A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots (1162 views)
Nanomedicine (ISSN: 1549-9642, 1549-9634, 1549-9642electronic), 2011 Dec; 7(6): 925-934.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 6.692, 5-year impact factor: 7.013
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-82255175122&partnerID=40&md5=bdbebccf6cdde0038f3a48b0f2a3fe9e
Keywords: Delivery, Peptide, Quantum Dots, Virus, Cargo Molecules, Cell-Penetrating Peptide, Endocytotic Pathway, Herpes Simplex, Herpes Simplex Virus Type 1, Intracellular Delivery, Intracellular Drug Delivery, Living Cell, Membrane Bilayers, Membrane Diffusion, Membrane Translocation, Physio-Chemical Properties, Small Molecules, Vaccine Development, Cell Membranes, Cytology, Gene Therapy, Glycoproteins, Semiconductor Quantum Dots, Cell Penetrating Peptide, Unclassified Drug, Virus Protein, Article, Controlled Study, Drug Delivery System, Membrane Fusion, Nonhuman, Protein Transport, Amino Acid Sequence, Cell Membrane Permeability, Cell Survival, Drug Carriers, Hela Cells, Herpesvirus 1, Molecular Sequence Data, Viral Envelope Proteins, Human Herpesvirus 1,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, Division of Biostructures - University of Naples Federico II, Napoli, Italy.
Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, Univ. of Naples Federico II, Napoli, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Napoli, Italy
Department of Experimental Medicine, II University of Naples, Napoli, Italy
IIT at CRIB, Center for Advanced Biomaterials in Health Care, Napoli, Italy
References:
Chakrabarti, R., Wylie, D.E., Schuster, S.M., Transfer of monoclonal antibodies into mammalian cells by electroporation (1989) J Biol Chem, 264, pp. 15494-1550
Arnheiter, H., Haller, O., Antiviral state against influenza virus neutralized by microinjection of antibodies to interferon-induced Mx proteins (1988) EMBO J, 7, pp. 1315-1320
Schwarze, S.R., Dowdy, S.F., In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA (2000) Trends Pharmacol Sci, 21, pp. 45-48
Vives, E., Brodin, P., Lebleu, B., A truncated HIV-1 TAT protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus (1997) J Biol Chem, 272, pp. 16010-16017
Dietz, G.P., Bahr, M., Delivery of bioactive molecules into the cell: the Trojan horse approach (2004) Mol Cell Neurosci, 27, pp. 85-131
Mae, M., Langel, U., Cell-penetrating peptides as vectors for peptide, protein and oligonucleotide delivery (2006) Curr Opin Pharmacol, 6, pp. 509-514
Stewart, K.M., Horton, K.L., Kelley, S.O., Cell-penetrating peptides as delivery vehicles for biology and medicine (2008) Org Biomol Chem, 6, pp. 2242-2255
Derossi, D., Calvet, S., Trembleau, A., Brunissen, A., Chassaing, G., Prochiantz, A., Cell internalization of the third helix of the antennapedia homeodomain is receptor-independent (1996) J Biol Chem, 271, pp. 18188-18193
Elliott, G., O'Hare, P., Intercellular trafficking and protein delivery by a herpes virus structural protein (1997) Cell, 88, pp. 223-233
Pooga, M., Hallbrink, M., Zorko, M., Langel, U., Cell penetration by transportan (1998) FASEB J, 12, pp. 67-77
Oehlke, J., Scheller, A., Wiesner, B., Krause, E., Beyermann, M., Klauschenz, E., Cellular uptake of an alpha-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically (1998) Biochim Biophys Acta, 1414, pp. 127-139
Rojas, M., Donahue, J.P., Tan, Z., Lin, Y.Z., Genetic engineering of proteins with cell membrane permeability (1998) Nat Biotechnol, 16, pp. 370-375
Futaki, S., Suzuki, T., Ohashi, W., Yagami, T., Tanaka, S., Ueda, K., Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery (2001) J Biol Chem, 276, pp. 5836-5840
Heitz, F., Morris, M.C., Divita, G., Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics (2009) Brit J Pharm, 157, pp. 195-206
Richard, J.P., Melikov, K., Vives, E., Ramos, C., Verbeure, B., Gait, M.J., Cell-penetrating peptides: a re-evaluation of the mechanism of cellular uptake (2003) J Biol Chem, 278, pp. 585-590
Suzuki, T., Futaki, S., Niwa, M., Tanaka, S., Ueda, K., Sugiura, Y., Possible existence of common internalization mechanisms among arginine-rich peptides (2002) J Biol Chem, 277, pp. 2437-2443
Duchardt, F., Fotin-Mleczek, M., Schwarz, H., Fischer, R., Brock, R., A comprehensive model for the cellular uptake of cationic cell-penetrating peptides (2007) Traffic, 8, pp. 848-866
Brooks, H., Lebleu, B., Vives, E., TAT peptide-mediated cellular delivery: back to basics (2005) Adv Drug Deliv Rev, 57, pp. 559-577
Galdiero, S., Falanga, A., Vitiello, M., Browne, H., Pedone, C., Galdiero, M., Fusogenic domains in herpes simplex virus type 1 glycoprotein H (2005) J Biol Chem, 280, pp. 28632-28643
Galdiero, S., Galdiero, M., Pedone, C., Falanga, A., Vitiello, M., Method For Delivery Of Molecules Into Intracellular Targets - Provisional. n°US61/285,619. 12/11/2009Drin, G., Mazel, M., Clair, P., Mathieu, D., Kaczorek, M., Temsamani, J., Physico-chemical requirements for cellular uptake of pAntp peptide: role of lipid-binding affinity (2001) Eur J Biochem, 268, pp. 1304-1314
Pinaud, F., Clarke, S., Sittner, A., Dahan, M., Probing cellular events, one quantum dot at a time (2010) Nat Methods, 7, pp. 275-285
Medintz, I.L., Pons, T., Delehanty, J.B., Susumu, K., Brunel, F.M., Dawson, P.E., Intracellular delivery of quantum dot-protein cargos mediated by cell penetrating peptides (2008) Bioconjug Chem, 19, pp. 1785-1795
Lee, H., Kim, I.-K., Park, T.G., Intracellular trafficking and unpacking of siRNA/quantum dot-PEI complexes modified with and without cell penetrating peptide: confocal and flow cytometric FRET analysis (2010) Bioconjug Chem, 21, pp. 289-295
Delehanty, J.B., Bradburne, C.E., Boeneman, K., Susumu, K., Farrell, D., Mei, B.C., Delivering quantum dot-peptide bioconjugates to the cellular cytosol: escaping from the endolysosomal system (2010) Integr Biol, 2, pp. 265-277
Yeh, H.-Y., Yates, M.V., Mulchandani, A., Chen, W., Molecular beacon-quantum dot-Au nanoparticle hybrid nanoprobes for visualizing virus replication in living cells (2010) Chem Commun, 46, pp. 3914-3916
Jung, J., Solanki, A., Memoli, K.A., Kamei, K., Kim, H., Drahl, M.A., Selective inhibition of human brain tumor cells through multifunctional quantum-dot-based siRNA delivery (2010) Angew Chem Int Ed, 49, pp. 103-107
Rapaport, D., Shai, Y., Interaction of fluorescently labeled pardaxin and its analogues with lipid bilayers (1991) J Biol Chem, 266, pp. 23769-23775
Mosmann, T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays (1983) J Immunol Methods, 65, pp. 55-63
Imahashi, D., Quantitation of LDH isoenzymes by the fluorimetric and colorimetric methods (1968) Can J Med Technol, 30, pp. 235-248
Hope, M.J., Bally, M.B., Webb, G., Cullis, P.R., Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential (1985) Biochim Biophys Acta, 812, pp. 55-65
Fiske, C.H., SubbaRow, Y., The colorimetric determination of phosphorus (1925) J Biol Chem, 66, pp. 374-389
Cummings, J.E., Vanderlock, T.K., Aggregation and hemi-fusion of anionic vesicles induced by the antimicrobial peptide cryptdin-4 (2007) Biochim Biophys Acta, 1768, pp. 1796-1804
Ellens, H., Bentz, J., Szoka, F.C., PH-induced destabilization of phosphatidylethanolamine-containing liposomes: role of bilayer contact (1984) Biochemistry, 23, pp. 1532-1538
Parente, R.A., Nir, S., Szoka, F.C., Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA (1990) Biochemistry, 29, pp. 8713-8719
Matsuzaki, K., Murase, O., Fujii, N., Miyajima, K., Translocation of a channel-forming antimicrobial peptide, magainin 2, across lipid bilayers by forming a pore (1995) Biochemistry, 34, pp. 6521-6526
Deshayes, S., Gerbal-Chaloin, S., Morris, M.C., Aldrian-Herrada, G., Charnet, P., Divita, G., On the mechanism of non-endosomial peptide-mediated cellular delivery of nucleic acids (2004) Biochim Biophys Acta, 1667, pp. 141-147
Deshayes, S., Heitz, A., Morris, M.C., Charnet, P., Divita, G., Heitz, F., Insight into the mechanism of internalization of the cell-penetrating carrier peptide Pep-1 through conformational analysis (2004) Biochemistry, 43, pp. 1449-1457
Thorén, P.E., Persson, D., Lincoln, P., Nordén, B., Membrane destabilizing properties of cell-penetrating peptides (2005) Biophys Chem, 114, pp. 169-179
McIntyre, J., Sleight, R., Fluorescence assay for phospholipids membrane asymmetry (1991) Biochemistry, 30, pp. 11819-11827
Angeletti, C., Nichols, J.W., Dithionite quenching rate measurement of the inside-outside membrane bilayer distribution of 7-nitrobenz-2-oxa-1,3-diazol-4-yl-labeled phospholipids (1998) Biochemistry, 37, pp. 15114-15119
Drin, G., Cottin, S., Blanc, E., Rees, A.R., Temsamani, J., Studies on the internalization mechanism of cationic cell-penetrating peptides (2003) J Bio Chem, 278, pp. 31192-31201
Schwarze, S. R., Dowdy, S. F., In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA (2000) Trends Pharmacol Sci, 21, pp. 45-48
Dietz, G. P., Bahr, M., Delivery of bioactive molecules into the cell: the Trojan horse approach (2004) Mol Cell Neurosci, 27, pp. 85-131
Stewart, K. M., Horton, K. L., Kelley, S. O., Cell-penetrating peptides as delivery vehicles for biology and medicine (2008) Org Biomol Chem, 6, pp. 2242-2255
Richard, J. P., Melikov, K., Vives, E., Ramos, C., Verbeure, B., Gait, M. J., Cell-penetrating peptides: a re-evaluation of the mechanism of cellular uptake (2003) J Biol Chem, 278, pp. 585-590
Medintz, I. L., Pons, T., Delehanty, J. B., Susumu, K., Brunel, F. M., Dawson, P. E., Intracellular delivery of quantum dot-protein cargos mediated by cell penetrating peptides (2008) Bioconjug Chem, 19, pp. 1785-1795
Lee, H., Kim, I. -K., Park, T. G., Intracellular trafficking and unpacking of siRNA/quantum dot-PEI complexes modified with and without cell penetrating peptide: confocal and flow cytometric FRET analysis (2010) Bioconjug Chem, 21, pp. 289-295
Delehanty, J. B., Bradburne, C. E., Boeneman, K., Susumu, K., Farrell, D., Mei, B. C., Delivering quantum dot-peptide bioconjugates to the cellular cytosol: escaping from the endolysosomal system (2010) Integr Biol, 2, pp. 265-277
Yeh, H. -Y., Yates, M. V., Mulchandani, A., Chen, W., Molecular beacon-quantum dot-Au nanoparticle hybrid nanoprobes for visualizing virus replication in living cells (2010) Chem Commun, 46, pp. 3914-3916
Hope, M. J., Bally, M. B., Webb, G., Cullis, P. R., Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential (1985) Biochim Biophys Acta, 812, pp. 55-65
Fiske, C. H., SubbaRow, Y., The colorimetric determination of phosphorus (1925) J Biol Chem, 66, pp. 374-389
Cummings, J. E., Vanderlock, T. K., Aggregation and hemi-fusion of anionic vesicles induced by the antimicrobial peptide cryptdin-4 (2007) Biochim Biophys Acta, 1768, pp. 1796-1804
Parente, R. A., Nir, S., Szoka, F. C., Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA (1990) Biochemistry, 29, pp. 8713-8719
Thor n, P. E., Persson, D., Lincoln, P., Nord n, B., Membrane destabilizing properties of cell-penetrating peptides (2005) Biophys Chem, 114, pp. 169-179
Nanomedicine (ISSN: 1549-9642, 1549-9634, 1549-9642electronic), 2011 Dec; 7(6): 925-934.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 6.692, 5-year impact factor: 7.013
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-82255175122&partnerID=40&md5=bdbebccf6cdde0038f3a48b0f2a3fe9e
Keywords: Delivery, Peptide, Quantum Dots, Virus, Cargo Molecules, Cell-Penetrating Peptide, Endocytotic Pathway, Herpes Simplex, Herpes Simplex Virus Type 1, Intracellular Delivery, Intracellular Drug Delivery, Living Cell, Membrane Bilayers, Membrane Diffusion, Membrane Translocation, Physio-Chemical Properties, Small Molecules, Vaccine Development, Cell Membranes, Cytology, Gene Therapy, Glycoproteins, Semiconductor Quantum Dots, Cell Penetrating Peptide, Unclassified Drug, Virus Protein, Article, Controlled Study, Drug Delivery System, Membrane Fusion, Nonhuman, Protein Transport, Amino Acid Sequence, Cell Membrane Permeability, Cell Survival, Drug Carriers, Hela Cells, Herpesvirus 1, Molecular Sequence Data, Viral Envelope Proteins, Human Herpesvirus 1,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, Division of Biostructures - University of Naples Federico II, Napoli, Italy.
Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, Univ. of Naples Federico II, Napoli, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Napoli, Italy
Department of Experimental Medicine, II University of Naples, Napoli, Italy
IIT at CRIB, Center for Advanced Biomaterials in Health Care, Napoli, Italy
References:
Chakrabarti, R., Wylie, D.E., Schuster, S.M., Transfer of monoclonal antibodies into mammalian cells by electroporation (1989) J Biol Chem, 264, pp. 15494-1550
Arnheiter, H., Haller, O., Antiviral state against influenza virus neutralized by microinjection of antibodies to interferon-induced Mx proteins (1988) EMBO J, 7, pp. 1315-1320
Schwarze, S.R., Dowdy, S.F., In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA (2000) Trends Pharmacol Sci, 21, pp. 45-48
Vives, E., Brodin, P., Lebleu, B., A truncated HIV-1 TAT protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus (1997) J Biol Chem, 272, pp. 16010-16017
Dietz, G.P., Bahr, M., Delivery of bioactive molecules into the cell: the Trojan horse approach (2004) Mol Cell Neurosci, 27, pp. 85-131
Mae, M., Langel, U., Cell-penetrating peptides as vectors for peptide, protein and oligonucleotide delivery (2006) Curr Opin Pharmacol, 6, pp. 509-514
Stewart, K.M., Horton, K.L., Kelley, S.O., Cell-penetrating peptides as delivery vehicles for biology and medicine (2008) Org Biomol Chem, 6, pp. 2242-2255
Derossi, D., Calvet, S., Trembleau, A., Brunissen, A., Chassaing, G., Prochiantz, A., Cell internalization of the third helix of the antennapedia homeodomain is receptor-independent (1996) J Biol Chem, 271, pp. 18188-18193
Elliott, G., O'Hare, P., Intercellular trafficking and protein delivery by a herpes virus structural protein (1997) Cell, 88, pp. 223-233
Pooga, M., Hallbrink, M., Zorko, M., Langel, U., Cell penetration by transportan (1998) FASEB J, 12, pp. 67-77
Oehlke, J., Scheller, A., Wiesner, B., Krause, E., Beyermann, M., Klauschenz, E., Cellular uptake of an alpha-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically (1998) Biochim Biophys Acta, 1414, pp. 127-139
Rojas, M., Donahue, J.P., Tan, Z., Lin, Y.Z., Genetic engineering of proteins with cell membrane permeability (1998) Nat Biotechnol, 16, pp. 370-375
Futaki, S., Suzuki, T., Ohashi, W., Yagami, T., Tanaka, S., Ueda, K., Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery (2001) J Biol Chem, 276, pp. 5836-5840
Heitz, F., Morris, M.C., Divita, G., Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics (2009) Brit J Pharm, 157, pp. 195-206
Richard, J.P., Melikov, K., Vives, E., Ramos, C., Verbeure, B., Gait, M.J., Cell-penetrating peptides: a re-evaluation of the mechanism of cellular uptake (2003) J Biol Chem, 278, pp. 585-590
Suzuki, T., Futaki, S., Niwa, M., Tanaka, S., Ueda, K., Sugiura, Y., Possible existence of common internalization mechanisms among arginine-rich peptides (2002) J Biol Chem, 277, pp. 2437-2443
Duchardt, F., Fotin-Mleczek, M., Schwarz, H., Fischer, R., Brock, R., A comprehensive model for the cellular uptake of cationic cell-penetrating peptides (2007) Traffic, 8, pp. 848-866
Brooks, H., Lebleu, B., Vives, E., TAT peptide-mediated cellular delivery: back to basics (2005) Adv Drug Deliv Rev, 57, pp. 559-577
Galdiero, S., Falanga, A., Vitiello, M., Browne, H., Pedone, C., Galdiero, M., Fusogenic domains in herpes simplex virus type 1 glycoprotein H (2005) J Biol Chem, 280, pp. 28632-28643
Galdiero, S., Galdiero, M., Pedone, C., Falanga, A., Vitiello, M., Method For Delivery Of Molecules Into Intracellular Targets - Provisional. n°US61/285,619. 12/11/2009Drin, G., Mazel, M., Clair, P., Mathieu, D., Kaczorek, M., Temsamani, J., Physico-chemical requirements for cellular uptake of pAntp peptide: role of lipid-binding affinity (2001) Eur J Biochem, 268, pp. 1304-1314
Pinaud, F., Clarke, S., Sittner, A., Dahan, M., Probing cellular events, one quantum dot at a time (2010) Nat Methods, 7, pp. 275-285
Medintz, I.L., Pons, T., Delehanty, J.B., Susumu, K., Brunel, F.M., Dawson, P.E., Intracellular delivery of quantum dot-protein cargos mediated by cell penetrating peptides (2008) Bioconjug Chem, 19, pp. 1785-1795
Lee, H., Kim, I.-K., Park, T.G., Intracellular trafficking and unpacking of siRNA/quantum dot-PEI complexes modified with and without cell penetrating peptide: confocal and flow cytometric FRET analysis (2010) Bioconjug Chem, 21, pp. 289-295
Delehanty, J.B., Bradburne, C.E., Boeneman, K., Susumu, K., Farrell, D., Mei, B.C., Delivering quantum dot-peptide bioconjugates to the cellular cytosol: escaping from the endolysosomal system (2010) Integr Biol, 2, pp. 265-277
Yeh, H.-Y., Yates, M.V., Mulchandani, A., Chen, W., Molecular beacon-quantum dot-Au nanoparticle hybrid nanoprobes for visualizing virus replication in living cells (2010) Chem Commun, 46, pp. 3914-3916
Jung, J., Solanki, A., Memoli, K.A., Kamei, K., Kim, H., Drahl, M.A., Selective inhibition of human brain tumor cells through multifunctional quantum-dot-based siRNA delivery (2010) Angew Chem Int Ed, 49, pp. 103-107
Rapaport, D., Shai, Y., Interaction of fluorescently labeled pardaxin and its analogues with lipid bilayers (1991) J Biol Chem, 266, pp. 23769-23775
Mosmann, T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays (1983) J Immunol Methods, 65, pp. 55-63
Imahashi, D., Quantitation of LDH isoenzymes by the fluorimetric and colorimetric methods (1968) Can J Med Technol, 30, pp. 235-248
Hope, M.J., Bally, M.B., Webb, G., Cullis, P.R., Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential (1985) Biochim Biophys Acta, 812, pp. 55-65
Fiske, C.H., SubbaRow, Y., The colorimetric determination of phosphorus (1925) J Biol Chem, 66, pp. 374-389
Cummings, J.E., Vanderlock, T.K., Aggregation and hemi-fusion of anionic vesicles induced by the antimicrobial peptide cryptdin-4 (2007) Biochim Biophys Acta, 1768, pp. 1796-1804
Ellens, H., Bentz, J., Szoka, F.C., PH-induced destabilization of phosphatidylethanolamine-containing liposomes: role of bilayer contact (1984) Biochemistry, 23, pp. 1532-1538
Parente, R.A., Nir, S., Szoka, F.C., Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA (1990) Biochemistry, 29, pp. 8713-8719
Matsuzaki, K., Murase, O., Fujii, N., Miyajima, K., Translocation of a channel-forming antimicrobial peptide, magainin 2, across lipid bilayers by forming a pore (1995) Biochemistry, 34, pp. 6521-6526
Deshayes, S., Gerbal-Chaloin, S., Morris, M.C., Aldrian-Herrada, G., Charnet, P., Divita, G., On the mechanism of non-endosomial peptide-mediated cellular delivery of nucleic acids (2004) Biochim Biophys Acta, 1667, pp. 141-147
Deshayes, S., Heitz, A., Morris, M.C., Charnet, P., Divita, G., Heitz, F., Insight into the mechanism of internalization of the cell-penetrating carrier peptide Pep-1 through conformational analysis (2004) Biochemistry, 43, pp. 1449-1457
Thorén, P.E., Persson, D., Lincoln, P., Nordén, B., Membrane destabilizing properties of cell-penetrating peptides (2005) Biophys Chem, 114, pp. 169-179
McIntyre, J., Sleight, R., Fluorescence assay for phospholipids membrane asymmetry (1991) Biochemistry, 30, pp. 11819-11827
Angeletti, C., Nichols, J.W., Dithionite quenching rate measurement of the inside-outside membrane bilayer distribution of 7-nitrobenz-2-oxa-1,3-diazol-4-yl-labeled phospholipids (1998) Biochemistry, 37, pp. 15114-15119
Drin, G., Cottin, S., Blanc, E., Rees, A.R., Temsamani, J., Studies on the internalization mechanism of cationic cell-penetrating peptides (2003) J Bio Chem, 278, pp. 31192-31201
Schwarze, S. R., Dowdy, S. F., In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA (2000) Trends Pharmacol Sci, 21, pp. 45-48
Dietz, G. P., Bahr, M., Delivery of bioactive molecules into the cell: the Trojan horse approach (2004) Mol Cell Neurosci, 27, pp. 85-131
Stewart, K. M., Horton, K. L., Kelley, S. O., Cell-penetrating peptides as delivery vehicles for biology and medicine (2008) Org Biomol Chem, 6, pp. 2242-2255
Richard, J. P., Melikov, K., Vives, E., Ramos, C., Verbeure, B., Gait, M. J., Cell-penetrating peptides: a re-evaluation of the mechanism of cellular uptake (2003) J Biol Chem, 278, pp. 585-590
Medintz, I. L., Pons, T., Delehanty, J. B., Susumu, K., Brunel, F. M., Dawson, P. E., Intracellular delivery of quantum dot-protein cargos mediated by cell penetrating peptides (2008) Bioconjug Chem, 19, pp. 1785-1795
Lee, H., Kim, I. -K., Park, T. G., Intracellular trafficking and unpacking of siRNA/quantum dot-PEI complexes modified with and without cell penetrating peptide: confocal and flow cytometric FRET analysis (2010) Bioconjug Chem, 21, pp. 289-295
Delehanty, J. B., Bradburne, C. E., Boeneman, K., Susumu, K., Farrell, D., Mei, B. C., Delivering quantum dot-peptide bioconjugates to the cellular cytosol: escaping from the endolysosomal system (2010) Integr Biol, 2, pp. 265-277
Yeh, H. -Y., Yates, M. V., Mulchandani, A., Chen, W., Molecular beacon-quantum dot-Au nanoparticle hybrid nanoprobes for visualizing virus replication in living cells (2010) Chem Commun, 46, pp. 3914-3916
Hope, M. J., Bally, M. B., Webb, G., Cullis, P. R., Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential (1985) Biochim Biophys Acta, 812, pp. 55-65
Fiske, C. H., SubbaRow, Y., The colorimetric determination of phosphorus (1925) J Biol Chem, 66, pp. 374-389
Cummings, J. E., Vanderlock, T. K., Aggregation and hemi-fusion of anionic vesicles induced by the antimicrobial peptide cryptdin-4 (2007) Biochim Biophys Acta, 1768, pp. 1796-1804
Parente, R. A., Nir, S., Szoka, F. C., Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA (1990) Biochemistry, 29, pp. 8713-8719
Thor n, P. E., Persson, D., Lincoln, P., Nord n, B., Membrane destabilizing properties of cell-penetrating peptides (2005) Biophys Chem, 114, pp. 169-179
A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots
UNLABELLED: Cell membranes are impermeable to most molecules that are not actively imported by living cells, including all macromolecules and even small molecules whose physiochemical properties prevent passive membrane diffusion. However, recently, we have seen the development of increasingly sophisticated methodology for intracellular drug delivery. Cell-penetrating peptides (CPPs), short peptides believed to enter cells by penetrating cell membranes, have attracted great interest in the hope of enhancing gene therapy, vaccine development and drug delivery. Nevertheless, to achieve an efficient intracellular delivery, further strategies to bypass the endocytotic pathway must be investigated. We report on a novel peptide molecule derived from glycoprotein gH of herpes simplex type I virus that is able to traverse the membrane bilayer and to transport a cargo into the cytoplasm with novel properties in comparison with existing CPPs. We use as cargo molecule quantum dots that do not significantly traverse the membrane bilayer on their own.; FROM THE CLINICAL EDITOR: Cell-penetrating peptides have recently attracted great interest in optimizing gene therapy, vaccine development and drug delivery. In this study, a peptide derived from glycoprotein gH of herpes simplex I is investigated from this standpoint. Copyright 2011 Elsevier Inc. All rights reserved.
UNLABELLED: Cell membranes are impermeable to most molecules that are not actively imported by living cells, including all macromolecules and even small molecules whose physiochemical properties prevent passive membrane diffusion. However, recently, we have seen the development of increasingly sophisticated methodology for intracellular drug delivery. Cell-penetrating peptides (CPPs), short peptides believed to enter cells by penetrating cell membranes, have attracted great interest in the hope of enhancing gene therapy, vaccine development and drug delivery. Nevertheless, to achieve an efficient intracellular delivery, further strategies to bypass the endocytotic pathway must be investigated. We report on a novel peptide molecule derived from glycoprotein gH of herpes simplex type I virus that is able to traverse the membrane bilayer and to transport a cargo into the cytoplasm with novel properties in comparison with existing CPPs. We use as cargo molecule quantum dots that do not significantly traverse the membrane bilayer on their own.; FROM THE CLINICAL EDITOR: Cell-penetrating peptides have recently attracted great interest in optimizing gene therapy, vaccine development and drug delivery. In this study, a peptide derived from glycoprotein gH of herpes simplex I is investigated from this standpoint. Copyright 2011 Elsevier Inc. All rights reserved.
A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots
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A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots
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Depalo N, Corricelli M, De Paola I, Valente G, Iacobazzi RM, Altamura E, Debellis D, Comegna D, Fanizza E, Denora N, Laquintana V, Mavelli F, Striccoli M, Saviano M, Agostiano A, Del Gatto A, Zaccaro L, Curri ML
* NIR Emitting Nanoprobes Based on Cyclic RGD Motif Conjugated PbS Quantum Dots for Integrin-Targeted Optical Bioimaging (420 views) (PDF 184 views)
Acs Appl Mater Inter (ISSN: 1944-8244), 2017 Dec 13; 9(49): 43113-43126.
Impact Factor: 8.097
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Galdiero S, Falanga A, Morelli G, Galdiero M
* gH625: A milestone in understanding the many roles of membranotropic peptides (530 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2015 Jan; 1848(PA): 16-25.
Impact Factor: 5.158
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Vitiello G, Falanga A, Petruk AA, Merlino A, Fragneto G, Paduano L, Galdiero S, D'Errico G
* Fusion of raft-like lipid bilayers operated by a membranotropic domain of the HSV-type I glycoprotein gH occurs through a cholesterol-dependent mechanism (381 views)
Soft Matter (ISSN: 1744-683x), 2015; 11(15): 3003-3016.
Impact Factor: 3.798
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Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
* Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery (454 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(5): 415-425.
Impact Factor: 1.951
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Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (510 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2014 Jul; 20(7): 468-478.
Impact Factor: 1.546
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Accardo A, Vitiello M, Tesauro D, Galdiero M, Finamore E, Martora F, Mansi R, Ringhieri P, Morelli G
* Self-assembled or mixed peptide amphiphile micelles from herpes simplex virus glycoproteins as potential immunomodulatory treatment (491 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 May 7; 9(1): 2137-2148.
Impact Factor: 4.383
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Cantisani M, Falanga A, Incoronato N, Russo L, De Simone A, Morelli G, Berisio R, Galdiero M, Galdiero S
* Conformational modifications of gB from herpes simplex virus type 1 analyzed by synthetic peptides (704 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2013 Nov 14; 56(21): 8366-8376.
Impact Factor: 5.48
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Scudiero O, Galdiero S, Nigro E, Del Vecchio L, Di Noto R, Cantisani M, Colavita I, Galdiero M, Cassiman JJ, Daniele A, Pedone C, Salvatore F
* Chimeric beta-defensin analogs, including the novel 3NI analog, display salt-resistant antimicrobial activity and lack toxicity in human epithelial cell lines (554 views)
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2013 Apr; 57(4): 1701-1708.
Impact Factor: 4.451
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Galdiero S, Falanga A, Tarallo R, Russo L, Galdiero E, Cantisani M, Morelli G, Galdiero M
* Peptide inhibitors against herpes simplex virus infections (1149 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Mar; 19(3): 148-158.
Impact Factor: 1.862
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Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (447 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
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Galdiero S, Russo L, Falanga A, Cantisani M, Vitiello M, Fattorusso R, Malgieri G, Galdiero M, Isernia C
* Structure and Orientation of the gH625-644 Membrane Interacting Region of Herpes Simplex Virus Type 1 in a Membrane Mimetic System (384 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Apr 10; 51(14): 3121-3128.
Impact Factor: 3.377
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Falanga A, Tarallo R, Vitiello G, Vitiello M, Perillo E, Cantisani M, D'Errico G, Galdiero M, Galdiero S
* Biophysical Characterization and Membrane Interaction of the Two Fusion Loops of Glycoprotein B from Herpes Simplex Type I Virus (526 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 Feb 23; 7(2): N/D-N/D.
Impact Factor: 3.73
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Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (934 views)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
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Galdiero S, Vitiello M, Finamore E, Mansi R, Galdiero M, Morelli G, Tesauro D
* Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens (433 views)
Molecular Biosystems (ISSN: 1742-206x), 2012; 8(12): 3166-3177.
Impact Factor: 3.35
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Tarallo R, Accardo A, Falanga A, Guarnieri D, Vitiello G, Netti P, D'Errico G, Morelli G, Galdiero S
* Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (459 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Impact Factor: 5.925
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Vitiello G, Falanga A, Galdiero M, Marsh D, Galdiero S, D'Errico G
* Lipid composition modulates the interaction of peptides deriving from herpes simplex virus type I glycoproteins B and H with biomembranes (687 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Oct; 1808(10): 2517-2526.
Impact Factor: 3.99
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Scudiero O, Galdiero S, Cantisani M, Di Noto R, Vitiello M, Galdiero M, Naclerio G, Cassiman JJ, Pedone C, Castaldo G, Salvatore F
* Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity (643 views)
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2010 Jun; 54(6): 2312-2322.
Impact Factor: 4.672
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Galdiero S, Falanga A, Vitiello M, Raiola L, Russo L, Pedone C, Isernia C, Galdiero M
* The presence of a single N-terminal histidine residue enhances the fusogenic properties of a Membranotropic peptide derived from herpes simplex virus type 1 glycoprotein (471 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2010 May 28; 285(22): 17123-17136.
Impact Factor: 5.328
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Galdiero S, Falanga A, Vitiello G, Vitiello M, Pedone C, D'Errico G, Galdiero M
* Role of membranotropic sequences from herpes simplex virus type I glycoproteins B and H in the fusion process (557 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0005-2736, 0925-4439), 2010 Mar; 1798(3): 579-591.
Impact Factor: 4.647
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Angeli C, Improta R, Santoro F
* On the controversial nature of the 1 B-1(u) and 2 B-1(u) states of trans-stilbene: The n-electron valence state perturbation theory approach (295 views)
J Chem Phys (ISSN: 0021-9606, 0897-690online, 0021-9606printed), 2009 May 7; 130(17): N/D-N/D.
Impact Factor: 3.093
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Galdiero S, Falanga A, Vitiello M, Raiola L, Fattorusso R, Browne H, Pedone C, Isernia C, Galdiero M
* Analysis of a membrane interacting region of herpes simplex virus type 1 glycoprotein (632 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 31; 283(44): 29993-30009.
Impact Factor: 5.52
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Galdiero S, Vitiello M, Falanga A, D'Isanto M, Cantisani M, Kampanaraki A, Benedetti E, Browne H, Galdiero M
* Peptides containing membrane-interacting motifs inhibit herpes simplex virus type 1 infectivity (458 views)
Peptides (ISSN: 0196-9781, 1873-5169electronic, 0196-9781linking), 2008 Sep; 29(9): 1461-1471.
Impact Factor: 2.565
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Galdiero S, Vitiello M, D'Isanto M, Falanga A, Cantisani M, Browne H, Pedone C, Galdiero M
* The identification and characterization of fusogenic domains in herpes virus glycoprotein B molecules (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2008 Mar 25; 9(5): 758-767.
Impact Factor: 3.322
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Galdiero S, Falanga A, Vitiello M, D'Isanto M, Collins C, Orrei V, Browne H, Pedone C, Galdiero M
* Evidence for a role of the membrane-proximal region of herpes simplex virus type 1 glycoprotein H in membrane fusion and virus inhibition (618 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 885-895.
Impact Factor: 3.446
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Dalla Bona A, Formaggio F, Peggion C, Kaptein B, Broxterman Quirinus B, Galdiero S, Galdiero M, Vitiello M, Benedetti E, Toniolo C
* Synthesis, conformation, and bioactivity of novel analogues of the antiviral lipopeptide halovir (501 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 748-757.
Impact Factor: 1.801
View Export to BibTeX Export to EndNote
Galdiero S, Vitiello M, D'Isanto M, Falanga A, Collins C, Raieta K, Pedone C, Browne H, Galdiero M
* Analysis of synthetic peptides from heptad-repeat domains of herpes simplex virus type 1 glycoproteins H and (619 views)
Journal Of General Virology (ISSN: 0022-1317), 2006 May; 87: 1085-1097.
Impact Factor: 3.11
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Galdiero S, Falanga A, Vitiello M, Browne H, Pedone C, Galdiero M
* Fusogenic domains in herpes simplex virus type 1 glycoprotein (593 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Sep 5; 280(31): 28632-28643.
Impact Factor: 5.854
View Export to BibTeX Export to EndNote
Galdiero S, Vitiello M, D'Isanto M, Di Niola E, Peluso L, Raieta K, Pedone C, Galdiero M, Benedetti E
* Induction of signaling pathways by herpes simplex virus type 1 through glycoprotein H peptides (617 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 494-502.
Impact Factor: 2.863
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* Metabolomic and oxidative effects of quantum dots-indolicidin on three generations of Daphnia magna (91 views)
Aquat Toxicol (ISSN: 0166-445xlinking), 2018 May; 198: 158-164.
Impact Factor: 0
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Depalo N, Corricelli M, De Paola I, Valente G, Iacobazzi RM, Altamura E, Debellis D, Comegna D, Fanizza E, Denora N, Laquintana V, Mavelli F, Striccoli M, Saviano M, Agostiano A, Del Gatto A, Zaccaro L, Curri ML
* NIR Emitting Nanoprobes Based on Cyclic RGD Motif Conjugated PbS Quantum Dots for Integrin-Targeted Optical Bioimaging (420 views) (PDF 184 views)
Acs Appl Mater Inter (ISSN: 1944-8244), 2017 Dec 13; 9(49): 43113-43126.
Impact Factor: 8.097
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Morelli G, Galdiero M
* gH625: A milestone in understanding the many roles of membranotropic peptides (530 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2015 Jan; 1848(PA): 16-25.
Impact Factor: 5.158
View Export to BibTeX Export to EndNote
Vitiello G, Falanga A, Petruk AA, Merlino A, Fragneto G, Paduano L, Galdiero S, D'Errico G
* Fusion of raft-like lipid bilayers operated by a membranotropic domain of the HSV-type I glycoprotein gH occurs through a cholesterol-dependent mechanism (381 views)
Soft Matter (ISSN: 1744-683x), 2015; 11(15): 3003-3016.
Impact Factor: 3.798
View Export to BibTeX Export to EndNote
Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
* Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery (454 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(5): 415-425.
Impact Factor: 1.951
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (510 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2014 Jul; 20(7): 468-478.
Impact Factor: 1.546
View Export to BibTeX Export to EndNote
Accardo A, Vitiello M, Tesauro D, Galdiero M, Finamore E, Martora F, Mansi R, Ringhieri P, Morelli G
* Self-assembled or mixed peptide amphiphile micelles from herpes simplex virus glycoproteins as potential immunomodulatory treatment (491 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 May 7; 9(1): 2137-2148.
Impact Factor: 4.383
View Export to BibTeX Export to EndNote
Cantisani M, Falanga A, Incoronato N, Russo L, De Simone A, Morelli G, Berisio R, Galdiero M, Galdiero S
* Conformational modifications of gB from herpes simplex virus type 1 analyzed by synthetic peptides (704 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2013 Nov 14; 56(21): 8366-8376.
Impact Factor: 5.48
View Export to BibTeX Export to EndNote
Scudiero O, Galdiero S, Nigro E, Del Vecchio L, Di Noto R, Cantisani M, Colavita I, Galdiero M, Cassiman JJ, Daniele A, Pedone C, Salvatore F
* Chimeric beta-defensin analogs, including the novel 3NI analog, display salt-resistant antimicrobial activity and lack toxicity in human epithelial cell lines (554 views)
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2013 Apr; 57(4): 1701-1708.
Impact Factor: 4.451
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Tarallo R, Russo L, Galdiero E, Cantisani M, Morelli G, Galdiero M
* Peptide inhibitors against herpes simplex virus infections (1149 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Mar; 19(3): 148-158.
Impact Factor: 1.862
View Export to BibTeX Export to EndNote
Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (447 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
View Export to BibTeX Export to EndNote
Galdiero S, Russo L, Falanga A, Cantisani M, Vitiello M, Fattorusso R, Malgieri G, Galdiero M, Isernia C
* Structure and Orientation of the gH625-644 Membrane Interacting Region of Herpes Simplex Virus Type 1 in a Membrane Mimetic System (384 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Apr 10; 51(14): 3121-3128.
Impact Factor: 3.377
View Export to BibTeX Export to EndNote
Falanga A, Tarallo R, Vitiello G, Vitiello M, Perillo E, Cantisani M, D'Errico G, Galdiero M, Galdiero S
* Biophysical Characterization and Membrane Interaction of the Two Fusion Loops of Glycoprotein B from Herpes Simplex Type I Virus (526 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 Feb 23; 7(2): N/D-N/D.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (934 views)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
View Export to BibTeX Export to EndNote
Galdiero S, Vitiello M, Finamore E, Mansi R, Galdiero M, Morelli G, Tesauro D
* Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens (433 views)
Molecular Biosystems (ISSN: 1742-206x), 2012; 8(12): 3166-3177.
Impact Factor: 3.35
View Export to BibTeX Export to EndNote
Tarallo R, Accardo A, Falanga A, Guarnieri D, Vitiello G, Netti P, D'Errico G, Morelli G, Galdiero S
* Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (459 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Impact Factor: 5.925
View Export to BibTeX Export to EndNote
Vitiello G, Falanga A, Galdiero M, Marsh D, Galdiero S, D'Errico G
* Lipid composition modulates the interaction of peptides deriving from herpes simplex virus type I glycoproteins B and H with biomembranes (687 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Oct; 1808(10): 2517-2526.
Impact Factor: 3.99
View Export to BibTeX Export to EndNote
Scudiero O, Galdiero S, Cantisani M, Di Noto R, Vitiello M, Galdiero M, Naclerio G, Cassiman JJ, Pedone C, Castaldo G, Salvatore F
* Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity (643 views)
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2010 Jun; 54(6): 2312-2322.
Impact Factor: 4.672
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Vitiello M, Raiola L, Russo L, Pedone C, Isernia C, Galdiero M
* The presence of a single N-terminal histidine residue enhances the fusogenic properties of a Membranotropic peptide derived from herpes simplex virus type 1 glycoprotein (471 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2010 May 28; 285(22): 17123-17136.
Impact Factor: 5.328
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Vitiello G, Vitiello M, Pedone C, D'Errico G, Galdiero M
* Role of membranotropic sequences from herpes simplex virus type I glycoproteins B and H in the fusion process (557 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0005-2736, 0925-4439), 2010 Mar; 1798(3): 579-591.
Impact Factor: 4.647
View Export to BibTeX Export to EndNote
Angeli C, Improta R, Santoro F
* On the controversial nature of the 1 B-1(u) and 2 B-1(u) states of trans-stilbene: The n-electron valence state perturbation theory approach (295 views)
J Chem Phys (ISSN: 0021-9606, 0897-690online, 0021-9606printed), 2009 May 7; 130(17): N/D-N/D.
Impact Factor: 3.093
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Vitiello M, Raiola L, Fattorusso R, Browne H, Pedone C, Isernia C, Galdiero M
* Analysis of a membrane interacting region of herpes simplex virus type 1 glycoprotein (632 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 31; 283(44): 29993-30009.
Impact Factor: 5.52
View Export to BibTeX Export to EndNote
Galdiero S, Vitiello M, Falanga A, D'Isanto M, Cantisani M, Kampanaraki A, Benedetti E, Browne H, Galdiero M
* Peptides containing membrane-interacting motifs inhibit herpes simplex virus type 1 infectivity (458 views)
Peptides (ISSN: 0196-9781, 1873-5169electronic, 0196-9781linking), 2008 Sep; 29(9): 1461-1471.
Impact Factor: 2.565
View Export to BibTeX Export to EndNote
Galdiero S, Vitiello M, D'Isanto M, Falanga A, Cantisani M, Browne H, Pedone C, Galdiero M
* The identification and characterization of fusogenic domains in herpes virus glycoprotein B molecules (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2008 Mar 25; 9(5): 758-767.
Impact Factor: 3.322
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Vitiello M, D'Isanto M, Collins C, Orrei V, Browne H, Pedone C, Galdiero M
* Evidence for a role of the membrane-proximal region of herpes simplex virus type 1 glycoprotein H in membrane fusion and virus inhibition (618 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 885-895.
Impact Factor: 3.446
View Export to BibTeX Export to EndNote
Dalla Bona A, Formaggio F, Peggion C, Kaptein B, Broxterman Quirinus B, Galdiero S, Galdiero M, Vitiello M, Benedetti E, Toniolo C
* Synthesis, conformation, and bioactivity of novel analogues of the antiviral lipopeptide halovir (501 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 748-757.
Impact Factor: 1.801
View Export to BibTeX Export to EndNote
Galdiero S, Vitiello M, D'Isanto M, Falanga A, Collins C, Raieta K, Pedone C, Browne H, Galdiero M
* Analysis of synthetic peptides from heptad-repeat domains of herpes simplex virus type 1 glycoproteins H and (619 views)
Journal Of General Virology (ISSN: 0022-1317), 2006 May; 87: 1085-1097.
Impact Factor: 3.11
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Vitiello M, Browne H, Pedone C, Galdiero M
* Fusogenic domains in herpes simplex virus type 1 glycoprotein (593 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Sep 5; 280(31): 28632-28643.
Impact Factor: 5.854
View Export to BibTeX Export to EndNote
Galdiero S, Vitiello M, D'Isanto M, Di Niola E, Peluso L, Raieta K, Pedone C, Galdiero M, Benedetti E
* Induction of signaling pathways by herpes simplex virus type 1 through glycoprotein H peptides (617 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 494-502.
Impact Factor: 2.863
View Export to BibTeX Export to EndNote
29 Records (27 excluding Abstracts).
Total impact factor: 111.919 (105.096 excluding Abstracts).
Total 5 year impact factor: 113.773 (106.352 excluding Abstracts).
Total impact factor: 111.919 (105.096 excluding Abstracts).
Total 5 year impact factor: 113.773 (106.352 excluding Abstracts).
1162 views. Last view on Sunday 04 June 2023, 18:53:34
ibb.cnr.it
