In vitro and in vivo evaluation of In-111-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging (587 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2004 Mar; 45(3): 485-494.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.362, 5-year impact factor: 6.119
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-2342573596&partnerID=40&md5=6fd6793ee746ca26f3216da8d901940e
Keywords: 111in, Cholecystokinin Receptors, Neuroendocrine Tumors, Peptides, Preclinical Studies, Cholecystokinin Octapeptide, Indium 111, Pentetate Indium In 111, Pentetic Acid, Cholecystokinin B Receptor, Diagnostic Agent, Drug Derivative, Indium Dtpa Glu G Cck8, Indium Dtpa-Glu-G-Cck8, Radiopharmaceutical Agent, Amino Terminal Sequence, Animal Experiment, Animal Model, Article, Controlled Study, Drug Clearance, Drug Distribution, Human, Human Cell, In Vitro Study, In Vivo Study, Incubation Time, Isotope Labeling, Ligand Binding, Mouse, Nonhuman, Priority Journal, Radioactivity, Tumor Xenograft, Cell Strain 3t3, Computer Assisted Emission Tomography, Evaluation, Metabolic Clearance Rate, Methodology, Nude Mouse, Scintiscanning, Squamous Cell Carcinoma, Tissue Distribution, Tumor Cell Line, 3t3 Cells, Sincalide, Emission-Computed,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale Delle Ricerche, Naples, Italy
Dipartimento di Chimica Biologica, Centro Interuniversitario Per la Ricerca Sui Peptidi Bioattivi, Università Federico II, Naples, Italy
Istituto Nazionale Tumori, Fondazione G. Pascale, Naples, Italy
Dipartimento di Scienze Biomorfologiche e Funzionali, Universitá Federico II, Naples, Italy
References:
Behr, T.M., Gotthardt, M., Barth, A., Behe, M., Imaging tumors with peptide-based radioligands (2001) Q J Nucl Med, 45, pp. 189-20
Kwekkeboom, D., Krenning, E.P., de Jong, M., Peptide receptor imaging and therapy (2000) J Nucl Med, 41, pp. 1704-1713
Virgolini, I., Raderer, M., Kurtaran, A., Vasoactive intestinal peptide-receptor imaging for the localization of intestinal adenocarcinomas and endocrine tumors (1994) N Engl J Med, 331, pp. 1116-1121
Reubi, J.C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocr Rev, 24, pp. 389-427
Wank, S.A., G protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: An exemplary family (1998) Am J Physiol, 274, pp. G607-G613
Reubi, J.C., Schaer, J.C., Waser, B., Cholecystokinin(CCK)-A and CCK-B/gastrin receptors in human tumors (1997) Cancer Res, 57, pp. 1377-1386
Behr, T.M., Jenner, N., Radetzky, S., Targeting of cholecystokinin-B/ gastrin receptors in vivo: Preclinical and initial clinical evaluation of the diagnostic and therapeutic potential of radiolabelled gastrin (1998) Eur J Nucl Med, 25, pp. 424-430
Behr, T.M., Behe, M., Angerstein, C., Cholecystokinin-B/gastrin receptor binding peptides: Preclinical development and evaluation of their diagnostic and therapeutic potential (1999) Clin Cancer Res, 5 (SUPPL.), pp. 3124s-3138s
Behe, M., Becker, W., Gotthardt, M., Angerstein, C., Behr, T.M., Improved kinetic stability of DTPA-DGlu as compared with conventional monofunctional DTPA in chelating indium and yttrium: Preclinical and initial clinical evaluation of radiometal labelled minigastrin derivatives (2003) Eur J Nucl Med Mol Imaging, 30, pp. 1140-1146
Reubi, J.C., Waser, B., Schaer, J.C., Unsulfated DTPA- and DOTA-CCK analogs as specific high-affinity ligands for CCK-B receptor-expressing human and rat tissues in vitro and in vivo (1998) Eur J Nucl Med, 25, pp. 481-490
de Jong, M., Bakker, W.H., Bernard, B.F., Preclinical and initial clinical evaluation of 111In-labeled nonsulfated CCK8 analog: A peptide for CCK-B receptor-targeted scintigraphy and radionuclide therapy (1999) J Nucl Med, 40, pp. 2081-2087
Kwekkeboom, D.J., Bakker, W.H., Kooij, P.P., Cholecystokinin receptor imaging using an octapeptide DTPA-CCK analogue in patients with medullary thyroid carcinoma (2000) Eur J Nucl Med, 27, pp. 1312-1317
Gigoux, V., Maigret, B., Escrieut, C., Arginine 197 of the cholecystokinin-A receptor binding site interacts with the sulfate of the peptide agonist cholecystokinin (1999) Protein Sci, 8, pp. 2347-2354
Pellegrini, M., Mierke, D.F., Molecular complex of cholecystokinin-8 and N-terminus of the cholecystokinin A receptor by NMR spectroscopy (1999) Biochemistry, 38, pp. 14775-14783
Giragossian, C., Mierke, D.F., Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin-2 receptor (2002) Biochemistry, 41, pp. 4560-4566
Anelli PL, Fedeli F, Gazzotti O, Lattuada L, Lux G, Rebasti F. L-Glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands. Bioconjug Chem. 1999
10:137-140Ito, M., Iwata, N., Taniguchi, T., Murayama, T., Chihara, K., Matsui, T., Functional characterization of two cholecystokinin-B/gastrin receptor isoforms: A preferential splice donor site in the human receptor gene (1994) Cell Growth Differ, 5, pp. 1127-1135
Giard, D.J., Aaronson, S.A., Todaro, G.J., In vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors (1973) J Natl Cancer Inst, 51, pp. 1417-1423
Fichna, J., Janecka, A., Synthesis of target-specific radiolabeled peptides for diagnostic imaging (2003) Bioconjug Chem, 14, pp. 3-17
Eckelman, W.C., The application of receptor theory to receptor-binding and enzyme-binding oncologic radiopharmaceuticals (1994) Nucl Med Biol, 21, pp. 759-769
Behr, T. M., Gotthardt, M., Barth, A., Behe, M., Imaging tumors with peptide-based radioligands (2001) Q J Nucl Med, 45, pp. 189-20
Reubi, J. C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocr Rev, 24, pp. 389-427
Wank, S. A., G protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: An exemplary family (1998) Am J Physiol, 274, pp. G607-G613
Reubi, J. C., Schaer, J. C., Waser, B., Cholecystokinin (CCK) -A and CCK-B/gastrin receptors in human tumors (1997) Cancer Res, 57, pp. 1377-1386
Behr, T. M., Jenner, N., Radetzky, S., Targeting of cholecystokinin-B/ gastrin receptors in vivo: Preclinical and initial clinical evaluation of the diagnostic and therapeutic potential of radiolabelled gastrin (1998) Eur J Nucl Med, 25, pp. 424-430
Behr, T. M., Behe, M., Angerstein, C., Cholecystokinin-B/gastrin receptor binding peptides: Preclinical development and evaluation of their diagnostic and therapeutic potential (1999) Clin Cancer Res, 5 (SUPPL.), pp. 3124s-3138s
Reubi, J. C., Waser, B., Schaer, J. C., Unsulfated DTPA- and DOTA-CCK analogs as specific high-affinity ligands for CCK-B receptor-expressing human and rat tissues in vitro and in vivo (1998) Eur J Nucl Med, 25, pp. 481-490
Kwekkeboom, D. J., Bakker, W. H., Kooij, P. P., Cholecystokinin receptor imaging using an octapeptide DTPA-CCK analogue in patients with medullary thyroid carcinoma (2000) Eur J Nucl Med, 27, pp. 1312-1317
10: 137-140Ito, M., Iwata, N., Taniguchi, T., Murayama, T., Chihara, K., Matsui, T., Functional characterization of two cholecystokinin-B/gastrin receptor isoforms: A preferential splice donor site in the human receptor gene (1994) Cell Growth Differ, 5, pp. 1127-1135
Giard, D. J., Aaronson, S. A., Todaro, G. J., In vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors (1973) J Natl Cancer Inst, 51, pp. 1417-1423
Eckelman, W. C., The application of receptor theory to receptor-binding and enzyme-binding oncologic radiopharmaceuticals (1994) Nucl Med Biol, 21, pp. 759-769
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2004 Mar; 45(3): 485-494.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.362, 5-year impact factor: 6.119
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-2342573596&partnerID=40&md5=6fd6793ee746ca26f3216da8d901940e
Keywords: 111in, Cholecystokinin Receptors, Neuroendocrine Tumors, Peptides, Preclinical Studies, Cholecystokinin Octapeptide, Indium 111, Pentetate Indium In 111, Pentetic Acid, Cholecystokinin B Receptor, Diagnostic Agent, Drug Derivative, Indium Dtpa Glu G Cck8, Indium Dtpa-Glu-G-Cck8, Radiopharmaceutical Agent, Amino Terminal Sequence, Animal Experiment, Animal Model, Article, Controlled Study, Drug Clearance, Drug Distribution, Human, Human Cell, In Vitro Study, In Vivo Study, Incubation Time, Isotope Labeling, Ligand Binding, Mouse, Nonhuman, Priority Journal, Radioactivity, Tumor Xenograft, Cell Strain 3t3, Computer Assisted Emission Tomography, Evaluation, Metabolic Clearance Rate, Methodology, Nude Mouse, Scintiscanning, Squamous Cell Carcinoma, Tissue Distribution, Tumor Cell Line, 3t3 Cells, Sincalide, Emission-Computed,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale Delle Ricerche, Naples, Italy
Dipartimento di Chimica Biologica, Centro Interuniversitario Per la Ricerca Sui Peptidi Bioattivi, Università Federico II, Naples, Italy
Istituto Nazionale Tumori, Fondazione G. Pascale, Naples, Italy
Dipartimento di Scienze Biomorfologiche e Funzionali, Universitá Federico II, Naples, Italy
References:
Behr, T.M., Gotthardt, M., Barth, A., Behe, M., Imaging tumors with peptide-based radioligands (2001) Q J Nucl Med, 45, pp. 189-20
Kwekkeboom, D., Krenning, E.P., de Jong, M., Peptide receptor imaging and therapy (2000) J Nucl Med, 41, pp. 1704-1713
Virgolini, I., Raderer, M., Kurtaran, A., Vasoactive intestinal peptide-receptor imaging for the localization of intestinal adenocarcinomas and endocrine tumors (1994) N Engl J Med, 331, pp. 1116-1121
Reubi, J.C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocr Rev, 24, pp. 389-427
Wank, S.A., G protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: An exemplary family (1998) Am J Physiol, 274, pp. G607-G613
Reubi, J.C., Schaer, J.C., Waser, B., Cholecystokinin(CCK)-A and CCK-B/gastrin receptors in human tumors (1997) Cancer Res, 57, pp. 1377-1386
Behr, T.M., Jenner, N., Radetzky, S., Targeting of cholecystokinin-B/ gastrin receptors in vivo: Preclinical and initial clinical evaluation of the diagnostic and therapeutic potential of radiolabelled gastrin (1998) Eur J Nucl Med, 25, pp. 424-430
Behr, T.M., Behe, M., Angerstein, C., Cholecystokinin-B/gastrin receptor binding peptides: Preclinical development and evaluation of their diagnostic and therapeutic potential (1999) Clin Cancer Res, 5 (SUPPL.), pp. 3124s-3138s
Behe, M., Becker, W., Gotthardt, M., Angerstein, C., Behr, T.M., Improved kinetic stability of DTPA-DGlu as compared with conventional monofunctional DTPA in chelating indium and yttrium: Preclinical and initial clinical evaluation of radiometal labelled minigastrin derivatives (2003) Eur J Nucl Med Mol Imaging, 30, pp. 1140-1146
Reubi, J.C., Waser, B., Schaer, J.C., Unsulfated DTPA- and DOTA-CCK analogs as specific high-affinity ligands for CCK-B receptor-expressing human and rat tissues in vitro and in vivo (1998) Eur J Nucl Med, 25, pp. 481-490
de Jong, M., Bakker, W.H., Bernard, B.F., Preclinical and initial clinical evaluation of 111In-labeled nonsulfated CCK8 analog: A peptide for CCK-B receptor-targeted scintigraphy and radionuclide therapy (1999) J Nucl Med, 40, pp. 2081-2087
Kwekkeboom, D.J., Bakker, W.H., Kooij, P.P., Cholecystokinin receptor imaging using an octapeptide DTPA-CCK analogue in patients with medullary thyroid carcinoma (2000) Eur J Nucl Med, 27, pp. 1312-1317
Gigoux, V., Maigret, B., Escrieut, C., Arginine 197 of the cholecystokinin-A receptor binding site interacts with the sulfate of the peptide agonist cholecystokinin (1999) Protein Sci, 8, pp. 2347-2354
Pellegrini, M., Mierke, D.F., Molecular complex of cholecystokinin-8 and N-terminus of the cholecystokinin A receptor by NMR spectroscopy (1999) Biochemistry, 38, pp. 14775-14783
Giragossian, C., Mierke, D.F., Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin-2 receptor (2002) Biochemistry, 41, pp. 4560-4566
Anelli PL, Fedeli F, Gazzotti O, Lattuada L, Lux G, Rebasti F. L-Glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands. Bioconjug Chem. 1999
10:137-140Ito, M., Iwata, N., Taniguchi, T., Murayama, T., Chihara, K., Matsui, T., Functional characterization of two cholecystokinin-B/gastrin receptor isoforms: A preferential splice donor site in the human receptor gene (1994) Cell Growth Differ, 5, pp. 1127-1135
Giard, D.J., Aaronson, S.A., Todaro, G.J., In vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors (1973) J Natl Cancer Inst, 51, pp. 1417-1423
Fichna, J., Janecka, A., Synthesis of target-specific radiolabeled peptides for diagnostic imaging (2003) Bioconjug Chem, 14, pp. 3-17
Eckelman, W.C., The application of receptor theory to receptor-binding and enzyme-binding oncologic radiopharmaceuticals (1994) Nucl Med Biol, 21, pp. 759-769
Behr, T. M., Gotthardt, M., Barth, A., Behe, M., Imaging tumors with peptide-based radioligands (2001) Q J Nucl Med, 45, pp. 189-20
Reubi, J. C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocr Rev, 24, pp. 389-427
Wank, S. A., G protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: An exemplary family (1998) Am J Physiol, 274, pp. G607-G613
Reubi, J. C., Schaer, J. C., Waser, B., Cholecystokinin (CCK) -A and CCK-B/gastrin receptors in human tumors (1997) Cancer Res, 57, pp. 1377-1386
Behr, T. M., Jenner, N., Radetzky, S., Targeting of cholecystokinin-B/ gastrin receptors in vivo: Preclinical and initial clinical evaluation of the diagnostic and therapeutic potential of radiolabelled gastrin (1998) Eur J Nucl Med, 25, pp. 424-430
Behr, T. M., Behe, M., Angerstein, C., Cholecystokinin-B/gastrin receptor binding peptides: Preclinical development and evaluation of their diagnostic and therapeutic potential (1999) Clin Cancer Res, 5 (SUPPL.), pp. 3124s-3138s
Reubi, J. C., Waser, B., Schaer, J. C., Unsulfated DTPA- and DOTA-CCK analogs as specific high-affinity ligands for CCK-B receptor-expressing human and rat tissues in vitro and in vivo (1998) Eur J Nucl Med, 25, pp. 481-490
Kwekkeboom, D. J., Bakker, W. H., Kooij, P. P., Cholecystokinin receptor imaging using an octapeptide DTPA-CCK analogue in patients with medullary thyroid carcinoma (2000) Eur J Nucl Med, 27, pp. 1312-1317
10: 137-140Ito, M., Iwata, N., Taniguchi, T., Murayama, T., Chihara, K., Matsui, T., Functional characterization of two cholecystokinin-B/gastrin receptor isoforms: A preferential splice donor site in the human receptor gene (1994) Cell Growth Differ, 5, pp. 1127-1135
Giard, D. J., Aaronson, S. A., Todaro, G. J., In vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors (1973) J Natl Cancer Inst, 51, pp. 1417-1423
Eckelman, W. C., The application of receptor theory to receptor-binding and enzyme-binding oncologic radiopharmaceuticals (1994) Nucl Med Biol, 21, pp. 759-769
In vitro and in vivo evaluation of In-111-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging
UNLABELLED: Regulatory peptides and their analogs are being extensively investigated as radiopharmaceuticals for cancer imaging and therapy. Receptors of the cholecystokinin family have been shown to be overexpressed in different types of neuroendocrine tumors. The purposes of this study were to evaluate the cholecystokinin octapeptide amide (CCK8) peptide tagged with a diethylenetriaminepentaacetic acid derivative (DTPAGlu) and to test whether a (111) In-labeled conjugate ((111) In-DTPAGlu-G-CCK8, a derivative containing the chelating agent DTPAGlu bound through a glycine linker at the N-terminal end of the bioactive peptide CCK8) is suitable for cholecystokinin-B receptor (CCKBR) imaging.; METHODS: CCK8 was synthesized by solid-phase techniques and covalently coupled to DTPAGlu through a glycine linker at its amino terminus. The compound was labeled with (111) In. The radiochemical purity and stability of the compound were assessed by chromatographic methods. NIH-3T3 and A431 cells overexpressing CCKBR were used to characterize the in vitro properties of the compound. Nude mice bearing control and CCKBR-overexpressing A431 xenografts were used as an in vivo model.; RESULTS: DTPAGlu-G-CCK8 showed rapid and efficient labeling with (111) In. The radiolabeled conjugate showed specific binding to both cell lines overexpressing CCKBR. Binding was saturable, with a dissociation constant of approximately 20 nmol/L in both cell systems. Both cell lines showed internalization of the ligand after interaction with the receptor. Biodistribution studies showed rapid localization of (111) In-DTPAGlu-G-CCK8 on CCKBR-overexpressing A431 xenografts that was severalfold higher than that on control tumors at all time points tested. Unbound activity showed rapid clearance of over 80% through the kidneys by 30 min after injection. The labeled peptide conjugate was very stable in serum but showed a rapid breakdown after injection. Incubation with kidney homogenates suggested that most breakdown occurred in the kidneys, favoring the clearance of unbound activity.; CONCLUSION: Our findings indicate that the in vitro and in vivo characteristics of (111) In-DTPAGlu-G-CCK8 are favorable for CCKBR imaging, as the peptide shows high-affinity binding to the receptor, is internalized in CCKBR-expressing cells, and shows avid uptake in CCKBR-overexpressing xenografts, with rapid clearance of unbound radioactivity through the kidneys. Furthermore, the ease of synthesis, high labeling efficiency, and chemical stability of DTPAGlu make this chelating moiety an ideal candidate for widespread use in peptide radiolabeling for nuclear medicine applications
UNLABELLED: Regulatory peptides and their analogs are being extensively investigated as radiopharmaceuticals for cancer imaging and therapy. Receptors of the cholecystokinin family have been shown to be overexpressed in different types of neuroendocrine tumors. The purposes of this study were to evaluate the cholecystokinin octapeptide amide (CCK8) peptide tagged with a diethylenetriaminepentaacetic acid derivative (DTPAGlu) and to test whether a (111) In-labeled conjugate ((111) In-DTPAGlu-G-CCK8, a derivative containing the chelating agent DTPAGlu bound through a glycine linker at the N-terminal end of the bioactive peptide CCK8) is suitable for cholecystokinin-B receptor (CCKBR) imaging.; METHODS: CCK8 was synthesized by solid-phase techniques and covalently coupled to DTPAGlu through a glycine linker at its amino terminus. The compound was labeled with (111) In. The radiochemical purity and stability of the compound were assessed by chromatographic methods. NIH-3T3 and A431 cells overexpressing CCKBR were used to characterize the in vitro properties of the compound. Nude mice bearing control and CCKBR-overexpressing A431 xenografts were used as an in vivo model.; RESULTS: DTPAGlu-G-CCK8 showed rapid and efficient labeling with (111) In. The radiolabeled conjugate showed specific binding to both cell lines overexpressing CCKBR. Binding was saturable, with a dissociation constant of approximately 20 nmol/L in both cell systems. Both cell lines showed internalization of the ligand after interaction with the receptor. Biodistribution studies showed rapid localization of (111) In-DTPAGlu-G-CCK8 on CCKBR-overexpressing A431 xenografts that was severalfold higher than that on control tumors at all time points tested. Unbound activity showed rapid clearance of over 80% through the kidneys by 30 min after injection. The labeled peptide conjugate was very stable in serum but showed a rapid breakdown after injection. Incubation with kidney homogenates suggested that most breakdown occurred in the kidneys, favoring the clearance of unbound activity.; CONCLUSION: Our findings indicate that the in vitro and in vivo characteristics of (111) In-DTPAGlu-G-CCK8 are favorable for CCKBR imaging, as the peptide shows high-affinity binding to the receptor, is internalized in CCKBR-expressing cells, and shows avid uptake in CCKBR-overexpressing xenografts, with rapid clearance of unbound radioactivity through the kidneys. Furthermore, the ease of synthesis, high labeling efficiency, and chemical stability of DTPAGlu make this chelating moiety an ideal candidate for widespread use in peptide radiolabeling for nuclear medicine applications
In vitro and in vivo evaluation of In-111-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging
| ▼ Clinical Oncology |
In vitro and in vivo evaluation of In-111-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging
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Impact Factor: 1.736
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Accardo A, Tesauro D, Del Pozzo L, Mangiapia G, Paduano L, Morelli G
* Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization (410 views)
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Impact Factor: 1.654
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Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (392 views)
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Impact Factor: 3.15
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Pulcrano M, Camera L, Pagano L, Del Vecchio S, Ferone D, Bodei L, Murgia A, Pace L, Storto G, Paganelli G, Colao A, Salvatore M, Lombardi G, Biondi B
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D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (424 views)
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Impact Factor: 2.823
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De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
* Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor (398 views)
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Impact Factor: 2.662
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
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Impact Factor: 4.627
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (606 views)
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Impact Factor: 3.446
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Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (410 views)
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Impact Factor: 1.768
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Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M
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Impact Factor: 0
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De Luca S, Saviano M, Lassiani L, Yannakopoulou K, Stefanidou P, Aloj L, Morelli G, Varnavas A
* Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their "receptor desmodynamic processes" (439 views)
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Impact Factor: 5.115
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De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (371 views)
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Impact Factor: 2.545
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (462 views)
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Impact Factor: 6.903
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Aloj L, Panico M, Caraco C, Del Vecchio S, Arra C, Affuso A, Accardo A, Mansi R, Tesauro D, De Luca S, Pedone C, Visentin R, Mazzi U, Morelli G, Salvatore M
* In vitro and in vivo characterization of Indium-111 and Technetium-99m labeled CCK-8 derivatives for CCK-B receptor imaging (547 views)
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Impact Factor: 1.091
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (472 views)
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Impact Factor: 2.863
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De Luca S, Ragone R, Bracco C, Digilio G, Tesauro D, Saviano M, Pedone C, Morelli G
* The role of segment 32-47 of cholecystokinin receptor type A in CCK8 binding: Synthesis, nuclear magnetic resonance, circular dichroism and fluorescence studies (349 views)
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Impact Factor: 1.377
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Camera L, Del Vecchio S, Quarantelli M, Ibello F, Pellegrino T, Salvatore M
* Radiolabeled somatostatin analogs in the diagnosis and staging of neuroendocrine tumors (329 views)
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Impact Factor: 1.621
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Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (325 views)
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Impact Factor: 1.691
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Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
* Radiolabeling approaches for cholecystokinin B receptor imaging (496 views)
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Impact Factor: 2.372
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De Luca S, Tesauro D, Di Lello P, Fattorusso R, Saviano M, Pedone C, Morelli G
* Synthesis and solution characterization of a porphyrin-CCK8 conjugate (443 views)
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Impact Factor: 1.451
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Ragone R, De Luca S, Tesauro D, Pedone C, Morelli G
Fluorescence studies on the binding between 1-47 fragment of cholecystokinin receptor CCKA-R(1-47) and nonsulfated cholecystokinin octapeptide CCK8 (419 views)
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Impact Factor: 2.405
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Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (317 views)
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Lastoria S, Vergara E, Palmieri G, Acampa W, Varrella P, Caracò C, Bianco RA, Muto P, Salvatore M
In vivo detection of malignant thymic masses by indium-111-DTPA-D- Phe1-octreotide scintigraphy (428 views)
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Impact Factor: 3.064
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Maurea S, Lastoria S, Caracò C, Klain M, Varrella P, Acampa W, Muto P, Salvatore M
The role of radiolabeled somatostatin analogs in adrenal imaging (377 views)
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Impact Factor: 1.042
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Lastoria S, Maurea S, Vergara E, Acampa W, Varrella P, Klain M, Muto P, Bernardy JD, Salvatore M
Comparison of labeled MIBG and somatostatin analogs in imaging neuroendocrine tumors (336 views)
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Impact Factor: 2.125
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* Pancreatic Neuroendocrine Tumors in Patients with Multiple Endocrine Neoplasia Type 1: Diagnostic Value of Different MRI Sequences (19 views)
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Pisciotta P, Cammarata FP, Stefano A, Romano F, Marchese V, Torrisi F, Forte GI, Cella L, Cirrone GAP, Petringa G, Gilardi MC, Cuttone G, Russo G
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Impact Factor: 2.24
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Lastoria S, Marciello F, Faggiano A, Aloj L, Caraco C, Aurilio M, D'Ambrosio L, Di Gennaro F, Ramundo V, Camera L, De LucaL, Fonti R, Napolitano V, Colao A
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Impact Factor: 3.131
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Nardon C, Boscutti G, Dalla Via L, Ringhieri P, Di Noto V, Morelli G, Accardo A, Fregona D
* CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics (470 views)
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Impact Factor: 2.319
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Marcucci G, Cianferotti L, Beck-Peccoz P, Capezzone M, Cetani F, Colao A, Davì MV, Degli Uberti E, Del Prato S, Elisei R, Faggiano A, Ferone D, Foresta C, Fugazzola L, Ghigo E, Giacchetti G, Giorgino F, Lenzi A, Malandrino P, Mannelli M, Marcocci C, Masi L, Pacini F, Opocher G, Radicioni A, Tonacchera M, Vigneri R, Zatelli MC, Brandi ML
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Impact Factor: 1.994
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De Luca S, Fonti R, Palmieri G, Federico P, Del Prete G, Pacelli R, Pace L, De Placido S, Salvatore M, Del Vecchio S
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Impact Factor: 2.857
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
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Impact Factor: 2.768
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Faggiano A, Ramundo V, Del Prete M, Marotta V, Marciello F, Camera L, Napolitano V, de LucaL, Lombardi G, Colao A
* Long-Acting Somatostatin Analogues are Highly Effective in Patients with Early Stage MEN-1-Related Well-Differentiated Neuroendocrine Tumors (223 views)
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Impact Factor: 3.537
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Tornesello AL, Aurilio M, Accardo A, Tarallo L, Barbieri A, Arra C, Tesauro D, Morelli G, Aloj L
* Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison (381 views)
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Impact Factor: 1.799
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Accardo A, Morisco A, Palladino P, Palumbo R, Tesauro D, Morelli G
* Amphiphilic CCK peptides assembled in supramolecular aggregates: Structural investigations and in vitro studies (509 views)
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Impact Factor: 3.534
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (409 views)
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Impact Factor: 0
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
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Impact Factor: 2.87
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Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
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Impact Factor: 6.747
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Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (362 views)
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Impact Factor: 2.02
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (429 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Del Pozzo L, Mangiapia G, Paduano L, Morelli G
* Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization (410 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): 903-910.
Impact Factor: 1.654
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (392 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
View Export to BibTeX Export to EndNote
Pulcrano M, Camera L, Pagano L, Del Vecchio S, Ferone D, Bodei L, Murgia A, Pace L, Storto G, Paganelli G, Colao A, Salvatore M, Lombardi G, Biondi B
* Usefulness of [(111)In-DTPA(0)] octreotide scintigraphy in a family with von Hippel-Lindau disease (360 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2008 Apr; 31(4): 352-359.
Impact Factor: 1.888
View Export to BibTeX Export to EndNote
D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (424 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
Impact Factor: 2.823
View Export to BibTeX Export to EndNote
De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
* Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor (398 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Sep 1; 15(17): 5845-5853.
Impact Factor: 2.662
View Export to BibTeX Export to EndNote
Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
View Export to BibTeX Export to EndNote
Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (606 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
View Export to BibTeX Export to EndNote
Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (410 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2007 Apr; 13(4): 211-219.
Impact Factor: 1.768
View Export to BibTeX Export to EndNote
Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M
* The EEE project (449 views)
Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980.
Impact Factor: 0
View Export to BibTeX Export to EndNote
De Luca S, Saviano M, Lassiani L, Yannakopoulou K, Stefanidou P, Aloj L, Morelli G, Varnavas A
* Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their "receptor desmodynamic processes" (439 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Apr 20; 49(8): 2456-2462.
Impact Factor: 5.115
View Export to BibTeX Export to EndNote
De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (371 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
Impact Factor: 2.545
View Export to BibTeX Export to EndNote
De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (462 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
View Export to BibTeX Export to EndNote
Aloj L, Panico M, Caraco C, Del Vecchio S, Arra C, Affuso A, Accardo A, Mansi R, Tesauro D, De Luca S, Pedone C, Visentin R, Mazzi U, Morelli G, Salvatore M
* In vitro and in vivo characterization of Indium-111 and Technetium-99m labeled CCK-8 derivatives for CCK-B receptor imaging (547 views)
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2004 Feb; 19(1): 93-98.
Impact Factor: 1.091
View Export to BibTeX Export to EndNote
Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (472 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
View Export to BibTeX Export to EndNote
De Luca S, Ragone R, Bracco C, Digilio G, Tesauro D, Saviano M, Pedone C, Morelli G
* The role of segment 32-47 of cholecystokinin receptor type A in CCK8 binding: Synthesis, nuclear magnetic resonance, circular dichroism and fluorescence studies (349 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2003 Mar; 9(3): 156-169.
Impact Factor: 1.377
View Export to BibTeX Export to EndNote
Camera L, Del Vecchio S, Quarantelli M, Ibello F, Pellegrino T, Salvatore M
* Radiolabeled somatostatin analogs in the diagnosis and staging of neuroendocrine tumors (329 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2003; 26(8Suppl): 60-62.
Impact Factor: 1.621
View Export to BibTeX Export to EndNote
Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (325 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2002 Jul; 8(7): 373-381.
Impact Factor: 1.691
View Export to BibTeX Export to EndNote
Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
* Radiolabeling approaches for cholecystokinin B receptor imaging (496 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002; 66(6): 370-380.
Impact Factor: 2.372
View Export to BibTeX Export to EndNote
De Luca S, Tesauro D, Di Lello P, Fattorusso R, Saviano M, Pedone C, Morelli G
* Synthesis and solution characterization of a porphyrin-CCK8 conjugate (443 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2001 Jul; 7(7): 386-394.
Impact Factor: 1.451
View Export to BibTeX Export to EndNote
Ragone R, De Luca S, Tesauro D, Pedone C, Morelli G
Fluorescence studies on the binding between 1-47 fragment of cholecystokinin receptor CCKA-R(1-47) and nonsulfated cholecystokinin octapeptide CCK8 (419 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000; 56(1): 47-53.
Impact Factor: 2.405
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Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
The pituitary uptake of In-111-DTPA-D-Phe(1)-octreotide in the normal pituitary and in pituitary adenomas (397 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 1999 Mar; 22(3): 176-183.
Impact Factor: 0.957
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (317 views)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
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Lastoria S, Vergara E, Palmieri G, Acampa W, Varrella P, Caracò C, Bianco RA, Muto P, Salvatore M
In vivo detection of malignant thymic masses by indium-111-DTPA-D- Phe1-octreotide scintigraphy (428 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 Apr; 39(4): 634-639.
Impact Factor: 3.064
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Maurea S, Lastoria S, Caracò C, Klain M, Varrella P, Acampa W, Muto P, Salvatore M
The role of radiolabeled somatostatin analogs in adrenal imaging (377 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1996 Sep; 23(6): 677-680.
Impact Factor: 1.042
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Lastoria S, Maurea S, Vergara E, Acampa W, Varrella P, Klain M, Muto P, Bernardy JD, Salvatore M
Comparison of labeled MIBG and somatostatin analogs in imaging neuroendocrine tumors (336 views)
Q J Nucl Med (ISSN: 1125-0135, 1124-3937), 1995 Dec; 39(4Suppl1): 145-149.
Impact Factor: 2.125
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41 Records (40 excluding Abstracts).
Total impact factor: 103.16 (99.623 excluding Abstracts).
Total 5 year impact factor: 111.188 (107.56 excluding Abstracts).
Total impact factor: 103.16 (99.623 excluding Abstracts).
Total 5 year impact factor: 111.188 (107.56 excluding Abstracts).
587 views. Last view on Tuesday 28 February 2023, 5:03:38
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