Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography (540 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
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Paper type: Journal Article,
Impact factor: 3.491, 5-year impact factor: 5.331
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0030117317&partnerID=40&md5=92e4db07046714c5293bb03e88e8eceb
Keywords: Folate Binding Protein, Folate Receptor, Gp38, Mov18, Ovarian Carcinoma, Carrier Protein, Cell Surface Receptor, Diagnostic Agent, Folate-Binding Protein, Monoclonal Antibody, Radioactive Iodine, Adult, Article, Autoradiography, Cell Culture, Chemistry, Colloid Carcinoma, Cystadenoma, Enzyme Immunoassay, Female, Human, Methodology, Middle Aged, Ovary Tumor, Adenocarcinoma, Mucinous, Antibodies, Serous, Immunoenzyme Techniques, Iodine Radioisotopes, Ovarian Neoplasms, Tumor Cells,
Affiliations:
Medicina Nucleare, II Facoltá di Medicina, Via S. Pansini, 5, 80131 Naples, Italy
References:
Not available.
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.491, 5-year impact factor: 5.331
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0030117317&partnerID=40&md5=92e4db07046714c5293bb03e88e8eceb
Keywords: Folate Binding Protein, Folate Receptor, Gp38, Mov18, Ovarian Carcinoma, Carrier Protein, Cell Surface Receptor, Diagnostic Agent, Folate-Binding Protein, Monoclonal Antibody, Radioactive Iodine, Adult, Article, Autoradiography, Cell Culture, Chemistry, Colloid Carcinoma, Cystadenoma, Enzyme Immunoassay, Female, Human, Methodology, Middle Aged, Ovary Tumor, Adenocarcinoma, Mucinous, Antibodies, Serous, Immunoenzyme Techniques, Iodine Radioisotopes, Ovarian Neoplasms, Tumor Cells,
Affiliations:
Medicina Nucleare, II Facoltá di Medicina, Via S. Pansini, 5, 80131 Naples, Italy
References:
Not available.
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography
Folate binding protein (FBP) GP38 is a membrane-associated glycoprotein that mediates the intracellular transport of folates. The enhanced expression of FBP in ovarian carcinomas provided a rational basis for clinical studies with specific monoclonal antibodies and some newly synthesized antifolate drugs. Because the outcome of these clinical studies ultimately depends on the degree of FBP expression, we measured the local concentration of FBP using I-125-MOv18 monoclonal antibody and quantitative autoradiography. Methods: Tissue sections from 37 specimens of ovarian carcinoma and 13 nonmalignant ovaries were incubated with increasing concentrations of I-125-MOv18 with and without an excess of unlabeled antibody. Tissue-bound radioactivity was measured by quantitative autoradiography. Results: Folate binding protein was found to be overexpressed in 91% of nonmucinous ovarian carcinomas, with local concentrations ranging between 1.14 and 82.84 pmole/g, Adjacent tumor sections simultaneously studied with I-125-MOv18 and a I-125-labeled folio add derivative showed matching and superimposable regional distributions of bound radioactivity of the two radioligands, indicating that the antigen, specifically recognized by I-125-MOv18 in nonmucinous ovarian carcinomas, is capable of binding folates. Nonmalignant ovaries did not contain measurable amounts of antigen when assayed with (125)MOv18 but showed a limited and specific binding of the I-125-folic acid derivative to tissue sections, The autoradiographic findings were confirmed by testing sections from mixtures of antigen-positive and antigen-negative cells, by immunoperoxidase staining with MOv18 on tumor sections and by biochemical identification of FBP in membrane fractions from tissue samples. Conclusion: Folate binding protein is overexpressed up to 80-90-fold in nonmucinous ovarian carcinomas compared with nonmalignant ovaries. Quantitation of FBP may provide a useful tool in the design of clinical studies with specific monoclonal antibodies and certain antifolate drugs that enter the cell through FBP.
Folate binding protein (FBP) GP38 is a membrane-associated glycoprotein that mediates the intracellular transport of folates. The enhanced expression of FBP in ovarian carcinomas provided a rational basis for clinical studies with specific monoclonal antibodies and some newly synthesized antifolate drugs. Because the outcome of these clinical studies ultimately depends on the degree of FBP expression, we measured the local concentration of FBP using I-125-MOv18 monoclonal antibody and quantitative autoradiography. Methods: Tissue sections from 37 specimens of ovarian carcinoma and 13 nonmalignant ovaries were incubated with increasing concentrations of I-125-MOv18 with and without an excess of unlabeled antibody. Tissue-bound radioactivity was measured by quantitative autoradiography. Results: Folate binding protein was found to be overexpressed in 91% of nonmucinous ovarian carcinomas, with local concentrations ranging between 1.14 and 82.84 pmole/g, Adjacent tumor sections simultaneously studied with I-125-MOv18 and a I-125-labeled folio add derivative showed matching and superimposable regional distributions of bound radioactivity of the two radioligands, indicating that the antigen, specifically recognized by I-125-MOv18 in nonmucinous ovarian carcinomas, is capable of binding folates. Nonmalignant ovaries did not contain measurable amounts of antigen when assayed with (125)MOv18 but showed a limited and specific binding of the I-125-folic acid derivative to tissue sections, The autoradiographic findings were confirmed by testing sections from mixtures of antigen-positive and antigen-negative cells, by immunoperoxidase staining with MOv18 on tumor sections and by biochemical identification of FBP in membrane fractions from tissue samples. Conclusion: Folate binding protein is overexpressed up to 80-90-fold in nonmucinous ovarian carcinomas compared with nonmalignant ovaries. Quantitation of FBP may provide a useful tool in the design of clinical studies with specific monoclonal antibodies and certain antifolate drugs that enter the cell through FBP.
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography
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Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography
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Gallo P, Saviano M, Rossi F, Pavone V, Pedone C, Ragone R, Stiuso P, Colonna G
SPECIFIC INTERACTION BETWEEN CYCLOPHILIN AND CYCLIC-PEPTIDES (523 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995 Sep; 36(3): 273-281.
Impact Factor: 2.425
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Del Vecchio S, Stoppelli MP, Carriere MV, Fonti R, Massa O, Li PY, Botti G, Cerra M, D'Aiuto G, Esposito G, Salvatore M
Human urokinase receptor concentration in malignant and benign breast tumors by in vitro quantitative autoradiography: Comparison with urokinase levels (333 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1993 Jul 1; 53(13): 3198-3206.
Impact Factor: 8.426
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Camera L, Del Vecchio S, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Evaluation of therapeutic response using iodine-131-B72. 3 monoclonal antibody in patients with ovarian carcinoma (593 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991 Apr; 18(4): 269-273.
Impact Factor: 2.692
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25 Records (24 excluding Abstracts).
Total impact factor: 104.396 (99.318 excluding Abstracts).
Total 5 year impact factor: 103.463 (98.385 excluding Abstracts).
Total impact factor: 104.396 (99.318 excluding Abstracts).
Total 5 year impact factor: 103.463 (98.385 excluding Abstracts).
540 views. Last view on Wednesday 18 September 2024, 18:13:32
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