Bone demineralization and vertebral fractures in endogenous cortisol excess: Role of disease etiology and gonadal status (894 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2006 May; 91(5): 1779-1784.
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Paper type: Journal Article,
Impact factor: 5.799, 5-year impact factor: 1.273
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33646406297&partnerID=40&md5=e9c726c99f1a5a25d24475f11c00d46d
Keywords: Corticotropin, Hydrocortisone, Adrenal Cortex Adenoma, Adrenal Cortex Carcinoma, Adult, Article, Bone Demineralization, Bone Density, Bone Turnover, Controlled Study, Cushing Disease, Dual Energy X Ray Absorptiometry, Female, Gonad, Human, Hypophysis Adenoma, Major Clinical Study, Osteolysis, Pathophysiology, Priority Journal, Vertebra Fracture, Adolescent, Adrenal Gland Neoplasms, Adrenocorticotropic Hormone, Aged, Biological Markers, Body Mass Index, Pathologic, Case-Control Studies, Cross-Sectional Studies, Middle Aged, Ovary, Prospective Studies, Risk Factors, Spinal Fractures, Testis,
Affiliations:
*** IBB - CNR ***
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Naples, Italy
Department of Biomorphological and Functional Sciences, Federico II University of Naples, 80131 Naples, Italy
References:
Not available.
J Clin Endocrinol Metab (ISSN: 0021-972x), 2006 May; 91(5): 1779-1784.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.799, 5-year impact factor: 1.273
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33646406297&partnerID=40&md5=e9c726c99f1a5a25d24475f11c00d46d
Keywords: Corticotropin, Hydrocortisone, Adrenal Cortex Adenoma, Adrenal Cortex Carcinoma, Adult, Article, Bone Demineralization, Bone Density, Bone Turnover, Controlled Study, Cushing Disease, Dual Energy X Ray Absorptiometry, Female, Gonad, Human, Hypophysis Adenoma, Major Clinical Study, Osteolysis, Pathophysiology, Priority Journal, Vertebra Fracture, Adolescent, Adrenal Gland Neoplasms, Adrenocorticotropic Hormone, Aged, Biological Markers, Body Mass Index, Pathologic, Case-Control Studies, Cross-Sectional Studies, Middle Aged, Ovary, Prospective Studies, Risk Factors, Spinal Fractures, Testis,
Affiliations:
*** IBB - CNR ***
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Naples, Italy
Department of Biomorphological and Functional Sciences, Federico II University of Naples, 80131 Naples, Italy
References:
Not available.
Bone demineralization and vertebral fractures in endogenous cortisol excess: Role of disease etiology and gonadal status
Introduction: The effects of endogenous cortisol (F) excess on bone mass and vertebral fractures have still not been thoroughly investigated. The aim of this cross-sectional case-control study was to investigate factors influencing bone demineralization and vertebral fractures in different conditions of F excess, i.e. Cushing's disease and adrenal and ectopic Cushing's syndrome. Materials and Methods: Eighty consecutive patients and 80 controls were prospectively enrolled: 37 patients (21 females) with pituitary ACTH-secreting adenoma, 18 (14 females) with adrenocortical adenoma, 15 (11 females) with adrenal carcinoma of mixed secretion, and 10 (three females) with ectopic ACTH secretion. The groups had similar age. At diagnosis, bone mineral density (BMD) was determined by the dual-energy x-ray absorptiometry technique at the lumbar spine (L1-L4) and femoral neck; vertebral fractures were investigated by standard spinal radiographs. Results: When comparing the groups with different etiology of F excess, the patients with ectopic ACTH secretion had higher F and lower BMD values than the other subgroups. Morning F (P = 0.03) and testosterone levels (P = 0.04) correlated with lumbar BMD. Vertebral fractures were found in 61 (76%) of the patients, were multiple in 52 (85%) of the cases, and clinically evident in 32 (52%). Only multiple fractures were more frequent in patients with ectopic ACTH hypersecretion (P < 0.05). Lumbar spine BMD was the best predictor of vertebral fractures (P < 0.01). Surprisingly, amenorrheic and eumenorrheic women had similar BMD values and fracture prevalence. Conclusion: A high prevalence (76%) of vertebral fracture was revealed, regardless of the etiology of the patients' hypercortisolism. The harmful effects of F excess at the spine were partly counterbalanced by the increased androgen production but were not affected by gonadal status in women. Copyright © 2006 by The Endocrine Society.
Introduction: The effects of endogenous cortisol (F) excess on bone mass and vertebral fractures have still not been thoroughly investigated. The aim of this cross-sectional case-control study was to investigate factors influencing bone demineralization and vertebral fractures in different conditions of F excess, i.e. Cushing's disease and adrenal and ectopic Cushing's syndrome. Materials and Methods: Eighty consecutive patients and 80 controls were prospectively enrolled: 37 patients (21 females) with pituitary ACTH-secreting adenoma, 18 (14 females) with adrenocortical adenoma, 15 (11 females) with adrenal carcinoma of mixed secretion, and 10 (three females) with ectopic ACTH secretion. The groups had similar age. At diagnosis, bone mineral density (BMD) was determined by the dual-energy x-ray absorptiometry technique at the lumbar spine (L1-L4) and femoral neck; vertebral fractures were investigated by standard spinal radiographs. Results: When comparing the groups with different etiology of F excess, the patients with ectopic ACTH secretion had higher F and lower BMD values than the other subgroups. Morning F (P = 0.03) and testosterone levels (P = 0.04) correlated with lumbar BMD. Vertebral fractures were found in 61 (76%) of the patients, were multiple in 52 (85%) of the cases, and clinically evident in 32 (52%). Only multiple fractures were more frequent in patients with ectopic ACTH hypersecretion (P < 0.05). Lumbar spine BMD was the best predictor of vertebral fractures (P < 0.01). Surprisingly, amenorrheic and eumenorrheic women had similar BMD values and fracture prevalence. Conclusion: A high prevalence (76%) of vertebral fracture was revealed, regardless of the etiology of the patients' hypercortisolism. The harmful effects of F excess at the spine were partly counterbalanced by the increased androgen production but were not affected by gonadal status in women. Copyright © 2006 by The Endocrine Society.
Bone demineralization and vertebral fractures in endogenous cortisol excess: Role of disease etiology and gonadal status
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Bone demineralization and vertebral fractures in endogenous cortisol excess: Role of disease etiology and gonadal status
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16 Records (16 excluding Abstracts).
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Total 5 year impact factor: 77.44 (77.44 excluding Abstracts).
Total impact factor: 67.201 (67.201 excluding Abstracts).
Total 5 year impact factor: 77.44 (77.44 excluding Abstracts).
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