Andrenocortical carcinomas: Twelve-year prospective experience (729 views)
World J Surg (ISSN: 0364-2313), 2004 Sep; 28(9): 896-903.
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Paper type: Journal Article,
Impact factor: 1.952, 5-year impact factor: 2.79
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-6344264964&partnerID=40&md5=9b1766d87c182402cc1baa1e393aa632
Keywords: Androstenedione, Estradiol, Estriol, Hydroxyprogesterone, Prasterone Sulfate, Testosterone, Adrenal Cortex Carcinoma, Adult, Arterial Pressure, Article, Cancer Recurrence, Cancer Staging, Cancer Surgery, Cardiovascular Risk, Clinical Article, Clinical Feature, Disease Association, Disease Severity, Early Diagnosis, Endocrine Function, Female, Human, Hyperadrenocorticism, Hypertension, Metabolic Regulation, Patient Monitoring, Prediction, Prognosis, Prospective Study, Rare Disease, Risk Factor, Adrenal Cortex Neoplasms, Adrenocortical Carcinoma, Middle Aged, Prospective Studies, Time Factors, Treatment Outcome,
Affiliations:
*** IBB - CNR ***
Dept. of Molec./Clin. Endocrinol., Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy
Dept. of Anat. Pathol. and Cytology, Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy
Dept. of Biomorphol. and Funct. Sci., Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy
Dept. of Molec. /Clin. Endocrinol., Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy
References:
Not available.
World J Surg (ISSN: 0364-2313), 2004 Sep; 28(9): 896-903.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.952, 5-year impact factor: 2.79
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-6344264964&partnerID=40&md5=9b1766d87c182402cc1baa1e393aa632
Keywords: Androstenedione, Estradiol, Estriol, Hydroxyprogesterone, Prasterone Sulfate, Testosterone, Adrenal Cortex Carcinoma, Adult, Arterial Pressure, Article, Cancer Recurrence, Cancer Staging, Cancer Surgery, Cardiovascular Risk, Clinical Article, Clinical Feature, Disease Association, Disease Severity, Early Diagnosis, Endocrine Function, Female, Human, Hyperadrenocorticism, Hypertension, Metabolic Regulation, Patient Monitoring, Prediction, Prognosis, Prospective Study, Rare Disease, Risk Factor, Adrenal Cortex Neoplasms, Adrenocortical Carcinoma, Middle Aged, Prospective Studies, Time Factors, Treatment Outcome,
Affiliations:
*** IBB - CNR ***
Dept. of Molec./Clin. Endocrinol., Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy
Dept. of Anat. Pathol. and Cytology, Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy
Dept. of Biomorphol. and Funct. Sci., Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy
Dept. of Molec. /Clin. Endocrinol., Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy
References:
Not available.
Andrenocortical carcinomas: Twelve-year prospective experience
Adrenocortical carcinoma (AC) is a rare tumor with poor prognosis. Twenty-two patients (14 F, 8 M; age 22 to 59 years; median, 43 years) with AC were evaluated prospectively in a single center: tumor stage was I-II in 12 cases and III-IV in 10. The overall survival in our cohort was 41.6 ± 42 months; 16 subjects are still alive. Curative surgery was followed by longer survival than debulking or no surgery (p < 0.0001). The first relapse was highly predictive for further recurrences. Recurrent ACs were progressively more aggressive, and they occurred with variable but ever shorter intervals. At diagnosis, 14 patients (63.5%) presented with features of clear adrenocortical hyperactivity. Despite the absence of clinical signs of hormonal excess, all other patients presented some abnormalities of steroid secretion. The most common clinical findingwas a recent diagnosis of moderate-to-severe hypertension (68%), poorly controlled by pharmacological treatment, often associated with multiple cardiovascular risk factors. High mitotic rate and undifferentiated polymorph cellular pattern were associated with worse prognosis. Response to treatments other than surgery (mitotane chemotherapy) was better in patients treated early after the first surgery. In conclusion, curative surgery was the most effective treatment. Monitoring arterial pressure, endocrine parameters, and metabolic parameters can be helpful for the early detection of AC recurrences.
Adrenocortical carcinoma (AC) is a rare tumor with poor prognosis. Twenty-two patients (14 F, 8 M; age 22 to 59 years; median, 43 years) with AC were evaluated prospectively in a single center: tumor stage was I-II in 12 cases and III-IV in 10. The overall survival in our cohort was 41.6 ± 42 months; 16 subjects are still alive. Curative surgery was followed by longer survival than debulking or no surgery (p < 0.0001). The first relapse was highly predictive for further recurrences. Recurrent ACs were progressively more aggressive, and they occurred with variable but ever shorter intervals. At diagnosis, 14 patients (63.5%) presented with features of clear adrenocortical hyperactivity. Despite the absence of clinical signs of hormonal excess, all other patients presented some abnormalities of steroid secretion. The most common clinical findingwas a recent diagnosis of moderate-to-severe hypertension (68%), poorly controlled by pharmacological treatment, often associated with multiple cardiovascular risk factors. High mitotic rate and undifferentiated polymorph cellular pattern were associated with worse prognosis. Response to treatments other than surgery (mitotane chemotherapy) was better in patients treated early after the first surgery. In conclusion, curative surgery was the most effective treatment. Monitoring arterial pressure, endocrine parameters, and metabolic parameters can be helpful for the early detection of AC recurrences.
Andrenocortical carcinomas: Twelve-year prospective experience
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Andrenocortical carcinomas: Twelve-year prospective experience
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Impact Factor: 19.358
View Export to BibTeX Export to EndNote
Maurea S, Soricelli A, Salvatore M
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Impact Factor: 0.643
View Export to BibTeX Export to EndNote
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10 Records (10 excluding Abstracts).
Total impact factor: 52.375 (52.375 excluding Abstracts).
Total 5 year impact factor: 50.385 (50.385 excluding Abstracts).
Total impact factor: 52.375 (52.375 excluding Abstracts).
Total 5 year impact factor: 50.385 (50.385 excluding Abstracts).
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