Monitoring disease progression in CADASIL with diffusion magnetic resonance imaging: A study with whole brain histogram analysis(811 views) Molko N, Pappata S, Mangin JF, Poupon F, Lebihan D, Bousser MG, Chabriat H
Keywords: Cadasil, Magnetic Resonance Imaging, Adult, Artery Disease, Article, Brain Infarction, Brain Injury, Clinical Article, Controlled Study, Correlation Analysis, Diffusion Tensor Imaging, Disease Course, Disease Marker, Female, Follow Up, Histogram, Human, Leukoencephalopathy, Mini Mental State Examination, Nuclear Magnetic Resonance Imaging, Priority Journal, Scoring System, Tissue Injury, Cross-Sectional Studies, Dementia, Multi-Infarct, Diffusion Magnetic Resonance Imaging, Disease Progression, Follow-Up Studies, Longitudinal Studies, Middle Aged, Neuropsychological Tests, Predictive Value Of Tests, Proto-Oncogene Proteins, Receptors, Cell Surface, Regression Analysis, Sensitivity And Specificity,
Affiliations: *** IBB - CNR ***
INSERM U562, IFR 49, SHFJ-CEA, Orsay, France
UNAF, IFR 49, SHFJ-CEA, Orsay, France
Department of Neurology, CHU Lariboisière, Service de Neurologie, 2 rue Ambroise Paré, 75010 Paris, France
INSERM U562, Orsay, Department of Neurology, CHU Lariboisiere, Paris, France.
References: Not available.
Monitoring disease progression in CADASIL with diffusion magnetic resonance imaging: A study with whole brain histogram analysis
Background and Purpose-In cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a large increase in water diffusion has been found both inside and outside the cerebral lesions as detected on conventional MRI. The aim of the present study was to assess the sensitivity of diffusion tensor imaging for monitoring the progression of cerebral tissue damage during the course of CADASIL. Methods-With the use of diffusion tensor imaging, whole brain trace of the diffusion tensor [Trace(D)] histograms were obtained in 22 CADASIL patients and 12 age-matched controls at baseline, in 14 patients after a mean delay of 21 months, and in 5 controls after a mean delay of 29 months. Parameters derived from these histograms (mean value, peak height, and peak location) were analyzed at baseline and during the follow-up. Results-At baseline, all the histogram parameters differed between patients and controls and were found to be significantly correlated with both the Mini-Mental State Examination score and Rankin Scale score in the patient group. The follow-up study showed a decrease in the peak height associated with an increase in the mean value of whole brain Trace(D) histograms in the 14 CADASIL patients scanned twice. The diffusion changes appeared larger in the patients whose Rankin score increased during the study period. Conclusions-These results suggest that the measurement of water diffusion over time is a sensitive marker for the progression of tissue damage in the brain. Thus, quantitative diffusion MRI can be used to monitor disease progression in CADASIL and possibly in other types of small-vessel brain disorders.
Monitoring disease progression in CADASIL with diffusion magnetic resonance imaging: A study with whole brain histogram analysis
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