Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II
Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II(585 views) Menchise V, De Simone G, Alterio V, Di Fiore A, Pedone C, Scozzafava A, Supuran CT
Keywords: 1 N (4 Sulfamoylphenylethyl) 2, 6 Trimethylpyridinium Perchlorate, Carbonate Dehydratase Ii, Carbonate Dehydratase Inhibitor, Carbonate Dehydratase Xii, Glutamine, Isoenzyme, Leucine, Phenylalanine, Sulfonamide, Threonine, Unclassified Drug, Valine, Amino Acid Sequence, Antineoplastic Activity, Article, Complex Formation, Crystal Structure, Drug Binding Site, Drug Structure, Hydrophilicity, Hydrophobicity, Protein Expression, Protein Targeting, Structure Analysis, X Ray Crystallography, Antigens, Antineoplastic Agents, Carbonic Anhydrase Ii, Cell Membrane Permeability, X-Ray, Humans, Models, Molecular, Molecular Structure, Protein Binding, Pyridinium Compounds, Quantitative Structure-Activity Relationship, Recombinant Proteins, Tumor Markers, Biological,
Affiliations: *** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone 16, 80134 Naples, Italy
Bioindustry Park del Canavese Spa, Via Ribes 5, 10010 Colleretto Giacosa (Torino), Italy
Dipartimento delle Scienze Biologiche, Sezione Biostrutture, University of Naples Federico II, via Mezzocannone 16, 80134 Naples, Italy
Università degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Via della Lastruccia 3, 50019 Sesto Fiorentino (Florence), Italy
Universit degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Via della Lastruccia 3, 50019 Sesto Fiorentino (Florence), Italy
References: Not available.
Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II
Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II
No results.
Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II