Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients (1451 views)
Diabetes Care (ISSN: 1935-5548, 0149-5992, 1935-5548electronic), 2012 Jul; 35(7): 1429-1435.
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Paper type: Journal Article, Randomized Controlled Trial, Research Support, Non-U. S. Gov'T,
Impact factor: 7.735, 5-year impact factor: 7.555
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84862885081&partnerID=40&md5=fe7808f7fdab090d4d2f442a45206d3a
Keywords: Metformin, Monounsaturated Fatty Acid, Adult, Aerobic Exercise, Aged, Article, Blood Glucose Monitoring, Body Weight, Caloric Intake, Carbohydrate Diet, Clinical Article, Controlled Study, Diet Therapy, Fat Content, Fat Intake, Fatty Liver, Female, Glycemic Index, High Fiber Diet, Human, Lipid Diet, Non Insulin Dependent Diabetes Mellitus, Parallel Design, Physical Activity, Qualitative Analysis, Randomized Controlled Trial, Reference Value, Risk Reduction, Treatment Duration, Treatment Response, Weight Reduction, Type 2, Middle Aged, Type 2 Blood Diet Therapy, Fats Analysis, Monounsaturated Administration, Dosage, Fatty Liver Prevention, Liver Metabolism, Metformin Therapeutic Use,
Affiliations:
*** IBB - CNR ***
Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy.
Biostructure and Bioimaging Institute, National Research Council, Naples, Italy
Department of Biomorphological and Functional Science, Federico II University, Naples, Italy
References:
Not available.
Diabetes Care (ISSN: 1935-5548, 0149-5992, 1935-5548electronic), 2012 Jul; 35(7): 1429-1435.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Randomized Controlled Trial, Research Support, Non-U. S. Gov'T,
Impact factor: 7.735, 5-year impact factor: 7.555
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84862885081&partnerID=40&md5=fe7808f7fdab090d4d2f442a45206d3a
Keywords: Metformin, Monounsaturated Fatty Acid, Adult, Aerobic Exercise, Aged, Article, Blood Glucose Monitoring, Body Weight, Caloric Intake, Carbohydrate Diet, Clinical Article, Controlled Study, Diet Therapy, Fat Content, Fat Intake, Fatty Liver, Female, Glycemic Index, High Fiber Diet, Human, Lipid Diet, Non Insulin Dependent Diabetes Mellitus, Parallel Design, Physical Activity, Qualitative Analysis, Randomized Controlled Trial, Reference Value, Risk Reduction, Treatment Duration, Treatment Response, Weight Reduction, Type 2, Middle Aged, Type 2 Blood Diet Therapy, Fats Analysis, Monounsaturated Administration, Dosage, Fatty Liver Prevention, Liver Metabolism, Metformin Therapeutic Use,
Affiliations:
*** IBB - CNR ***
Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy.
Biostructure and Bioimaging Institute, National Research Council, Naples, Italy
Department of Biomorphological and Functional Science, Federico II University, Naples, Italy
References:
Not available.
Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients
OBJECTIVE - To evaluate the effects of qualitative dietary changes and the interaction with aerobic exercise training on liver fat content independent of weight loss in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS - With use of a factorial 2 x 2 randomized parallel-group design, 37 men and 8 women, aged 35-70 years, with type 2 diabetes in satisfactory blood glucose control on diet or diet plusmetformin treatmentwere assigned to one of the following groups for an 8-week period: 1) high-carbohydrate/high-fiber/low-glycemic index diet (CHO/fiber group), 2) high-MUFA diet (MUFA group), 3) high-carbohydrate/high- fiber/low- glycemic index diet plus physical activity program (CHO/fiber+Ex group), and 4) high-MUFA diet plus physical activity program (MUFA+Ex group). Before and after intervention, hepatic fat content was measured by 1H NMR. RESULTS - Dietary compliance was optimal and body weight remained stable in all groups. Liver fat content decreased more in MUFA (-29%) and MUFA+Ex (-25%) groups than in CHO/fiber (-4%) and CHO/fiber+Ex groups (-6%). Two-way repeated-measures ANOVA, including baseline values as covariate, showed a significant effect on liver fat content for diet (P = 0.006), with no effects for exercise training (P = 0.789) or diet-exercise interaction (P = 0.712). CONCLUSIONS - An isocaloric diet enriched in MUFA compared with a diet higher in carbohydrate and fiber was associated with a clinically relevant reduction of hepatic fat content in type 2 diabetic patients independent of an aerobic training program and should be considered for the nutritional management of hepatic steatosis in people with type 2 diabetes. © 2012 by the American Diabetes Association.
OBJECTIVE - To evaluate the effects of qualitative dietary changes and the interaction with aerobic exercise training on liver fat content independent of weight loss in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS - With use of a factorial 2 x 2 randomized parallel-group design, 37 men and 8 women, aged 35-70 years, with type 2 diabetes in satisfactory blood glucose control on diet or diet plusmetformin treatmentwere assigned to one of the following groups for an 8-week period: 1) high-carbohydrate/high-fiber/low-glycemic index diet (CHO/fiber group), 2) high-MUFA diet (MUFA group), 3) high-carbohydrate/high- fiber/low- glycemic index diet plus physical activity program (CHO/fiber+Ex group), and 4) high-MUFA diet plus physical activity program (MUFA+Ex group). Before and after intervention, hepatic fat content was measured by 1H NMR. RESULTS - Dietary compliance was optimal and body weight remained stable in all groups. Liver fat content decreased more in MUFA (-29%) and MUFA+Ex (-25%) groups than in CHO/fiber (-4%) and CHO/fiber+Ex groups (-6%). Two-way repeated-measures ANOVA, including baseline values as covariate, showed a significant effect on liver fat content for diet (P = 0.006), with no effects for exercise training (P = 0.789) or diet-exercise interaction (P = 0.712). CONCLUSIONS - An isocaloric diet enriched in MUFA compared with a diet higher in carbohydrate and fiber was associated with a clinically relevant reduction of hepatic fat content in type 2 diabetic patients independent of an aerobic training program and should be considered for the nutritional management of hepatic steatosis in people with type 2 diabetes. © 2012 by the American Diabetes Association.
Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients
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Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients
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View Export to BibTeX Export to EndNote
Ferrara LA, Mancini M, De Simone GD, Turco S, Iovine C, Marotta T, Mainenti G, Mancini M
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Impact Factor: 0.61
View Export to BibTeX Export to EndNote
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Impact Factor: 2.476
View Export to BibTeX Export to EndNote
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17 Records (17 excluding Abstracts).
Total impact factor: 53.04 (53.04 excluding Abstracts).
Total 5 year impact factor: 58.189 (58.189 excluding Abstracts).
Total impact factor: 53.04 (53.04 excluding Abstracts).
Total 5 year impact factor: 58.189 (58.189 excluding Abstracts).
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