Keywords: Brain Imaging, Eeg, Pet, Spect, Werner, S Syndrome, Fluorodeoxyglucose F 18, Hexamethylpropylene Amine Oxime Technetium Tc 99m, Adult, Angiography, Article, Case Report, Central Nervous System, Computer Assisted Tomography, Diagnostic Imaging, Electroencephalogram, Electromyogram, Female, Human, Nuclear Magnetic Resonance Imaging, Positron Emission Tomography, Priority Journal, Werner Syndrome, Emission-Computed, Single-Photon, Aging Pathology, Brain Pathology, Werner Syndrome Pathology,
Affiliations: Dept. of Clin. and Exp. Medicine, University of Naples Federico II, via S. Pansini 5, 80131 Naples, Italy
C.N.R. Center for Nuclear Medicine, Department of Diagnostic Imaging, University of Naples Federico II, via S. Pansini 5, 80131 Naples, Italy
Department of Neurophysiology, Medical School, University of Naples Federico II, via S. Pansini 5, 80131 Naples, Italy
C. N. R. Center for Nuclear Medicine, Department of Diagnostic Imaging, University of Naples Federico II, via S. Pansini 5, 80131 Naples, Italy
Department of Clinical and Experimental Medicine, University of Naples Federico II, Italy.
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Premature aging in Werner's syndrome spares the central nervous system
Werner's Syndrome is a rare genetic disease, characterized by premature aging of many tissues and organs. We studied the brain morphology and function in two patients with Werner's syndrome to assess the possible involvement of the central nervous system in this premature aging process. The two patients (brother and sister, respectively) were studied by magnetic resonance imaging (MRI) and angiography (MRA), single photon emission computed tomography (SPECT) with (99mTc)-d,l-hexamethyl propilene amine oxime (HMPAO), positron emission tomography (PET) with 2(18F)-Fluoro-2-deoxyglucose (FDG), electroencephalography (EEG), and electromyography (EMG). Some of these investigations were also repeated after 1 year. The results of all these studies were normal. The premature aging process in patients with Werner's syndrome, while affecting most tissues, seems to spare the central nervous system.
Premature aging in Werner's syndrome spares the central nervous system