Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography (420 views visite)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 3.491, 5-year impact factor Impact factor a 5 anni: 5.331
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0030117317&partnerID=40&md5=92e4db07046714c5293bb03e88e8eceb
Keywords Parole chiave: Folate Binding Protein, Folate Receptor, Gp38, Mov18, Ovarian Carcinoma, Carrier Protein, Cell Surface Receptor, Diagnostic Agent, Folate-Binding Protein, Monoclonal Antibody, Radioactive Iodine, Adult, Article, Autoradiography, Cell Culture, Chemistry, Colloid Carcinoma, Cystadenoma, Enzyme Immunoassay, Female, Human, Methodology, Middle Aged, Ovary Tumor, Adenocarcinoma, Mucinous, Antibodies, Serous, Immunoenzyme Techniques, Iodine Radioisotopes, Ovarian Neoplasms, Tumor Cells,
Affiliations Affiliazioni:
Medicina Nucleare, II Facoltá di Medicina, Via S. Pansini, 5, 80131 Naples, Italy
References Riferimenti:
Antony, A.C., The biological chemistry of folate receptors (1992) Blood, 79, pp. 2807-282
Kamen, B.A., Wang, M.T., Streckfuss, A.J., Peryea, X., Anderson, R.G.W., Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles (1988) J Biol Chem, 263, pp. 13602-13609
Luhrs, C.A., Slomiany, B.L., A human membrane-associated folate binding protein is anchored by a glycosylphosphatidylinositol tail (1989) J Biol Chem, 264, pp. 21446-21449
Weitman, S.D., Lark, R.H., Coney, L.R., Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues (1992) Cancer Res, 52, pp. 3396-3401
Kamen, B.A., Capdevila, A., Receptor-mediated folate accumulation is regulated by the cellular folate content (1986) Proc Natl Acad Sci USA, 83, pp. 5983-5987
Kane, M.A., Elwood, P.C., Portillo, R.M., Influence of immunoreactive folate-binding proteins of extracellular folate concentration on cultured human cells (1988) J Clin Invest, 81, pp. 1398-1406
Miotti, S., Canevari, S., Menard, S., Characterization of human ovarian carcinoma-associated antigens defined by novel monoclonal antibodies with tumor-restricted specificity (1987) Int J Cancer, 39, pp. 297-303
Coney, L.R., Tomassetti, A., Carayannopoulos, L., Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate binding protein (1991) Cancer Res, 51, pp. 6125-6132
Campbell, I.G., Jones, T.A., Foulkes, W.D., Trowsdale, J., Folate binding protein is a marker for ovarian carcinoma (1991) Cancer Res, 51, pp. 5329-5338
Veggian, R., Fasolato, S., Menard, S., Immunohistochemical reactivity of a monoclonal antibody prepared against human ovarian carcinoma on normal and pathological female genital tissues (1989) Tumori, 75, pp. 510-513
Mamovani, L.T., Miotti, S., Menard, S., Folate binding protein distribution in normal tissues and biological fluids from ovarian carcinoma patients as detected by the monoclonal antibodies MOv18 and MOv19 (1994) Eur J Cancer, 30, pp. 363-369
Weitman, S.D., Weinberg, A.G., Coney, L.R., Zurawski, V.R., Jennings, D.S., Kamen, B.A., Cellular localization of the folate receptor: Potential role in drug toxicity and folate homeostasis (1992) Cancer Res, 52, pp. 6708-6711
Crippa, F., Buraggi, G.L., Di Re, E., Radioimmunoscintigraphy of ovarian cancer with the MOv18 monoclonal antibody (1991) Eur J Cancer, 27, pp. 724-729
Molthoff, C.J.M., Buist, M.R., Kenemans, P., Pinedo, H.M., Boven, E., Experimental and clinical analysis of the characteristics of a chimeric monoclonal antibody, MOv18, reactive with an ovarian cancer-associated antigen (1992) J Nucl Med, 33, pp. 2000-2005
Mezzanzanica, D., Garrido, M.A., Neblock, D.S., Human T-lymphocytes targeted against an established human ovarian carcinoma with a bispecific F(ab')2 antibody prolong host survival in a murine xenograft model (1991) Cancer Res, 51, pp. 5716-5721
Bolhuis, R.L.H., Lamers, C.H.J., Goey, S.H., Adoptive immunotherapy of ovarian carcinoma with BS-MAb-targeted lymphocytes: A multicenter study (1992) Int J Cancer, 7 (SUPPL.), pp. 78-81
Jansen, G., Schornagel, J.H., Westerhof, G.R., Rijksen, G., Newell, D.R., Jackman, A.L., Multiple membrane transport systems for the uptake of folate based thymidylate synthase inhibitors (1990) Cancer Res, 50, pp. 7544-7548
Westerhof, G.R., Jansen, G., Van Emmerik, N., Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells, role of carrier- and receptor-mediated transport systems (1991) Cancer Res, 51, pp. 5507-5513
Calvert, A.H., Newell, D.R., Jackman, A.L., Recent preclinical and clinical studies with the thymidylate synthase inhibitor N10-propargyl-5,8-dideazafolic acid (CB3717) (1987) Natl Cancer Inst Monogr, 5, pp. 213-218
Cantwell, B.M.J., Macaulay, V., Harris, A.L., Phase II study of the antifolate N10-propargyl-5,8-dideazafolic acid (CB3717) in advanced breast cancer (1988) Eur J Cancer Clin Oncol, 24, pp. 733-736
Jackman, A.L., Newell, D.R., Jodrell, D.I., In vitro and in vivo studies with 2-desamino-2-CH3-N10-propargyl-5,8-dideazafolate (ICI 198583), an inhibitor of thymidylate synthase (1989) Chemistry and Biology of Pieridines, pp. 1023-1026. , Curtius HC, Gishla S, Blau N, eds. Berlin: Walter de Gruyter & Co
Young, A.B., Frey, K.A., Agranoff, B.W., Receptor assay: In vitro and in vivo (1986) Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and Heart, pp. 73-111. , Phelps M, Mazziotta J, Schelbert H, eds. New York: Raven Press
Del Vecchio, S., Reynolds, J.C., Blasberg, R.G., Measurement of local Mr 97000 and 250000 protein antigen concentration in sections of human melanoma tumor using in vitro quantitative autoradiography (1988) Cancer Res, 48, pp. 5475-5481
Fraker, P.J., Speck, J.C., Protein and cell membrane iodinations with a sparingly soluble chloramide 1,3,4,6 tetrachloro-3 alpha, 6 alpha-diphenylglycouril (1978) Biochim Biophys Res Commun, 80, pp. 49-857
Bradford, M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding (1976) Anal Biochem, 72, pp. 248-254
Lindmo, T., Boven, E., Cuttitta, F., Fedorko, J., Bunn, P.A., Determination of the immunoreactive fraction of radiolabeled monoclonal antibodies by linear extrapolation to binding at infinite antigen excess (1984) J Immunol Methods, 72, pp. 77-89
Del Vecchio, S., Stoppelli, M.P., Carriero, M.V., Human urokinase receptor concentration in malignant and benign breast tumors by in vitro quantitative autoradiography: Comparison with urokinase levels (1993) Cancer Res, 53, pp. 3198-3206
Hsu, S.M., Raine, L., Fanger, H., Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures (1981) J Histochem Cytochem, 29, pp. 577-580
Silva, C.M., Tully, D.B., Petch, L.A., Jewell, M.C., Cidlowski, J.A., Application of a protein-blotting procedure to the study of human glucocorticoid receptor interactions with DNA (1987) Proc Natl Acad Sci USA, 84, pp. 1744-1748
Sands, H., Jones, P.L., Shah, S.A., Palme, D., Vessella, R.L., Gallagher, B.M., Correlation of vascular permeability and blood flow with monoclonal antibody uptake by human Clouser and renal cell xenografts (1988) Cancer Res, 48, pp. 188-193
Sung, C., Youle, R.J., Dedrick, R.L., Pharmacokinetic analysis of immunotoxin uptake in solid tumors. role of plasma kinetics, capillary permeability, and binding (1990) Cancer Res, 50, pp. 7382-7392
Juweid, M., Neumann, R., Paik, C., Micropharmacology of monoclonal antibodies in solid tumors: Direct experimental evidence for a binding site barrier (1992) Cancer Res, 52, pp. 5144-5153
Shockley, T.R., Lin, K., Sung, C., A quantitative analysis of tumor specific monoclonal antibody uptake by human melanoma xenografts: Effects of antibody immunological properties and tumor antigen expression levels (1992) Cancer Res, 52, pp. 357-366
Ross, J.F., Chaudhuri, P.K., Ratnam, M., Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines (1994) Cancer, 73, pp. 2432-2443
Page, T.S., Owen, W.C., Price, K., Elwood, P.C., Expression of the human placental folate receptor transcripts is regulated in human tissues (1993) J Mol Biol, 229, pp. 1175-1183
Shen, F., Ross, J.F., Wang, X., Ratnam, M., Identification of a novel folate receptor, a truncated receptor, and receptor type β in hematopoietic cells: CDNA cloning, expression, immunoreactivity, and tissue specificity (1994) Biochemistry, 33, pp. 1209-1215
Sadasivan, E., Da Costa, M., Rothenberg, S.P., Brink, L., Purification, properties, and immunological characterization of folate-binding proteins from human leukemia cells (1987) Biochim Biophys Acta, 925, pp. 36-47
Antony, A. C., The biological chemistry of folate receptors (1992) Blood, 79, pp. 2807-282
Kamen, B. A., Wang, M. T., Streckfuss, A. J., Peryea, X., Anderson, R. G. W., Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles (1988) J Biol Chem, 263, pp. 13602-13609
Luhrs, C. A., Slomiany, B. L., A human membrane-associated folate binding protein is anchored by a glycosylphosphatidylinositol tail (1989) J Biol Chem, 264, pp. 21446-21449
Weitman, S. D., Lark, R. H., Coney, L. R., Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues (1992) Cancer Res, 52, pp. 3396-3401
Kamen, B. A., Capdevila, A., Receptor-mediated folate accumulation is regulated by the cellular folate content (1986) Proc Natl Acad Sci USA, 83, pp. 5983-5987
Kane, M. A., Elwood, P. C., Portillo, R. M., Influence of immunoreactive folate-binding proteins of extracellular folate concentration on cultured human cells (1988) J Clin Invest, 81, pp. 1398-1406
Coney, L. R., Tomassetti, A., Carayannopoulos, L., Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate binding protein (1991) Cancer Res, 51, pp. 6125-6132
Campbell, I. G., Jones, T. A., Foulkes, W. D., Trowsdale, J., Folate binding protein is a marker for ovarian carcinoma (1991) Cancer Res, 51, pp. 5329-5338
Mamovani, L. T., Miotti, S., Menard, S., Folate binding protein distribution in normal tissues and biological fluids from ovarian carcinoma patients as detected by the monoclonal antibodies MOv18 and MOv19 (1994) Eur J Cancer, 30, pp. 363-369
Weitman, S. D., Weinberg, A. G., Coney, L. R., Zurawski, V. R., Jennings, D. S., Kamen, B. A., Cellular localization of the folate receptor: Potential role in drug toxicity and folate homeostasis (1992) Cancer Res, 52, pp. 6708-6711
Molthoff, C. J. M., Buist, M. R., Kenemans, P., Pinedo, H. M., Boven, E., Experimental and clinical analysis of the characteristics of a chimeric monoclonal antibody, MOv18, reactive with an ovarian cancer-associated antigen (1992) J Nucl Med, 33, pp. 2000-2005
Bolhuis, R. L. H., Lamers, C. H. J., Goey, S. H., Adoptive immunotherapy of ovarian carcinoma with BS-MAb-targeted lymphocytes: A multicenter study (1992) Int J Cancer, 7 (SUPPL.), pp. 78-81
Westerhof, G. R., Jansen, G., Van Emmerik, N., Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells, role of carrier- and receptor-mediated transport systems (1991) Cancer Res, 51, pp. 5507-5513
Calvert, A. H., Newell, D. R., Jackman, A. L., Recent preclinical and clinical studies with the thymidylate synthase inhibitor N10-propargyl-5, 8-dideazafolic acid (CB3717) (1987) Natl Cancer Inst Monogr, 5, pp. 213-218
Cantwell, B. M. J., Macaulay, V., Harris, A. L., Phase II study of the antifolate N10-propargyl-5, 8-dideazafolic acid (CB3717) in advanced breast cancer (1988) Eur J Cancer Clin Oncol, 24, pp. 733-736
Jackman, A. L., Newell, D. R., Jodrell, D. I., In vitro and in vivo studies with 2-desamino-2-CH3-N10-propargyl-5, 8-dideazafolate (ICI 198583), an inhibitor of thymidylate synthase (1989) Chemistry and Biology of Pieridines, pp. 1023-1026. , Curtius HC, Gishla S, Blau N, eds. Berlin: Walter de Gruyter & Co
Young, A. B., Frey, K. A., Agranoff, B. W., Receptor assay: In vitro and in vivo (1986) Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and Heart, pp. 73-111. , Phelps M, Mazziotta J, Schelbert H, eds. New York: Raven Press
Fraker, P. J., Speck, J. C., Protein and cell membrane iodinations with a sparingly soluble chloramide 1, 3, 4, 6 tetrachloro-3 alpha, 6 alpha-diphenylglycouril (1978) Biochim Biophys Res Commun, 80, pp. 49-857
Hsu, S. M., Raine, L., Fanger, H., Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures (1981) J Histochem Cytochem, 29, pp. 577-580
Silva, C. M., Tully, D. B., Petch, L. A., Jewell, M. C., Cidlowski, J. A., Application of a protein-blotting procedure to the study of human glucocorticoid receptor interactions with DNA (1987) Proc Natl Acad Sci USA, 84, pp. 1744-1748
Sung, C., Youle, R. J., Dedrick, R. L., Pharmacokinetic analysis of immunotoxin uptake in solid tumors. role of plasma kinetics, capillary permeability, and binding (1990) Cancer Res, 50, pp. 7382-7392
Shockley, T. R., Lin, K., Sung, C., A quantitative analysis of tumor specific monoclonal antibody uptake by human melanoma xenografts: Effects of antibody immunological properties and tumor antigen expression levels (1992) Cancer Res, 52, pp. 357-366
Ross, J. F., Chaudhuri, P. K., Ratnam, M., Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines (1994) Cancer, 73, pp. 2432-2443
Page, T. S., Owen, W. C., Price, K., Elwood, P. C., Expression of the human placental folate receptor transcripts is regulated in human tissues (1993) J Mol Biol, 229, pp. 1175-1183
Shen, F., Ross, J. F., Wang, X., Ratnam, M., Identification of a novel folate receptor, a truncated receptor, and receptor type in hematopoietic cells: CDNA cloning, expression, immunoreactivity, and tissue specificity (1994) Biochemistry, 33, pp. 1209-1215
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 3.491, 5-year impact factor Impact factor a 5 anni: 5.331
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0030117317&partnerID=40&md5=92e4db07046714c5293bb03e88e8eceb
Keywords Parole chiave: Folate Binding Protein, Folate Receptor, Gp38, Mov18, Ovarian Carcinoma, Carrier Protein, Cell Surface Receptor, Diagnostic Agent, Folate-Binding Protein, Monoclonal Antibody, Radioactive Iodine, Adult, Article, Autoradiography, Cell Culture, Chemistry, Colloid Carcinoma, Cystadenoma, Enzyme Immunoassay, Female, Human, Methodology, Middle Aged, Ovary Tumor, Adenocarcinoma, Mucinous, Antibodies, Serous, Immunoenzyme Techniques, Iodine Radioisotopes, Ovarian Neoplasms, Tumor Cells,
Affiliations Affiliazioni:
Medicina Nucleare, II Facoltá di Medicina, Via S. Pansini, 5, 80131 Naples, Italy
References Riferimenti:
Antony, A.C., The biological chemistry of folate receptors (1992) Blood, 79, pp. 2807-282
Kamen, B.A., Wang, M.T., Streckfuss, A.J., Peryea, X., Anderson, R.G.W., Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles (1988) J Biol Chem, 263, pp. 13602-13609
Luhrs, C.A., Slomiany, B.L., A human membrane-associated folate binding protein is anchored by a glycosylphosphatidylinositol tail (1989) J Biol Chem, 264, pp. 21446-21449
Weitman, S.D., Lark, R.H., Coney, L.R., Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues (1992) Cancer Res, 52, pp. 3396-3401
Kamen, B.A., Capdevila, A., Receptor-mediated folate accumulation is regulated by the cellular folate content (1986) Proc Natl Acad Sci USA, 83, pp. 5983-5987
Kane, M.A., Elwood, P.C., Portillo, R.M., Influence of immunoreactive folate-binding proteins of extracellular folate concentration on cultured human cells (1988) J Clin Invest, 81, pp. 1398-1406
Miotti, S., Canevari, S., Menard, S., Characterization of human ovarian carcinoma-associated antigens defined by novel monoclonal antibodies with tumor-restricted specificity (1987) Int J Cancer, 39, pp. 297-303
Coney, L.R., Tomassetti, A., Carayannopoulos, L., Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate binding protein (1991) Cancer Res, 51, pp. 6125-6132
Campbell, I.G., Jones, T.A., Foulkes, W.D., Trowsdale, J., Folate binding protein is a marker for ovarian carcinoma (1991) Cancer Res, 51, pp. 5329-5338
Veggian, R., Fasolato, S., Menard, S., Immunohistochemical reactivity of a monoclonal antibody prepared against human ovarian carcinoma on normal and pathological female genital tissues (1989) Tumori, 75, pp. 510-513
Mamovani, L.T., Miotti, S., Menard, S., Folate binding protein distribution in normal tissues and biological fluids from ovarian carcinoma patients as detected by the monoclonal antibodies MOv18 and MOv19 (1994) Eur J Cancer, 30, pp. 363-369
Weitman, S.D., Weinberg, A.G., Coney, L.R., Zurawski, V.R., Jennings, D.S., Kamen, B.A., Cellular localization of the folate receptor: Potential role in drug toxicity and folate homeostasis (1992) Cancer Res, 52, pp. 6708-6711
Crippa, F., Buraggi, G.L., Di Re, E., Radioimmunoscintigraphy of ovarian cancer with the MOv18 monoclonal antibody (1991) Eur J Cancer, 27, pp. 724-729
Molthoff, C.J.M., Buist, M.R., Kenemans, P., Pinedo, H.M., Boven, E., Experimental and clinical analysis of the characteristics of a chimeric monoclonal antibody, MOv18, reactive with an ovarian cancer-associated antigen (1992) J Nucl Med, 33, pp. 2000-2005
Mezzanzanica, D., Garrido, M.A., Neblock, D.S., Human T-lymphocytes targeted against an established human ovarian carcinoma with a bispecific F(ab')2 antibody prolong host survival in a murine xenograft model (1991) Cancer Res, 51, pp. 5716-5721
Bolhuis, R.L.H., Lamers, C.H.J., Goey, S.H., Adoptive immunotherapy of ovarian carcinoma with BS-MAb-targeted lymphocytes: A multicenter study (1992) Int J Cancer, 7 (SUPPL.), pp. 78-81
Jansen, G., Schornagel, J.H., Westerhof, G.R., Rijksen, G., Newell, D.R., Jackman, A.L., Multiple membrane transport systems for the uptake of folate based thymidylate synthase inhibitors (1990) Cancer Res, 50, pp. 7544-7548
Westerhof, G.R., Jansen, G., Van Emmerik, N., Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells, role of carrier- and receptor-mediated transport systems (1991) Cancer Res, 51, pp. 5507-5513
Calvert, A.H., Newell, D.R., Jackman, A.L., Recent preclinical and clinical studies with the thymidylate synthase inhibitor N10-propargyl-5,8-dideazafolic acid (CB3717) (1987) Natl Cancer Inst Monogr, 5, pp. 213-218
Cantwell, B.M.J., Macaulay, V., Harris, A.L., Phase II study of the antifolate N10-propargyl-5,8-dideazafolic acid (CB3717) in advanced breast cancer (1988) Eur J Cancer Clin Oncol, 24, pp. 733-736
Jackman, A.L., Newell, D.R., Jodrell, D.I., In vitro and in vivo studies with 2-desamino-2-CH3-N10-propargyl-5,8-dideazafolate (ICI 198583), an inhibitor of thymidylate synthase (1989) Chemistry and Biology of Pieridines, pp. 1023-1026. , Curtius HC, Gishla S, Blau N, eds. Berlin: Walter de Gruyter & Co
Young, A.B., Frey, K.A., Agranoff, B.W., Receptor assay: In vitro and in vivo (1986) Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and Heart, pp. 73-111. , Phelps M, Mazziotta J, Schelbert H, eds. New York: Raven Press
Del Vecchio, S., Reynolds, J.C., Blasberg, R.G., Measurement of local Mr 97000 and 250000 protein antigen concentration in sections of human melanoma tumor using in vitro quantitative autoradiography (1988) Cancer Res, 48, pp. 5475-5481
Fraker, P.J., Speck, J.C., Protein and cell membrane iodinations with a sparingly soluble chloramide 1,3,4,6 tetrachloro-3 alpha, 6 alpha-diphenylglycouril (1978) Biochim Biophys Res Commun, 80, pp. 49-857
Bradford, M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding (1976) Anal Biochem, 72, pp. 248-254
Lindmo, T., Boven, E., Cuttitta, F., Fedorko, J., Bunn, P.A., Determination of the immunoreactive fraction of radiolabeled monoclonal antibodies by linear extrapolation to binding at infinite antigen excess (1984) J Immunol Methods, 72, pp. 77-89
Del Vecchio, S., Stoppelli, M.P., Carriero, M.V., Human urokinase receptor concentration in malignant and benign breast tumors by in vitro quantitative autoradiography: Comparison with urokinase levels (1993) Cancer Res, 53, pp. 3198-3206
Hsu, S.M., Raine, L., Fanger, H., Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures (1981) J Histochem Cytochem, 29, pp. 577-580
Silva, C.M., Tully, D.B., Petch, L.A., Jewell, M.C., Cidlowski, J.A., Application of a protein-blotting procedure to the study of human glucocorticoid receptor interactions with DNA (1987) Proc Natl Acad Sci USA, 84, pp. 1744-1748
Sands, H., Jones, P.L., Shah, S.A., Palme, D., Vessella, R.L., Gallagher, B.M., Correlation of vascular permeability and blood flow with monoclonal antibody uptake by human Clouser and renal cell xenografts (1988) Cancer Res, 48, pp. 188-193
Sung, C., Youle, R.J., Dedrick, R.L., Pharmacokinetic analysis of immunotoxin uptake in solid tumors. role of plasma kinetics, capillary permeability, and binding (1990) Cancer Res, 50, pp. 7382-7392
Juweid, M., Neumann, R., Paik, C., Micropharmacology of monoclonal antibodies in solid tumors: Direct experimental evidence for a binding site barrier (1992) Cancer Res, 52, pp. 5144-5153
Shockley, T.R., Lin, K., Sung, C., A quantitative analysis of tumor specific monoclonal antibody uptake by human melanoma xenografts: Effects of antibody immunological properties and tumor antigen expression levels (1992) Cancer Res, 52, pp. 357-366
Ross, J.F., Chaudhuri, P.K., Ratnam, M., Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines (1994) Cancer, 73, pp. 2432-2443
Page, T.S., Owen, W.C., Price, K., Elwood, P.C., Expression of the human placental folate receptor transcripts is regulated in human tissues (1993) J Mol Biol, 229, pp. 1175-1183
Shen, F., Ross, J.F., Wang, X., Ratnam, M., Identification of a novel folate receptor, a truncated receptor, and receptor type β in hematopoietic cells: CDNA cloning, expression, immunoreactivity, and tissue specificity (1994) Biochemistry, 33, pp. 1209-1215
Sadasivan, E., Da Costa, M., Rothenberg, S.P., Brink, L., Purification, properties, and immunological characterization of folate-binding proteins from human leukemia cells (1987) Biochim Biophys Acta, 925, pp. 36-47
Antony, A. C., The biological chemistry of folate receptors (1992) Blood, 79, pp. 2807-282
Kamen, B. A., Wang, M. T., Streckfuss, A. J., Peryea, X., Anderson, R. G. W., Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles (1988) J Biol Chem, 263, pp. 13602-13609
Luhrs, C. A., Slomiany, B. L., A human membrane-associated folate binding protein is anchored by a glycosylphosphatidylinositol tail (1989) J Biol Chem, 264, pp. 21446-21449
Weitman, S. D., Lark, R. H., Coney, L. R., Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues (1992) Cancer Res, 52, pp. 3396-3401
Kamen, B. A., Capdevila, A., Receptor-mediated folate accumulation is regulated by the cellular folate content (1986) Proc Natl Acad Sci USA, 83, pp. 5983-5987
Kane, M. A., Elwood, P. C., Portillo, R. M., Influence of immunoreactive folate-binding proteins of extracellular folate concentration on cultured human cells (1988) J Clin Invest, 81, pp. 1398-1406
Coney, L. R., Tomassetti, A., Carayannopoulos, L., Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate binding protein (1991) Cancer Res, 51, pp. 6125-6132
Campbell, I. G., Jones, T. A., Foulkes, W. D., Trowsdale, J., Folate binding protein is a marker for ovarian carcinoma (1991) Cancer Res, 51, pp. 5329-5338
Mamovani, L. T., Miotti, S., Menard, S., Folate binding protein distribution in normal tissues and biological fluids from ovarian carcinoma patients as detected by the monoclonal antibodies MOv18 and MOv19 (1994) Eur J Cancer, 30, pp. 363-369
Weitman, S. D., Weinberg, A. G., Coney, L. R., Zurawski, V. R., Jennings, D. S., Kamen, B. A., Cellular localization of the folate receptor: Potential role in drug toxicity and folate homeostasis (1992) Cancer Res, 52, pp. 6708-6711
Molthoff, C. J. M., Buist, M. R., Kenemans, P., Pinedo, H. M., Boven, E., Experimental and clinical analysis of the characteristics of a chimeric monoclonal antibody, MOv18, reactive with an ovarian cancer-associated antigen (1992) J Nucl Med, 33, pp. 2000-2005
Bolhuis, R. L. H., Lamers, C. H. J., Goey, S. H., Adoptive immunotherapy of ovarian carcinoma with BS-MAb-targeted lymphocytes: A multicenter study (1992) Int J Cancer, 7 (SUPPL.), pp. 78-81
Westerhof, G. R., Jansen, G., Van Emmerik, N., Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells, role of carrier- and receptor-mediated transport systems (1991) Cancer Res, 51, pp. 5507-5513
Calvert, A. H., Newell, D. R., Jackman, A. L., Recent preclinical and clinical studies with the thymidylate synthase inhibitor N10-propargyl-5, 8-dideazafolic acid (CB3717) (1987) Natl Cancer Inst Monogr, 5, pp. 213-218
Cantwell, B. M. J., Macaulay, V., Harris, A. L., Phase II study of the antifolate N10-propargyl-5, 8-dideazafolic acid (CB3717) in advanced breast cancer (1988) Eur J Cancer Clin Oncol, 24, pp. 733-736
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Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography
Folate binding protein (FBP) GP38 is a membrane-associated glycoprotein that mediates the intracellular transport of folates. The enhanced expression of FBP in ovarian carcinomas provided a rational basis for clinical studies with specific monoclonal antibodies and some newly synthesized antifolate drugs. Because the outcome of these clinical studies ultimately depends on the degree of FBP expression, we measured the local concentration of FBP using I-125-MOv18 monoclonal antibody and quantitative autoradiography. Methods: Tissue sections from 37 specimens of ovarian carcinoma and 13 nonmalignant ovaries were incubated with increasing concentrations of I-125-MOv18 with and without an excess of unlabeled antibody. Tissue-bound radioactivity was measured by quantitative autoradiography. Results: Folate binding protein was found to be overexpressed in 91% of nonmucinous ovarian carcinomas, with local concentrations ranging between 1.14 and 82.84 pmole/g, Adjacent tumor sections simultaneously studied with I-125-MOv18 and a I-125-labeled folio add derivative showed matching and superimposable regional distributions of bound radioactivity of the two radioligands, indicating that the antigen, specifically recognized by I-125-MOv18 in nonmucinous ovarian carcinomas, is capable of binding folates. Nonmalignant ovaries did not contain measurable amounts of antigen when assayed with (125)MOv18 but showed a limited and specific binding of the I-125-folic acid derivative to tissue sections, The autoradiographic findings were confirmed by testing sections from mixtures of antigen-positive and antigen-negative cells, by immunoperoxidase staining with MOv18 on tumor sections and by biochemical identification of FBP in membrane fractions from tissue samples. Conclusion: Folate binding protein is overexpressed up to 80-90-fold in nonmucinous ovarian carcinomas compared with nonmalignant ovaries. Quantitation of FBP may provide a useful tool in the design of clinical studies with specific monoclonal antibodies and certain antifolate drugs that enter the cell through FBP.
Folate binding protein (FBP) GP38 is a membrane-associated glycoprotein that mediates the intracellular transport of folates. The enhanced expression of FBP in ovarian carcinomas provided a rational basis for clinical studies with specific monoclonal antibodies and some newly synthesized antifolate drugs. Because the outcome of these clinical studies ultimately depends on the degree of FBP expression, we measured the local concentration of FBP using I-125-MOv18 monoclonal antibody and quantitative autoradiography. Methods: Tissue sections from 37 specimens of ovarian carcinoma and 13 nonmalignant ovaries were incubated with increasing concentrations of I-125-MOv18 with and without an excess of unlabeled antibody. Tissue-bound radioactivity was measured by quantitative autoradiography. Results: Folate binding protein was found to be overexpressed in 91% of nonmucinous ovarian carcinomas, with local concentrations ranging between 1.14 and 82.84 pmole/g, Adjacent tumor sections simultaneously studied with I-125-MOv18 and a I-125-labeled folio add derivative showed matching and superimposable regional distributions of bound radioactivity of the two radioligands, indicating that the antigen, specifically recognized by I-125-MOv18 in nonmucinous ovarian carcinomas, is capable of binding folates. Nonmalignant ovaries did not contain measurable amounts of antigen when assayed with (125)MOv18 but showed a limited and specific binding of the I-125-folic acid derivative to tissue sections, The autoradiographic findings were confirmed by testing sections from mixtures of antigen-positive and antigen-negative cells, by immunoperoxidase staining with MOv18 on tumor sections and by biochemical identification of FBP in membrane fractions from tissue samples. Conclusion: Folate binding protein is overexpressed up to 80-90-fold in nonmucinous ovarian carcinomas compared with nonmalignant ovaries. Quantitation of FBP may provide a useful tool in the design of clinical studies with specific monoclonal antibodies and certain antifolate drugs that enter the cell through FBP.
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography
No results. Nessun risultato. |
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography
Smaldone G, Balasco N, Vigorita M, Ruggiero A, Cozzolino S, Berisio R, Del Vecchio P, Graziano G, Vitagliano L
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Human urokinase receptor concentration in malignant and benign breast tumors by in vitro quantitative autoradiography: Comparison with urokinase levels (248 visite)
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Smaldone G, Balasco N, Vigorita M, Ruggiero A, Cozzolino S, Berisio R, Del Vecchio P, Graziano G, Vitagliano L
* Domain communication in Thermotoga maritima Arginine Binding Protein unraveled through protein dissection (191 visite)
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Impact Factor: 3.909
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Venuta A, Moret F, Dal Poggetto G, Esposito D, Fraix A, Avitabile C, Ungaro F, Malinconico M, Sortino S, Romanelli A, Laurienzo P, Reddi E, Quaglia F
* Shedding light on surface exposition of poly(ethylene glycol) and folate targeting units on nanoparticles of poly(ε-caprolactone) diblock copolymers: Beyond a paradigm (311 visite)
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Impact Factor: 0
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Sacchi S, Cappelletti P, Pirone L, Smaldone G, Pedone E, Pollegioni L
* Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility (248 visite)
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Impact Factor: 2.999
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Smaldone G, Vigorita M, Ruggiero A, Balasco N, Dattelbaum JD, D'Auria S, Del Vecchio P, Graziano G, Vitagliano L
* Proline 235 plays a key role in the regulation of the oligomeric states of Thermotoga maritima Arginine Binding Protein (275 visite)
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Impact Factor: 4.932
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Impact Factor: 4.249
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Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
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Impact Factor: 8.535
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Ruggiero A, Dattelbaum JD, Pennacchio A, Iozzino L, Staiano M, Luchansky MS, Der BS, Berisio R, D'Auria S, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of ligand-free and arginine-bound forms of Thermotoga maritima arginine-binding protein (342 visite)
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Impact Factor: 0.506
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Janda E, Palmieri C, Pisano A, Pontoriero M, Iaccino E, Falcone C, Fiume G, Gaspari M, Nevolo M, Di Salle E, Rossi A, De Laurentiis A, Greco A, Di Napoli D, Verheij E, Britti D, Lavecchia L, Quinto I, Scala G
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Impact Factor: 9.898
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Gulyas B, Vas A, Toth M, Takano A, Varrone A, Cselenyi Z, Schain M, Mattsson P, Halldin C
* Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine (541 visite)
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Impact Factor: 5.895
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Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
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Galdiero S, Galdiero M, Pedone C
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Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (529 visite)
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Clin Pharmacol Ther Clinical Pharmacology And Therapeutics (ISSN: 0009-9236), 2006; 80(6): 633-645.
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Tauchmanovà L, Pensabene M, Capuano I, Spagnoletti I, Zeppa P, Del Vecchio S, Mainenti PP, De Rosa G, Colao A, Contegiacomo A
* Poorly differentiated small cell neuroendocrine carcinoma localized in three different endocrine glands: Response to chemotherapy and octreotide LAR (312 visite)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2005 Apr; 28(4): 371-378.
Impact Factor: 1.496
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (426 visite)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
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Berisio R, Vitagliano L, Mazzarella L, Zagari A
Crystal Structure Of A Collagen-Like Polypeptide With Repeating Sequence Pro-Hyp-Gly At 1. 4 Ang Resolution: Implications For Collagen Hydration (396 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000; 56(1): 8-13.
Impact Factor: 2.405
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Gallo P, Saviano M, Rossi F, Pavone V, Pedone C, Ragone R, Stiuso P, Colonna G
SPECIFIC INTERACTION BETWEEN CYCLOPHILIN AND CYCLIC-PEPTIDES (448 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995 Sep; 36(3): 273-281.
Impact Factor: 2.425
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Del Vecchio S, Stoppelli MP, Carriere MV, Fonti R, Massa O, Li PY, Botti G, Cerra M, D'Aiuto G, Esposito G, Salvatore M
Human urokinase receptor concentration in malignant and benign breast tumors by in vitro quantitative autoradiography: Comparison with urokinase levels (248 visite)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1993 Jul 1; 53(13): 3198-3206.
Impact Factor: 8.426
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Camera L, Del Vecchio S, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Evaluation of therapeutic response using iodine-131-B72. 3 monoclonal antibody in patients with ovarian carcinoma (431 visite)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991 Apr; 18(4): 269-273.
Impact Factor: 2.692
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24 Records (23 escludendo Abstract e Conferenze).
Impact factor totale: 104.396 (99.318 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 103.463 (98.385 escludendo Abstract e Conferenze).
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