Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (431 views)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Oct; 43(4): 1615-1623.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.914, 5-year impact factor: 3.742
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84867574744&partnerID=40&md5=36c16fbbb9a4ecc4e710d50fc4e99207
Keywords: 2-Propanone, Nucleopeptide, Thymine, 1 Thyminyl Acetic Acid, 3 Bis (1 Thyminyl) 2 Propanone, Acetic Acid Derivative, Acetone, Aromatic Compound, Chemical Compound, Copper Chloride Dihydrate, Copper Ion, Double Stranded Rna, Heteroaromatic Compound, Nickel Chloride Hexahydrate, Nucleic Acid, Protein, Serine, Unclassified Drug, Article, Binding Affinity, Chemical Reaction, Circular Dichroism, Dakin West Reaction, Degradation, Drug Delivery System, Electrospray Mass Spectrometry, Ionic Strength, Metal Binding, Nuclear Magnetic Resonance, Priority Journal, Synthesis, Temperature, Ultraviolet Radiation, X Ray Analysis, Cations, Divalent, Crystallography, X-Ray, Drug Carriers, Humans, Ketones, Magnetic Resonance Spectroscopy, Molecular Structure, Osmolar Concentration, Peptide Nucleic Acids, Double-Stranded, Electrospray Ionization, 3 Bis(1 Thyminyl) 2 Propanone,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, 80134, Naples, Italy. giovanni.roviello@cnr.it
Department of the Technology, Centro Direzionale Napoli, University of Naples Parthenope, Isola C4, 80143 Naples, Italy
Dipartimento Delle Scienze Biologiche, Universit of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy
References:
Altomare, A., Burla, M. C., Camalli, M., Cascarano, G. L., Giacovazzo, C., Guagliardi, A., Moliterni, A. G. G., Spagna, R., SIR97: Anew tool for crystal structure determination and refinement (1999) J Appl Cryst, 32, pp. 115-119. , 10. 1107/S0021889898007717 1: CAS: 528: DyaK1MXhsFOrsbo%3
Curran, T. T., Implementation of the Dakin-West reaction for the preparation of an -Amino-pentafluoroethyl ketone (1995) J Fluorine Chem, 74, pp. 107-112. , 10. 1016/0022-1139 (95) 03251-8 1: CAS: 528: DyaK2MXotFCksbc%3D
Dakin, H. D., West, R. A., General reaction of amino acids i and II (1928) J Biol Chem, 78, pp. 91-105. , 1: CAS: 528: DyaB1cXis12kuw%3D%3D
Fei, Z., Liu, Y., Yan, Z., Fan, D., Alexander, A., Yang, J. H., Targeting viral dsRNA for antiviral prophylaxis (2009) FASEB J., , doi: 10. 1096/fj. 09-144915
Kaiser, C., Audia, V. H., Carter, J. P., McPherson, D. W., Waid, P. P., Lowe, V. C., Noronha-Blob, L., Synthesis and antimuscarinic activity of some 1-cycloalkyl-1-hydroxy-1- phenyl-3- (4-substituted piperazinyl) -2-propanones and related compounds (1993) J Med Chem, 36, pp. 610-616. , 8496940 10. 1021/jm00057a010 1: CAS: 528: DyaK3sXhs12jtLc%3D
Kawase, M., Hirabayashi, M., Kumakura, H., Saito, S., Yamamoto, K., The Dakin-West reaction of N-Alkoxycarbonyl-N-Alkyl- -Amino acids employing trifluoroacetic anhydride (2000) Chem Pharm Bull, 48, pp. 114-119. , 10705486 10. 1248/cpb. 48. 114 1: CAS: 528: DC%2BD3cXmvFahtg%3D%3D
Krzyzanowska, D., Lisowski, M., Kochman, M., UV-difference and CD spectroscopy studies on juvenile hormone binding to its carrier protein (1998) J Pept Res, 51, pp. 96-102. , 9516043 10. 1111/j. 1399-3011. 1998. tb00625. x 1: CAS: 528: DyaK1cXptlyluw%3D%3D
Rocchi, R., Borin, G., Marchiori, F., Moroder, L., Peggion, E., Scoffone, E., Crescenzi, V., Quadrifoglio, F., Interaction of S-protein with S-peptide and with synthetic S-peptide analogs. Aspectroscopic and calorimetric investigation (1972) Biochemistry, 11, pp. 50-57. , 5061871 10. 1021/bi00751a010 1: CAS: 528: DyaE38XlsFCrtw%3D%3D
Rother, A., Bobbitt, J. M., Schwarting, A. E., Structure and synthesis of the alkaloid anaferine (1962) Chem Ind (London), pp. 654-655
Roviello, G. N., Musumeci, D., Castiglione, M., Bucci, E. M., Pedone, C., Benedetti, E., Solid phase synthesis and RNA-binding studies of Aserum-resistant nucleo-epsilon-peptide (2009) J Pept Sci, 15, pp. 155-160. , 18985708 10. 1002/psc. 1072 1: CAS: 528: DC%2BD1MXis1ant78%3D
Roviello, G. N., Benedetti, E., Pedone, C., Bucci, E. M., Nucleobase-containing peptides: An overview of their characteristic features and applications (2010) Amino Acids, 39, pp. 45-57. , 20349320 10. 1007/s00726-010-0567-6 1: CAS: 528: DC%2BC3cXntVert7o%3D
Sheldrick, G. M., (1996) SADABS, Program for Empirical Absorption Correction, , University of G ttingen Germany
Tran, K., Bickar, D., Dakin-West synthesis of -Aryl ketones (2006) J Org Chem, 71, pp. 6640-6643. , 16901161 10. 1021/jo0607966 1: CAS: 528: DC%2BD28XmvFejtL0%3D
Varughese, S., Draper, S. M., Solid state conformational preferences of Aflexible molecular backbone derived from acetone: Dependence on electron donating/withdrawing ability of substitutions (2010) Cryst Grow des, 10, pp. 2298-2305. , 10. 1021/cg100021f 1: CAS: 528: DC%2BC3cXktVyiuro%3D
Curran, T.T., Implementation of the Dakin-West reaction for the preparation of an α-Amino-pentafluoroethyl ketone (1995) J Fluorine Chem, 74, pp. 107-112. , 10.1016/0022-1139(95)03251-8 1:CAS:528:DyaK2MXotFCksbc%3D
Dakin, H.D., West, R.A., General reaction of amino acids i and II (1928) J Biol Chem, 78, pp. 91-105. , 1:CAS:528:DyaB1cXis12kuw%3D%3D
Roviello, G.N., Musumeci, D., Castiglione, M., Bucci, E.M., Pedone, C., Benedetti, E., Solid phase synthesis and RNA-binding studies of Aserum-resistant nucleo-epsilon-peptide (2009) J Pept Sci, 15, pp. 155-160. , 18985708 10.1002/psc.1072 1:CAS:528:DC%2BD1MXis1ant78%3D
Roviello, G.N., Benedetti, E., Pedone, C., Bucci, E.M., Nucleobase-containing peptides: An overview of their characteristic features and applications (2010) Amino Acids, 39, pp. 45-57. , 20349320 10.1007/s00726-010-0567-6 1:CAS:528:DC%2BC3cXntVert7o%3D
Sheldrick, G.M., (1996) SADABS, Program for Empirical Absorption Correction, , University of Göttingen Germany
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Oct; 43(4): 1615-1623.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.914, 5-year impact factor: 3.742
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84867574744&partnerID=40&md5=36c16fbbb9a4ecc4e710d50fc4e99207
Keywords: 2-Propanone, Nucleopeptide, Thymine, 1 Thyminyl Acetic Acid, 3 Bis (1 Thyminyl) 2 Propanone, Acetic Acid Derivative, Acetone, Aromatic Compound, Chemical Compound, Copper Chloride Dihydrate, Copper Ion, Double Stranded Rna, Heteroaromatic Compound, Nickel Chloride Hexahydrate, Nucleic Acid, Protein, Serine, Unclassified Drug, Article, Binding Affinity, Chemical Reaction, Circular Dichroism, Dakin West Reaction, Degradation, Drug Delivery System, Electrospray Mass Spectrometry, Ionic Strength, Metal Binding, Nuclear Magnetic Resonance, Priority Journal, Synthesis, Temperature, Ultraviolet Radiation, X Ray Analysis, Cations, Divalent, Crystallography, X-Ray, Drug Carriers, Humans, Ketones, Magnetic Resonance Spectroscopy, Molecular Structure, Osmolar Concentration, Peptide Nucleic Acids, Double-Stranded, Electrospray Ionization, 3 Bis(1 Thyminyl) 2 Propanone,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, 80134, Naples, Italy. giovanni.roviello@cnr.it
Department of the Technology, Centro Direzionale Napoli, University of Naples Parthenope, Isola C4, 80143 Naples, Italy
Dipartimento Delle Scienze Biologiche, Universit of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy
References:
Altomare, A., Burla, M. C., Camalli, M., Cascarano, G. L., Giacovazzo, C., Guagliardi, A., Moliterni, A. G. G., Spagna, R., SIR97: Anew tool for crystal structure determination and refinement (1999) J Appl Cryst, 32, pp. 115-119. , 10. 1107/S0021889898007717 1: CAS: 528: DyaK1MXhsFOrsbo%3
Curran, T. T., Implementation of the Dakin-West reaction for the preparation of an -Amino-pentafluoroethyl ketone (1995) J Fluorine Chem, 74, pp. 107-112. , 10. 1016/0022-1139 (95) 03251-8 1: CAS: 528: DyaK2MXotFCksbc%3D
Dakin, H. D., West, R. A., General reaction of amino acids i and II (1928) J Biol Chem, 78, pp. 91-105. , 1: CAS: 528: DyaB1cXis12kuw%3D%3D
Fei, Z., Liu, Y., Yan, Z., Fan, D., Alexander, A., Yang, J. H., Targeting viral dsRNA for antiviral prophylaxis (2009) FASEB J., , doi: 10. 1096/fj. 09-144915
Kaiser, C., Audia, V. H., Carter, J. P., McPherson, D. W., Waid, P. P., Lowe, V. C., Noronha-Blob, L., Synthesis and antimuscarinic activity of some 1-cycloalkyl-1-hydroxy-1- phenyl-3- (4-substituted piperazinyl) -2-propanones and related compounds (1993) J Med Chem, 36, pp. 610-616. , 8496940 10. 1021/jm00057a010 1: CAS: 528: DyaK3sXhs12jtLc%3D
Kawase, M., Hirabayashi, M., Kumakura, H., Saito, S., Yamamoto, K., The Dakin-West reaction of N-Alkoxycarbonyl-N-Alkyl- -Amino acids employing trifluoroacetic anhydride (2000) Chem Pharm Bull, 48, pp. 114-119. , 10705486 10. 1248/cpb. 48. 114 1: CAS: 528: DC%2BD3cXmvFahtg%3D%3D
Krzyzanowska, D., Lisowski, M., Kochman, M., UV-difference and CD spectroscopy studies on juvenile hormone binding to its carrier protein (1998) J Pept Res, 51, pp. 96-102. , 9516043 10. 1111/j. 1399-3011. 1998. tb00625. x 1: CAS: 528: DyaK1cXptlyluw%3D%3D
Rocchi, R., Borin, G., Marchiori, F., Moroder, L., Peggion, E., Scoffone, E., Crescenzi, V., Quadrifoglio, F., Interaction of S-protein with S-peptide and with synthetic S-peptide analogs. Aspectroscopic and calorimetric investigation (1972) Biochemistry, 11, pp. 50-57. , 5061871 10. 1021/bi00751a010 1: CAS: 528: DyaE38XlsFCrtw%3D%3D
Rother, A., Bobbitt, J. M., Schwarting, A. E., Structure and synthesis of the alkaloid anaferine (1962) Chem Ind (London), pp. 654-655
Roviello, G. N., Musumeci, D., Castiglione, M., Bucci, E. M., Pedone, C., Benedetti, E., Solid phase synthesis and RNA-binding studies of Aserum-resistant nucleo-epsilon-peptide (2009) J Pept Sci, 15, pp. 155-160. , 18985708 10. 1002/psc. 1072 1: CAS: 528: DC%2BD1MXis1ant78%3D
Roviello, G. N., Benedetti, E., Pedone, C., Bucci, E. M., Nucleobase-containing peptides: An overview of their characteristic features and applications (2010) Amino Acids, 39, pp. 45-57. , 20349320 10. 1007/s00726-010-0567-6 1: CAS: 528: DC%2BC3cXntVert7o%3D
Sheldrick, G. M., (1996) SADABS, Program for Empirical Absorption Correction, , University of G ttingen Germany
Tran, K., Bickar, D., Dakin-West synthesis of -Aryl ketones (2006) J Org Chem, 71, pp. 6640-6643. , 16901161 10. 1021/jo0607966 1: CAS: 528: DC%2BD28XmvFejtL0%3D
Varughese, S., Draper, S. M., Solid state conformational preferences of Aflexible molecular backbone derived from acetone: Dependence on electron donating/withdrawing ability of substitutions (2010) Cryst Grow des, 10, pp. 2298-2305. , 10. 1021/cg100021f 1: CAS: 528: DC%2BC3cXktVyiuro%3D
Curran, T.T., Implementation of the Dakin-West reaction for the preparation of an α-Amino-pentafluoroethyl ketone (1995) J Fluorine Chem, 74, pp. 107-112. , 10.1016/0022-1139(95)03251-8 1:CAS:528:DyaK2MXotFCksbc%3D
Dakin, H.D., West, R.A., General reaction of amino acids i and II (1928) J Biol Chem, 78, pp. 91-105. , 1:CAS:528:DyaB1cXis12kuw%3D%3D
Roviello, G.N., Musumeci, D., Castiglione, M., Bucci, E.M., Pedone, C., Benedetti, E., Solid phase synthesis and RNA-binding studies of Aserum-resistant nucleo-epsilon-peptide (2009) J Pept Sci, 15, pp. 155-160. , 18985708 10.1002/psc.1072 1:CAS:528:DC%2BD1MXis1ant78%3D
Roviello, G.N., Benedetti, E., Pedone, C., Bucci, E.M., Nucleobase-containing peptides: An overview of their characteristic features and applications (2010) Amino Acids, 39, pp. 45-57. , 20349320 10.1007/s00726-010-0567-6 1:CAS:528:DC%2BC3cXntVert7o%3D
Sheldrick, G.M., (1996) SADABS, Program for Empirical Absorption Correction, , University of Göttingen Germany
Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties
This work deals with the Dakin-West synthesis, starting from the nucleoamino acid 1-thyminyl acetic acid, as well the NMR, ESI MS, and X-ray characterization of Aheteroaromatic compound denominated by us T2CO, comprising two thymine moieties anchored to A2-propanonic unit, the spectroscopic properties of which were studied by UV as Afunction of temperature and ionic strength. Preliminary binding-studies with molecules of biomedical interest such as nucleic acids and proteins, performed on samples containing T2CO, suggested that this molecule is able to interact very weakly with double-stranded RNA, whereas it does not seem to bind other nucleic acids or proteins. Moreover, by studies with fresh human serum we found that T 2CO is resistant to enzymatic degradation till 24 h, whereas UV metal binding-studies, performed using solutions of copper (II) chloride dihydrate and nickel (II) chloride hexahydrate, revealed Acertain ability of T 2CO to bind copper (II) cation. Finally, by CD spectroscopy we investigated the influence of T2CO on the already described supramolecular networks based on l-serine-containing nucleopeptides. More particularly, we found that T2CO is able to increase the level of structuration of the non-covalent supramolecular assembly of the chiral nucleopeptides, which is Afeature of remarkable interest for the development of innovative drug delivery tools. © 2012 Springer-Verlag.
This work deals with the Dakin-West synthesis, starting from the nucleoamino acid 1-thyminyl acetic acid, as well the NMR, ESI MS, and X-ray characterization of Aheteroaromatic compound denominated by us T2CO, comprising two thymine moieties anchored to A2-propanonic unit, the spectroscopic properties of which were studied by UV as Afunction of temperature and ionic strength. Preliminary binding-studies with molecules of biomedical interest such as nucleic acids and proteins, performed on samples containing T2CO, suggested that this molecule is able to interact very weakly with double-stranded RNA, whereas it does not seem to bind other nucleic acids or proteins. Moreover, by studies with fresh human serum we found that T 2CO is resistant to enzymatic degradation till 24 h, whereas UV metal binding-studies, performed using solutions of copper (II) chloride dihydrate and nickel (II) chloride hexahydrate, revealed Acertain ability of T 2CO to bind copper (II) cation. Finally, by CD spectroscopy we investigated the influence of T2CO on the already described supramolecular networks based on l-serine-containing nucleopeptides. More particularly, we found that T2CO is able to increase the level of structuration of the non-covalent supramolecular assembly of the chiral nucleopeptides, which is Afeature of remarkable interest for the development of innovative drug delivery tools. © 2012 Springer-Verlag.
Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties
Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties
Other filter: ([btitle,keywords] "2-Propanone" OR [bti ...
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Roviello V, Musumeci D, Mokhir A, Roviello GN
* Evidence of Protein Binding by a Nucleopeptide Based on a Thyminedecorated L-Diaminopropanoic Acid through CD and In Silico Studies (26 views) (PDF 12 views)
Curr Med Chem (ISSN: 0929-8673linking), 2021 Jul; 28(24): 5004-5015.
Impact Factor: 4.53
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Scognamiglio PL, Platella C, Napolitano E, Musumeci D, Roviello GN
* From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides (28 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2021 Jun 10; 26(12): 3558-3558.
Impact Factor: 4.411
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Musumeci D, Mokhir A, Roviello GN
* Synthesis and nucleic acid binding evaluation of a thyminyl L-diaminobutanoic acid-based nucleopeptide (151 views)
Bioorg Chem (ISSN: 0045-2068linking, 1090-2120electronic), 2020 Jul; 100: 103862-103870.
Impact Factor: 4.831
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Musumeci D, Roviello V, Roviello GN
* DNA- and RNA-binding ability of oligoDapT, a nucleobase-decorated peptide, for biomedical applications (1546 views)
Int J Nanomed (ISSN: 1176-9114linking, 1178-2013electronic), 2018 May 1; 2018:13: 2613-2629.
Impact Factor: 4.3
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Pirtskhalava M, Egoyan A, Mirtskhulava M, Roviello GN
* A COMPUTER MODELING STUDY OF BINDING PROPERTIES OF CHIRAL NUCLEOPEPTIDE FOR BIOMEDICAL APPLICATIONS (388 views)
Georgian Med News (ISSN: 1512-0112print, 1512-0112linking), 2017 Dec; (273): 1123-1128.
Impact Factor: 0
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Roviello GN, Musumeci D
* Synthetic approaches to nucleopeptides containing all the four nucleobases, and nucleic acid-binding studies on a mixed-sequence nucleo-oligolysine (435 views)
Rsc Adv (ISSN: 2046-2069), 2016 Jun; 6: 63578-63585.
Impact Factor: 3.108
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Roviello GN, Vicidomini C, Di Gaetano S, Capasso D, Musumeci D, Roviello V
* Solid phase synthesis and RNA-binding activity of an arginine-containing nucleopeptide (399 views)
Rsc Adv (ISSN: 2046-2069), 2016; 6(17): 14140-14148.
Impact Factor: 3.108
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Roviello GN, Musumeci D, Roviello V, Pirtskhalava M, Egoyan A, Mirtskhulava M
* Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure (375 views)
Beilstein J Nanotech (ISSN: 2190-4286), 2015; 6(1): 1338-1347.
Impact Factor: 2.778
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Roviello GN, Musumeci D, D'Alessandro C, Pedone C
* Binding ability of a thymine-functionalized oligolysine towards nucleic acids (347 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2014 Feb 1; 22(3): 997-1002.
Impact Factor: 2.793
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Roviello GN, Roviello GN, Musumeci D, Capasso D, Di Gaetano S, Costanzo M, Pedone C
* Synthesis and supramolecular assembly of 1, 3-bis(1 '-uracilyl)-2-propanone (404 views)
Rsc Adv (ISSN: 2046-2069), 2014; 4(54): 28691-28698.
Impact Factor: 3.84
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Roviello GN, Musumeci D, D'Alessandro C, Pedone C
* Synthesis of a thymine-functionalized nucleoamino acid for the solid phase assembly of cationic nucleopeptides (485 views)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2013 Oct; 45(4): 779-784.
Impact Factor: 3.653
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis of a diaminopropanoic acid-based nucleoamino acid and assembly of cationic nucleopeptides for biomedical applications (444 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2012 Dec; 43(6): 2537-2543.
Impact Factor: 3.914
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis and characterization of a novel ester-based nucleoamino acid for the assembly of aromatic nucleopeptides for biomedical applications (529 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2011 Sep 30; 415(1-2): 206-210.
Impact Factor: 3.35
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Evidences for supramolecular organization of nucleopeptides: Synthesis, spectroscopic and biological studies of a novel dithymine l-serine tetrapeptide (532 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 Apr; 7(4): 1073-1080.
Impact Factor: 3.534
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Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (464 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Sep; 39(3): 795-800.
Impact Factor: 4.106
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Roviello GN, Benedetti E, Pedone C, Bucci EM
* Nucleobase-containing peptides: An overview of their characteristic features and applications (742 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Jun; 39(1): 45-57.
Impact Factor: 4.106
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Roviello GN, Di Gaetano S, Capasso D, Cesarani A, Bucci EM, Pedone C
* Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity (443 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 May; 38(5): 1489-1496.
Impact Factor: 4.106
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Roviello GN, Musumeci D, Pedone C, Bucci EM
* Synthesis, Characterization And Hybridization Studies Of An Alternate Nucleo-Epsilon/Gamma-Peptide: Complexes Formation With Natural Nucleic Acids (449 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Jan; 38(1): 103-111.
Impact Factor: 4.106
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Roviello GN, Musumeci D, Moccia M, Castiglione M, Sapio R, Valente M, Bucci EM, Perretta G, Pedone C
* Dabpna: Design, Synthesis And Nucleic Acids Binding Studies (413 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1307-1310.
Impact Factor: 0.723
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Roviello GN, Moccia M, Sapio R, Valente M, Bucci EM, Castiglione M, Pedone C, Perretta G, Benedetti E, Musumeci D
* Synthesis, Characterization And Hybridization Studies Of New Nucleo-Gamma-Peptides Based On Diaminobutyric Acid (478 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 829-835.
Impact Factor: 1.801
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23 Records (23 excluding Abstracts).
Total impact factor: 84.527 (84.527 excluding Abstracts).
Total 5 year impact factor: 82.424 (82.424 excluding Abstracts).
Total impact factor: 84.527 (84.527 excluding Abstracts).
Total 5 year impact factor: 82.424 (82.424 excluding Abstracts).
431 views. Last view on Saturday 18 March 2023, 7:30:07
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