Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells (444 views)
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2013 Sep 19; 20(5): 633-647.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.907, 5-year impact factor: 5.237
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84886397132&partnerID=40&md5=d0b2ab7e9c5b373123d15f57f0a1b230
Keywords: Anaplastic Thyroid Carcinoma, Dna Damage, Irradiation, Oncolytic Virus, 2 Morpholino 6 (1 Thianthrenyl) 4 Pyranone, Atm Protein, Checkpoint Kinase 1, D 922 947, Gamma Histone H2ax, Mre11 Protein, Nibrin, Oncolytic Adenovirus, Rad50 Protein, Unclassified Drug, Adenovirus Infection, Animal Experiment, Animal Model, Article, Cancer Radiotherapy, Carcinoma Cell, Cell Death, Cell Killing, Controlled Study, Dna Repair, Drug Cytotoxicity, Drug Effect, Drug Efficacy, Histone Phosphorylation, Human, Human Cell, In Vivo Study, Ionizing Radiation, Life Cycle, Mouse, Multimodal Chemotherapy, Nonhuman, Oncolytic Virotherapy, Tumor Xenograft, Virus Entry, Virus Replication,
Affiliations:
*** IBB - CNR ***
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia, Università di Napoli Federico II, via S. Pansini 5, 80131 Napoli, Italy
Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale Delle Ricerche, Napoli, Italy
Dipartimento di Diagnostica per Immagini e Radioterapia, Università Federico II, Napoli, Italy
Barts Cancer Institute, Centre for Molecular Oncology, Queen Mary University of London, London, United Kingdom
Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, United States
References:
Abou El Hassan, M.A., Van Der Meulen-Muileman, I., Abbas, S., Kruyt, F.A., Conditionally replicating adenoviruses kill tumor cells via a basic apoptotic machinery-independent mechanism that resembles necrosislike programmed cell death (2004) Journal of Virology, 78, pp. 12243-12251. , (doi:10.1128/JVI.78.22.12243-12251.2004
Anders, M., Christian, C., McMahon, M., McCormick, F., Korn, W.M., Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells (2003) Cancer Research, 63, pp. 2088-2095
Baird, S.K., Aerts, J.L., Eddaoudi, A., Lockley, M., Lemoine, N.R., McNeish, I.A., Oncolytic adenoviral mutants induce a novel mode of programmed cell death in ovarian cancer (2008) Oncogene, 27, pp. 3081-3090. , (doi:10.1038/sj.onc. 1210977)
Bhattacharyya, M., Francis, J., Eddouadi, A., Lemoine, N.R., Hallden, G., An oncolytic adenovirus defective in pRb-binding (dl922-947) can efficiently eliminate pancreatic cancer cells and tumors in vivo in combination with 5-FU or gemcitabine (2011) Cancer Gene Therapy, 18, pp. 734-743. , (doi:10.1038/cgt.2011.45)
Bieler, A., Mantwill, K., Holzmuller, R., Jurchott, K., Kaszubiak, A., Stark, S., Glockzin, G., Gansbacher, B., Impact of radiation therapy on the oncolytic adenovirus dl520: Implications on the treatment of glioblastoma (2008) Radiotherapy and Oncology, 86, pp. 419-427. , (doi:10.1016/j.radonc.2007.10.009)
Botta, G., Perruolo, G., Libertini, S., Cassese, A., Abagnale, A., Beguinot, F., Formisano, P., Portella, G., PED/PEA-15 modulates coxsackievirusadenovirus receptor expression and adenoviral infectivity via ERK-mediated signals in glioma cells (2010) Human Gene Therapy, 21, pp. 1067-1076. , (doi:10.1089/hum.2009.181)
Botta, G., Passaro, C., Libertini, S., Abagnale, A., Barbato, S., Maione, A.S., Hallden, G., Portella, G., Inhibition of autophagy enhances the effects of E1A-defective oncolytic adenovirus dl922-947 against glioma cells in vitro and in vivo (2012) Human Gene Therapy, 23, pp. 623-634. , (doi:10.1089/hum.2011.120)
Cheong, S.C., Wang, Y., Meng, J.H., Hill, R., Sweeney, K., Kirn, D., Lemoine, N.R., Hallden, G., E1A-expressing adenoviral E3B mutants act synergistically with chemotherapeutics in immunocompetent tumor models (2008) Cancer Gene Therapy, 15, pp. 40-50. , (doi:10.1038/sj.cgt.7701099)
Connell, C.M., Shibata, A., Tookman, L.A., Archibald, K.M., Flak, M.B., Pirlo, K.J., Lockley, M., McNeish, I.A., Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells (2011) Journal of Clinical Investigation, 121, pp. 1283-1297. , (doi:10.1172/JCI43976)
Davy, C., Doorbar, J., G2/M cell cycle arrest in the life cycle of viruses (2007) Virology, 368, pp. 219-226. , (doi:10.1016/j.virol.2007.05.043)
Eager, R.M., Nemunaitis, J., Clinical development directions in oncolytic viral therapy (2011) Cancer Gene Therapy, 18, pp. 305-317. , (doi:10.1038/ cgt.2011.7)
Geoerger, B., Grill, J., Opolon, P., Morizet, J., Aubert, G., Lecluse, Y., Van Beusechem, V.W., Vassal, G., Potentiation of radiation therapy by the oncolytic adenovirus dl1520 (ONYX-015) in human malignant glioma xenografts (2003) British Journal of Cancer, 89, pp. 577-584. , (doi:10.1038/sj.bjc.6601102)
Heise, C., Sampson-Johannes, A., Williams, A., McCormick, F., Von Hoff, D.D., Kirn, D.H., ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents (1997) Nature Medicine, 3, pp. 639-645. , (doi:10.1038/nm0697-639)
Heise, C., Hermiston, T., Johnson, L., Brooks, G., Sampson-Johannes, A., Williams, A., Hawkins, L., Kirn, D., A An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy (2000) Nature Medicine, 6, pp. 1134-1139. , (doi:10.1038/80474)
Heise, C., Lemmon, M., Kirn, D., B Efficacy with a replication-selective adenovirus plus cisplatin-based chemotherapy: Dependence on sequencing but not p53 functional status or route of administration (2000) Clinical Cancer Research, 6, pp. 4908-4914
Hickson, I., Zhao, Y., Richardson, C.J., Green, S.J., Martin, N.M., Orr, A.I., Reaper, P.M., Smith, G.C., Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM (2004) Cancer Research, 64, pp. 9152-9159. , (doi:10.1158/ 0008-5472.CAN-04-2727)
Immonen, A., Vapalahti, M., Tyynela, K., Hurskainen, H., Sandmair, A., Vanninen, R., Langford, G., Yla-Herttuala, S., AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: A randomised, controlled study (2004) Molecular Therapy, 10, pp. 967-972. , (doi:10.1016/j.ymthe.2004.08.002)
Jiang, H., Gomez-Manzano, C., Lang, F.F., Alemany, R., Fueyo, J., Oncolytic adenovirus: Preclinical and clinical studies in patients with human malignant gliomas (2009) Current Gene Therapy, 9, pp. 422-427. , (doi:10.2174/ 156652309789753356)
Kuroda, S., Fujiwara, T., Shirakawa, Y., Yamasaki, Y., Yano, S., Uno, F., Tazawa, H., Noma, K., Telomerase-dependent oncolytic adenovirus sensitizes human cancer cells to ionizing radiation via inhibition of DNA repair machinery (2010) Cancer Research, 70, pp. 9339-9348. , (doi:10.1158/0008-5472.CAN-10-2333)
Lamfers, M.L., Grill, J., Dirven, C.M., Van Beusechem, V.W., Geoerger, B., Van Den Berg, J., Alemany, R., Vassal, G., Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy (2002) Cancer Research, 62, pp. 5736-5742
Lao-Sirieix, P., Brais, R., Lovat, L., Coleman, N., Fitzgerald, R.C., Cell cycle phase abnormalities do not account for disordered proliferation in Barrett's carcinogenesis (2004) Neoplasia, 6, pp. 751-760. , (doi:10.1593/neo.04280)
Lavin, M.F., ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks (2007) Oncogene, 26, pp. 7749-7758. , (doi:10.1038/sj.onc.1210880)
Libertini, S., Iacuzzo, I., Ferraro, A., Vitale, M., Bifulco, M., Fusco, A., Portella, G., Lovastatin enhances the replication of the oncolytic adenovirus dl1520 and its antineoplastic activity against anaplastic thyroid carcinoma cells (2007) Endocrinology, 148, pp. 5186-5194. , (doi:10.1210/ en.2007-0752)
Lilley, C.E., Schwartz, R.A., Weitzman, M.D., Using or abusing: Viruses and the cellular DNA damage response (2007) Trends in Microbiology, 15, pp. 119-126. , (doi:10.1016/j.tim.2007.01.003)
Lin, S.F., Gao, S.P., Price, D.L., Li, S., Chou, T.C., Singh, P., Huang, Y.Y., Wong, R.J., Synergy of a herpes oncolytic virus and paclitaxel for anaplastic thyroid cancer (2008) Clinical Cancer Research, 14, pp. 1519-1528. , (doi:10.1158/1078-0432.CCR-07-4628)
Lin, S.F., Price, D.L., Chen, C.H., Brader, P., Li, S., Gonzalez, L., Zhang, Q., Szalay, A.A., Oncolytic vaccinia virotherapy of anaplastic thyroid cancer in vivo (2008) Journal of Clinical Endocrinology and Metabolism, 93, pp. 4403-4407. , (doi:10.1210/jc.2008-0316)
Lisby, M., Barlow, J.H., Burgess, R.C., Rothstein, R., Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins (2004) Cell, 118, pp. 699-713. , (doi:10.1016/j.cell.2004. 08.015)
Liu, C., Sarkaria, J.N., Petell, C.A., Paraskevakou, G., Zollman, P.J., Schroeder, M., Carlson, B., James, C.D., Combination of measles virus virotherapy and radiation therapy has synergistic activity in the treatment of glioblastoma multiforme (2007) Clinical Cancer Research, 13, pp. 7155-7165. , (doi:10.1158/1078-0432.CCR-07-1306)
Lockley, M., Fernandez, M., Wang, Y., Li, N.F., Conroy, S., Lemoine, N., McNeish, I., Activity of the adenoviral E1A deletion mutant dl922-947 in ovarian cancer: Comparison with E1A wild-type viruses, bioluminescence monitoring, and intraperitoneal delivery in icodextrin (2006) Cancer Research, 66, pp. 989-998. , (doi:10.1158/0008-5472.CAN-05-2691)
Nichols, G.J., Schaack, J., Ornelles, D.A., Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication (2009) Journal of Virology, 83, pp. 5987-5998. , (doi:10.1128/ JVI.00091-09)
Oberg, D., Yanover, E., Adam, V., Sweeney, K., Costas, C., Lemoine, N.R., Hallden, G., Improved potency and selectivity of an oncolytic E1ACR2 and E1B19K deleted adenoviral mutant in prostate and pancreatic cancers (2010) Clinical Cancer Research, 16, pp. 541-553. , (doi:10.1158/ 1078-0432.CCR-09-1960)
O'shea, C.C., Johnson, L., Bagus, B., Choi, S., Nicholas, C., Shen, A., Boyle, L., Kunich, J., Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity (2004) Cancer Cell, 6, pp. 611-623. , (doi:10.1016/j.ccr.2004.11.012)
Portella, G., Scala, S., Vitagliano, D., Vecchio, G., Fusco, A., ONYX-015, an E1B gene-defective adenovirus, induces cell death in human anaplastic thyroid carcinoma cell lines (2002) Journal of Clinical Endocrinology and Metabolism, 87, pp. 2525-2531. , (doi:10.1210/jc.87.6.2525)
Portella, G., Pacelli, R., Libertini, S., Cella, L., Vecchio, G., Salvatore, M., Fusco, A., ONYX-015 enhances radiation-induced death of human anaplastic thyroid carcinoma cells (2003) Journal of Clinical Endocrinology and Metabolism, 88, pp. 5027-5032. , (doi:10.1210/jc.2003-030385)
Qian, J., Yang, J., Dragovic, A.F., Abu-Isa, E., Lawrence, T.S., Zhang, M., Ionizing radiation-induced adenovirus infection is mediated by Dynamin 2 (2005) Cancer Research, 65, pp. 5493-5497. , (doi:10.1158/0008-5472. CAN-04-4526)
Radhakrishnan, S., Miranda, E., Ekblad, M., Holford, A., Pizarro, M.T., Lemoine, N.R., Hallden, G., Efficacy of oncolytic mutants targeting pRb and p53 pathways is synergistically enhanced when combined with cytotoxic drugs in prostate cancer cells and tumor xenografts (2010) Human Gene Therapy, 21, pp. 1311-1325. , (doi:10.1089/hum.2010.019)
Schweppe, R.E., Klopper, J.P., Korch, C., Pugazhenthi, U., Benezra, M., Knauf, J.A., Fagin, J.A., Smallridge, R.C., Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification (2008) Journal of Clinical Endocrinology and Metabolism, 93, pp. 4331-4341. , (doi:10.1210/jc.2008-1102)
Seidman, M.A., Hogan, S.M., Wendland, R.L., Worgall, S., Crystal, R.G., Leopold, P.L., Variation in adenovirus receptor expression and adenovirus vector-mediated transgene expression at defined stages of the cell cycle (2001) Molecular Therapy, 4, pp. 13-21. , (doi:10.1006/mthe.2001. 0414)
Sherr, C.J., McCormick, F., The RB and p53 pathways in cancer (2002) Cancer Cell, 2, pp. 103-112. , (doi:10.1016/S1535-6108(02) 00102-2)
Smallridge, R.C., Marlow, L.A., Copland, J.A., Anaplastic thyroid cancer: Molecular pathogenesis and emerging therapies (2009) Endocrine-Related Cancer, 16, pp. 17-44. , (doi:10.1677/ERC-08-0154)
Smith, J., Tho, L.M., Xu, N., Gillespie, D.A., The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer (2010) Advances in Cancer Research, 108, pp. 73-112. , (doi:10.1016/B978-0-12-380888-2.00003-0)
Taccaliti, A., Silvetti, F., Palmonella, G., Boscaro, M., Anaplastic thyroid carcinoma (2012) Frontiers InEndocrinology, 384. , (doi:10 3389/fendo.2012.00084)
Tallarida, R.J., Drug synergism: Its detection and applications (2001) Journal of Pharmacological and Experimental Therapeutics, 298, pp. 865-872
Touchefeu, Y., Vassaux, G., Harrington, K.J., Oncolytic viruses in radiation oncology (2011) Radiotherapy and Oncology, 99, pp. 262-270. , (doi:10.1016/j.radonc.2011.05.078)
Vichai, V., Kirtikara, K., Sulforhodamine B colorimetric assay for cytotoxicity screening (2006) Nature Protocols, 1, pp. 1112-1116. , (doi:10.1038/ nprot.2006.179)
Ward, I.M., Chen, J., Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress (2001) Journal of Biological Chemistry, 276, pp. 47759-47762. , (doi:10.1074/jbc. M009785200)
Yong, R.L., Shinojima, N., Fueyo, J., Gumin, J., Vecil, G.G., Marini, F.C., Bogler, O., Lang, F.F., Human bone marrow-derived mesenchymal stem cells for intravascular delivery of oncolytic adenovirus Delta24-RGD to human gliomas (2009) Cancer Research, 69, pp. 8932-8940. , (doi:10.1158/0008-5472.CAN-08-3873)
Zhang, M., Li, S., Li, J., Ensminger, W.D., Lawrence, T.S., Ionizing radiation increases adenovirus uptake and improves transgene expression in intrahepatic colon cancer xenografts (2003) Molecular Therapy, 8, pp. 21-28. , (doi:10.1016/S1525-0016(03) 00143-6)
Abou El Hassan, M. A., Van Der Meulen-Muileman, I., Abbas, S., Kruyt, F. A., Conditionally replicating adenoviruses kill tumor cells via a basic apoptotic machinery-independent mechanism that resembles necrosislike programmed cell death (2004) Journal of Virology, 78, pp. 12243-12251. , (doi: 10. 1128/JVI. 78. 22. 12243-12251. 2004
Baird, S. K., Aerts, J. L., Eddaoudi, A., Lockley, M., Lemoine, N. R., McNeish, I. A., Oncolytic adenoviral mutants induce a novel mode of programmed cell death in ovarian cancer (2008) Oncogene, 27, pp. 3081-3090. , (doi: 10. 1038/sj. onc. 1210977)
Cheong, S. C., Wang, Y., Meng, J. H., Hill, R., Sweeney, K., Kirn, D., Lemoine, N. R., Hallden, G., E1A-expressing adenoviral E3B mutants act synergistically with chemotherapeutics in immunocompetent tumor models (2008) Cancer Gene Therapy, 15, pp. 40-50. , (doi: 10. 1038/sj. cgt. 7701099)
Connell, C. M., Shibata, A., Tookman, L. A., Archibald, K. M., Flak, M. B., Pirlo, K. J., Lockley, M., McNeish, I. A., Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells (2011) Journal of Clinical Investigation, 121, pp. 1283-1297. , (doi: 10. 1172/JCI43976)
Eager, R. M., Nemunaitis, J., Clinical development directions in oncolytic viral therapy (2011) Cancer Gene Therapy, 18, pp. 305-317. , (doi: 10. 1038/ cgt. 2011. 7)
Lamfers, M. L., Grill, J., Dirven, C. M., Van Beusechem, V. W., Geoerger, B., Van Den Berg, J., Alemany, R., Vassal, G., Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy (2002) Cancer Research, 62, pp. 5736-5742
Lavin, M. F., ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks (2007) Oncogene, 26, pp. 7749-7758. , (doi: 10. 1038/sj. onc. 1210880)
Lilley, C. E., Schwartz, R. A., Weitzman, M. D., Using or abusing: Viruses and the cellular DNA damage response (2007) Trends in Microbiology, 15, pp. 119-126. , (doi: 10. 1016/j. tim. 2007. 01. 003)
Lin, S. F., Gao, S. P., Price, D. L., Li, S., Chou, T. C., Singh, P., Huang, Y. Y., Wong, R. J., Synergy of a herpes oncolytic virus and paclitaxel for anaplastic thyroid cancer (2008) Clinical Cancer Research, 14, pp. 1519-1528. , (doi: 10. 1158/1078-0432. CCR-07-4628)
Lin, S. F., Price, D. L., Chen, C. H., Brader, P., Li, S., Gonzalez, L., Zhang, Q., Szalay, A. A., Oncolytic vaccinia virotherapy of anaplastic thyroid cancer in vivo (2008) Journal of Clinical Endocrinology and Metabolism, 93, pp. 4403-4407. , (doi: 10. 1210/jc. 2008-0316)
Nichols, G. J., Schaack, J., Ornelles, D. A., Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication (2009) Journal of Virology, 83, pp. 5987-5998. , (doi: 10. 1128/ JVI. 00091-09)
O'shea, C. C., Johnson, L., Bagus, B., Choi, S., Nicholas, C., Shen, A., Boyle, L., Kunich, J., Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity (2004) Cancer Cell, 6, pp. 611-623. , (doi: 10. 1016/j. ccr. 2004. 11. 012)
Schweppe, R. E., Klopper, J. P., Korch, C., Pugazhenthi, U., Benezra, M., Knauf, J. A., Fagin, J. A., Smallridge, R. C., Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification (2008) Journal of Clinical Endocrinology and Metabolism, 93, pp. 4331-4341. , (doi: 10. 1210/jc. 2008-1102)
Seidman, M. A., Hogan, S. M., Wendland, R. L., Worgall, S., Crystal, R. G., Leopold, P. L., Variation in adenovirus receptor expression and adenovirus vector-mediated transgene expression at defined stages of the cell cycle (2001) Molecular Therapy, 4, pp. 13-21. , (doi: 10. 1006/mthe. 2001. 0414)
Sherr, C. J., McCormick, F., The RB and p53 pathways in cancer (2002) Cancer Cell, 2, pp. 103-112. , (doi: 10. 1016/S1535-6108 (02) 00102-2)
Smallridge, R. C., Marlow, L. A., Copland, J. A., Anaplastic thyroid cancer: Molecular pathogenesis and emerging therapies (2009) Endocrine-Related Cancer, 16, pp. 17-44. , (doi: 10. 1677/ERC-08-0154)
Smith, J., Tho, L. M., Xu, N., Gillespie, D. A., The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer (2010) Advances in Cancer Research, 108, pp. 73-112. , (doi: 10. 1016/B978-0-12-380888-2. 00003-0)
Tallarida, R. J., Drug synergism: Its detection and applications (2001) Journal of Pharmacological and Experimental Therapeutics, 298, pp. 865-872
Ward, I. M., Chen, J., Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress (2001) Journal of Biological Chemistry, 276, pp. 47759-47762. , (doi: 10. 1074/jbc. M009785200)
Yong, R. L., Shinojima, N., Fueyo, J., Gumin, J., Vecil, G. G., Marini, F. C., Bogler, O., Lang, F. F., Human bone marrow-derived mesenchymal stem cells for intravascular delivery of oncolytic adenovirus Delta24-RGD to human gliomas (2009) Cancer Research, 69, pp. 8932-8940. , (doi: 10. 1158/0008-5472. CAN-08-3873)
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2013 Sep 19; 20(5): 633-647.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.907, 5-year impact factor: 5.237
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84886397132&partnerID=40&md5=d0b2ab7e9c5b373123d15f57f0a1b230
Keywords: Anaplastic Thyroid Carcinoma, Dna Damage, Irradiation, Oncolytic Virus, 2 Morpholino 6 (1 Thianthrenyl) 4 Pyranone, Atm Protein, Checkpoint Kinase 1, D 922 947, Gamma Histone H2ax, Mre11 Protein, Nibrin, Oncolytic Adenovirus, Rad50 Protein, Unclassified Drug, Adenovirus Infection, Animal Experiment, Animal Model, Article, Cancer Radiotherapy, Carcinoma Cell, Cell Death, Cell Killing, Controlled Study, Dna Repair, Drug Cytotoxicity, Drug Effect, Drug Efficacy, Histone Phosphorylation, Human, Human Cell, In Vivo Study, Ionizing Radiation, Life Cycle, Mouse, Multimodal Chemotherapy, Nonhuman, Oncolytic Virotherapy, Tumor Xenograft, Virus Entry, Virus Replication,
Affiliations:
*** IBB - CNR ***
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia, Università di Napoli Federico II, via S. Pansini 5, 80131 Napoli, Italy
Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale Delle Ricerche, Napoli, Italy
Dipartimento di Diagnostica per Immagini e Radioterapia, Università Federico II, Napoli, Italy
Barts Cancer Institute, Centre for Molecular Oncology, Queen Mary University of London, London, United Kingdom
Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, United States
References:
Abou El Hassan, M.A., Van Der Meulen-Muileman, I., Abbas, S., Kruyt, F.A., Conditionally replicating adenoviruses kill tumor cells via a basic apoptotic machinery-independent mechanism that resembles necrosislike programmed cell death (2004) Journal of Virology, 78, pp. 12243-12251. , (doi:10.1128/JVI.78.22.12243-12251.2004
Anders, M., Christian, C., McMahon, M., McCormick, F., Korn, W.M., Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells (2003) Cancer Research, 63, pp. 2088-2095
Baird, S.K., Aerts, J.L., Eddaoudi, A., Lockley, M., Lemoine, N.R., McNeish, I.A., Oncolytic adenoviral mutants induce a novel mode of programmed cell death in ovarian cancer (2008) Oncogene, 27, pp. 3081-3090. , (doi:10.1038/sj.onc. 1210977)
Bhattacharyya, M., Francis, J., Eddouadi, A., Lemoine, N.R., Hallden, G., An oncolytic adenovirus defective in pRb-binding (dl922-947) can efficiently eliminate pancreatic cancer cells and tumors in vivo in combination with 5-FU or gemcitabine (2011) Cancer Gene Therapy, 18, pp. 734-743. , (doi:10.1038/cgt.2011.45)
Bieler, A., Mantwill, K., Holzmuller, R., Jurchott, K., Kaszubiak, A., Stark, S., Glockzin, G., Gansbacher, B., Impact of radiation therapy on the oncolytic adenovirus dl520: Implications on the treatment of glioblastoma (2008) Radiotherapy and Oncology, 86, pp. 419-427. , (doi:10.1016/j.radonc.2007.10.009)
Botta, G., Perruolo, G., Libertini, S., Cassese, A., Abagnale, A., Beguinot, F., Formisano, P., Portella, G., PED/PEA-15 modulates coxsackievirusadenovirus receptor expression and adenoviral infectivity via ERK-mediated signals in glioma cells (2010) Human Gene Therapy, 21, pp. 1067-1076. , (doi:10.1089/hum.2009.181)
Botta, G., Passaro, C., Libertini, S., Abagnale, A., Barbato, S., Maione, A.S., Hallden, G., Portella, G., Inhibition of autophagy enhances the effects of E1A-defective oncolytic adenovirus dl922-947 against glioma cells in vitro and in vivo (2012) Human Gene Therapy, 23, pp. 623-634. , (doi:10.1089/hum.2011.120)
Cheong, S.C., Wang, Y., Meng, J.H., Hill, R., Sweeney, K., Kirn, D., Lemoine, N.R., Hallden, G., E1A-expressing adenoviral E3B mutants act synergistically with chemotherapeutics in immunocompetent tumor models (2008) Cancer Gene Therapy, 15, pp. 40-50. , (doi:10.1038/sj.cgt.7701099)
Connell, C.M., Shibata, A., Tookman, L.A., Archibald, K.M., Flak, M.B., Pirlo, K.J., Lockley, M., McNeish, I.A., Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells (2011) Journal of Clinical Investigation, 121, pp. 1283-1297. , (doi:10.1172/JCI43976)
Davy, C., Doorbar, J., G2/M cell cycle arrest in the life cycle of viruses (2007) Virology, 368, pp. 219-226. , (doi:10.1016/j.virol.2007.05.043)
Eager, R.M., Nemunaitis, J., Clinical development directions in oncolytic viral therapy (2011) Cancer Gene Therapy, 18, pp. 305-317. , (doi:10.1038/ cgt.2011.7)
Geoerger, B., Grill, J., Opolon, P., Morizet, J., Aubert, G., Lecluse, Y., Van Beusechem, V.W., Vassal, G., Potentiation of radiation therapy by the oncolytic adenovirus dl1520 (ONYX-015) in human malignant glioma xenografts (2003) British Journal of Cancer, 89, pp. 577-584. , (doi:10.1038/sj.bjc.6601102)
Heise, C., Sampson-Johannes, A., Williams, A., McCormick, F., Von Hoff, D.D., Kirn, D.H., ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents (1997) Nature Medicine, 3, pp. 639-645. , (doi:10.1038/nm0697-639)
Heise, C., Hermiston, T., Johnson, L., Brooks, G., Sampson-Johannes, A., Williams, A., Hawkins, L., Kirn, D., A An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy (2000) Nature Medicine, 6, pp. 1134-1139. , (doi:10.1038/80474)
Heise, C., Lemmon, M., Kirn, D., B Efficacy with a replication-selective adenovirus plus cisplatin-based chemotherapy: Dependence on sequencing but not p53 functional status or route of administration (2000) Clinical Cancer Research, 6, pp. 4908-4914
Hickson, I., Zhao, Y., Richardson, C.J., Green, S.J., Martin, N.M., Orr, A.I., Reaper, P.M., Smith, G.C., Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM (2004) Cancer Research, 64, pp. 9152-9159. , (doi:10.1158/ 0008-5472.CAN-04-2727)
Immonen, A., Vapalahti, M., Tyynela, K., Hurskainen, H., Sandmair, A., Vanninen, R., Langford, G., Yla-Herttuala, S., AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: A randomised, controlled study (2004) Molecular Therapy, 10, pp. 967-972. , (doi:10.1016/j.ymthe.2004.08.002)
Jiang, H., Gomez-Manzano, C., Lang, F.F., Alemany, R., Fueyo, J., Oncolytic adenovirus: Preclinical and clinical studies in patients with human malignant gliomas (2009) Current Gene Therapy, 9, pp. 422-427. , (doi:10.2174/ 156652309789753356)
Kuroda, S., Fujiwara, T., Shirakawa, Y., Yamasaki, Y., Yano, S., Uno, F., Tazawa, H., Noma, K., Telomerase-dependent oncolytic adenovirus sensitizes human cancer cells to ionizing radiation via inhibition of DNA repair machinery (2010) Cancer Research, 70, pp. 9339-9348. , (doi:10.1158/0008-5472.CAN-10-2333)
Lamfers, M.L., Grill, J., Dirven, C.M., Van Beusechem, V.W., Geoerger, B., Van Den Berg, J., Alemany, R., Vassal, G., Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy (2002) Cancer Research, 62, pp. 5736-5742
Lao-Sirieix, P., Brais, R., Lovat, L., Coleman, N., Fitzgerald, R.C., Cell cycle phase abnormalities do not account for disordered proliferation in Barrett's carcinogenesis (2004) Neoplasia, 6, pp. 751-760. , (doi:10.1593/neo.04280)
Lavin, M.F., ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks (2007) Oncogene, 26, pp. 7749-7758. , (doi:10.1038/sj.onc.1210880)
Libertini, S., Iacuzzo, I., Ferraro, A., Vitale, M., Bifulco, M., Fusco, A., Portella, G., Lovastatin enhances the replication of the oncolytic adenovirus dl1520 and its antineoplastic activity against anaplastic thyroid carcinoma cells (2007) Endocrinology, 148, pp. 5186-5194. , (doi:10.1210/ en.2007-0752)
Lilley, C.E., Schwartz, R.A., Weitzman, M.D., Using or abusing: Viruses and the cellular DNA damage response (2007) Trends in Microbiology, 15, pp. 119-126. , (doi:10.1016/j.tim.2007.01.003)
Lin, S.F., Gao, S.P., Price, D.L., Li, S., Chou, T.C., Singh, P., Huang, Y.Y., Wong, R.J., Synergy of a herpes oncolytic virus and paclitaxel for anaplastic thyroid cancer (2008) Clinical Cancer Research, 14, pp. 1519-1528. , (doi:10.1158/1078-0432.CCR-07-4628)
Lin, S.F., Price, D.L., Chen, C.H., Brader, P., Li, S., Gonzalez, L., Zhang, Q., Szalay, A.A., Oncolytic vaccinia virotherapy of anaplastic thyroid cancer in vivo (2008) Journal of Clinical Endocrinology and Metabolism, 93, pp. 4403-4407. , (doi:10.1210/jc.2008-0316)
Lisby, M., Barlow, J.H., Burgess, R.C., Rothstein, R., Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins (2004) Cell, 118, pp. 699-713. , (doi:10.1016/j.cell.2004. 08.015)
Liu, C., Sarkaria, J.N., Petell, C.A., Paraskevakou, G., Zollman, P.J., Schroeder, M., Carlson, B., James, C.D., Combination of measles virus virotherapy and radiation therapy has synergistic activity in the treatment of glioblastoma multiforme (2007) Clinical Cancer Research, 13, pp. 7155-7165. , (doi:10.1158/1078-0432.CCR-07-1306)
Lockley, M., Fernandez, M., Wang, Y., Li, N.F., Conroy, S., Lemoine, N., McNeish, I., Activity of the adenoviral E1A deletion mutant dl922-947 in ovarian cancer: Comparison with E1A wild-type viruses, bioluminescence monitoring, and intraperitoneal delivery in icodextrin (2006) Cancer Research, 66, pp. 989-998. , (doi:10.1158/0008-5472.CAN-05-2691)
Nichols, G.J., Schaack, J., Ornelles, D.A., Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication (2009) Journal of Virology, 83, pp. 5987-5998. , (doi:10.1128/ JVI.00091-09)
Oberg, D., Yanover, E., Adam, V., Sweeney, K., Costas, C., Lemoine, N.R., Hallden, G., Improved potency and selectivity of an oncolytic E1ACR2 and E1B19K deleted adenoviral mutant in prostate and pancreatic cancers (2010) Clinical Cancer Research, 16, pp. 541-553. , (doi:10.1158/ 1078-0432.CCR-09-1960)
O'shea, C.C., Johnson, L., Bagus, B., Choi, S., Nicholas, C., Shen, A., Boyle, L., Kunich, J., Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity (2004) Cancer Cell, 6, pp. 611-623. , (doi:10.1016/j.ccr.2004.11.012)
Portella, G., Scala, S., Vitagliano, D., Vecchio, G., Fusco, A., ONYX-015, an E1B gene-defective adenovirus, induces cell death in human anaplastic thyroid carcinoma cell lines (2002) Journal of Clinical Endocrinology and Metabolism, 87, pp. 2525-2531. , (doi:10.1210/jc.87.6.2525)
Portella, G., Pacelli, R., Libertini, S., Cella, L., Vecchio, G., Salvatore, M., Fusco, A., ONYX-015 enhances radiation-induced death of human anaplastic thyroid carcinoma cells (2003) Journal of Clinical Endocrinology and Metabolism, 88, pp. 5027-5032. , (doi:10.1210/jc.2003-030385)
Qian, J., Yang, J., Dragovic, A.F., Abu-Isa, E., Lawrence, T.S., Zhang, M., Ionizing radiation-induced adenovirus infection is mediated by Dynamin 2 (2005) Cancer Research, 65, pp. 5493-5497. , (doi:10.1158/0008-5472. CAN-04-4526)
Radhakrishnan, S., Miranda, E., Ekblad, M., Holford, A., Pizarro, M.T., Lemoine, N.R., Hallden, G., Efficacy of oncolytic mutants targeting pRb and p53 pathways is synergistically enhanced when combined with cytotoxic drugs in prostate cancer cells and tumor xenografts (2010) Human Gene Therapy, 21, pp. 1311-1325. , (doi:10.1089/hum.2010.019)
Schweppe, R.E., Klopper, J.P., Korch, C., Pugazhenthi, U., Benezra, M., Knauf, J.A., Fagin, J.A., Smallridge, R.C., Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification (2008) Journal of Clinical Endocrinology and Metabolism, 93, pp. 4331-4341. , (doi:10.1210/jc.2008-1102)
Seidman, M.A., Hogan, S.M., Wendland, R.L., Worgall, S., Crystal, R.G., Leopold, P.L., Variation in adenovirus receptor expression and adenovirus vector-mediated transgene expression at defined stages of the cell cycle (2001) Molecular Therapy, 4, pp. 13-21. , (doi:10.1006/mthe.2001. 0414)
Sherr, C.J., McCormick, F., The RB and p53 pathways in cancer (2002) Cancer Cell, 2, pp. 103-112. , (doi:10.1016/S1535-6108(02) 00102-2)
Smallridge, R.C., Marlow, L.A., Copland, J.A., Anaplastic thyroid cancer: Molecular pathogenesis and emerging therapies (2009) Endocrine-Related Cancer, 16, pp. 17-44. , (doi:10.1677/ERC-08-0154)
Smith, J., Tho, L.M., Xu, N., Gillespie, D.A., The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer (2010) Advances in Cancer Research, 108, pp. 73-112. , (doi:10.1016/B978-0-12-380888-2.00003-0)
Taccaliti, A., Silvetti, F., Palmonella, G., Boscaro, M., Anaplastic thyroid carcinoma (2012) Frontiers InEndocrinology, 384. , (doi:10 3389/fendo.2012.00084)
Tallarida, R.J., Drug synergism: Its detection and applications (2001) Journal of Pharmacological and Experimental Therapeutics, 298, pp. 865-872
Touchefeu, Y., Vassaux, G., Harrington, K.J., Oncolytic viruses in radiation oncology (2011) Radiotherapy and Oncology, 99, pp. 262-270. , (doi:10.1016/j.radonc.2011.05.078)
Vichai, V., Kirtikara, K., Sulforhodamine B colorimetric assay for cytotoxicity screening (2006) Nature Protocols, 1, pp. 1112-1116. , (doi:10.1038/ nprot.2006.179)
Ward, I.M., Chen, J., Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress (2001) Journal of Biological Chemistry, 276, pp. 47759-47762. , (doi:10.1074/jbc. M009785200)
Yong, R.L., Shinojima, N., Fueyo, J., Gumin, J., Vecil, G.G., Marini, F.C., Bogler, O., Lang, F.F., Human bone marrow-derived mesenchymal stem cells for intravascular delivery of oncolytic adenovirus Delta24-RGD to human gliomas (2009) Cancer Research, 69, pp. 8932-8940. , (doi:10.1158/0008-5472.CAN-08-3873)
Zhang, M., Li, S., Li, J., Ensminger, W.D., Lawrence, T.S., Ionizing radiation increases adenovirus uptake and improves transgene expression in intrahepatic colon cancer xenografts (2003) Molecular Therapy, 8, pp. 21-28. , (doi:10.1016/S1525-0016(03) 00143-6)
Abou El Hassan, M. A., Van Der Meulen-Muileman, I., Abbas, S., Kruyt, F. A., Conditionally replicating adenoviruses kill tumor cells via a basic apoptotic machinery-independent mechanism that resembles necrosislike programmed cell death (2004) Journal of Virology, 78, pp. 12243-12251. , (doi: 10. 1128/JVI. 78. 22. 12243-12251. 2004
Baird, S. K., Aerts, J. L., Eddaoudi, A., Lockley, M., Lemoine, N. R., McNeish, I. A., Oncolytic adenoviral mutants induce a novel mode of programmed cell death in ovarian cancer (2008) Oncogene, 27, pp. 3081-3090. , (doi: 10. 1038/sj. onc. 1210977)
Cheong, S. C., Wang, Y., Meng, J. H., Hill, R., Sweeney, K., Kirn, D., Lemoine, N. R., Hallden, G., E1A-expressing adenoviral E3B mutants act synergistically with chemotherapeutics in immunocompetent tumor models (2008) Cancer Gene Therapy, 15, pp. 40-50. , (doi: 10. 1038/sj. cgt. 7701099)
Connell, C. M., Shibata, A., Tookman, L. A., Archibald, K. M., Flak, M. B., Pirlo, K. J., Lockley, M., McNeish, I. A., Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells (2011) Journal of Clinical Investigation, 121, pp. 1283-1297. , (doi: 10. 1172/JCI43976)
Eager, R. M., Nemunaitis, J., Clinical development directions in oncolytic viral therapy (2011) Cancer Gene Therapy, 18, pp. 305-317. , (doi: 10. 1038/ cgt. 2011. 7)
Lamfers, M. L., Grill, J., Dirven, C. M., Van Beusechem, V. W., Geoerger, B., Van Den Berg, J., Alemany, R., Vassal, G., Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy (2002) Cancer Research, 62, pp. 5736-5742
Lavin, M. F., ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks (2007) Oncogene, 26, pp. 7749-7758. , (doi: 10. 1038/sj. onc. 1210880)
Lilley, C. E., Schwartz, R. A., Weitzman, M. D., Using or abusing: Viruses and the cellular DNA damage response (2007) Trends in Microbiology, 15, pp. 119-126. , (doi: 10. 1016/j. tim. 2007. 01. 003)
Lin, S. F., Gao, S. P., Price, D. L., Li, S., Chou, T. C., Singh, P., Huang, Y. Y., Wong, R. J., Synergy of a herpes oncolytic virus and paclitaxel for anaplastic thyroid cancer (2008) Clinical Cancer Research, 14, pp. 1519-1528. , (doi: 10. 1158/1078-0432. CCR-07-4628)
Lin, S. F., Price, D. L., Chen, C. H., Brader, P., Li, S., Gonzalez, L., Zhang, Q., Szalay, A. A., Oncolytic vaccinia virotherapy of anaplastic thyroid cancer in vivo (2008) Journal of Clinical Endocrinology and Metabolism, 93, pp. 4403-4407. , (doi: 10. 1210/jc. 2008-0316)
Nichols, G. J., Schaack, J., Ornelles, D. A., Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication (2009) Journal of Virology, 83, pp. 5987-5998. , (doi: 10. 1128/ JVI. 00091-09)
O'shea, C. C., Johnson, L., Bagus, B., Choi, S., Nicholas, C., Shen, A., Boyle, L., Kunich, J., Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity (2004) Cancer Cell, 6, pp. 611-623. , (doi: 10. 1016/j. ccr. 2004. 11. 012)
Schweppe, R. E., Klopper, J. P., Korch, C., Pugazhenthi, U., Benezra, M., Knauf, J. A., Fagin, J. A., Smallridge, R. C., Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification (2008) Journal of Clinical Endocrinology and Metabolism, 93, pp. 4331-4341. , (doi: 10. 1210/jc. 2008-1102)
Seidman, M. A., Hogan, S. M., Wendland, R. L., Worgall, S., Crystal, R. G., Leopold, P. L., Variation in adenovirus receptor expression and adenovirus vector-mediated transgene expression at defined stages of the cell cycle (2001) Molecular Therapy, 4, pp. 13-21. , (doi: 10. 1006/mthe. 2001. 0414)
Sherr, C. J., McCormick, F., The RB and p53 pathways in cancer (2002) Cancer Cell, 2, pp. 103-112. , (doi: 10. 1016/S1535-6108 (02) 00102-2)
Smallridge, R. C., Marlow, L. A., Copland, J. A., Anaplastic thyroid cancer: Molecular pathogenesis and emerging therapies (2009) Endocrine-Related Cancer, 16, pp. 17-44. , (doi: 10. 1677/ERC-08-0154)
Smith, J., Tho, L. M., Xu, N., Gillespie, D. A., The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer (2010) Advances in Cancer Research, 108, pp. 73-112. , (doi: 10. 1016/B978-0-12-380888-2. 00003-0)
Tallarida, R. J., Drug synergism: Its detection and applications (2001) Journal of Pharmacological and Experimental Therapeutics, 298, pp. 865-872
Ward, I. M., Chen, J., Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress (2001) Journal of Biological Chemistry, 276, pp. 47759-47762. , (doi: 10. 1074/jbc. M009785200)
Yong, R. L., Shinojima, N., Fueyo, J., Gumin, J., Vecil, G. G., Marini, F. C., Bogler, O., Lang, F. F., Human bone marrow-derived mesenchymal stem cells for intravascular delivery of oncolytic adenovirus Delta24-RGD to human gliomas (2009) Cancer Research, 69, pp. 8932-8940. , (doi: 10. 1158/0008-5472. CAN-08-3873)
Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells
dl922-947 is an oncolytic adenovirus potentially suitable for the treatment of aggressive localized tumors, such as anaplastic thyroid carcinoma (ATC). In this study, we have analyzed the effects of dl922-947 in combination with ionizing radiations, testing different schedules of administration and observing synergistic effects only when ATC cells were irradiated 24 h prior to viral infection. Cells undergoing combined treatment exhibited a marked increase in cell death and viral replication, suggesting that irradiation blocks cells in a more permissive state for viral life cycle. We also show that dl922-947 triggers a DNA damage response, characterized by mobilization of the MRN complex (composed by Mre11-Rad50-Nbs1), accumulation of gH2AX, and activation of the checkpoint kinases ataxia telangiectasia mutated (ATM) and Chk1. Based on these observations, we speculate that the DNA damage response acts as a cellular protective mechanism to hinder viral infection and replication. To confirm this hypothesis, we demonstrate that the ATM inhibitor KU55933 increased the oncolytic activity of dl922-947 and its replication. Finally, we validate the potential therapeutic use of this approach by showing in vivo that the combined treatment slows tumor xenograft growth more potently than either irradiation or infection alone. © 2013 Society for Endocrinology.
dl922-947 is an oncolytic adenovirus potentially suitable for the treatment of aggressive localized tumors, such as anaplastic thyroid carcinoma (ATC). In this study, we have analyzed the effects of dl922-947 in combination with ionizing radiations, testing different schedules of administration and observing synergistic effects only when ATC cells were irradiated 24 h prior to viral infection. Cells undergoing combined treatment exhibited a marked increase in cell death and viral replication, suggesting that irradiation blocks cells in a more permissive state for viral life cycle. We also show that dl922-947 triggers a DNA damage response, characterized by mobilization of the MRN complex (composed by Mre11-Rad50-Nbs1), accumulation of gH2AX, and activation of the checkpoint kinases ataxia telangiectasia mutated (ATM) and Chk1. Based on these observations, we speculate that the DNA damage response acts as a cellular protective mechanism to hinder viral infection and replication. To confirm this hypothesis, we demonstrate that the ATM inhibitor KU55933 increased the oncolytic activity of dl922-947 and its replication. Finally, we validate the potential therapeutic use of this approach by showing in vivo that the combined treatment slows tumor xenograft growth more potently than either irradiation or infection alone. © 2013 Society for Endocrinology.
Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells
Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells
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Impact Factor: 2.76
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Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G
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Impact Factor: 23.523
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Esposito L, Banyasz A, Douki T, Perron M, Markovitsi D, Improta R
* Effect of C5-methylation of cytosine on the photoreactivity of DNA: A joint experimental and computational study of TCG trinucleotides (363 views)
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Impact Factor: 12.113
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Cefalo G, Massimino M, Ruggiero A, Barone G, Ridola V, Spreafico F, Potepan P, Abate ME, Mascarin M, Garrè ML, Perilongo G, Madon E, Colosimo C, Riccardi R
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Impact Factor: 6.776
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Antoniali G, Lirussi L, D'Ambrosio C, Dal Piaz F, Vascotto C, Casarano E, Marasco D, Scaloni A, Fogolari F, Tell G
* SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements (531 views)
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Impact Factor: 4.466
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Conson M, Cella L, Comerci M, Faiella A, Liuzzi R, Albano A, Salvatore M, Pacelli R, Quarantelli M
* Dti And Attention Function. Dose-Response Evaluation In Partial Brain Irradiation (367 views)
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Impact Factor: 4.363
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Perri F, Dell'Oca I, Muto P, Schiavone C, Aversa C, Fulciniti F, Solla R, Scarpati GD, Buonerba C, Di Lorenzo G, Caponigro F
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World Journal Of Clinical Cases (ISSN: 2307-8960), 2014; 2(7): 297-300.
Impact Factor: 0.895
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Severino V, Alessio N, Farina A, Sandomenico A, Cipollaro M, Peluso G, Galderisi U, Chambery A
* Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells (728 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2013 Nov 7; 4(11): e911-e911.
Impact Factor: 5.177
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
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Impact Factor: 4.906
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Bera S, De Rosa V, Rachidi W, Diamond AM
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Impact Factor: 3.497
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Poletto M, Vascotto C, Scognamiglio PL, Lirussi L, Marasco D, Tell G
* Role Of The Unstructured N-Terminal Domain Of The Human Apurinic/Apyrimidinic Endonuclease 1 (hape1) In The Modulation Of Its Interaction With Nucleic Acids And Nucleophosmin (npm1) (495 views)
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Impact Factor: 4.779
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Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (460 views)
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Impact Factor: 2.464
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Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G
* Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells (675 views)
Mol Biol Cell (ISSN: 1059-1524), 2012 Oct 15; 23(20): 4079-4096.
Impact Factor: 4.803
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Calce E, Bugatti V, Vittoria V, De Luca S
* Solvent-Free Synthesis of Modified Pectin Compounds Promoted by Microwave Irradiation (419 views)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2012 Oct; 17(10): 12234-12242.
Impact Factor: 2.428
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Banyasz A, Douki T, Improta R, Gustavsson T, Onidas D, Vaya I, Perron M, Markovitsi D
* Electronic excited states responsible for dimer formation upon UV absorption directly by thymine strands: Joint experimental and theoretical study (360 views)
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Impact Factor: 10.677
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (932 views)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
* Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (361 views)
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Impact Factor: 3.73
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (3606 views)
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Impact Factor: 3.733
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De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (550 views)
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Impact Factor: 3.279
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Cella L, Liuzzi R, Conson M, Torre G, Caterino M, De Rosa N, Picardi M, Camera L, Solla R, Farella A, Salvatore M, Pacelli R
* Dosimetric predictors of asymptomatic heart valvular dysfunction following mediastinal irradiation for Hodgkin's lymphoma (440 views)
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Impact Factor: 5.58
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Palmieri D, Valentino T, D'Angelo D, De Martino I, Postiglione I, Pacelli R, Croce CM, Fedele M, Fusco A
* HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents (872 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
Impact Factor: 6.373
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Rachidi W, De Rosa V
Selenium protects against the cytotoxic and genotoxic effects of oxidative stress both as an anti-oxidant and by stimulating DNA damage repair (306 views)
Bulletin Du Cancer (ISSN: 0007-4551), 2011 Mar; 98: N/D-N/D.
Impact Factor: 0.672
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Torre G, Conson M, Liuzzi R, Caterino M, De Rosa N, Picardi M, Camera L, Solla R, Farella A, Salvatore M, Pacelli R, Cella L
* Asymptomatic Heart Disease After Mediastinal Irradiation In Hodgkin'S Lymphoma: Preliminary Findings (290 views)
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Impact Factor: 5.58
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Erkekoǧlu P, Rachidi W, De Rosa V, Giray B, Favier A, Hincal F
* Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells (554 views)
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Impact Factor: 5.707
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Gustavsson T, Improta R, Markovitsi D
DNA/RNA: Building blocks of life under UV irradiation (258 views)
J Phys Chem Lett (ISSN: 1948-7185, 1948-7185electronic, 1948-7185linking), 2010 Jul 1; 1(13): 2025-2030.
Impact Factor: 6.687
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Romano S, D'Angelillo A, Pacelli R, Staibano S, De Luna E, Bisogni R, Eskelinen EL, Mascolo M, Calì G, Arra C, Romano M
* Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells (449 views)
Cell Death Differ (ISSN: 1350-9047, 1476-5403electronic, 1350-9047linking), 2010 Jan; 17(1): 145-157.
Impact Factor: 9.05
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Visco AM, Campo N, Vagliasindi LI, Tabbì G
* STUDY OF THE RADICAL SPECIES INDUCED BY ELECTRON-BEAM IRRADIATION IN VACUUM ON BIOMEDICAL UHMWPE (283 views)
International Journal Of Polymer Analysis And Characterization (ISSN: 1023-666x), 2010; 15(7): 424-437.
Impact Factor: 0.814
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Sandomenico A, Monti SM, Sabatella M, De Capua A, Tornatore L, Doti N, Viparelli F, Dathan NA, Pedone C, Ruvo M, Marasco D
* Protein-protein interactions: a simple strategy to identify binding sites and peptide antagonists (573 views)
Chem Biol Drug Des (ISSN: 1747-0285, 1747-0277), 2009 May; 73(5): 483-493.
Impact Factor: 2.473
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Cella L, Ciscognetti N, Martin G, Liuzzi R, Punzo G, Solla R, Farella A, Salvatore M, Pacelli R
* Preoperative Radiation Treatment for Rectal Cancer: Comparison of Target Coverage and Small Bowel NTCP in Conventional vs. 3D-Conformal Planning (487 views)
Med Dosim (ISSN: 0958-3947, 1873-4022), 2009 Mar; 34(1): 75-81.
Impact Factor: 1.256
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (423 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
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Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A
* HMGA1 protein is a novel target of the ATM kinase (482 views)
European Journal Of Cancer (ISSN: 0959-8049), 2008 Nov; 44(17): 2668-2679.
Impact Factor: 4.475
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Tornatore L, Marasco D, Dathan N, Vitale RM, Benedetti E, Papa S, Franzoso G, Ruvo M, Monti SM
* Gadd45 beta forms a homodimeric complex that binds tightly to MKK7 (467 views)
J Mol Biol (ISSN: 0022-2836, 0022-2283, 1089-8638), 2008 Apr 18; 378(1): 97-111.
Impact Factor: 5.673
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Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
* Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (606 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2007 Sep 13; 26(42): 6167-6175.
Impact Factor: 6.44
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Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (489 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jun 29; 282(26): 19029-19041.
Impact Factor: 5.581
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Minopoli G, Stante M, Napolitano F, Telese F, Aloia L, De Felice M, Di Lauro R, Pacelli R, Brunetti A, Zambrano N, Russo T
* Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage (522 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jan 12; 282(2): 831-835.
Impact Factor: 5.581
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Iommelli F, Zannetti A, Pepe S, Sabbatino F, Laus G, Ghidelli L, Solla R, Scala S, Del Vecchio S, Salvatore M, Pacelli R
* Inhibition of NF-kappa B activity potentiates ionizing radiation and cisplatin induced cell killing of anaplastic thyroid carcinoma cells (422 views)
Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 2006 Apr; 47: N/D-N/D.
Impact Factor: 0
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Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U, Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M
* Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy (520 views)
Apoptosis (ISSN: 1360-8185), 2006 Jan; 11(1): 57-66.
Impact Factor: 3.421
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d'Alesio V, Pacelli R, Durante M, Canale Cama G, Cella L, Gialanella G, Grossi G, Pugliese M, Punzo G, Sardi I, Scampoli P, Solla R, Salvatore M
* Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients (343 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003 Nov 1; 57(3): 732-738.
Impact Factor: 4.285
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (467 views)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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Lomax AJ, Cella L, Weber D, Kurtz JM, Miralbell R
* Potential role of IMRT and protons in the treatment of the breast and regional nodes (332 views)
Int J Rad Oncol Biol Phys, 2003 Mar 1; 48(3Supplement): 785-792.
Impact Factor: 0.155
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Lomax AJ, Cella L, Weber D, Kurtz JM, Miralbell R
* Potential role of intensity-modulated photons and protons in the treatment of the breast and regional nodes (371 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003; 55(3): 785-792.
Impact Factor: 4.285
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Tabbì G, Cassino C, Cavigiolio G, Colangelo D, Ghiglia A, Viano I, Osella D
* Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process (642 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2002 Dec 19; 45(26): 5786-5796.
Impact Factor: 4.566
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Monfrecola G, Procaccini EM, D'Onofrio D, Roberti G, Liuzzi R, Staibano S, Manco A, De Rosa G, Santoianni P
* Hyperpigmentation induced by topical 5-aminolaevulinic acid plus visible light (462 views)
J Photochem Photobiol B (ISSN: 1011-1344, 1011-1344print, 1011-1344linking), 2002 Nov; 68(2-3): 147-155.
Impact Factor: 1.573
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Cella L, Lomax A, Miralbell R
* Potential role of intensity modulated proton beams in prostate cancer radiotherapy (324 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2001; 49(1): 217-223.
Impact Factor: 3.327
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Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (406 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
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Durante M, Cella L, Furusawa Y, George K, Gialanella G, Grossi G, Pugliese M, Saito M, Yang TC
The effect of track structure on the induction of chromosomal aberrations in murine cells (737 views)
Int J Radiat Biol International Journal Of Radiation Biology (ISSN: 0955-3002), 1998 Mar; 73(3): 253-262.
Impact Factor: 2.579
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Wink DA, Hanbauer I, Grisham MB, Laval F, Nims RW, Laval J, Cook J, Pacelli R, Liebmann J, Krishna M, Ford PC, Mitchell JB
Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms (691 views)
Current Topics In Cellular Regulation (ISSN: 0070-2137), 1996; 34: 159-187.
Impact Factor: 4.375
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Pacelli R, Wink DA, Cook JA, Krishna MC, DeGraff W, Friedman N, Tsokos M, Samuni A, Mitchell JB
NITRIC-OXIDE POTENTIATES HYDROGEN PEROXIDE-INDUCED KILLING OF ESCHERICHIA-COLI (428 views)
Journal Of Experimental Medicine (ISSN: 0022-1007), 1995 Nov 1; 182(5): 1469-1479.
Impact Factor: 14.384
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Condorelli G, Costanzo LL, De Guidi G, Giuffrida S, Rizzarelli E, Vecchio G
INHIBITION OF PHOTOHEMOLYSIS BY COPPER(II) COMPLEXES WITH SOD-LIKE ACTIVITY (489 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1994 Jun; 54(4): 257-265.
Impact Factor: 1.342
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* Microwave Heating Promotes the S-Alkylation of Aziridine Catalyzed by Molecular Sieves: A Post-Synthetic Approach to Lanthionine-Containing Peptides (23 views)
Molecules (ISSN: 1420-3049linking), 2021 Oct 11; 26(20): 1-9.
Impact Factor: 4.411
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Fasano M, Perri F, Della Corte CM, Di Liello R, Della Vittoria Scarpati G, Cascella M, Ottaiano A, Ciardiello F, Solla R
* Translational Insights and New Therapeutic Perspectives in Head and Neck Tumors (10 views)
Biomedicines (ISSN: 2227-9059linking), 2021 Aug 19; 9(8): N/D-N/D.
Impact Factor: 4.757
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Zeni O, Romeo S, Sannino A, Palumbo R, Scarfì MR
* Evidence of bystander effect induced by radiofrequency radiation in a human neuroblastoma cell line (36 views) (PDF 18 views)
Environ Res (ISSN: 0013-9351linking), 2021 May; 196: 110935-110935.
Impact Factor: 5.715
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Monti S, Paganelli C, Buizza G, Preda L, Valvo F, Baroni G, Palma G, Cella L
* A novel framework for spatial normalization of dose distributions in voxel-based analyses of brain irradiation outcomes (48 views)
Phys Med (ISSN: 1120-1797linking), 2020 Jan; 69: 164-169.
Impact Factor: 2.485
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Esposito MV, Minopoli G, Esposito L, D'Argenio V, Di Maggio F, Sasso E, D'Aiuto M, Zambrano N, Salvatore F
* A Functional Analysis of the Unclassified Pro2767Ser BRCA2 Variant Reveals Its Potential Pathogenicity that Acts by Hampering DNA Binding and Homology-Mediated DNA Repair (142 views)
Cancers (ISSN: 2072-6694linking), 2019 Sep 28; 11(10): N/D-N/D.
Impact Factor: 6.102
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Palma G, Monti S, Conson M, Pacelli R, Cella L
* Normal tissue complication probability (NTCP) models for modern radiation therapy (117 views)
Semin Oncol (ISSN: 0093-7754linking), 2019 Jun; 46(3): 210-218.
Impact Factor: 3.606
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Orlandella FM, Mariniello RM, Iervolino PLC, Auletta L, De Stefano AE, Ugolini C, Greco A, Mirabelli P, Pane K, Franzese M, Denaro M, Basolo F, Salvatore G
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Mol Carcinog (ISSN: 0899-1987linking), 2019 Mar 4; 58(7): 1181-1193.
Impact Factor: 3.851
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Perri F, Della Vittoria Scarpati G, Caponigro F, Ionna F, Longo F, Buonopane S, Muto P, Di Marzo M, Pisconti S, Solla R
* Management of recurrent nasopharyngeal carcinoma: current perspectives (168 views)
Oncotargets Ther (ISSN: 1178-6930linking), 2019 Feb 26; 12: 1583-1591.
Impact Factor: 2.272
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Banyasz A, Martinez-fernandez L, Improta R, Ketola TM, Balty C, Markovitsi D
* Radicals generated in alternating guanine-cytosine duplexes by direct absorption of low-energy UV radiation (286 views)
Phys Chem Chem Phys (ISSN: 1463-9084electronic, 1463-9076linking), 2018 Aug 22; 20(33): 21381-21389.
Impact Factor: 3.454
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Goerke S, Breitling J, Zaiss M, Windschuh J, Kunz P, Schuenke P, Paech D, Longo DL, Klika KD, Ladd ME, Bachert P
* Dual-frequency irradiation CEST-MRI of endogenous bulk mobile proteins (286 views)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2018 Jun; 31(6): e3920-N/D.
Impact Factor: 2.872
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Tommasino F, Durante M, D'Avino V, Liuzzi R, Conson M, Farace P, PalmaG, Schwarz M, Cella L, Pacelli R
* Model-based approach for quantitative estimates of skin, heart, and lung toxicity risk for left-side photon and proton irradiation after breast-conserving surgery (257 views)
Acta Oncol (ISSN: 0284-186x, 0284-186xlinking), 2017 May; 56(5): 730-736.
Impact Factor: 3.473
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Martínez-fernández L, Granucci G, Pollum M, Crespo-hernández CE, Persico M, Corral I
* Decoding the Molecular Basis for the Population Mechanism of the Triplet Phototoxic Precursors in UVA Light-Activated Pyrimidine Anticancer Drugs (363 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(11): 2619-2627.
Impact Factor: 5.16
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Cella L, D'Avino V, Palma G, Conson M, Liuzzi R, Picardi M, Pressello MC, Boboc GI, Battistini R, Donato V, Pacelli R
* Modeling the risk of radiation-induced lung fibrosis: Irradiated heart tissue is as important as irradiated lung (400 views) (PDF 197 views)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 0167-8140linking), 2015 Aug 12; 117(1): 36-43.
Impact Factor: 4.817
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Forestier A, Douki T, De Rosa V, Beal D, Rachidi W
* Combination of Abeta Secretion and Oxidative Stress in an Alzheimer-Like Cell Line Leads to the Over-Expression of the Nucleotide Excision Repair Proteins DDB2 and XPC (353 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015 Jul 30; 16(8): 17422-17444.
Impact Factor: 3.257
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Galdiero E, Maselli V, Falanga A, Gesuele R, Galdiero S, Fulgione D, Guida M
* Integrated analysis of the ecotoxicological and genotoxic effects of the antimicrobial peptide melittin on Daphnia magna and Pseudokirchneriella subcapitata (599 views)
Environ Pollut (ISSN: 0269-7491), 2015; 203: 145-152.
Impact Factor: 4.839
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Morra F, Luise C, Visconti R, Staibano S, Merolla F, Ilardi G, Guggino G, Paladino S, Sarnataro D, Franco R, Monaco R, Zitomarino F, Pacelli R, Monaco G, Rocco G, Cerrato A, Linardopoulos S, Muller MT, Celetti A
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Impact Factor: 5.531
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Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (522 views)
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Impact Factor: 2.76
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Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G
* Cancer-selective targeting of the NF-kappaB survival pathway with GADD45beta/MKK7 inhibitors (623 views)
Cancer Cell (ISSN: 1535-6108), 2014 Oct 13; 26(4): 495-508.
Impact Factor: 23.523
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Esposito L, Banyasz A, Douki T, Perron M, Markovitsi D, Improta R
* Effect of C5-methylation of cytosine on the photoreactivity of DNA: A joint experimental and computational study of TCG trinucleotides (363 views)
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Impact Factor: 12.113
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Cefalo G, Massimino M, Ruggiero A, Barone G, Ridola V, Spreafico F, Potepan P, Abate ME, Mascarin M, Garrè ML, Perilongo G, Madon E, Colosimo C, Riccardi R
* Temozolomide is an active agent in children with recurrent medulloblastoma/primitive neuroectodermal tumor: An Italian multi-institutional phase II trial (365 views)
Neuro-Oncology (ISSN: 1522-8517), 2014 May; 16(5): 748-753.
Impact Factor: 6.776
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Antoniali G, Lirussi L, D'Ambrosio C, Dal Piaz F, Vascotto C, Casarano E, Marasco D, Scaloni A, Fogolari F, Tell G
* SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements (531 views)
Mol Biol Cell (ISSN: 1059-1524), 2014 Feb 15; 25(4): 532-547.
Impact Factor: 4.466
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Conson M, Cella L, Comerci M, Faiella A, Liuzzi R, Albano A, Salvatore M, Pacelli R, Quarantelli M
* Dti And Attention Function. Dose-Response Evaluation In Partial Brain Irradiation (367 views)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 0167-8140linking), 2014; 111: 361-361.
Impact Factor: 4.363
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Perri F, Dell'Oca I, Muto P, Schiavone C, Aversa C, Fulciniti F, Solla R, Scarpati GD, Buonerba C, Di Lorenzo G, Caponigro F
* Optimal management of a patient with recurrent nasopharyngeal carcinoma (302 views)
World Journal Of Clinical Cases (ISSN: 2307-8960), 2014; 2(7): 297-300.
Impact Factor: 0.895
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Severino V, Alessio N, Farina A, Sandomenico A, Cipollaro M, Peluso G, Galderisi U, Chambery A
* Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells (728 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2013 Nov 7; 4(11): e911-e911.
Impact Factor: 5.177
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Bera S, De Rosa V, Rachidi W, Diamond AM
* Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention? (639 views)
Mutagenesismutagenesis (ISSN: 0267-8357, 1464-3804electronic, 0267-8357linking), 2013 Mar; 28(2): 127-134.
Impact Factor: 3.497
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Poletto M, Vascotto C, Scognamiglio PL, Lirussi L, Marasco D, Tell G
* Role Of The Unstructured N-Terminal Domain Of The Human Apurinic/Apyrimidinic Endonuclease 1 (hape1) In The Modulation Of Its Interaction With Nucleic Acids And Nucleophosmin (npm1) (495 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2013; 452(3): 545-557.
Impact Factor: 4.779
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Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (460 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
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Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G
* Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells (675 views)
Mol Biol Cell (ISSN: 1059-1524), 2012 Oct 15; 23(20): 4079-4096.
Impact Factor: 4.803
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Calce E, Bugatti V, Vittoria V, De Luca S
* Solvent-Free Synthesis of Modified Pectin Compounds Promoted by Microwave Irradiation (419 views)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2012 Oct; 17(10): 12234-12242.
Impact Factor: 2.428
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Banyasz A, Douki T, Improta R, Gustavsson T, Onidas D, Vaya I, Perron M, Markovitsi D
* Electronic excited states responsible for dimer formation upon UV absorption directly by thymine strands: Joint experimental and theoretical study (360 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2012 Sep 12; 134(36): 14834-14845.
Impact Factor: 10.677
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (932 views)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
* Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (361 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 24; 7(5): N/D-N/D.
Impact Factor: 3.73
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (3606 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (550 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
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Cella L, Liuzzi R, Conson M, Torre G, Caterino M, De Rosa N, Picardi M, Camera L, Solla R, Farella A, Salvatore M, Pacelli R
* Dosimetric predictors of asymptomatic heart valvular dysfunction following mediastinal irradiation for Hodgkin's lymphoma (440 views)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 1879-0887electronic), 2011 Nov; 101(2): 316-321.
Impact Factor: 5.58
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Palmieri D, Valentino T, D'Angelo D, De Martino I, Postiglione I, Pacelli R, Croce CM, Fedele M, Fusco A
* HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents (872 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
Impact Factor: 6.373
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Rachidi W, De Rosa V
Selenium protects against the cytotoxic and genotoxic effects of oxidative stress both as an anti-oxidant and by stimulating DNA damage repair (306 views)
Bulletin Du Cancer (ISSN: 0007-4551), 2011 Mar; 98: N/D-N/D.
Impact Factor: 0.672
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Torre G, Conson M, Liuzzi R, Caterino M, De Rosa N, Picardi M, Camera L, Solla R, Farella A, Salvatore M, Pacelli R, Cella L
* Asymptomatic Heart Disease After Mediastinal Irradiation In Hodgkin'S Lymphoma: Preliminary Findings (290 views)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 1879-0887electronic), 2011; 99: s424-s424.
Impact Factor: 5.58
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Erkekoǧlu P, Rachidi W, De Rosa V, Giray B, Favier A, Hincal F
* Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells (554 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2010 Aug 15; 49(4): 559-566.
Impact Factor: 5.707
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Gustavsson T, Improta R, Markovitsi D
DNA/RNA: Building blocks of life under UV irradiation (258 views)
J Phys Chem Lett (ISSN: 1948-7185, 1948-7185electronic, 1948-7185linking), 2010 Jul 1; 1(13): 2025-2030.
Impact Factor: 6.687
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Romano S, D'Angelillo A, Pacelli R, Staibano S, De Luna E, Bisogni R, Eskelinen EL, Mascolo M, Calì G, Arra C, Romano M
* Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells (449 views)
Cell Death Differ (ISSN: 1350-9047, 1476-5403electronic, 1350-9047linking), 2010 Jan; 17(1): 145-157.
Impact Factor: 9.05
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Visco AM, Campo N, Vagliasindi LI, Tabbì G
* STUDY OF THE RADICAL SPECIES INDUCED BY ELECTRON-BEAM IRRADIATION IN VACUUM ON BIOMEDICAL UHMWPE (283 views)
International Journal Of Polymer Analysis And Characterization (ISSN: 1023-666x), 2010; 15(7): 424-437.
Impact Factor: 0.814
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Sandomenico A, Monti SM, Sabatella M, De Capua A, Tornatore L, Doti N, Viparelli F, Dathan NA, Pedone C, Ruvo M, Marasco D
* Protein-protein interactions: a simple strategy to identify binding sites and peptide antagonists (573 views)
Chem Biol Drug Des (ISSN: 1747-0285, 1747-0277), 2009 May; 73(5): 483-493.
Impact Factor: 2.473
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Cella L, Ciscognetti N, Martin G, Liuzzi R, Punzo G, Solla R, Farella A, Salvatore M, Pacelli R
* Preoperative Radiation Treatment for Rectal Cancer: Comparison of Target Coverage and Small Bowel NTCP in Conventional vs. 3D-Conformal Planning (487 views)
Med Dosim (ISSN: 0958-3947, 1873-4022), 2009 Mar; 34(1): 75-81.
Impact Factor: 1.256
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (423 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
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Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A
* HMGA1 protein is a novel target of the ATM kinase (482 views)
European Journal Of Cancer (ISSN: 0959-8049), 2008 Nov; 44(17): 2668-2679.
Impact Factor: 4.475
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Tornatore L, Marasco D, Dathan N, Vitale RM, Benedetti E, Papa S, Franzoso G, Ruvo M, Monti SM
* Gadd45 beta forms a homodimeric complex that binds tightly to MKK7 (467 views)
J Mol Biol (ISSN: 0022-2836, 0022-2283, 1089-8638), 2008 Apr 18; 378(1): 97-111.
Impact Factor: 5.673
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Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
* Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (606 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2007 Sep 13; 26(42): 6167-6175.
Impact Factor: 6.44
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Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (489 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jun 29; 282(26): 19029-19041.
Impact Factor: 5.581
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Minopoli G, Stante M, Napolitano F, Telese F, Aloia L, De Felice M, Di Lauro R, Pacelli R, Brunetti A, Zambrano N, Russo T
* Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage (522 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jan 12; 282(2): 831-835.
Impact Factor: 5.581
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Iommelli F, Zannetti A, Pepe S, Sabbatino F, Laus G, Ghidelli L, Solla R, Scala S, Del Vecchio S, Salvatore M, Pacelli R
* Inhibition of NF-kappa B activity potentiates ionizing radiation and cisplatin induced cell killing of anaplastic thyroid carcinoma cells (422 views)
Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 2006 Apr; 47: N/D-N/D.
Impact Factor: 0
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Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U, Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M
* Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy (520 views)
Apoptosis (ISSN: 1360-8185), 2006 Jan; 11(1): 57-66.
Impact Factor: 3.421
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d'Alesio V, Pacelli R, Durante M, Canale Cama G, Cella L, Gialanella G, Grossi G, Pugliese M, Punzo G, Sardi I, Scampoli P, Solla R, Salvatore M
* Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients (343 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003 Nov 1; 57(3): 732-738.
Impact Factor: 4.285
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (467 views)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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Lomax AJ, Cella L, Weber D, Kurtz JM, Miralbell R
* Potential role of IMRT and protons in the treatment of the breast and regional nodes (332 views)
Int J Rad Oncol Biol Phys, 2003 Mar 1; 48(3Supplement): 785-792.
Impact Factor: 0.155
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Lomax AJ, Cella L, Weber D, Kurtz JM, Miralbell R
* Potential role of intensity-modulated photons and protons in the treatment of the breast and regional nodes (371 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003; 55(3): 785-792.
Impact Factor: 4.285
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Tabbì G, Cassino C, Cavigiolio G, Colangelo D, Ghiglia A, Viano I, Osella D
* Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process (642 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2002 Dec 19; 45(26): 5786-5796.
Impact Factor: 4.566
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Monfrecola G, Procaccini EM, D'Onofrio D, Roberti G, Liuzzi R, Staibano S, Manco A, De Rosa G, Santoianni P
* Hyperpigmentation induced by topical 5-aminolaevulinic acid plus visible light (462 views)
J Photochem Photobiol B (ISSN: 1011-1344, 1011-1344print, 1011-1344linking), 2002 Nov; 68(2-3): 147-155.
Impact Factor: 1.573
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Cella L, Lomax A, Miralbell R
* Potential role of intensity modulated proton beams in prostate cancer radiotherapy (324 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2001; 49(1): 217-223.
Impact Factor: 3.327
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Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (406 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
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Durante M, Cella L, Furusawa Y, George K, Gialanella G, Grossi G, Pugliese M, Saito M, Yang TC
The effect of track structure on the induction of chromosomal aberrations in murine cells (737 views)
Int J Radiat Biol International Journal Of Radiation Biology (ISSN: 0955-3002), 1998 Mar; 73(3): 253-262.
Impact Factor: 2.579
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Wink DA, Hanbauer I, Grisham MB, Laval F, Nims RW, Laval J, Cook J, Pacelli R, Liebmann J, Krishna M, Ford PC, Mitchell JB
Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms (691 views)
Current Topics In Cellular Regulation (ISSN: 0070-2137), 1996; 34: 159-187.
Impact Factor: 4.375
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Pacelli R, Wink DA, Cook JA, Krishna MC, DeGraff W, Friedman N, Tsokos M, Samuni A, Mitchell JB
NITRIC-OXIDE POTENTIATES HYDROGEN PEROXIDE-INDUCED KILLING OF ESCHERICHIA-COLI (428 views)
Journal Of Experimental Medicine (ISSN: 0022-1007), 1995 Nov 1; 182(5): 1469-1479.
Impact Factor: 14.384
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Condorelli G, Costanzo LL, De Guidi G, Giuffrida S, Rizzarelli E, Vecchio G
INHIBITION OF PHOTOHEMOLYSIS BY COPPER(II) COMPLEXES WITH SOD-LIKE ACTIVITY (489 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1994 Jun; 54(4): 257-265.
Impact Factor: 1.342
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65 Records (59 excluding Abstracts).
Total impact factor: 299.846 (275.323 excluding Abstracts).
Total 5 year impact factor: 273.863 (250.315 excluding Abstracts).
Total impact factor: 299.846 (275.323 excluding Abstracts).
Total 5 year impact factor: 273.863 (250.315 excluding Abstracts).
444 views. Last view on Saturday 18 March 2023, 9:11:26
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