Bacterial cell division regulation by Ser/Thr kinases: A structural perspective

Bacterial cell division regulation by Ser/Thr kinases: A structural perspective (581 views)

Ruggiero A, De Simone P, Smaldone G, Squeglia F, Berisio R

Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 756-766.

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Paper type: Journal Article, Research Support, Non-U. S. Gov'T, Review,

Impact factor: 2.326, 5-year impact factor: 3.148

Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84874885193&partnerID=40&md5=e6a6d71f0101e25b4e511522ba9c32d2

Keywords: Cell Division, Peptidoglycan, Phosphorylation, Structure, Protein Kinase, Bacterial Cell Division, Bacterial Phenomena And Functions, Bacterial Virulence, Cell Cycle, Cell Growth, Dimerization, Eukaryote, Gram Positive Bacterium, Host Pathogen Interaction, Nonhuman, Nuclear Magnetic Resonance Spectroscopy, Phenotype, Review, Enzyme Activation, Protein Structure, Tertiary, Protein-Serine-Threonine Kinases, Bacteria Cytology Enzymology, Peptides Chemistry Metabolism, Protein-Serine-Threonine Kinases Chemistry Metabolism,

Affiliations:
*** IBB - CNR ***

Institute of Biostructure and Bioimaging, CNR, Via Mezzocannone, 16, I-80134 Napoli, Italy
Department of Chemistry, University of Naples Federico II, I-80134 - Via Cinthia 4, Napoli, Italy

References:
Molle, V., Kremer, L., Division and cell envelope regulation by ser/thr phosphorylation: Mycobacterium shows the way (2010) Mol. Microbiol, 75, pp. 1064-107

Liebeke, M., Meyer, H., Donat, S., Ohlsen, K., Lalk, M., A metabolomic view of staphylococcus aureus and its ser/thr kinase and phosphatase deletion mutants: Involvement in cell wall biosynthesis (2010) Chem. Biol, 17, pp. 820-830

Bakal, C.J., Davies, J.E., No longer an exclusive club: Eukaryotic signalling domains in bacteria (2000) Trends Cell Biol, 10, pp. 32-38

Kennelly, P.J., Potts, M., Fancy meeting you here! A fresh look at prokaryotic protein phosphorylation (1996) J. Bacteriol, 178, pp. 4759-4764

Shi, L., Potts, M., Kennelly, P.J., The serine, threonine, and/or tyrosine-specific protein kinases and protein phosphatases of prokaryotic organisms: A family portrait (1998) FEMS Microbiol. Rev, 22, pp. 229-253

Hussain, H., Branny, P., Allan, E., A eukaryotic-type serine/threonine protein kinase is required for biofilm formation, genetic competence, and acid resistance in streptococcus mutans (2006) J. Bacteriol, 188, pp. 1628-1632

Fiuza, M., Canova, M.J., Zanella-Cleon, I., Becchi, M., Cozzone, A.J., Mateos, L.M., Kremer, L., Molle, V., From the characterization of the four serine/threonine protein kinases (pkna/b/g/l) of corynebacterium glutamicum toward the role of pkna and pknb in cell division (2008) J. Biologica. Chem, 283, pp. 18099-18112

Madec, E., Laszkiewicz, A., Iwanicki, A., Obuchowski, M., Seror, S., Characterization of a membrane-linked ser/thr protein kinase in bacillus subtilis, implicated in developmental processes (2002) Mol. Microbiol, 46, pp. 571-586

Madec, E., Stensballe, A., Kjellstrom, S., Cladiere, L., Obuchowski, M., Jensen, O.N., Seror, S.J., Mass spectrometry and site-directed mutagenesis identify several autophosphorylated residues required for the activity of prkc, a ser/thr kinase from bacillus subtilis (2003) J. Mol. Biol, 330, pp. 459-472

Absalon, C., Obuchowski, M., Madec, E., Delattre, D., Holland, I.B., Seror, S.J., Cpga, ef-tu and the stressosome protein yezb are substrates of the ser/thr kinase/phosphatase couple, prkc/prpc, in bacillus subtilis (2009) Microbiology, 155, pp. 932-943

Perez, J., Castaneda-Garcia, A., Jenke-Kodama, H., Muller, R., Munoz-Dorado, J., (2008) Eukaryotic-like Protein Kinases In the Prokaryotes and The Myxobacterial Kinome, 105, pp. 15950-15955

Munoz-Dorado, J., Inouye, S., Inouye, M.A., Gene encoding a protein serine/threonine kinase is required for normal development of m. Xanthus, a gram-negative bacterium (1991) Cell, 67, pp. 995-1006

Rajagopal, L., Clancy, A., Rubens, C.E.A., eukaryotic type serine/threonine kinase and phosphatase in streptococcus agalactiae reversibly phosphorylate an inorganic pyrophosphatase and affect growth, cell segregation, and virulence (2003) J. Biologica. Chem, 278, pp. 14429-14441

Echenique, J., Kadioglu, A., Romao, S., Andrew, P.W., Trombe, M.C., Protein serine/threonine kinase stkp positively controls virulence and competence in streptococcus pneumoniae (2004) Infect. Immun, 72, pp. 2434-2437

Novakova, L., Saskova, L., Pallova, P., Janecek, J., Novotna, J., Ulrych, A., Echenique, J., Branny, P., Characterization of a eukaryotic type serine/threonine protein kinase and protein phosphatase of streptococcus pneumoniae and identification of kinase substrates (2005) FEBS J, 272, pp. 1243-1254

Beilharz, K., Novakova, L., Fadda, D., Branny, P., Massidda, O., Veening, J.W., Control of cell division in streptococcus pneumoniae by the conserved ser/thr protein kinase stkp (2012) Proc. Nat. Acad. Sci. USA, 109, pp. E905-E913

Beres, S.B., Sylva, G.L., Barbian, K.D., Lei, B., Hoff, J.S., Mammarella, N.D., Liu, M.Y., Musser, J.M., Genome sequence of a serotype m3 strain of group a streptococcus: Phage-encoded toxins, the high-virulence phenotype, and clone emergence (2002) Proc. Nat. Acad. Sci. USA, 99, pp. 10078-10083

Pancholi, V., Boel, G., Jin, H., Streptococcus pyogenes ser/thr kinase-regulated cell wall hydrolase is a cell division planerecognizing and chain-forming virulence factor (2010) J. Biol. Chem, 285, pp. 30861-30874

Av-Gay, Y., Everett, M., The eukaryotic-like ser/thr protein kinases of mycobacterium tuberculosis (2000) Trends Microbiol, 8, pp. 238-244

Ulrich, L.E., Koonin, E.V., Zhulin, I.B., One-component systems dominate signal transduction in prokaryotes (2005) Trends Microbiol, 13, pp. 52-56

Jones, G., Dyson, P., Evolution of transmembrane protein kinases implicated in coordinating remodeling of gram-positive peptidoglycan: Inside versus outside (2006) J. Bacteriol, 188, pp. 7470-7476

Yeats, C., Finn, R.D., Bateman, A., The pasta domain: A betalactam-binding domain (2002) Trends Biochem. Sci, 27, p. 438

Young, T.A., Delagoutte, B., Endrizzi, J.A., Falick, A.M., Alber, T., Structure of mycobacterium tuberculosis pknb supports a universal activation mechanism for ser/thr protein kinases (2003) Nature Struct. Biol, 10, pp. 168-174

Mieczkowski, C., Iavarone, A.T., Alber, T., Auto-activation mechanism of the mycobacterium tuberculosis pknb receptor ser/thr kinase (2008) EMBO J, 27, pp. 3186-3197

Lombana, T.N., Echols, N., Good, M.C., Thomsen, N.D., Ng, H.L., Greenstein, A.E., Falick, A.M., Alber, T., Allosteric activation mechanism of the mycobacterium tuberculosis receptor ser/thr protein kinase, pknb (2010) Structure, 18, pp. 1667-1677

Wehenkel, A., Fernandez, P., Bellinzoni, M., Catherinot, V., Barilone, N., Labesse, G., Jackson, M., Alzari, P.M., The structure of pknb in complex with mitoxantrone, an atp-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria (2006) FEBS Lett, 580, pp. 3018-3022

Ortiz-Lombardia, M., Pompeo, F., Boitel, B., Alzari, P.M., Crystal structure of the catalytic domain of the pknb serine/threonine kinase from mycobacterium tuberculosis (2003) J. Biol. Chem, 278, pp. 13094-13100

Barthe, P., Mukamolova, G.V., Roumestand, C., Cohen-Gonsaud, M., The structure of pknb extracellular pasta domain from mycobacterium tuberculosis suggests a ligand-dependent kinase activation (2010) Structure, 18, pp. 606-615

Ruggiero, A., Squeglia, F., Marasco, D., Marchetti, R., Molinaro, A., Berisio, R., X-ray structural studies of the entire extracellular region of the serine/threonine kinase prkc from staphylococcus aureus (2011) Biochem. J, 435, pp. 33-41

Good, M.C., Greenstein, A.E., Young, T.A., Ng, H.L., Alber, T., Sensor domain of the mycobacterium tuberculosis receptor ser/thr protein kinase, pknd, forms a highly symmetric beta propeller (2004) J. Mol. Biol, 339, pp. 459-469

Cavazos, A., Prigozhin, D.M., Alber, T., Structure of the sensor domain of mycobacterium tuberculosis pknh receptor kinase reveals a conserved binding cleft (2012) J. Mol. Biol.

Pereira, S.F., Goss, L., Dworkin, J., Eukaryote-like serine/threonine kinases and phosphatases in bacteria (2011) Microbiol. Mol. Biol. Rev., MMBR, 75, pp. 192-212

Alber, T., Signaling mechanisms of the mycobacterium tuberculosis receptor ser/thr protein kinases (2009) Curr. Opin. Struct. Biol, 19, pp. 650-657

Harry, E.J., Bacterial cell division: Regulating z-ring formation (2001) Mol. Microbiol, 40, pp. 795-803

Wu, L.J., Errington, J., Nucleoid occlusion and bacterial cell division (2012) Nature Reviews. Microbiology, 10, pp. 8-12

Trevors, J.T., Evolution of cell division in bacteria (2004) Theory Biosci, 123, pp. 3-15

Nanninga, N., Morphogenesis of escherichia coli (1998) Microbiol. Mol. Biol. Rev.,: MMBR, 62, pp. 110-129

Dajkovic, A., Lutkenhaus, J., Z ring as executor of bacterial cell division (2006) J. Mol. Microbiol. Biotechnol, 11, pp. 140-151

Hett, E.C., Rubin, E.J., Bacterial growth and cell division: A mycobacterial perspective (2008) Microbiol. Mol. Biol. Rev, 72, pp. 126-156. , MMBR, table of contents

Dziadek, J., Rutherford, S.A., Madiraju, M.V., Atkinson, M.A., Rajagopalan, M., Conditional expression of mycobacterium smegmatis ftsz, an essential cell division gene (2003) Microbiology, 149, pp. 1593-1603

Lutkenhaus, J.F., Wolf-Watz, H., Donachie, W.D., Organization of genes in the ftsa-enva region of the escherichia coli genetic map and identification of a new fts locus (ftsz) (1980) J. Bacteriol, 142, pp. 615-620

Margolin, W., Ftsz and the division of prokaryotic cells and organelles (2005) Nat. Rev. Mol. Biol, 6, pp. 862-871

Shen, B., Lutkenhaus, J., Examination of the interaction between ftsz and mincn in e. Coli suggests how minc disrupts z rings (2010) Mol. Microbiol, 75, pp. 1285-1298

Hu, Z., Lutkenhaus, J., Topological regulation of cell division in escherichia coli involves rapid pole to pole oscillation of the division inhibitor minc under the control of mind and mine (1999) Mol. Microbiol, 34, pp. 82-90

Levin, P.A., Shim, J.J., Grossman, A.D., Effect of mincd on ftsz ring position and polar septation in bacillus subtilis (1998) J. Bacteriol, 180, pp. 6048-6051

Bernhardt, T.G., de Boer, P.A., Slma, a nucleoid-associated, ftsz binding protein required for blocking septal ring assembly over chromosomes in e (2005) Coli. Mol. Cell, 18, pp. 555-564

Brennan, P.J., Structure, function, and biogenesis of the cell wall of mycobacterium tuberculosis (2003) Tuberculosis, 83, pp. 91-97

Hett, E.C., Chao, M.C., Deng, L.L., Rubin, E.J., A mycobacterial enzyme essential for cell division synergizes with resuscitationpromoting factor (2008) PLOS Pathog, 4. , In the press

Fukushima, T., Kitajima, T., Yamaguchi, H., Ouyang, Q., Furuhata, K., Yamamoto, H., Shida, T., Sekiguchi, J., Identification and characterization of novel cell wall hydrolase cwlt: A twodomain autolysin exhibiting n-acetylmuramidase and dlendopeptidase activities (2008) J. Biol. Chem, 283, pp. 11117-11125

Aramini, J.M., Rossi, P., Huang, Y.J., Zhao, L., Jiang, M., Maglaqui, M., Xiao, R., Montelione, G.T., Solution nmr structure of the nlpc/p60 domain of lipoprotein spr from escherichia coli: Structural evidence for a novel cysteine peptidase catalytic triad (2008) Biochemistry, 47, pp. 9715-9717

Ruggiero, A., Marasco, D., Squeglia, F., Soldini, S., Pedone, E., Pedone, C., Berisio, R., Structure and functional regulation of ripa, a mycobacterial enzyme essential for daughter cell separation (2010) Structure, 18, pp. 1184-1190

Mukamolova, G.V., Turapov, O.A., Young, D.I., Kaprelyants, A.S., Kell, D.B., Young, M., A family of autocrine growth factors in mycobacterium tuberculosis (2002) Mol. Microbiol, 46, pp. 623-635

Telkov, M.V., Demina, G.R., Voloshin, S.A., Salina, E.G., Dudik, T.V., Stekhanova, T.N., Mukamolova, G.V., Kaprelyants, A.S., Proteins of the rpf (resuscitation promoting factor) family are peptidoglycan hydrolases (2006) Biochem. Biokhimiia, 71, pp. 414-422

Kaprelyants, A.S., Mukamolova, G.V., Ruggiero, A., Makarov, V.A., Demina, G.R., Shleeva, M.O., Potapov, V.D., Shramko, P.A., Resuscitation-promoting factors (rpf): In search of inhibitors (2012) Pro. Pept. Lett

Nanninga, N., Cell division and peptidoglycan assembly in escherichia coli (1991) Mol. Microbiol, 5, pp. 791-795

Beltramini, A.M., Mukhopadhyay, C.D., Pancholi, V., Modulation of cell wall structure and antimicrobial susceptibility by a staphylococcus aureus eukaryote-like serine/threonine kinase and phosphatase (2009) Infect. Immunit, 77, pp. 1406-1416

Hempel, A.M., Cantlay, S., Molle, V., Wang, S.B., Naldrett, M.J., Parker, J.L., Richards, D.M., Flardh, K., The ser/thr protein kinase afsk regulates polar growth and hyphal branching in the filamentous bacteria streptomyces (2012) Proc. Nat. Acad. Sci. USA, 109, pp. E2371-E2379

Cole, S.T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S.V., Barrell, B.G., Deciphering the biology of mycobacterium tuberculosis from the complete genome sequence (1998) Nature, 393, pp. 537-544

Kang, C.M., Abbott, D.W., Park, S.T., Dascher, C.C., Cantley, L.C., Husson, R.N., The mycobacterium tuberculosis serine/threonine kinases pkna and pknb: Substrate identification and regulation of cell shape (2005) Genes Develop, 19, pp. 1692-1704

Thakur, M., Chakraborti, P.K., Gtpase activity of mycobacterial ftsz is impaired due to its transphosphorylation by the eukaryotic-type ser/thr kinase, pkna (2006) J. Biol. Chem, 281, pp. 40107-40113

Parikh, A., Verma, S.K., Khan, S., Prakash, B., Nandicoori, V.K., Pknb-mediated phosphorylation of a novel substrate, nacetylglucosamine-1-phosphate uridyltransferase, modulates its acetyltransferase activity (2009) J. Mol. Biol, 386, pp. 451-464

Dasgupta, A., Datta, P., Kundu, M., Basu, J., The serine/threonine kinase pknb of mycobacterium tuberculosis phosphorylates pbpa, a penicillin-binding protein required for cell division (2006) Microbiology, 152, pp. 493-504

Wehenkel, A., Bellinzoni, M., Grana, M., Duran, R., Villarino, A., Fernandez, P., Andre-Leroux, G., Alzari, P.M., Mycobacterial ser/thr protein kinases and phosphatases: Physiological roles and therapeutic potential (2008) Biochim. Et Biophys. Acta, 1784, pp. 193-202

Mir, M., Asong, J., Li, X., Cardot, J., Boons, G.J., Husson, R.N., The extracytoplasmic domain of the mycobacterium tuberculosis ser/thr kinase pknb binds specific muropeptides and is required for pknb localization (2011) PLoS Pathog, 7, pp. e1002182

Shah, I.M., Laaberki, M.H., Popham, D.L., Dworkin, J., A eukaryotic-like ser/thr kinase signals bacteria to exit dormancy in response to peptidoglycan fragments (2008) Cell, 135, pp. 486-496

Paracuellos, P., Ballandras, A., Robert, X., Kahn, R., Herve, M., Mengin-Lecreulx, D., Cozzone, A.J., Gouet, P., The extended conformation of the 2.9-a crystal structure of the threepasta domain of a ser/thr kinase from the human pathogen staphylococcus aureus (2010) J. Mol. Biol, 404, pp. 847-858

Rakette, S., Donat, S., Ohlsen, K., Stehle, T., Structural analysis of staphylococcus aureus serine/threonine kinase pknb (2012) PloS One, 7, pp. e39136

Scherr, N., Honnappa, S., Kunz, G., Mueller, P., Jayachandran, R., Winkler, F., Pieters, J., Steinmetz, M.O., Structural basis for the specific inhibition of protein kinase g, a virulence factor of mycobacterium tuberculosis (2007) Proc. Nat. Acad. Sci. USA, 104, pp. 12151-12156

Gay, L.M., Ng, H.L., Alber, T., A conserved dimer and global conformational changes in the structure of apo-pkne ser/thr protein kinase from mycobacterium tuberculosis (2006) J. Mol.Biol, 360, pp. 409-420

Gee, C.L., Papavinasasundaram, K.G., Blair, S.R., Baer, C.E., Falick, A.M., King, D.S., Griffin, J.E., Alber, T., A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria (2012) Sci. Signal, 5, p. 7

Dey, M., Cao, C., Dar, A.C., Tamura, T., Ozato, K., Sicheri, F., Dever, T.E., Mechanistic link between pkr dimerization, autophosphorylation, and eif2alpha substrate recognition (2005) Cell, 122, pp. 901-913

Korennykh, A.V., Egea, P.F., Korostelev, A.A., Finer-Moore, J., Zhang, C., Shokat, K.M., Stroud, R.M., Walter, P., The unfolded protein response signals through high-order assembly of ire1 (2009) Nature, 457, pp. 687-693

Greenstein, A.E., Echols, N., Lombana, T.N., King, D.S., Alber, T., Allosteric activation by dimerization of the pknd receptor ser/thr protein kinase from mycobacterium tuberculosis (2007) J. Biol. Chem, 282, pp. 11427-11435

Villarino, A., Duran, R., Wehenkel, A., Fernandez, P., England, P., Brodin, P., Cole, S.T., Alzari, P.M., Proteomic identification of m. Tuberculosis protein kinase substrates: Pknb recruits gara, a fha domain-containing protein, through activation loop-mediated interactions (2005) J. Mol. Biol, 350, pp. 953-963

Lougheed, K.E., Osborne, S.A., Saxty, B., Whalley, D., Chapman, T., Bouloc, N., Chugh, J., Buxton, R.S., Effective inhibitors of the essential kinase pknb and their potential as anti-mycobacterial agents (2011) Tuberculosis, 91, pp. 277-286

Finn, R.D., Tate, J., Mistry, J., Coggill, P.C., Sammut, S.J., Hotz, H.R., Ceric, G., Bateman, A., The pfam protein families database (2008) Nucleic Acids Res, 36, pp. D281-D288

Holm, L., Rosenstrom, P., Dali server: Conservation mapping in 3d (2010) Nucleic Acids Res, 38, pp. W545-W549

Berisio, R., Ciccarelli, L., Squeglia, F., de Simone, A., Vitagliano, L., Structural and dynamic properties of incomplete immunoglobulin-like fold domains (2012) Pro. Pept. Lett, 19, pp. 1045-1053

Vitagliano, L., Ruggiero, A., Pedone, C., Berisio, R., A molecular dynamics study of pilus subunits: Insights into pilus biogenesis (2007) J. Mol. Biol, 367, pp. 935-941

Richardson, J.S., Richardson, D.C., Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation (2002) Proc. Nat. Acad. Sci. USA, 99, pp. 2754-2759

de Simone, A., Dhulesia, A., Soldi, G., Vendruscolo, M., Hsu, S.T., Chiti, F., Dobson, C.M., Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility (2011) Proc. Nat. Acad. Sci. USA, 108, pp. 21057-21062

Squeglia, F., Marchetti, R., Ruggiero, A., Lanzetta, R., Marasco, D., Dworkin, J., Petoukhov, M., Silipo, A., Chemical basis of peptidoglycan discrimination by prkc, a key kinase involved in bacterial resuscitation from dormancy (2011) J. Am. Chem. Soc, 133, pp. 20676-20679

Lim, J.H., Kim, M.S., Kim, H.E., Yano, T., Oshima, Y., Aggarwal, K., Goldman, W.E., Oh, B.H., Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins (2006) J. Biol. Chem, 281, pp. 8286-8295

Pares, S., Mouz, N., Petillot, Y., Hakenbeck, R., Dideberg, O., Xray structure of streptococcus pneumoniae pbp2x, a primary penicillin target enzyme (1996) Nat. Struct Biol, 3, pp. 284-289

Gordon, E., Mouz, N., Duee, E., Dideberg, O., The crystal structure of the penicillin-binding protein 2x from streptococcus pneumoniae and its acyl-enzyme form: Implication in drug resistance (2000) J. Mol. Biol, 299, pp. 477-485

Debarbouille, M., Dramsi, S., Dussurget, O., Nahori, M.A., Vaganay, E., Jouvion, G., Cozzone, A., Duclos, B., Characterization of a serine/threonine kinase involved in virulence of staphylococcus aureus (2009) J. Bacteriol, 191, pp. 4070-4081

Rodkey, E.A., Drawz, S.M., Sampson, J.M., Bethel, C.R., Bonomo, R.A., van den Akker, F., Crystal structure of a preacylation complex of the beta-lactamase inhibitor, sulbactam, bound to a sulfenamide bond containing thiol-beta-lactamase (2012) J. Am. Chem. Soc

Pozzi, C., Waters, E.M., Rudkin, J.K., Schaeffer, C.R., Lohan, A.J., Tong, P., Loftus, B.J., O'Gara, J.P., Methicillin resistance alters the biofilm phenotype and attenuates virulence in staphylococcus aureus device-associated infections (2012) PLoS Pathog, 8, pp. e1002626

Berisio, R., Schluenzen, F., Harms, J., Bashan, A., Auerbach, T., Baram, D., Yonath, A., Structural insight into the role of the ribosomal tunnel in cellular regulation (2003) Nat. Struct. Biol, 10, pp. 366-370

Amit, M., Berisio, R., Baram, D., Harms, J., Bashan, A., Yonath, A., A crevice adjoining the ribosome tunnel: Hints for cotranslational folding (2005) FEBS Lett, 579, pp. 3207-3213

Agmon, I., Auerbach, T., Baram, D., Bartels, H., Bashan, A., Berisio, R., Fucini, P., Zarivach, R., On peptide bond formation, translocation, nascent protein progression and the regulatory properties of ribosomes. Derived on 20 october 2002 at the 28th febs meeting in istanbul (2003) Euro. J. Biochem. / FEBS, 270, pp. 2543-2556

Pronin, S.V., Kozmin, S.A., Synthesis of streptolydigin, a potent bacterial rna polymerase inhibitor (2010) J. Am. Chem. Soc, 132, pp. 14394-14396

Angehrn, P., Goetschi, E., Gmuender, H., Hebeisen, P., Hennig, M., Kuhn, B., Luebbers, T., Schmitt-Hoffmann, A., A new DNA gyrase inhibitor subclass of the cyclothialidine family based on a bicyclic dilactam-lactone scaffold. Synthesis and antibacterial properties (2011) J. Med. Chem, 54, pp. 2207-2224

Greenstein, A.E., Grundner, C., Echols, N., Gay, L.M., Lombana, T.N., Miecskowski, C.A., Pullen, K.E., Alber, T., Structure/function studies of ser/thr and tyr protein phosphorylation in mycobacterium tuberculosis (2005) J. Mol. Microbiol. Biotechnol, 9, pp. 167-181

Ruggiero, A., Tizzano, B., Pedone, E., Pedone, C., Wilmanns, M., Berisio, R., Crystal structure of the resuscitation-promoting factor (deltaduf)rpfb from m (2009) Tuberculosis. J. Mol. Biol, 385, pp. 153-162

Bateman, A., Coin, L., Durbin, R., Finn, R.D., Hollich, V., Griffiths-Jones, S., Khanna, A., Eddy, S.R., The pfam protein families database (2004) Nucleic Acids Res, 32, pp. D138-D141

Bakal, C. J., Davies, J. E., No longer an exclusive club: Eukaryotic signalling domains in bacteria (2000) Trends Cell Biol, 10, pp. 32-38

Kennelly, P. J., Potts, M., Fancy meeting you here! A fresh look at prokaryotic protein phosphorylation (1996) J. Bacteriol, 178, pp. 4759-4764

Beres, S. B., Sylva, G. L., Barbian, K. D., Lei, B., Hoff, J. S., Mammarella, N. D., Liu, M. Y., Musser, J. M., Genome sequence of a serotype m3 strain of group a streptococcus: Phage-encoded toxins, the high-virulence phenotype, and clone emergence (2002) Proc. Nat. Acad. Sci. USA, 99, pp. 10078-10083

Ulrich, L. E., Koonin, E. V., Zhulin, I. B., One-component systems dominate signal transduction in prokaryotes (2005) Trends Microbiol, 13, pp. 52-56

Young, T. A., Delagoutte, B., Endrizzi, J. A., Falick, A. M., Alber, T., Structure of mycobacterium tuberculosis pknb supports a universal activation mechanism for ser/thr protein kinases (2003) Nature Struct. Biol, 10, pp. 168-174

Lombana, T. N., Echols, N., Good, M. C., Thomsen, N. D., Ng, H. L., Greenstein, A. E., Falick, A. M., Alber, T., Allosteric activation mechanism of the mycobacterium tuberculosis receptor ser/thr protein kinase, pknb (2010) Structure, 18, pp. 1667-1677

Good, M. C., Greenstein, A. E., Young, T. A., Ng, H. L., Alber, T., Sensor domain of the mycobacterium tuberculosis receptor ser/thr protein kinase, pknd, forms a highly symmetric beta propeller (2004) J. Mol. Biol, 339, pp. 459-469

Pereira, S. F., Goss, L., Dworkin, J., Eukaryote-like serine/threonine kinases and phosphatases in bacteria (2011) Microbiol. Mol. Biol. Rev., MMBR, 75, pp. 192-212

Harry, E. J., Bacterial cell division: Regulating z-ring formation (2001) Mol. Microbiol, 40, pp. 795-803

Wu, L. J., Errington, J., Nucleoid occlusion and bacterial cell division (2012) Nature Reviews. Microbiology, 10, pp. 8-12

Trevors, J. T., Evolution of cell division in bacteria (2004) Theory Biosci, 123, pp. 3-15

Hett, E. C., Rubin, E. J., Bacterial growth and cell division: A mycobacterial perspective (2008) Microbiol. Mol. Biol. Rev, 72, pp. 126-156. , MMBR, table of contents

Lutkenhaus, J. F., Wolf-Watz, H., Donachie, W. D., Organization of genes in the ftsa-enva region of the escherichia coli genetic map and identification of a new fts locus (ftsz) (1980) J. Bacteriol, 142, pp. 615-620

Levin, P. A., Shim, J. J., Grossman, A. D., Effect of mincd on ftsz ring position and polar septation in bacillus subtilis (1998) J. Bacteriol, 180, pp. 6048-6051

Bernhardt, T. G., de Boer, P. A., Slma, a nucleoid-associated, ftsz binding protein required for blocking septal ring assembly over chromosomes in e (2005) Coli. Mol. Cell, 18, pp. 555-564

Brennan, P. J., Structure, function, and biogenesis of the cell wall of mycobacterium tuberculosis (2003) Tuberculosis, 83, pp. 91-97

Hett, E. C., Chao, M. C., Deng, L. L., Rubin, E. J., A mycobacterial enzyme essential for cell division synergizes with resuscitationpromoting factor (2008) PLOS Pathog, 4. , In the press

Aramini, J. M., Rossi, P., Huang, Y. J., Zhao, L., Jiang, M., Maglaqui, M., Xiao, R., Montelione, G. T., Solution nmr structure of the nlpc/p60 domain of lipoprotein spr from escherichia coli: Structural evidence for a novel cysteine peptidase catalytic triad (2008) Biochemistry, 47, pp. 9715-9717

Mukamolova, G. V., Turapov, O. A., Young, D. I., Kaprelyants, A. S., Kell, D. B., Young, M., A family of autocrine growth factors in mycobacterium tuberculosis (2002) Mol. Microbiol, 46, pp. 623-635

Telkov, M. V., Demina, G. R., Voloshin, S. A., Salina, E. G., Dudik, T. V., Stekhanova, T. N., Mukamolova, G. V., Kaprelyants, A. S., Proteins of the rpf (resuscitation promoting factor) family are peptidoglycan hydrolases (2006) Biochem. Biokhimiia, 71, pp. 414-422

Beltramini, A. M., Mukhopadhyay, C. D., Pancholi, V., Modulation of cell wall structure and antimicrobial susceptibility by a staphylococcus aureus eukaryote-like serine/threonine kinase and phosphatase (2009) Infect. Immunit, 77, pp. 1406-1416

Hempel, A. M., Cantlay, S., Molle, V., Wang, S. B., Naldrett, M. J., Parker, J. L., Richards, D. M., Flardh, K., The ser/thr protein kinase afsk regulates polar growth and hyphal branching in the filamentous bacteria streptomyces (2012) Proc. Nat. Acad. Sci. USA, 109, pp. E2371-E2379

Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Barrell, B. G., Deciphering the biology of mycobacterium tuberculosis from the complete genome sequence (1998) Nature, 393, pp. 537-544

Kang, C. M., Abbott, D. W., Park, S. T., Dascher, C. C., Cantley, L. C., Husson, R. N., The mycobacterium tuberculosis serine/threonine kinases pkna and pknb: Substrate identification and regulation of cell shape (2005) Genes Develop, 19, pp. 1692-1704

Shah, I. M., Laaberki, M. H., Popham, D. L., Dworkin, J., A eukaryotic-like ser/thr kinase signals bacteria to exit dormancy in response to peptidoglycan fragments (2008) Cell, 135, pp. 486-496

Gay, L. M., Ng, H. L., Alber, T., A conserved dimer and global conformational changes in the structure of apo-pkne ser/thr protein kinase from mycobacterium tuberculosis (2006) J. Mol. Biol, 360, pp. 409-420

Gee, C. L., Papavinasasundaram, K. G., Blair, S. R., Baer, C. E., Falick, A. M., King, D. S., Griffin, J. E., Alber, T., A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria (2012) Sci. Signal, 5, p. 7

Korennykh, A. V., Egea, P. F., Korostelev, A. A., Finer-Moore, J., Zhang, C., Shokat, K. M., Stroud, R. M., Walter, P., The unfolded protein response signals through high-order assembly of ire1 (2009) Nature, 457, pp. 687-693

Greenstein, A. E., Echols, N., Lombana, T. N., King, D. S., Alber, T., Allosteric activation by dimerization of the pknd receptor ser/thr protein kinase from mycobacterium tuberculosis (2007) J. Biol. Chem, 282, pp. 11427-11435

Lougheed, K. E., Osborne, S. A., Saxty, B., Whalley, D., Chapman, T., Bouloc, N., Chugh, J., Buxton, R. S., Effective inhibitors of the essential kinase pknb and their potential as anti-mycobacterial agents (2011) Tuberculosis, 91, pp. 277-286

Finn, R. D., Tate, J., Mistry, J., Coggill, P. C., Sammut, S. J., Hotz, H. R., Ceric, G., Bateman, A., The pfam protein families database (2008) Nucleic Acids Res, 36, pp. D281-D288

Richardson, J. S., Richardson, D. C., Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation (2002) Proc. Nat. Acad. Sci. USA, 99, pp. 2754-2759

Lim, J. H., Kim, M. S., Kim, H. E., Yano, T., Oshima, Y., Aggarwal, K., Goldman, W. E., Oh, B. H., Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins (2006) J. Biol. Chem, 281, pp. 8286-8295

Rodkey, E. A., Drawz, S. M., Sampson, J. M., Bethel, C. R., Bonomo, R. A., van den Akker, F., Crystal structure of a preacylation complex of the beta-lactamase inhibitor, sulbactam, bound to a sulfenamide bond containing thiol-beta-lactamase (2012) J. Am. Chem. Soc

Pronin, S. V., Kozmin, S. A., Synthesis of streptolydigin, a potent bacterial rna polymerase inhibitor (2010) J. Am. Chem. Soc, 132, pp. 14394-14396

Bacterial cell division regulation by Ser/Thr kinases: A structural perspective

Recent genetic, biochemical and structural studies have established that eukaryotic-like Ser/Thr protein-kinases are critical mediators of developmental changes and host pathogen interactions in bacteria. Although with lower abundance compared to their homologues from eukaryotes, Ser/Thr protein-kinases are widespread in gram-positive bacteria. These data underline a key role of reversible Ser/Thr phosphorylation in bacterial physiology and virulence. Numerous studies have revealed how phosphorylation/dephosphorylation of Ser/Thr protein-kinases governs cell division and cell wall biosynthesis and that Ser/Thr protein kinases are responsible for distinct phenotypes, dependent on different environmental signals. In this review we discuss the current understandings of Ser/Thr protein-kinases functional processes based on structural data. © 2012 Bentham Science Publishers.

Bacterial cell division regulation by Ser/Thr kinases: A structural perspective

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Bacterial cell division regulation by Ser/Thr kinases: A structural perspective

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Correale S, Ruggiero A, Capparelli R, Pedone E, Berisio R
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Correale S, Ruggiero A, Pedone E, Berisio R
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Greco A, Fiumara G, Gargiulo S, Gramanzini M, Brunetti A, Cuocolo A
* High-resolution positron emission tomography/computed tomography imaging of the mouse heart (466 views)
Exp Physiol Experimental Physiology (ISSN: 1469-445x, 0958-0670), 2013 Mar; 98(3): 645-651.
Impact Factor: 2.871
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Buanne P, Renzone G, Monteleone F, Vitale M, Monti SM, Sandomenico A, Garbi C, Montanaro D, Accardo M, Troncone G, Zatovicova M, Csaderova L, Supuran CT, Pastorekova S, Scaloni A, De Simone G, Zambrano N
* Characterization of carbonic anhydrase ix interactome reveals proteins assisting its nuclear localization in hypoxic cells (393 views)
J Proteome Res (ISSN: 1535-3893), 2013 Jan; 12(1): 282-292.
Impact Factor: 5.001
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Pandini G, Pace V, Copani A, Squatrito S, Milardi D, Vigneri R
* Insulin has multiple antiamyloidogenic effects on human neuronal cells (628 views)
Endocrinology (ISSN: 0013-7227, 1945-7170), 2013 Jan; 154(1): 375-387.
Impact Factor: 4.644
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Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
* Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (510 views)
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Impact Factor: 2.61
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Carotenuto A, Cipolletta E, Gomez-Monterrey I, Sala M, Vernieri E, Limatola A, Bertamino A, Musella S, Sorriento D, Grieco P, Trimarco B, Novellino E, Iaccarino G, Campiglia P
* Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors (527 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013; 69: 384-392.
Impact Factor: 3.432
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (461 views)
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
Impact Factor: 5.533
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (508 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Galdiero S, Falanga A, Cantisani M, Tarallo R, della Pepa ME, D'Oriano V, Galdiero M
* Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins (629 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 843-854.
Impact Factor: 2.326
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Berisio R
* Editorial: cell processes in bacterial diseases (409 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1011-1012.
Impact Factor: 1.994
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (932 views)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
* Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (361 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 24; 7(5): N/D-N/D.
Impact Factor: 3.73
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (3606 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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Sciacca MF, Chillemi R, Sciuto S, Pappalardo M, La Rosa C, Grasso D, Milardi D
* Interactions of two O-phosphorylresveratrol derivatives with model membranes (337 views)
Arch Biochem Biophys (ISSN: 1096-0384, 0003-3986), 2012 May; 521(1-2): 111-116.
Impact Factor: 0
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Doti N, Scognamiglio PL, Madonna S, Scarponi C, Ruvo M, Perretta G, Albanesi C, Marasco D
* New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries (996 views)
Biochemical Journal, 2012 Apr 1; 443: 231-240.
Impact Factor: 4.779
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Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (614 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
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Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (525 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
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De Simone G
* Editorial: Zinc Metallo-Enzymes As Target For Drug Design (423 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 820-1012.
Impact Factor: 4.07
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Galdiero S, Vitiello M, Finamore E, Mansi R, Galdiero M, Morelli G, Tesauro D
* Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens (419 views)
Molecular Biosystems (ISSN: 1742-206x), 2012; 8(12): 3166-3177.
Impact Factor: 3.35
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (349 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D.
Impact Factor: 2.882
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Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (423 views)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
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Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (517 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
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Fusco A, Santulli G, Sorriento D, Cipolletta E, Garbi C, Dorn GW, Trimarco B, Feliciello A, Iaccarino G
* Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis (422 views)
Cell Signal (ISSN: 0898-6568), 2012; 24(2): 468-475.
Impact Factor: 4.304
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Cantisani M, Vitiello M, Falanga A, Finamore E, Galdiero M, Galdiero S
* Peptides complementary to the active loop of porin P2 from Haemophilus influenzae modulate its activity (510 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2012; 7: 2361-2371.
Impact Factor: 3.463
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Squeglia F, Marchetti R, Ruggiero A, Lanzetta R, Marasco D, Dworkin J, Petoukhov M, Molinaro A, Berisio R, Silipo A
* Chemical basis of peptidoglycan discrimination by PrkC, a key kinase involved in bacterial resuscitation from dormancy (371 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2011 Dec 28; 133(51): 20676-20679.
Impact Factor: 9.907
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Palmieri D, Valentino T, D'Angelo D, De Martino I, Postiglione I, Pacelli R, Croce CM, Fedele M, Fusco A
* HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents (872 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
Impact Factor: 6.373
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Janda E, Palmieri C, Pisano A, Pontoriero M, Iaccino E, Falcone C, Fiume G, Gaspari M, Nevolo M, Di Salle E, Rossi A, De Laurentiis A, Greco A, Di Napoli D, Verheij E, Britti D, Lavecchia L, Quinto I, Scala G
* Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtkγ (451 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2011 Jun 16; 117(24): 6520-6531.
Impact Factor: 9.898
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Ruggiero A, Squeglia F, Marasco D, Marchetti R, Molinaro A, Berisio R
* X-ray structural studies of the entire extracellular region of the serine/threonine kinase PrkC from Staphylococcus aureus (510 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2011 Apr 1; 435(1): 33-41.
Impact Factor: 4.897
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Lusso P, Vangelista L, Cimbro R, Secchi M, Sironi F, Longhi R, Faiella M, Maglio O, Pavone V
* Molecular engineering of RANTES peptide mimetics with potent anti-HIV-1 activity (568 views)
Faseb J (ISSN: 0892-6638, 0892-6638linking), 2011 Apr; 25(4): 1230-1243.
Impact Factor: 5.712
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Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M
* AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (433 views)
Cardiovascular Research (ISSN: 0008-6363), 2010 Oct; 88(1): 101-110.
Impact Factor: 6.051
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Ruggiero A, Squeglia F, Izzo V, Silipo A, Vitagliano L, Molinaro A, Berisio R
* Expression, purification, crystallization and preliminary x-ray crystallographic analysis of the peptidoglycan binding region of the ser/thr kinase PrkC from staphylococcus aureus (379 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2010 Oct; 17(10): 1296-1299.
Impact Factor: 1.849
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Ruggiero A, Marasco D, Squeglia F, Soldini S, Pedone E, Pedone C, Berisio R
* Structure and functional regulation of RipA, a mycobacterial enzyme essential for daughter cell separation (419 views)
Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2010 Sep 8; 18(9): 1184-1190.
Impact Factor: 6.337
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Gautier B, Goncalves V, Diana D, Di Stasi R, Teillet F, Lenoir C, Huguenot F, Garbay C, Fattorusso R, D'Andrea LD, Vidal M, Inguimbert N
* Biochemical and Structural Analysis of the Binding Determinants of a Vascular Endothelial Growth Factor Receptor Peptidic Antagonist (526 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jun 10; 53(11): 4428-4440.
Impact Factor: 5.207
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Alfieri A, Pasanisi F, Salzano S, Esposito L, Martone D, Tafuri D, Daniele A, Contaldo F, Sacchetti L, Zagari A, Buono P
* Functional analysis of melanocortin-4-receptor mutants identified in severely obese subjects living in Southern Italy (395 views)
Gene (ISSN: 0378-1119), 2010 Jun 1; 457(1-2): 35-41.
Impact Factor: 2.266
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (578 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Galasso G, De Rosa R, Piscione F, Iaccarino G, Vosa C, Sorriento D, Piccolo R, Rapacciuolo A, Walsh K, Chiariello M
* Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failure (301 views)
Eur J Heart Fail European Journal Of Heart Failure (ISSN: 1388-9842), 2010; 12(12): 1290-1296.
Impact Factor: 4.512
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Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
* Viral fusion peptides induce several signal transduction pathway activations that are essential for interleukin-10 and beta-interferon production (476 views)
Intervirology (ISSN: 1423-0100, 0300-5526), 2010; 53(6): 381-389.
Impact Factor: 1.756
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Farina AR, Tacconelli A, Cappabianca L, Cea G, Chioda A, Romanelli A, Pensato S, Pedone C, Gulino A, Mackay AR
* The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells (388 views)
Oncogene (ISSN: 1476-5594, 0950-9232), 2009 Nov 19; 28(46): 4075-4094.
Impact Factor: 7.135
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Farina AR, Tacconelli A, Cappabianca L, Cea G, Panella S, Chioda A, Romanelli A, Pedone C, Gulino A, Mackay AR
* The alternative TrkAIII splice variant targets the centrosome and promotes genetic instability (358 views)
Mol Cell Biol (ISSN: 1098-5549, 0270-7306), 2009 Sep 1; 29(17): 4812-4830.
Impact Factor: 6.057
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D'Andrea LD, Del Gatto A, De Rosa L, Romanelli A, Pedone C
* Peptides targeting angiogenesis related growth factor receptors (14509 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1873-4286, 1381-6128), 2009 Jul; 15(21): 2414-2429.
Impact Factor: 4.414
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Illario M, Monaco S, Cavallo AL, Esposito I, Formisano P, D'Andrea LD, Cipolletta E, Trimarco B, Fenzi G, Rossi G, Vitale M
* Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake (385 views)
Cell Signal (ISSN: 0898-6568), 2009 May; 21(5): 786-792.
Impact Factor: 4.094
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Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
* Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth (403 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Apr 28; 106(17): 7137-7142.
Impact Factor: 9.432
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Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
* A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (394 views)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Impact Factor: 4.087
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De Rosa A, Criscuolo C, Mancini P, De Martino M, Giordano IA, Pappata S, Filla A, De Michele G
* Genetic screening for LRRK2 gene G2019S mutation in Parkinson's disease patients from Southern Italy (257 views)
Parkinsonism Relat D (ISSN: 1353-8020print, 1353-8020linking, 1873-5126electronic), 2009 Mar; 15(3): 242-244.
Impact Factor: 2.406
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Ruggiero A, Tizzano B, Pedone E, Pedone C, Wilmanns M, Berisio R
* Crystal Structure of the Resuscitation-Promoting Factor (Delta DUF)RpfB from M. tuberculosis (571 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009 Jan 9; 385(1): 153-162.
Impact Factor: 3.871
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Tornatore L, Montil SM, Marasco D, Dathan N, Vitale RM, Benedetti E, Pedone C, Papa S, Franzoso G, Ruvo M
* Gadd45beta dimerization does not affect MKK7 binding (360 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 367-368.
Impact Factor: 2.02
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Cittadini A, Monti MG, Castiello MC, D'Arco E, Galasso G, Sorriento D, Saldamarco L, De Paulis A, Napoli R, Iaccarino G, Saccà L
* Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury (401 views)
J Thromb Haemost Journal Of Thrombosis And Haemostasis (ISSN: 1538-7933), 2009; 7(11): 1920-1928.
Impact Factor: 6.069
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Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (553 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Dec 5; 283(49): 34250-34259.
Impact Factor: 5.52
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Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A
* HMGA1 protein is a novel target of the ATM kinase (482 views)
European Journal Of Cancer (ISSN: 0959-8049), 2008 Nov; 44(17): 2668-2679.
Impact Factor: 4.475
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Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M
* Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells (437 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Sep 1; 283(31): 21769-21778.
Impact Factor: 5.52
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Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (537 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Impact Factor: 6.488
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Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R
* Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength (394 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 1; 47(26): 6928-6935.
Impact Factor: 3.379
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (408 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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Tornatore L, Marasco D, Dathan N, Vitale RM, Benedetti E, Papa S, Franzoso G, Ruvo M, Monti SM
* Gadd45 beta forms a homodimeric complex that binds tightly to MKK7 (467 views)
J Mol Biol (ISSN: 0022-2836, 0022-2283, 1089-8638), 2008 Apr 18; 378(1): 97-111.
Impact Factor: 5.673
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Colangelo AM, Bianco MR, Vitagliano L, Cavaliere C, Cirillo G, De Gioia L, Diana D, Colombo D, Redaelli C, Zaccaro L, Morelli G, Papa M, Sarmientos P, Alberghina L, Martegani E
* A New Nerve Growth Factor (ngf)-Mimetic Peptide Active On Neuropathic Pain In Rats (657 views)
J Neurosci (ISSN: 0270-6474, 0270-0647, 1529-2401), 2008 Mar 12; 28(11): 2698-2709.
Impact Factor: 7.452
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Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L
* The role of membrane glycoprotein plasma cell antigen 1 ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities (874 views)
Endocrine Reviews (ISSN: 0163-769x), 2008 Feb; 29(1): 62-75.
Impact Factor: 18.562
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Atlante A, Amadoro G, Bobba A, De Bari L, Corsetti V, Pappalardo G, Marra E, Calissano P, Passarella S
* A Peptide Containing Residues 26-44 Of Tau Protein Impairs Mithocondrial Oxodative Phosphorylation Acting At The Level Of The Adenine Nucleotide Translocator (288 views)
Biochimica Et Biophysica Acta, 2008; 1777: 1289-1300.
Impact Factor: 1.722
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Atlante A, Amadoro G, Bobba A, de Bari L, Corsetti V, Pappalardo G, Marra E, Calissano P, Passarella S
* A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator (507 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 0006-3002linking), 2008; 1777(10): 1289-1300.
Impact Factor: 4.447
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (753 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
* Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (606 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2007 Sep 13; 26(42): 6167-6175.
Impact Factor: 6.44
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Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (489 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jun 29; 282(26): 19029-19041.
Impact Factor: 5.581
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Minopoli G, Stante M, Napolitano F, Telese F, Aloia L, De Felice M, Di Lauro R, Pacelli R, Brunetti A, Zambrano N, Russo T
* Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage (522 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jan 12; 282(2): 831-835.
Impact Factor: 5.581
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Pailot A, D'Ambrosio K, Corbier C, Talfournier F, Branlant G
* Invariant Thr(244) is essential for the efficient acylation step of the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans (338 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2006 Dec 15; 400: 521-530.
Impact Factor: 4.1
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Galdiero S, Vitiello M, Amodeo P, D'Isanto M, Cantisani M, Pedone C, Galdiero M
* Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae (514 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Apr 11; 45(14): 4491-4501.
Impact Factor: 3.633
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D'Ambrosio K, Pailot A, Talfournier F, Didierjean C, Benedetti E, Aubry A, Branlant G, Corbier C
* The first crystal structure of a thioacylenzyme intermediate in the ALDH family: New coenzyme conformation and relevance to catalysis (388 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Mar 7; 45(9): 2978-2986.
Impact Factor: 3.633
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (565 views)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (491 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Iaccarino G, Izzo R, Trimarco V, Cipolletta E, Lanni F, Sorriento D, Iovino GL, Rozza F, De Luca N, Priante O, Di Renzo G, Trimarco B
* β 2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension (381 views)
Clin Pharmacol Ther Clinical Pharmacology And Therapeutics (ISSN: 0009-9236), 2006; 80(6): 633-645.
Impact Factor: 8.066
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Fiory F, Alberobello AT, Miele C, Oriente F, Esposito I, Corbo V, Ruvo M, Tizzano B, Rasmussen TE, Gammeltoft S, Formisano P, Beguinot F
* Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling (462 views)
Mol Cell Biol (ISSN: 0270-7306, 1098-5549), 2005 Dec; 25(24): 10803-10814.
Impact Factor: 7.093
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Palladino P, Tizzano B, Pedone C, Ragone R, Rossi F, Saviano G, Tancredi T, Benedetti E
* Structural determinants of unexpected agonist activity in a retro-peptide analogue of the SDF-1α N-terminus (377 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 Oct 10; 579(24): 5293-5298.
Impact Factor: 3.415
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Tedesco I, Nappo A, Petitto F, Iacomino G, Nazzaro F, Palumbo R, Russo Gian L
* Antioxidant and cytotoxic properties of lyophilized beer extracts on HL-60 cell line (669 views)
Nutr Cancer (ISSN: 0163-5581), 2005; 52(1): 74-83.
Impact Factor: 2.426
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (380 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (545 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M
* A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (475 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 459-466.
Impact Factor: 2.863
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Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (354 views)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
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Galdiero S, Vitiello M, D'Isanto M, Di Niola E, Peluso L, Raieta K, Pedone C, Galdiero M, Benedetti E
* Induction of signaling pathways by herpes simplex virus type 1 through glycoprotein H peptides (589 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 494-502.
Impact Factor: 2.863
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Galdiero S, Capasso D, Vitiello M, D'Isanto M, Di Niola E, Monti S, Ruvo M, Pedone C, Galdiero M
* Protein P2 from Haemophilus influenzae: The role of its surface exposed loops on the mitogen-activated protein kinase cascade (320 views)
Peptide Revolution, 2004; N/D: N/D-N/D.
Impact Factor: 4.659
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Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (491 views)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
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Spalletti-cernia D, Sorrentino R, Di Gaetano S, Arciello A, Garbi C, Piccoli R, D'Alessio G, Vecchio G, Laccetti P, Santoro M
* Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis (384 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2003 Jun; 88(6): 2900-2907.
Impact Factor: 5.873
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Galdiero S, Capasso D, Vitiello M, D'Isanto M, Pedone C, Galdiero M
* Protein P2 from Haemophilus influenzae: The role of its surface exposed loops on the mitogen-activated protein kinase cascade (376 views)
Infection And Immunity (ISSN: 0019-9567), 2003 May; 71(5): 2798-2809.
Impact Factor: 3.875
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (437 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (416 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (670 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
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Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S
* Fusion in Coq (479 views)
Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2001; 2178LNCS: 583-596.
Impact Factor: 0.415
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (402 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
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Russo GL, Della Pietra V, Mercurio C, Palumbo R, Iacomino G, Russo M, Tosto M, Zappia V
Protective effects of butyric acid in colon cancer (245 views)
Adv Exp Med Biol (ISSN: 0065-2598print, 0065-2598linking), 1999; 472: 131-147.
Impact Factor: 0.446
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Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (327 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 1993 Sep; 37(3): 150-156.
Impact Factor: 1.269
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Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
Cytosine arabinoside increases the binding of 125I-labelled epidermal growth factor and 125I-transferrin and enhances the in vitro targeting of human tumour cells with anti-(growth factor receptor) mAb (236 views)
Cancer Immunol Immunother (ISSN: 0340-7004linking), 1993 Aug; 37 (3 ): 150-156.
Impact Factor: 4.293
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Del Vecchio S, Stoppelli MP, Carriere MV, Fonti R, Massa O, Li PY, Botti G, Cerra M, D'Aiuto G, Esposito G, Salvatore M
Human urokinase receptor concentration in malignant and benign breast tumors by in vitro quantitative autoradiography: Comparison with urokinase levels (289 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1993 Jul 1; 53(13): 3198-3206.
Impact Factor: 8.426
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Arena G, Bindoni M, Cardile V, Maccarrone G, Riello MC, Rizzarelli E, Sciuto S
Cytotoxic and cytostatic activity of copper(II) complexes. Importance of the speciation for the correct interpretation of the in vitro biological results (477 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Apr 1; 50(1): 31-45.
Impact Factor: 1.342
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FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (446 views)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
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Oliva A, Marrone G, Della Ragione F, Riccio V, Palumbo R, Rossano F, Zappia V
Isolation and characterization of human embryonic osteoblasts (441 views)
Calcif Tissue Int (ISSN: 0171-967xprint, 0171-967xlinking), 1992 Nov; 51(5): 356-362.
Impact Factor: 2.364
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Scala S, Pacelli R, Iaffaioli RV, Normanno N, Pepe S, Frasci G, Genua G, Tsuruo T, Tagliaferri P, Bianco AR
Reversal of adriamycin resistance by recombinant α-interferon in multidrug-resistant human colon carcinoma LoVo-doxorubicin cells (559 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1991 Sep 15; 51(18): 4898-4902.
Impact Factor: 8.426
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Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID
Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells (442 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1990 Dec 15; 50(24): 7858-7862.
Impact Factor: 8.426
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140 Records (133 excluding Abstracts).
Total impact factor: 720.921 (686.361 excluding Abstracts).
Total 5 year impact factor: 724.986 (690.246 excluding Abstracts).

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