; 7(8): 1691-1699.
Impact Factor: 4.44
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Sica F, Adinolfi S, Vitagliano L, Zagari A, Capasso S, Mazzarella L
Cosolute effect on crystallization of two dinucleotide complexes of bovine seminal ribonuclease from concentrated salt solutions (330 views)
J Cryst Growth (ISSN: 0022-0248), 1996; 168(1-4): 192-197.
Impact Factor: 1.259
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Capasso S, Di Donato A, Esposito L, Sica F, Sorrentino G, Vitagliano L, Zagari A, Mazzarella L
Deamidation in proteins: The crystal structure of bovine pancreatic ribonuclease with an isoaspartyl residue at position 67 (600 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1996; 257(3): 492-496.
Impact Factor: 5.673
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32 Records (31 excluding Abstracts).
Total impact factor: 126.186 (121.972 excluding Abstracts).
Total 5 year impact factor: 128.218 (123.96 excluding Abstracts).
Total impact factor: 126.186 (121.972 excluding Abstracts).
Total 5 year impact factor: 128.218 (123.96 excluding Abstracts).
481 views. Last view on Sunday 13 October 2024, 18:24:18
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