Advances in brain imaging: A new ethical challenge (288 views) (PDF public 390 views)
Ann Ist Super Sanita (ISSN: 0021-2571), 1997; 33(4): 483-488.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Review,
Impact factor: 0.343, 5-year impact factor: 0.962
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0031311199&partnerID=40&md5=c7b54da1d2e572278f124dea6daa27db
Keywords: Brain Imaging, Brain Research, Clinical Ethics, Bioethics, Brain Angiography, Brain Disease, Brain Mapping, Computer Assisted Emission Tomography, Computer Assisted Tomography, Confidentiality, Diagnostic Imaging, Echoencephalography, Histology, Human, Human Experiment, Informed Consent, Medical Ethics, Mental Disease, Nuclear Magnetic Resonance Imaging, Pathology, Radiography, Review, Safety, Scintiscanning, Single Photon Emission Computer Tomography, Cerebral Angiography, Human Experimentation, Mental Disorders, Emission-Computed, Single-Photon, X-Ray Computed, Brain Anatomy, Histology Pathology Radiography Radionuclide Imaging, Brain Diseases Diagnosis Pathology, Diagnostic Imaging Adverse Effects Ethics Trends, Mental Disorders Diagnosis Pathology,
Affiliations:
Centro per la Medicina Nucleare, Consiglio Nazionale delle Ricerche, Naples, Italy
References:
Hounsfield, G.N., Computerised transverse axial scanning tomography. Part I. Description of the system (1973) Br. J. Radiol., 46, pp. 1016-102
Lauterbur, P.C., Image formation by induced local interactions: Examples employing nuclear magnetic resonance (1973) Nature, 242, pp. 190-191
Atias, S.W., (1991) Magnetic Resonance Imaging of the Brain and the Spine, , Raven Press, New York
Kelley, R.E., (1994) Functional Neuroimaging, , Futura Publishing Co, Armonk (NY)
Phelps, M.E., Mazziotta, J.C., Schelbert, H.R., (1985) Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and the Heart, , Raven Press, New York
Kramer, E.L., Sanger, J.J., (1995) Clinical SPECT Imaging, , Raven Press, New York
Ross, B., Michaelis, T., Clinical applications of magnetic resonance spectroscopy (1994) Magn. Reson. Quart., 10, pp. 191-247
Rosen, B.R., Aronen, H.J., Kwong, K.K., Advances in clinical neuroimaging: Functional MR imaging techniques (1993) Radiographics, 13, pp. 889-896
Belliveau, J.W., Kennedy, D.N., Mckinstry, R.C., Functional mapping of the human visual cortex using magnetic resonance imaging (1991) Science, 254, pp. 716-719
Gordon, R., (1983) Great Medical Disasters, , Hutchinson, London
Abrams, N., Brucker, M.D., (1993) Medical Ethics: A Clinical Textbook End Reference for the Health Care Professions, , MA MIT Press, Cambridge
Kety, S.S., Schmidt, C.F., The nitrous oxide method for the quantitative determination of cerebral blood flow in man: Theory, procedure and normal values (1948) J. Clin. Invest., 27, pp. 476-483
Ingvar, D.H., Lassen, N.A., Regional blood flow of the cerebral cortex determined by krypton-85 (1962) Acta Physiol. Scand., 54, pp. 325-338
Lassen, N.A., Munck, O., The cerebral blood flow in man determined by the use of radioactive krypton (1955) Acta Physiol. Scand., 33, pp. 30-49
Olesen, J., Paulson, O.B., Lassen, N.A., Regional cerebral blood flow in man determined by the initial slope of clearance of intraarterially injected 133 Xenon (1971) Stroke, 2, pp. 515-539
Gallen, C.C., Sobel, D.F., Lewin, J.D., Neuromagnetic mapping of brain function (1993) Radiology, 187, pp. 863-868
Shellock, F.G., Kanal, E., (1994) Magnetic Resonance: Bioeffects, Safety and Patient Management, , Raven Press, New York
Beauchamp, T.L., Childless, J.F., (1983) Principles of Biomedical Ethics, , Oxford University Press Inc., New York
Phelps, M.E., Huang, S.C., Hoffman, E.J., Tomographic measurements of local cerebral glucose metabolic rate in humans with (F-18) 2-fluoro-2-deoxygiucose: Validation of a method (1979) Ann. Neurol., 6, pp. 371-388
Lannotti, F., Fieschi, C., Alfano, B., Simplified, non-invasive PET measurement of blood-brain-barrier permeability (1987) J. Comput. Assist. Tomogr., 11, pp. 390-397
Alfano, B., Brunetti, A., Arpaia, M., Multiparametric display of spin echo data from MR brain studies (1995) J. Magn. Reson. Imag., 5, pp. 217-225
Jackson, E.F., Narayana, P.A., Falcone, J.C., Reproducibility of nonparametric feature map segmentation for determination of normal human intracranial volumes with MR imaging data (1994) J. Magn. Reson. Imag., 4, pp. 692-700
Hounsfield, G. N., Computerised transverse axial scanning tomography. Part I. Description of the system (1973) Br. J. Radiol., 46, pp. 1016-102
Lauterbur, P. C., Image formation by induced local interactions: Examples employing nuclear magnetic resonance (1973) Nature, 242, pp. 190-191
Atias, S. W., (1991) Magnetic Resonance Imaging of the Brain and the Spine, , Raven Press, New York
Kelley, R. E., (1994) Functional Neuroimaging, , Futura Publishing Co, Armonk (NY)
Phelps, M. E., Mazziotta, J. C., Schelbert, H. R., (1985) Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and the Heart, , Raven Press, New York
Kramer, E. L., Sanger, J. J., (1995) Clinical SPECT Imaging, , Raven Press, New York
Rosen, B. R., Aronen, H. J., Kwong, K. K., Advances in clinical neuroimaging: Functional MR imaging techniques (1993) Radiographics, 13, pp. 889-896
Belliveau, J. W., Kennedy, D. N., Mckinstry, R. C., Functional mapping of the human visual cortex using magnetic resonance imaging (1991) Science, 254, pp. 716-719
Kety, S. S., Schmidt, C. F., The nitrous oxide method for the quantitative determination of cerebral blood flow in man: Theory, procedure and normal values (1948) J. Clin. Invest., 27, pp. 476-483
Ingvar, D. H., Lassen, N. A., Regional blood flow of the cerebral cortex determined by krypton-85 (1962) Acta Physiol. Scand., 54, pp. 325-338
Lassen, N. A., Munck, O., The cerebral blood flow in man determined by the use of radioactive krypton (1955) Acta Physiol. Scand., 33, pp. 30-49
Gallen, C. C., Sobel, D. F., Lewin, J. D., Neuromagnetic mapping of brain function (1993) Radiology, 187, pp. 863-868
Shellock, F. G., Kanal, E., (1994) Magnetic Resonance: Bioeffects, Safety and Patient Management, , Raven Press, New York
Beauchamp, T. L., Childless, J. F., (1983) Principles of Biomedical Ethics, , Oxford University Press Inc., New York
Phelps, M. E., Huang, S. C., Hoffman, E. J., Tomographic measurements of local cerebral glucose metabolic rate in humans with (F-18) 2-fluoro-2-deoxygiucose: Validation of a method (1979) Ann. Neurol., 6, pp. 371-388
Jackson, E. F., Narayana, P. A., Falcone, J. C., Reproducibility of nonparametric feature map segmentation for determination of normal human intracranial volumes with MR imaging data (1994) J. Magn. Reson. Imag., 4, pp. 692-700
Ann Ist Super Sanita (ISSN: 0021-2571), 1997; 33(4): 483-488.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Review,
Impact factor: 0.343, 5-year impact factor: 0.962
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0031311199&partnerID=40&md5=c7b54da1d2e572278f124dea6daa27db
Keywords: Brain Imaging, Brain Research, Clinical Ethics, Bioethics, Brain Angiography, Brain Disease, Brain Mapping, Computer Assisted Emission Tomography, Computer Assisted Tomography, Confidentiality, Diagnostic Imaging, Echoencephalography, Histology, Human, Human Experiment, Informed Consent, Medical Ethics, Mental Disease, Nuclear Magnetic Resonance Imaging, Pathology, Radiography, Review, Safety, Scintiscanning, Single Photon Emission Computer Tomography, Cerebral Angiography, Human Experimentation, Mental Disorders, Emission-Computed, Single-Photon, X-Ray Computed, Brain Anatomy, Histology Pathology Radiography Radionuclide Imaging, Brain Diseases Diagnosis Pathology, Diagnostic Imaging Adverse Effects Ethics Trends, Mental Disorders Diagnosis Pathology,
Affiliations:
Centro per la Medicina Nucleare, Consiglio Nazionale delle Ricerche, Naples, Italy
References:
Hounsfield, G.N., Computerised transverse axial scanning tomography. Part I. Description of the system (1973) Br. J. Radiol., 46, pp. 1016-102
Lauterbur, P.C., Image formation by induced local interactions: Examples employing nuclear magnetic resonance (1973) Nature, 242, pp. 190-191
Atias, S.W., (1991) Magnetic Resonance Imaging of the Brain and the Spine, , Raven Press, New York
Kelley, R.E., (1994) Functional Neuroimaging, , Futura Publishing Co, Armonk (NY)
Phelps, M.E., Mazziotta, J.C., Schelbert, H.R., (1985) Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and the Heart, , Raven Press, New York
Kramer, E.L., Sanger, J.J., (1995) Clinical SPECT Imaging, , Raven Press, New York
Ross, B., Michaelis, T., Clinical applications of magnetic resonance spectroscopy (1994) Magn. Reson. Quart., 10, pp. 191-247
Rosen, B.R., Aronen, H.J., Kwong, K.K., Advances in clinical neuroimaging: Functional MR imaging techniques (1993) Radiographics, 13, pp. 889-896
Belliveau, J.W., Kennedy, D.N., Mckinstry, R.C., Functional mapping of the human visual cortex using magnetic resonance imaging (1991) Science, 254, pp. 716-719
Gordon, R., (1983) Great Medical Disasters, , Hutchinson, London
Abrams, N., Brucker, M.D., (1993) Medical Ethics: A Clinical Textbook End Reference for the Health Care Professions, , MA MIT Press, Cambridge
Kety, S.S., Schmidt, C.F., The nitrous oxide method for the quantitative determination of cerebral blood flow in man: Theory, procedure and normal values (1948) J. Clin. Invest., 27, pp. 476-483
Ingvar, D.H., Lassen, N.A., Regional blood flow of the cerebral cortex determined by krypton-85 (1962) Acta Physiol. Scand., 54, pp. 325-338
Lassen, N.A., Munck, O., The cerebral blood flow in man determined by the use of radioactive krypton (1955) Acta Physiol. Scand., 33, pp. 30-49
Olesen, J., Paulson, O.B., Lassen, N.A., Regional cerebral blood flow in man determined by the initial slope of clearance of intraarterially injected 133 Xenon (1971) Stroke, 2, pp. 515-539
Gallen, C.C., Sobel, D.F., Lewin, J.D., Neuromagnetic mapping of brain function (1993) Radiology, 187, pp. 863-868
Shellock, F.G., Kanal, E., (1994) Magnetic Resonance: Bioeffects, Safety and Patient Management, , Raven Press, New York
Beauchamp, T.L., Childless, J.F., (1983) Principles of Biomedical Ethics, , Oxford University Press Inc., New York
Phelps, M.E., Huang, S.C., Hoffman, E.J., Tomographic measurements of local cerebral glucose metabolic rate in humans with (F-18) 2-fluoro-2-deoxygiucose: Validation of a method (1979) Ann. Neurol., 6, pp. 371-388
Lannotti, F., Fieschi, C., Alfano, B., Simplified, non-invasive PET measurement of blood-brain-barrier permeability (1987) J. Comput. Assist. Tomogr., 11, pp. 390-397
Alfano, B., Brunetti, A., Arpaia, M., Multiparametric display of spin echo data from MR brain studies (1995) J. Magn. Reson. Imag., 5, pp. 217-225
Jackson, E.F., Narayana, P.A., Falcone, J.C., Reproducibility of nonparametric feature map segmentation for determination of normal human intracranial volumes with MR imaging data (1994) J. Magn. Reson. Imag., 4, pp. 692-700
Hounsfield, G. N., Computerised transverse axial scanning tomography. Part I. Description of the system (1973) Br. J. Radiol., 46, pp. 1016-102
Lauterbur, P. C., Image formation by induced local interactions: Examples employing nuclear magnetic resonance (1973) Nature, 242, pp. 190-191
Atias, S. W., (1991) Magnetic Resonance Imaging of the Brain and the Spine, , Raven Press, New York
Kelley, R. E., (1994) Functional Neuroimaging, , Futura Publishing Co, Armonk (NY)
Phelps, M. E., Mazziotta, J. C., Schelbert, H. R., (1985) Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and the Heart, , Raven Press, New York
Kramer, E. L., Sanger, J. J., (1995) Clinical SPECT Imaging, , Raven Press, New York
Rosen, B. R., Aronen, H. J., Kwong, K. K., Advances in clinical neuroimaging: Functional MR imaging techniques (1993) Radiographics, 13, pp. 889-896
Belliveau, J. W., Kennedy, D. N., Mckinstry, R. C., Functional mapping of the human visual cortex using magnetic resonance imaging (1991) Science, 254, pp. 716-719
Kety, S. S., Schmidt, C. F., The nitrous oxide method for the quantitative determination of cerebral blood flow in man: Theory, procedure and normal values (1948) J. Clin. Invest., 27, pp. 476-483
Ingvar, D. H., Lassen, N. A., Regional blood flow of the cerebral cortex determined by krypton-85 (1962) Acta Physiol. Scand., 54, pp. 325-338
Lassen, N. A., Munck, O., The cerebral blood flow in man determined by the use of radioactive krypton (1955) Acta Physiol. Scand., 33, pp. 30-49
Gallen, C. C., Sobel, D. F., Lewin, J. D., Neuromagnetic mapping of brain function (1993) Radiology, 187, pp. 863-868
Shellock, F. G., Kanal, E., (1994) Magnetic Resonance: Bioeffects, Safety and Patient Management, , Raven Press, New York
Beauchamp, T. L., Childless, J. F., (1983) Principles of Biomedical Ethics, , Oxford University Press Inc., New York
Phelps, M. E., Huang, S. C., Hoffman, E. J., Tomographic measurements of local cerebral glucose metabolic rate in humans with (F-18) 2-fluoro-2-deoxygiucose: Validation of a method (1979) Ann. Neurol., 6, pp. 371-388
Jackson, E. F., Narayana, P. A., Falcone, J. C., Reproducibility of nonparametric feature map segmentation for determination of normal human intracranial volumes with MR imaging data (1994) J. Magn. Reson. Imag., 4, pp. 692-700
Advances in brain imaging: A new ethical challenge
Technical advances in the past 25 years permitted substantial advances in the neuroimaging field, expanding the diagnostic and research potentials and significally reducing the use of old invasive imaging techniques for research purposes. The safer procedures now available allow acquisition of reference data, morphological assessment and functional characterisation from healthy volunteers. However, enrollment of volunteers is still a sensitive ethical issue. Ethical problems related to informed consent, for both research and diagnostic procedures, in patients with neuropsychiatric disorders represent an additional crucial issue. Furthermore, with both functional and structural neuroimaging studies, there is a theoretical risk of violation of individual privacy. Research in the neuroimaging field should tend to increase the amount of information obtained through appropriate post-processing procedures, including multimodality image fusion, and to limit stress and discomfort.
Technical advances in the past 25 years permitted substantial advances in the neuroimaging field, expanding the diagnostic and research potentials and significally reducing the use of old invasive imaging techniques for research purposes. The safer procedures now available allow acquisition of reference data, morphological assessment and functional characterisation from healthy volunteers. However, enrollment of volunteers is still a sensitive ethical issue. Ethical problems related to informed consent, for both research and diagnostic procedures, in patients with neuropsychiatric disorders represent an additional crucial issue. Furthermore, with both functional and structural neuroimaging studies, there is a theoretical risk of violation of individual privacy. Research in the neuroimaging field should tend to increase the amount of information obtained through appropriate post-processing procedures, including multimodality image fusion, and to limit stress and discomfort.
Advances in brain imaging: A new ethical challenge
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Advances in brain imaging: A new ethical challenge
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Varnäs K, Nyberg S, Halldin C, Varrone A, Takano A, Karlsson P, Andersson J, McCarthy D, Smith M, Pierson ME, Söderström J, Farde L
* Quantitative analysis of [11C]AZ10419369 binding to 5-HT 1B receptors in human brain (412 views)
J Cereb Blood Flow Metab (ISSN: 0271-678x), 2011 Jan; 31(1): 113-123.
Impact Factor: 5.008
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Amorosi S, Vigliano I, Del Giudice E, Panico L, Maruotti GM, Fusco A, Quarantelli M, Ciccone C, Ursini MV, Martinelli P, Pignata C
* Brain alteration in a Nude/SCID fetus carrying FOXN1 homozygous mutation (401 views)
J Neurol Sci (ISSN: 0022-510x), 2010 Nov 15; 298(1-2): 121-123.
Impact Factor: 2.167
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Bruni AC, Bernardi L, Colao R, Rubino E, Smirne N, Frangipane F, Terni B, Curcio SA, Mirabelli M, Clodomiro A, Di Lorenzo R, Maletta R, Anfossi M, Gallo M, Geracitano S, Tomaino C, Muraca MG, Leotta A, Lio SG, Pinessi L, Rainero I, Sorbi S, Nee L, Milan G, Pappata S, Postiglione A, Abbamondi N, Forloni G, St George Hyslop P, Rogaeva E, Bugiani O, Giaccone G, Foncin JF, Spillantini MG, Puccio G
* Worldwide distribution of PSEN1 Met146Leu mutation: A large variability for a founder mutation (761 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2010 Mar 9; 74(10): 798-806.
Impact Factor: 8.017
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Varrone A, Asenbaum S, Vander Borght T, Booij J, Nobili F, Någren K, Darcourt J, Kapucu OL, Tatsch K, Bartenstein P, Van Laere K
* EANM procedure guidelines for PET brain imaging using [18F]FDG, version (628 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2103-2110.
Impact Factor: 4.531
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Covelli EM, Brunetti A, Di Lauro A, Sullo P, Mazzarella G, Tedeschi E, Belfiore G
* Clinical impact of correlative [123I]-FP-CIT brain imaging and neurological findings in suspect Parkinson's disease (360 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2004 Oct; 108(4): 417-425.
Impact Factor: 1.368
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Galderisi S, Mucci A, Quarantelli M, Volpe U, Amati G, Alfano B, Maj M
* Structural and functional brain imaging findings in deficit and nondeficit schizophrenia (299 views)
International Journal Of Neuropsychopharmacology (ISSN: 1461-1457), 2004 Jun; 7: N/D-N/D.
Impact Factor: 4.128
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Le Bihan D, Mangin JF, Poupon C, Clark CA, Pappata S, Molko N, Chabriat H
* Diffusion tensor imaging: Concepts and applications (3488 views)
J Magn Reson Imaging (ISSN: 1053-1807, 1522-2586electronic), 2001 Apr; 13(4): 534-546.
Impact Factor: 2.41
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Quarantelli M, Alfano B, Larobina M, Tedeschi E, Brunetti A, Covelli EM, Ciarmiello A, Mainolfi C, Salvatore M
Frequency encoding for simultaneous display of multimodality images (805 views) (PDF 193 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1999 Mar; 40(3): 442-447.
Impact Factor: 3.326
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Soricelli A, Cuocolo A, Varrone A, Discepolo A, Tedeschi E, Mainenti PP, Grivet-Fojaja MR, Covelli EM, Postiglione A, Salvatore M
Technetium-99m-tetrofosmin uptake in brain tumors by SPECT: Comparison with thallium-201 imaging (416 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 May; 39(5): 802-806.
Impact Factor: 3.064
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Alfano B, Quarantelli M, Brunetti A, Larobina M, Covelli EM, Tedeschi E, Salvatore M
Reproducibility of intracranial volume measurement by unsupervised multispectral brain segmentation (532 views) (PDF 595 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 1998 Mar; 39(3): 497-499.
Impact Factor: 2.962
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Alfano B, Brunetti A, Covelli EM, Quarantelli M, Panico M, Ciarmiello A, Salvatore M
Unsupervised, automated segmentation of the normal brain using a multispectral relaxometric magnetic resonance approach (513 views) (PDF 689 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 1997 Jan; 37(1): 84-93.
Impact Factor: 3.012
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Postiglione A, Soricelli A, Covelli EM, Iazzetta N, Ruocco A, Milan G, Santoro L, Alfano B, Brunetti A
Premature aging in Werner's syndrome spares the central nervous system (490 views) (PDF 210 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 1996 May; 17(3): 325-330.
Impact Factor: 2.872
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Alfano B, Brunetti A, Arpaia M, Ciarmiello A, Covelli EM, Salvatore M
Multiparametric display of spin-echo data from MR studies of brain (316 views) (PDF 620 views)
J Magn Reson Imaging (ISSN: 1053-1807, 1522-2586electronic), 1995 Mar; 5(2): 217-225.
Impact Factor: 1.277
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Postiglione A, Soricelli A, Cicerano U, Mansi L, De Chiara S, Gallotta G, Schettini G, Salvatore M
Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct (357 views)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic, 1043-6618linking), 1991 Apr; 23(3): 241-246.
Impact Factor: 0.47
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21 Records (19 excluding Abstracts).
Total impact factor: 72.149 (62.804 excluding Abstracts).
Total 5 year impact factor: 85.336 (75.547 excluding Abstracts).
Total impact factor: 72.149 (62.804 excluding Abstracts).
Total 5 year impact factor: 85.336 (75.547 excluding Abstracts).
288 views. Last view on Saturday 14 January 2023, 20:08:23
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